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Awad MM, Katayama R, McTigue M, Liu W, Deng YL, Brooun A, Friboulet L, Huang D, Falk MD, Timofeevski S, Wilner KD, Lockerman EL, Khan TM, Mahmood S, Gainor JF, Digumarthy SR, Stone JR, Mino-Kenudson M, Christensen JG, Iafrate AJ, Engelman JA, Shaw AT

Acquired Resistance to Crizotinib from a Mutation in CD74-ROS1.
N Engl J Med. 2013;368(25):2395-401 - PMID: 23724914 - PMCID: PMC3878821 - DOI: 10.1056/NEJMoa1215530

Olumi AF, Kaufman DS, Zietman A, Harisinghani MG, Wu CL

Case records of the Massachusetts General Hospital. Case 25-2013. A 71-year-old man with hematuria and a mass in the bladder.
N Engl J Med. 2013;369(7):660-7 - PMID: 23944304 - DOI: 10.1056/NEJMcpc1209278

Simmons LH, Guimaraes AR, Zukerberg LR

Case 6-2013.
N Engl J Med. 2013;368(8):757-65 - PMID: 23425169 - DOI: 10.1056/NEJMcpc1208149

Steele DJ, Kasmar AG, Guimaraes AR, Dekker JP

Case records of the Massachusetts General Hospital. Case 3-2013. A 72-year-old woman with abdominal pain and distention after peritoneal dialysis.
N Engl J Med. 2013;368(4):375-85 - PMID: 23343067 - DOI: 10.1056/NEJMcpc1208142

Stone JH, Patel VI, Oliveira GR, Stone JR

Case 38-2012.
N Engl J Med. 2012;367(24):2335-46 - PMID: 23234517 - DOI: 10.1056/NEJMcpc1209330

Merkel PA, McCarty D, Sharma A, Stone JR

Case records of the Massachusetts General Hospital. Case 31-2008. A 39-year-old man with chest pain, arthralgias, and a mediastinal mass.
N Engl J Med. 2008;359:1603-14 - PMID: 18843125 - DOI: 10.1056/NEJMcpc0805310

Brass SD, Durand ML, Stone JH, Chen JW, Stone JR

Case records of the Massachusetts General Hospital. Case 36-2008. A 59-year-old man with chronic daily headache.
N Engl J Med. 2008;359(21):2267-78 - PMID: 19020329 - DOI: 10.1056/NEJMcpc0805313

Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R

Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
N Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749

Kaufman DS, McDougal WS, Harisinghani MG, Wu CL

Case records of the Massachusetts General Hospital. Case 30-2009. A 77-year-old man with recurrent transitional-cell carcinoma of the ureter.
N Engl J Med. 2009;361(13):1292-9 - PMID: 19776411 - DOI: 10.1056/NEJMcpc0900642

Zella GC, Gee MS, Badizadegan K

Case records of the Massachusetts General Hospital. Case 25-2012. A 15-year-old boy with abdominal pain, hematochezia, and anemia.
N Engl J Med. 2012;367(7):659-67 - PMID: 22894579 - DOI: 10.1056/NEJMcpc1111578

Hunt DP, Becker AE, Guimaraes AR, Stemmer-Rachamimov A, Misdraji J

Case records of the Massachusetts General Hospital. Case 21-2012. A 27-year-old man with fatigue, weakness, weight loss, and decreased libido.
N Engl J Med. 2012;367(2):157-69 - PMID: 22784119 - DOI: 10.1056/NEJMcpc1110053

Kaufman DS, Zietman AL, Dahl DM, Harisinghani MG, Wu CL

Case records of the Massachusetts General Hospital. Case 5-2011. A 65-year-old man with hematuria after treatment for prostate cancer.
N Engl J Med. 2011;364(7):667-75 - PMID: 21323545 - DOI: 10.1056/NEJMcpc1005310

Bazari H, Guimaraes AR, Kushner YB

Case records of the Massachusetts General Hospital. Case 20-2012. A 77-year-old man with leg edema, hematuria, and acute renal failure.
N Engl J Med. 2012;366(26):2503-15 - PMID: 22738101 - DOI: 10.1056/NEJMcpc1111577

Karchmer AW, MacGillivray TE, Healey TT, Stone JR

Case records of the Massachusetts General Hospital. Case 1-2011. A 35-year-old man with fever, bacteremia, and a mass in the left atrium.
N Engl J Med. 2011;364(2):158-66 - PMID: 21226582 - DOI: 10.1056/NEJMcpc1004362

Sabatine MS, Jaffer FA, Staats PN, Stone JR

Case records of the Massachusetts General Hospital. Case 28-2010. A 32-year-old woman, 3 weeks post partum, with substernal chest pain.
N Engl J Med. 2010;363(12):1164-73 - PMID: 20843252 - DOI: 10.1056/NEJMcpc1000966

Kaufman DS, Zietman AL, McDougal WS, Dahl DM, Harisinghani MG, Wu CL

Case records of the Massachusetts General Hospital. Case 9-2012. A 67-year-old man with a persistently elevated PSA level.
N Engl J Med. 2012;366(12):1143-50 - PMID: 22435374 - DOI: 10.1056/NEJMcpc1104320

Ng AK, Abramson JS, Digumarthy SR, Reingold JS, Stone JR

Case 24-2010.
N Engl J Med. 2010;363(7):664-675 - PMID: 20818858 - DOI: 10.1056/NEJMcpc1004087

Stone JH, Papaliodis GN, Dunbar MR, Stone JR

Case 4-2010 -- a 53-year-old man with arthralgias, oral ulcers, vision loss, and vocal-cord paralysis.
N Engl J Med. 2010;362(6):537-46 - PMID: 20147720 - DOI: 10.1056/NEJMcpc0910090

Weissleder R

Scaling down imaging: molecular mapping of cancer in mice
Nat Rev Cancer. 2002;2:1-8 - PMID: 11902581 - DOI: 10.1038/nrc701

Celso CL, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, Cote D, Rowe DW, Lin CP, Scadden DT.

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
Nature. 2009;457(7225):92-6 - PMID: 19052546 - PMCID: PMC2820276 - DOI: 10.1038/nature07434

Weissleder R, Pittet MJ

Imaging in the era of molecular oncology
Nature. 2008;452:580-589 - PMID: 18385732 - PMCID: PMC2708079 - DOI: 10.1038/nature06917

Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T

Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541

Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J

Dedifferentiation of committed epithelial cells into stem cells in vivo.
Nature. 2013;503(7475):218-23 - PMID: 24196716 - PMCID: PMC4035230 - DOI: 10.1038/nature12777

Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A

Charting a dynamic DNA methylation landscape of the human genome.
Nature. 2013;500(7463):477-81 - PMID: 23925113 - PMCID: PMC3821869 - DOI: 10.1038/nature12433

Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, Bernstein BE, Kellis M, Regev A, Rinn JL, Lander ES

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.
Nature. 2009;458(7235):223-7 - PMID: 19182780 - PMCID: PMC2754849 - DOI: 10.1038/nature07672

Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES

Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Nature. 2008;454(7205):766-70 - PMID: 18600261 - PMCID: PMC2896277 - DOI: 10.1038/nature07107

Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A

Dissecting direct reprogramming through integrative genomic analysis.
Nature. 2008;454(7200):49-55 - PMID: 18509334 - PMCID: PMC2754827 - DOI: 10.1038/nature07056

Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Celso CL, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP

In vivo imaging of T(reg) cells providing immune privilege to the haematopoietic stem-cell niche.
Nature. 2011;474(7350):216-9 - PMID: 21654805 - PMCID: PMC3725645 - DOI: 10.1038/nature10160

ENCODE Project Consortium, Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M

An integrated encyclopedia of DNA elements in the human genome.
Nature. 2012;489(7414):57-74 - PMID: 22955616 - PMCID: PMC3439153 - DOI: 10.1038/nature11247

Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE

Mapping and analysis of chromatin state dynamics in nine human cell types.
Nature. 2011;473(7345):43-9 - PMID: 21441907 - PMCID: PMC3088773 - DOI: 10.1038/nature09906

Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, Bernstein BE, Drier Y, Fonseca R, Gabriel SB, Hofmeister CC, Jagannath S, Jakubowiak AJ, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins LM, Onofrio R, Pugh TJ, Rajkumar SV, Ramos AH, Siegel DS, Sivachenko A, Stewart AK, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn WC, Garraway LA, Meyerson M, Lander ES, Getz G, Golub TR

Initial genome sequencing and analysis of multiple myeloma.
Nature. 2011;471(7339):467-72 - PMID: 21430775 - PMCID: PMC3560292 - DOI: 10.1038/nature09837

Adams GB, Alley IR, Chung UI, Chabner KT, Jeanson NT, Lo Celso C, Marsters ES, Chen M, Weinstein LS, Lin CP, Kronenberg HM, Scadden DT

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.
Nature. 2009;459(7243):103-7 - PMID: 19322176 - PMCID: PMC2761017 - DOI: 10.1038/nature07859

Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH

HDAC2 negatively regulates memory formation and synaptic plasticity.
Nature. 2009;459(7243):55-60 - PMID: 19424149 - PMCID: PMC3498958 - DOI: 10.1038/nature07925

Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders LM, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert BL, Chiosis G, Nimer SD, Bernstein BE, Verstovsek S, Levine RL

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
Nature. 2012;489(7414):155-9 - PMID: 22820254 - PMCID: PMC3991463 - DOI: 10.1038/nature11303

Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luster AD, Scadden DT, Lin CP

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.
Nature. 2005;435:969-73 - PMID: 15959517 - PMCID: PMC2570168 - DOI: 10.1038/nature03703

Dutta P*, Courties G*, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AN, Niessen HWM, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M

Myocardial infarction accelerates atherosclerosis
Nature. 2012;487(7407):325-9 - PMID: 22763456 - PMCID: PMC3401326 - DOI: 10.1038/nature11260

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149

Lo Celso C, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, C

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
Nature. 2009;457(7225):92-6 - PMID: 19052546 - PMCID: PMC2820276 - DOI: 10.1038/nature07434

Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES

Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140

Mikkelsen T, Ku M, Jaffe D, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim T, Koche R, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander E, Bernstein B

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
Nature. 2007;448(7153):553-60 - PMID: 17603471 - PMCID: PMC2921165 - DOI: 10.1038/nature06008

Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ

Epigenetic memory in induced pluripotent stem cells.
Nature. 2010;467(7313):285-90 - PMID: 20644535 - PMCID: PMC3150836 - DOI: 10.1038/nature09342

Walhout AJM, Aebersold R, Meyer T, Bork P, Kirschner MW

Systems Biology: What's the Next Challenge?
Cell. 2011;144:6

Jiang H, Shukla A, Wang X, Chen WY, Bernstein BE, Roeder RG

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains.
Cell. 2011;144(4):513-25 - PMID: 21335234 - PMCID: PMC3572774 - DOI: 10.1016/j.cell.2011.01.020

Pittet MJ, Weissleder R

Intravital imaging.
Cell. 2011;147(5):983-91 - PMID: 22118457 - PMCID: PMC3824153 - DOI: 10.1016/j.cell.2011.11.004

Zullo JM, Demarco IA, Piqué-Regi R, Gaffney DJ, Epstein CB, Spooner CJ, Luperchio TR, Bernstein BE, Pritchard JK, Reddy KL, Singh H

DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Cell. 2012;149(7):1474-87 - PMID: 22726435 - DOI: 10.1016/j.cell.2012.04.035

Ram O, Goren A, Amit I, Shoresh N, Yosef N, Ernst J, Kellis M, Gymrek M, Issner R, Coyne M, Durham T, Zhang X, Donaghey J, Epstein CB, Regev A, Bernstein BE

Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells.
Cell. 2011;147(7):1628-39 - PMID: 22196736 - PMCID: PMC3312319 - DOI: 10.1016/j.cell.2011.09.057

Schreiber S, Bernstein B

Signaling network model of chromatin.
Cell. 2002;111(6):771-8 - PMID: 12526804 - DOI: 10.1016/s0092-8674(02)01196-0

Bernstein B, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey D, Huebert D, McMahon S, Karlsson E, Kulbokas E, Gingeras T, Schreiber S, Lander E

Genomic maps and comparative analysis of histone modifications in human and mouse.
Cell. 2005;120(2):169-81 - PMID: 15680324 - DOI: 10.1016/j.cell.2005.01.001

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
Cell. 2012;149(3):656-70 - PMID: 22541435 - PMCID: PMC3472002 - DOI: 10.1016/j.cell.2012.01.058

Bernstein B, Mikkelsen T, Xie X, Kamal M, Huebert D, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber S, Lander E

A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Cell. 2006;125(2):315-26 - PMID: 16630819 - DOI: 10.1016/j.cell.2006.02.041
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