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Finn KM, Sutphin PD, Carlson JCT, Raskin KA, Van Cott EM

Case 17-2021: An 82-Year-Old Woman with Pain, Swelling, and Ecchymosis of the Left Arm.
N Engl J Med. 2021;384(23):2242-2250 - PMID: 34107184 - DOI: 10.1056/NEJMcpc2100281

Choi S, Zhang B, Ma S, Gonzalez-Celeiro M, Stein D, Jin X, Kim ST, Kang YL, Besnard A, Rezza A, Grisanti L, Buenrostro JD, Rendl M, Nahrendorf M, Sahay A, Hsu YC

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Nature. 2021;592(7854):428-432 - PMID: 33790465 - PMCID: PMC8923613 - DOI: 10.1038/s41586-021-03417-2

Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT, Bernstein BE

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Nature. 2021;595(7866):309-314 - PMID: 33953401 - PMCID: PMC9166167 - DOI: 10.1038/s41586-021-03520-4

McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6

Naxerova K

Mutation fingerprints encode cellular histories.
Nature. 2021;597(7876):334-336 - PMID: 34433973 - DOI: 10.1038/d41586-021-02269-0

Heyde A, Rohde D, McAlpine CS, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Muñoz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Cell. 2021;184(5):1348-1361.e22 - PMID: 33636128 - PMCID: PMC8109274 - DOI: 10.1016/j.cell.2021.01.049

Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
Cell. 2021;184(9):2503-2519.e17 - PMID: 33838111 - PMCID: PMC8376083 - DOI: 10.1016/j.cell.2021.03.025

Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, Li A, Jaeger AM, Hwang WL, Westcott PMK, Manos MP, Holovatska MM, Hodi FS, Regev A, Santagata S, Jacks T

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Cell. 2021;184(19):4996-5014.e26 - PMID: 34534464 - PMCID: PMC8522630 - DOI: 10.1016/j.cell.2021.08.020

Shareef SJ, Bevill SM, Raman AT, Aryee MJ, van Galen P, Hovestadt V, Bernstein BE

Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells.
Nat Biotechnol. 2021;39(9):1086-1094 - PMID: 33958785 - PMCID: PMC8434949 - DOI: 10.1038/s41587-021-00910-x

Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T

The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
Cancer Cell. 2021;39(10):1342-1360.e14 - PMID: 34358448 - PMCID: PMC8511341 - DOI: 10.1016/j.ccell.2021.07.007

Bajpai G, Nahrendorf M

Infectious and lifestyle modifiers of immunity and host resilience.
Immunity. 2021;54(6):1110-1122 - PMID: 34107270 - DOI: 10.1016/j.immuni.2021.05.011

Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes.
Immunity. 2021;54(10):2338-2353.e6 - PMID: 34534439 - PMCID: PMC8604155 - DOI: 10.1016/j.immuni.2021.08.026

Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.
Eur Heart J. 2021;42(39):4077-4088 - PMID: 34279021 - PMCID: PMC8516477 - DOI: 10.1093/eurheartj/ehab371

Stiekema LCA, Willemsen L, Kaiser Y, Prange KHM, Wareham NJ, Boekholdt SM, Kuijk C, de Winther MPJ, Voermans C, Nahrendorf M, Stroes ESG, Kroon J

Impact of cholesterol on proinflammatory monocyte production by the bone marrow.
Eur Heart J. 2021;42(42):4309-4320 - PMID: 34343254 - PMCID: PMC8572558 - DOI: 10.1093/eurheartj/ehab465

Steffens S, Nahrendorf M, Madonna R

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies.
Eur Heart J. 2021;43(16):1533-1541 - PMID: 34897403 - PMCID: PMC9020986 - DOI: 10.1093/eurheartj/ehab842

Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer
Nat Nanotechnol. 2021;16(7):830-839 - PMID: 33958764 - PMCID: PMC8491539 - DOI: 10.1038/s41565-021-00897-1

Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H

An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma
Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7

Nahrendorf M

Response by Nahrendorf to Letter Regarding Article, "Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus".
Circulation. 2021;143(2):e7-e8 - PMID: 33428432 - PMCID: PMC7939058 - DOI: 10.1161/CIRCULATIONAHA.120.051633

Kilic T, Gessner I, Cho Y, Jeong N, Quintana J, Weissleder R, Lee H

Zwitterionic polymer electroplating facilitates the preparation of electrode surface for biosensing.
Adv Mater. 2021;34(8):e2107892 - PMID: 34890082 - PMCID: PMC8881349 - DOI: 10.1002/adma.202107892

Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen I, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain RK, Vander Heiden MG

Fatty acid synthesis is required for breast cancer brain metastasis.
Nat Cancer. 2021;2(4):414-428 - PMID: 34179825 - PMCID: PMC8223728 - DOI: 10.1038/s43018-021-00183-y

Lee CY, Degani I, Cheong J, Weissleder R, Lee JH, Cheon J, Lee H

Development of Integrated Systems for On-Site Infection Detection.
Acc Chem Res. 2021;54(21):3991-4000 - PMID: 34677927 - PMCID: PMC9099220 - DOI: 10.1021/acs.accounts.1c00498

Nahrendorf M

Innate Lymphoid Cells Participate in Myocardial Inflammation After Ischemia.
J Am Coll Cardiol. 2021;78(11):1143-1144 - PMID: 34503683 - DOI: 10.1016/j.jacc.2021.07.013

Aguirre AD, Arbab-Zadeh A, Soeda T, Fuster V, Jang IK

Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.
J Am Coll Cardiol. 2021;78(12):1257-1265 - PMID: 34531027 - PMCID: PMC9851427 - DOI: 10.1016/j.jacc.2021.06.050

van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R

Prosaposin mediates inflammation in atherosclerosis.
Sci Transl Med. 2021;13(584):eabe1433 - PMID: 33692130 - PMCID: PMC8209679 - DOI: 10.1126/scitranslmed.abe1433

Garris CS, Wong JL, Ravetch JV, Knorr DA

Dendritic cell targeting with Fc-enhanced CD40 antibody agonists induces durable antitumor immunity in humanized mouse models of bladder cancer.
Sci Transl Med. 2021;13(594):eabd1346 - PMID: 34011627 - PMCID: PMC8325152 - DOI: 10.1126/scitranslmed.abd1346

Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H

A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid
Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover

Ko J*, Wang Y*, Sheng K, Weitz DA, Weissleder R

Sequencing-Based Protein Analysis of Single Extracellular Vesicles
ACS Nano. 2021;15(3):5631-5638 - PMID: 33687214 - PMCID: PMC8742254 - DOI: 10.1021/acsnano.1c00782

Wang Z, Shin J, Park JH, Lee H, Kim DH, Liu H

Engineering Materials for Electrochemical Sweat Sensing
Adv Funct Mater. 2021;:ePub - DOI: 10.1002/adfm.202008130

Oki T, Mercier F, Kato H, Jung Y, McDonald TO, Spencer JA, Mazzola MC, van Gastel N, Lin CP, Michor F, Kitamura T, Scadden DT

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.
Nat Commun. 2021;12(1):245 - PMID: 33431855 - PMCID: PMC7801403 - DOI: 10.1038/s41467-020-20491-8

Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G

p53 dynamics vary between tissues and are linked with radiation sensitivity
Nat Commun. 2021;12(1):898 - PMID: 33563973 - PMCID: PMC7873198 - DOI: 10.1038/s41467-021-21145-z

Bénard A, Jacobsen A, Brunner M, Krautz C, Klösch B, Swierzy I, Naschberger E, Podolska MJ, Kouhestani D, David P, Birkholz T, Castellanos I, Trufa D, Sirbu H, Vetter M, Kremer AE, Hildner K, Hecker A, Edinger F, Tenbusch M, Mühl-Zürbes P, Steinkasserer A, Richter E, Streeck H, Berger MM, Brenner T, Weigand MA, Swirski FK, Schett G, Grützmann R, Weber GF

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Nat Commun. 2021;12(1):1112 - PMID: 33602937 - PMCID: PMC7893044 - DOI: 10.1038/s41467-021-21310-4

Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Nat Commun. 2021;12(1):6271 - PMID: 34725346 - PMCID: PMC8560803 - DOI: 10.1038/s41467-021-26571-7

Che M, Chaturvedi A, Munro SA, Pitzen SP, Ling A, Zhang W, Mentzer J, Ku SY, Puca L, Zhu Y, Bergman AM, Severson TM, Forster C, Liu Y, Hildebrand J, Daniel M, Wang TY, Selth LA, Hickey T, Zoubeidi A, Gleave M, Bareja R, Sboner A, Tilley W, Carroll JS, Tan W, Kohli M, Yang R, Hsieh AC, Murugan P, Zwart W, Beltran H, Huang RS, Dehm SM

Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Nat Commun. 2021;12(1):6377 - PMID: 34737261 - PMCID: PMC8568894 - DOI: 10.1038/s41467-021-26612-1

Gerhard GM, Bill R, Messemaker M, Klein AM, Pittet MJ

Tumor-infiltrating dendritic cell states are conserved across solid human cancers.
J Exp Med. 2021;218(1):ePub - PMID: 33601412 - PMCID: PMC7754678 - DOI: 10.1084/jem.20200264

Grune J, Yamazoe M, Nahrendorf M

Electroimmunology and cardiac arrhythmia.
Nat Rev Cardiol. 2021;18(8):547-564 - PMID: 33654273 - PMCID: PMC9703448 - DOI: 10.1038/s41569-021-00520-9

Yang Z*, Francisco J*, Reese AS, Spriggs DR, Im H, Castro CM

Addressing cervical cancer screening disparities through advances in artificial intelligence and nanotechnologies for cellular profiling.
Biophys Rev. 2021;2:011303 - PMID: 33842926 - PMCID: PMC8015256 - DOI: 10.1063/5.0043089

Payne NC, Kalyakina AS, Singh K, Tye MA, Mazitschek R

Bright and stable luminescent probes for target engagement profiling in live cells.
Nat Chem Biol. 2021;17(11):1168-1177 - PMID: 34675420 - PMCID: PMC8555866 - DOI: 10.1038/s41589-021-00877-5

Zhang Y, Kohrn BF, Yang M, Nachmanson D, Soong TR, Lee IH, Tao Y, Clevers H, Swisher EM, Brentnall TA, Loeb LA, Kennedy SR, Salk JJ, Naxerova K, Risques RA

PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.
Proc Natl Acad Sci U S A. 2021;118(31):ePub - PMID: 34330826 - PMCID: PMC8346827 - DOI: 10.1073/pnas.2023373118

Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz GR, Schmidt S, Chau C, Narsimhan R, Kullenberg EG, Zhu C, Linnoila J, Yao Z, Chen JW

d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation.
Proc Natl Acad Sci U S A. 2021;118(44):ePub - PMID: 34702739 - PMCID: PMC8673064 - DOI: 10.1073/pnas.2107663118

Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK

Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118

Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R

Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling
Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252

Guo JA, Hoffman HI, Weekes CD, Zheng L, Ting DT, Hwang WL

Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies.
Clin Cancer Res. 2021;27(14):3825-3833 - PMID: 33653818 - PMCID: PMC8282742 - DOI: 10.1158/1078-0432.CCR-20-4712

Guo JA, Hoffman HI, Shroff SG, Chen P, Hwang PG, Kim DY, Kim DW, Cheng SW, Zhao D, Mahal BA, Alshalalfa M, Niemierko A, Wo JY, Loeffler JS, Fernandez-Del Castillo C, Jacks T, Aguirre AJ, Hong TS, Mino-Kenudson M, Hwang WL

Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection.
Clin Cancer Res. 2021;27(10):2807-2815 - PMID: 33632928 - PMCID: PMC8127360 - DOI: 10.1158/1078-0432.CCR-20-4382

Koch PD, Quintana J, Ahmed MS, Kohler RH, Weissleder R

Small Molecule Imaging Agent for Mutant KRAS G12C
Advanced Therapeutics. 2021;:2000290 - DOI: 10.1002/adtp.202000290

Sun Z, Kim JH, Kim SH, Kim HR, Zhang K, Pan Y, Ko MK, Kim BM, Chu H, Lee HR, Kim HL, Kim JH, Fu X, Hyun YM, Yun KN, Kim JY, Lee DW, Song SY, Lin CP, Clark RA, Lee KH, Kupper TS, Park CO

Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis.
J Allergy Clin Immunol. 2021;147(5):1764-1777 - PMID: 33516870 - PMCID: PMC9272812 - DOI: 10.1016/j.jaci.2020.11.049

Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ

Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
Genes Dev. 2021;35(21-22):1527-1547 - PMID: 34711655 - PMCID: PMC8559676 - DOI: 10.1101/gad.349048.121

Ryu WS, Schellingerhout D, Hong KS, Jeong SW, Kim BJ, Kim JT, Lee KB, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Nahrendorf M, Lee J, Bae HJ, Kim DE

Relation of Pre-stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.
Ann Neurol. 2021;90(5):763-776 - PMID: 34536234 - PMCID: PMC9292882 - DOI: 10.1002/ana.26219

Pfirschke C, Zilionis R, Engblom C, Messemaker M, Zou AE, Rickelt S, Gort-Freitas NA, Lin Y, Bill R, Siwicki M, Gungabeesoon J, Sprachman MM, Marquard AN, Rodell CB, Cuccarese MF, Quintana J, Ahmed MS, Kohler RH, Savova V, Weissleder R, Klein AM, Pittet MJ

Macrophage-targeted therapy unlocks antitumoral crosstalk between IFN𝛾-secreting lymphocytes and IL12-producing dendritic cells.
Cancer Immunol Res. 2021;10(1):40-55 - PMID: 34795032 - PMCID: PMC10132467 - DOI: 10.1158/2326-6066.CIR-21-0326

Siwicki M, Pittet MJ

Versatile neutrophil functions in cancer.
Semin Immunol. 2021;57:101538 - PMID: 34876331 - DOI: 10.1016/j.smim.2021.101538

Rohde D, Nahrendorf M

Bad company: monocytes in HIV and atherosclerosis.
Cardiovasc Res. 2021;117(4):993-994 - PMID: 33693568 - PMCID: PMC7982997 - DOI: 10.1093/cvr/cvab058

Lee CY, Degani I, Cheong J, Lee JH, Choi HJ, Cheon J, Lee H

Fluorescence polarization system for rapid COVID-19 diagnosis
Biosens Bioelectron. 2021;178:113049 - PMID: 33540323 - PMCID: PMC7846465 - DOI: 10.1016/j.bios.2021.113049

Geisness AC, Azul M, Williams D, Szafraniec H, De Souza DC, Higgins JM, Wood DK

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease.
Haematologica. 2021;107(6):1438-1447 - PMID: 34706495 - PMCID: PMC9152977 - DOI: 10.3324/haematol.2021.278666

Gessner I, Park JH, Lin HY, Lee H, Weissleder R

Magnetic Gold Nanoparticles with Idealized Coating for Enhanced Point-Of-Care Sensing.
Adv Healthc Mater. 2021;11(2):e2102035 - PMID: 34747576 - PMCID: PMC8770610 - DOI: 10.1002/adhm.202102035

Taghdiri N, Calcagno DM, Fu Z, Huang K, Kohler RH, Weissleder R, Coleman TP, King KR

Macrophage calcium reporter mice reveal immune cell communication in vitro and in vivo.
Cell Rep Methods. 2021;1(8):ePub - PMID: 35079727 - PMCID: PMC8786215 - DOI: 10.1016/j.crmeth.2021.100132

Choi JH, Chin LK, Woo BM, Song Y, Seol MJ, Hong Y, Liu AQ, Jang S, Ploegh H, Im H, Lee D

Hydrogel-Based Stamping Technology for Solution-Free Blood Cell Staining.
ACS Appl Mater Interfaces. 2021;13(19):22124-22130 - PMID: 33870697 - DOI: 10.1021/acsami.0c22521

Arlauckas S, Oh N, Li R, Weissleder R, Miller MA

Macrophage imaging and subset analysis using single-cell RNA sequencing.
Nanotheranostics. 2021;5(1):36-56 - PMID: 33391974 - PMCID: PMC7738942 - DOI: 10.7150/ntno.50185

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):eabi7083 - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083

Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Gonçalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR

MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.
Blood Adv. 2021;5(5):1388-1402 - PMID: 33661300 - PMCID: PMC7948285 - DOI: 10.1182/bloodadvances.2020003670

Barrett TJ, Corr EM, van Solingen C, Schlamp F, Brown EJ, Koelwyn GJ, Lee AH, Shanley LC, Spruill TM, Bozal F, de Jong A, Newman AAC, Drenkova K, Silvestro M, Ramkhelawon B, Reynolds HR, Hochman JS, Nahrendorf M, Swirski FK, Fisher EA, Berger JS, Moore KJ

Chronic stress primes innate immune responses in mice and humans.
Cell Rep. 2021;36(10):109595 - PMID: 34496250 - PMCID: PMC8493594 - DOI: 10.1016/j.celrep.2021.109595

Wang C, Cheng D, Jalali Motlagh N, Kuellenberg EG, Wojtkiewicz GR, Schmidt SP, Stocker R, Chen JW

Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity.
J Med Chem. 2021;64(9):5874-5885 - PMID: 33945286 - PMCID: PMC8564765 - DOI: 10.1021/acs.jmedchem.1c00038

Calcagno DM, Zhang C, Toomu A, Huang K, Ninh VK, Miyamoto S, Aguirre AD, Fu Z, Heller Brown J, King KR

SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification.
J Am Heart Assoc. 2021;10(4):e019019 - PMID: 33525909 - PMCID: PMC7955351 - DOI: 10.1161/JAHA.120.019019

Ott C, Pappritz K, Hegemann N, John C, Jeuthe S, McAlpine CS, Iwamoto Y, Lauryn JH, Klages J, Klopfleisch R, Van Linthout S, Swirski F, Nahrendorf M, Kintscher U, Grune T, Kuebler WM, Grune J

Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice.
J Am Heart Assoc. 2021;10(23):e023131 - PMID: 34779224 - PMCID: PMC9075397 - DOI: 10.1161/JAHA.121.023131

Powe CE, James K, Higgins JM

Response to Letter to the Editor from Marie Monlun: "Longitudinal changes in the relationship between Hemoglobin A1c and glucose tolerance across pregnancy and post-partum".
J Clin Endocrinol Metab. 2021;106(1):e401-e402 - PMID: 32589732 - PMCID: PMC7765642 - DOI: 10.1210/clinem/dgaa402

Leong SP, Naxerova K, Keller L, Pantel K, Witte M

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels.
Clin Exp Metastasis. 2021;39(1):159-179 - PMID: 34767139 - PMCID: PMC8967809 - DOI: 10.1007/s10585-021-10120-z

Ong CS, Reinertsen E, Sun H, Moonsamy P, Mohan N, Funamoto M, Kaneko T, Shekar PS, Schena S, Lawton JS, D'Alessandro DA, Westover MB, Aguirre AD, Sundt TM

Prediction of operative mortality for patients undergoing cardiac surgical procedures without established risk scores.
J Thorac Cardiovasc Surg. 2021;165(4):1449-1459.e15 - PMID: 34607725 - PMCID: PMC8918430 - DOI: 10.1016/j.jtcvs.2021.09.010

Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, Zanoni I

Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation.
iScience. 2021;24(11):103256 - PMID: 34761180 - PMCID: PMC8567386 - DOI: 10.1016/j.isci.2021.103256

Jalali Motlagh N, Wang C, Kuellenberg EG, Wojtkiewicz GR, Schmidt S, Chen JW

D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity.
Cancers (Basel). 2021;13(24):ePub - PMID: 34944979 - PMCID: PMC8699108 - DOI: 10.3390/cancers13246360

Hou J, Lin CP, Intini G

Activation of creER recombinase in the mouse calvaria induces local recombination without effects on distant skeletal segments.
Sci Rep. 2021;11(1):8214 - PMID: 33859263 - PMCID: PMC8050205 - DOI: 10.1038/s41598-021-87611-2

Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI

Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV.
Am J Pathol. 2021;191(10):1774-1786 - PMID: 34303699 - PMCID: PMC8491092 - DOI: 10.1016/j.ajpath.2021.06.012

Koch PD, Quintana J, Ahmed M, Kohler RH, Weissleder R

Small Molecule Imaging Agent For Mutant Kras G12C
Adv Ther (Weinh). 2021;4(5):ePub - PMID: 33997272 - PMCID: PMC8115719 - DOI: 10.1002/adtp.202000290

Wu JW, Jung Y, Yeh SA, Seo Y, Runnels JM, Burns CS, Mizoguchi T, Ito K, Spencer JA, Lin CP

Intravital fluorescence microscopy with negative contrast.
PLoS ONE. 2021;16(8):e0255204 - PMID: 34351959 - PMCID: PMC8341626 - DOI: 10.1371/journal.pone.0255204

El-Awady R, Saleh E, Hamoudi R, Ramadan WS, Mazitschek R, Nael MA, Elokely KM, Abou-Gharbia M, Childers WE, Srinivasulu V, Aloum L, Menon V, Al-Tel TH

Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
Bioorg Med Chem. 2021;42:116251 - PMID: 34116381 - DOI: 10.1016/j.bmc.2021.116251

Luthria G, Lauffenburger D, Miller MA

Cell-Cell Communication Networks in Tissue: Toward Quantitatively Linking Structure with Function.
Curr Opin Syst Biol. 2021;27:ePub - PMID: 34693081 - PMCID: PMC8530179 - DOI: 10.1016/j.coisb.2021.05.002

Monteiro JLGC, Takusagawa T, Vasconcelos BCE, Pai SI, McCain JP, Guastaldi FPS

A rabbit model to investigate temporomandibular joint osteochondral regeneration.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021;134(1):20-27 - PMID: 35165066 - DOI: 10.1016/j.oooo.2021.12.004

Yang A, Mitchell M, Di Capua J, Som A, Huang J, Weissleder R, Kalva S, Uppot R

Microwave Ablation for Resolution of Persistent Biloma Following Hepatectomy and Cholecystectomy: Case Report.
Cardiovasc Intervent Radiol. 2021;45(3):387-390 - PMID: 34741197 - PMCID: PMC8570770 - DOI: 10.1007/s00270-021-02999-8

Ong CS, Reinertsen E, Moonsamy P, Young K, Song S, Axtell AL, Wolfe SB, Mohan N, Jassar AS, Aguirre AD, Sundt TM

Late onset atrial fibrillation in patients undergoing surgical aortic valve replacement.
J Card Surg. 2021;37(2):285-289 - PMID: 34699088 - DOI: 10.1111/jocs.16093

Sandoval DR, Clausen TM, Nora C, Cribbs AP, Denardo A, Clark AE, Garretson AF, Coker JKC, Narayanan A, Majowicz SA, Philpott M, Johansson C, Dunford JE, Spliid CB, Golden GJ, Payne NC, Tye MA, Nowell CJ, Griffis ER, Piermatteo A, Grunddal KV, Alle T, Magida JA, Hauser BM, Feldman J, Caradonna TM, Pu Y, Yin X, McVicar RN, Kwong EM, Weiss RJ, Downes M, Tsimikas S, Smidt AG, Ballatore C, Zengler K, Evans RM, Chanda SK, Croker BA, Leibel SL, Jose J, Mazitschek R, Oppermann U, Esko JD, Carlin AF, Gordts PLSM

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.
bioRxiv. 2021;:ePub - PMID: 33791697 - PMCID: PMC8010724 - DOI: 10.1101/2021.03.22.436522

Deyell M, Garris CS, Laughney AM

Cancer metastasis as a non-healing wound.
Br J Cancer. 2021;124(9):1491-1502 - PMID: 33731858 - PMCID: PMC8076293 - DOI: 10.1038/s41416-021-01309-w

Bill R, Deschler DG, Pittet MJ, Pai SI, Sadow PM, Park JC

Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands.
Cancer Rep (Hoboken). 2021;5(3):e1491 - PMID: 34231337 - PMCID: PMC8955062 - DOI: 10.1002/cnr2.1491

Foy BH, Sundt T, Carlson JCT, Aguirre AD, Higgins JM

White Blood Cell and Platelet Dynamics Define Human Inflammatory Recovery.
medRxiv. 2021;:ePub - PMID: 34189534 - PMCID: PMC8240689 - DOI: 10.1101/2021.06.19.21259181

Swami N, Hwang WL, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Pra AD, Huang F, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M

Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE).
Cancer Genet. 2021;258-259:61-68 - PMID: 34551377 - DOI: 10.1016/j.cancergen.2021.08.004
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