Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.
Case records of the Massachusetts General Hospital: Case 5-2014: 2014: A 59-year-old man with fever, confusion, thrombocytopenia, rash, and renal failure.
New Engl J Med. 2014;370(7):651-60 - PMID: 24521112
Direct measurement of local oxygen concentration in the bone marrow of live animals.
Dissecting neural differentiation regulatory networks through epigenetic footprinting.
Genetic and epigenetic fine mapping of causal autoimmune disease variants.
ABCB5 is a limbal stem cell gene required for corneal development and repair.
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors.
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.
Chronic variable stress activates hematopoietic stem cells
MARCOing Monocytes for Elimination.
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Imaging and Nanomedicine in Inflammatory Atherosclerosis.
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
FDG-PET/CT Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus.
TASER Electronic Control Devices and Cardiac Arrests: Coincidental or Causal?
Circulation. 2014;129(1):93-100 - PMID: 24396012
Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity.
Silencing of CCR2 in myocarditis.
Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study.
Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
Translational molecular imaging: repurposing an old technique to track cell migration into human atheroma.
J Am Coll Cardiol. 2014;64(10):1030-2 - PMID: 25190239
Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging.
Regulation and consequences of monocytosis.
Dynamic Biodistribution of Extracellular Vesicles In Vivo Using a Multimodal Imaging Reporter.
Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction.
Regulating repair: regulatory T cells in myocardial infarction.
Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions?
Fluorescent leukocytes enter plaque on the microscope stage.
Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium.
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria.
A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity.
Leukemia. 2014;28(9):1892-901 - PMID: 24518207
Discovery of biomarkers predictive of GSI response in triple negative breast cancer and adenoid cystic carcinoma.
A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.
An authentic imaging probe to track cell fate from beginning to end.
In vivo imaging of specific drug-target binding at subcellular resolution.
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease.
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.
Defining functional DNA elements in the human genome.
Intravital imaging of cardiac function at the single-cell level.
Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.
BuMPing iron with modified heparins.
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System
Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase (HDAC) Inhibitors by Multimodality Molecular Imaging in Living Subjects.
Harnessing the Intestinal Microbiome for Optimal Therapeutic Immunomodulation.
Cancer Res. 2014;74(16):4217-4221 - PMID: 25074615
Gut microbiome and anticancer immune response: really hot Sh*t!
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Intravital Imaging of Mesenchymal Stem Cell Trafficking and Association with Platelets and Neutrophils.
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.
Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer.
Oncogene. 2014;34(23):3053-62 - PMID: 25065595
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy.
Thromboprophylaxis is associated with reduced post-hospitalization venous thromboembolic events in patients with inflammatory bowel diseases.
Serum Inflammatory Markers and Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases.
Colonoscopy is Associated with a Reduced Risk for Colon Cancer and Mortality in Patients with Inflammatory Bowel Diseases.
Red Si-rhodamine drug conjugates enable imaging in GFP cells.
Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies.
Multiple Sclerosis: Myeloperoxidase Immunoradiology Improves Detection of Acute and Chronic Disease in Experimental Model.
Monocyte Fate in Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2014;35(2):272-9 - PMID: 25538208
Splenic Metabolic Activity Predicts Risk of Future Cardiovascular Events: Demonstration of a Cardiosplenic Axis in Humans.
JACC Cardiovasc Imaging. 2014;8(2):121-30 - PMID: 25577441
Magnetic sensing technology for molecular analyses.
Cardiac macrophages and their role in ischemic heart disease.
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
Magnetic Ligation Method for Quantitative Detection of MicroRNAs.
Imaging systemic inflammation in patients with acute myocardial infarction.
Circ Cardiovasc Imaging. 2014;7(5):762-4 - PMID: 25227235
Increased Microvascularization and Vessel Permeability Associate with Active Inflammation in Human Atheromata.
Two-Photon Antenna-Core Oxygen Probe with Enhanced Performance.
Effect of Small Molecule Modification on Single Cell Pharmacokinetics of PARP Inhibitors.
Automated motion artifact removal for intravital microscopy, without a priori information.
Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.
Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.
ACS Chem Biol. 2014;9(4):1061 - PMID: 22724584
Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke.
From proliferation to proliferation: monocyte lineage comes full circle.
Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes.
In Vivo Volume and Hemoglobin Dynamics of Human Red Blood Cells.
The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis.
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.
MicroRNA-130a is upregulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.
Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.
In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent.
Imaging cellular distribution of Bcl inhibitors using small molecule drug conjugates.
Monoalkoxy BODIPYs - A Fluorophore Class for Bioimaging.
In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor.
Eukaryotic V-ATPase: Novel Structural Findings and Functional Insights.
Biochim Biophys Acta. 2014;1837(6):857-879 - PMID: 24508215
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
The journey from stem cell to macrophage.
Myhre and LAPS syndromes: clinical and molecular review of 32 patients.
Advanced Motion Compensation Methods for Intravital Optical Microscopy.
Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis.
Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis.
Developmental Plasticity of red blood cell homeostasis.
Hereditary xerocytosis revisited.
Chemical Interrogation of the Malaria Kinome.
Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA.
Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging.
Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.
Optimal Brain MRI Protocol for New Neurological Complaint.
High throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.
Quantitative absorption cytometry for measuring red blood cell hemoglobin mass and volume.
Arterial Extracellular Matrix: A Mechanobiological Study of the Contributions and Interactions of Elastin and Collagen.
Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation.
Contemporary Surgical Approaches and Outcomes in Adults With Kommerell Diverticulum.
Ann Thorac Surg. 2014;98(4):1347-1354 - PMID: 25134861
In vivo imaging of microglia turnover in the mouse retina after ionizing radiation and dexamethasone treatment.
Invest Ophthalmol Vis Sci. 2014;55(8):5314-5319 - PMID: 25082884
Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging.
Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease.
Mononuclear phagocytes rapidly clear apoptotic epithelial cells in the proximal epididymis.
Characterization of multiphoton microscopy in the bone marrow following intravital laser osteotomy.
Femtosecond laser bone ablation with a high repetition rate fiber laser source.
Imaging Neuroinflammation - from Bench to Bedside.
Intravital imaging of hematopoietic stem cells in the mouse skull.
Methods Mol Biol. 2014;1185:247-65 - PMID: 25062634
Platinum Compounds for High-Resolution In Vivo Cancer Imaging.
Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes.
The Relationship Between Serial [(18) F]PBR06 PET Imaging of Microglial Activation and Motor Function Following Stroke in Mice.
Endocarditis and molecular imaging.
Computational pathology: an emerging definition.
Arch Pathol Lab Med. 2014;138(9):1133-8 - PMID: 25171694
Mode of Childbirth and Long-Term Outcomes in Women with Inflammatory Bowel Diseases.
Site-Specific Labeling of Proteins and Peptides with Trans-cyclooctene Containing Handles Capable of Tetrazine Ligation.
Novel prognostic tissue markers in congestive heart failure.
Cardiovasc Pathol. 2014;24(2):65-70 - PMID: 25453729
Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.
Int Orthop. 2014;39(1):161-172 - PMID: 25300398
Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.
Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents.
Extracellular Traps in Lipid-Rich Lesions of Carotid Atherosclerotic Plaques: Implications for Lipoprotein Retention and Lesion Progression.
J Vasc Interv Radiol. 2014;25(4):631-4 - PMID: 24581730
Retrospective cohort study of portacaval lymphadenopathy identified on multidetector CT and implications for follow-up.
Abdom Imaging. 2014;40(6):1481-6 - PMID: 25516214
Interpretation and reporting multiparametric prostate MRI: a primer for residents and novices.
Abdom Imaging. 2014;39(5):1036-51 - PMID: 24566965
Modelling and predicting the biological effects of nanomaterials.
SAR QSAR Environ Res. 2014;25(2):161-72 - PMID: 24625316
Red Blood Cell Population Dynamics.
Diffusion-Weighted Imaging of the Male Pelvis.
Magn Reson Imaging Clin N Am. 2014;22(2):145-163 - PMID: 24792675
The male pelvis.
Magn Reson Imaging Clin N Am. 2014;22(2):xi - PMID: 24792681
Clinical presentation and treatment considerations of a ruptured posterior spinal artery pseudoaneurysm.
J Clin Neurosci. 2014;21(7):1273-6 - PMID: 24572933
Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair.
Diversion ahead: imaging appearance of urinary diversions and reservoirs.
Clin Imaging. 2014;38(4):418-427 - PMID: 24602415
MDCT imaging of Alloderm biologic mesh spacers in the abdomen and pelvis - preliminary experience.
Clin Imaging. 2014;38(3):279-82 - PMID: 24556330
Monocyte recruitment and macrophage proliferation in atherosclerosis.
Kardiol Pol. 2014;72(4):311-4 - PMID: 24526549
Tracheal Tube Obstruction in Mechanically Ventilated Patients Assessed by High-resolution Computed Tomography.
Anesthesiology. 2014;121(6):1226-1235 - PMID: 25254903
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Nat Med. 2014;20(11):1301-9 - PMID: 25344738
Molecular imaging of macrophage enzyme activity in cardiac inflammation.
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis.
The 2013 symposium on pathology data integration and clinical decision support and the current state of field.
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.
Imaging windows for long-term intravital imaging: general overview
Intravital. 2014;3:2: e29917
Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.
Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases.
The role of TMPRSS6/matriptase-2 in iron regulation and anemia.
Quantitative human phenotyping: the next frontier in medicine.
Inflammation and repair in the ischaemic myocardium.
Hamostaseologie. 2014;35(1):34-6 - PMID: 25375277