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Ng TSC, Garlin MA, Weissleder R, Miller MA

Understanding the EPR effect through image-guided systems pharmacology
Theranostics. 2019;:ePub

Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R

Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy
Theranostics. 2019;9(26):8426-8436 - PMID: 31879528 - PMCID: PMC6924259 - DOI: 10.7150/thno.35434

Rodell CB, Koch PD, Weissleder R

Screening for new macrophage therapeutics.
Theranostics. 2019;9(25):7714-7729 - PMID: 31695796 - PMCID: PMC6831478 - DOI: 10.7150/thno.34421

Wang C, Pulli B, Jalali Motlagh N, Li A, Wojtkiewicz GR, Schmidt SP, Wu Y, Zeller MWG, Chen JW

A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales.
Theranostics. 2019;9(25):7525-7536 - PMID: 31695784 - PMCID: PMC6831463 - DOI: 10.7150/thno.36264

Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H

Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma.
Theranostics. 2022;12(5):1988-1998 - PMID: 35265194 - PMCID: PMC8899565 - DOI: 10.7150/thno.69094 - Cover

Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Sci Adv. 2018;4(3):eaar2766 - PMID: 29532035 - PMCID: PMC5842038 - DOI: 10.1126/sciadv.aar2766

Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA

Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy.
Sci Adv. 2020;6(21):ePub - PMID: 32937338 - PMCID: PMC7244320 - DOI: 10.1126/sciadv.aaz8521

Liebel M, Ortega Arroyo J, Beltrán VS, Osmond J, Jo A, Lee H, Quidant R, van Hulst NF

3D tracking of extracellular vesicles by holographic fluorescence imaging.
Sci Adv. 2020;6(45):ePub - PMID: 33148645 - PMCID: PMC7673696 - DOI: 10.1126/sciadv.abc2508

Ferguson S, Yang KS, Zelga P, Liss AS, Carlson JCT, Del Castillo CF, Weissleder R

Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer.
Sci Adv. 2022;8(16):eabm3453 - PMID: 35452280 - PMCID: PMC9032977 - DOI: 10.1126/sciadv.abm3453

Ng TSC, Hu H, Kronister S, Lee C, Li R, Gerosa L, Stopka SA, Burgenske DM, Khurana I, Regan MS, Vallabhaneni S, Putta N, Scott E, Matvey D, Giobbie-Hurder A, Kohler RH, Sarkaria JN, Parangi S, Sorger PK, Agar NYR, Jacene HA, Sullivan RJ, Buchbinder E, Mikula H, Weissleder R, Miller MA

Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Sci Adv. 2022;8(17):eabl6339 - PMID: 35486732 - PMCID: PMC9054019 - DOI: 10.1126/sciadv.abl6339

Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation.
Sci Adv. 2015;1(3):ePub - PMID: 26295063 - PMCID: PMC4539616 - DOI: 10.1126/sciadv.1400223

Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H

Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
Sci Adv. 2016;2(5):e1600300 - PMID: 28861468 - PMCID: PMC5565941 - DOI: 10.1126/sciadv.1600300

Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR

Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.
Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341

Cho YK, Kim H, Bénard A, Woo HK, Czubayko F, David P, Hansen FJ, Lee JI, Park JH, Schneck E, Weber GF, Shin IK, Lee H

Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing
Sci Adv. 2022;8:eabq4022 - PMID: 36129990 - PMCID: PMC9491722 - DOI: 10.1126/sciadv.abq4022

Choi Y, Park JH, Jo A, Lim CW, Park JM, Hwang JW, Lee KS, Kim YS, Lee H, Moon J

Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.
Sci Adv. 2025;11(1):eado6894 - PMID: 39742488 - PMCID: PMC11691634 - DOI: 10.1126/sciadv.ado6894

Gong D, Liu R, Cui Y, Rhodes M, Bae JW, Beechem JM, Hwang WL

Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer.
Sci Adv. 2025;11(42):eadx0632 - PMID: 41105767 - PMCID: PMC12533583 - DOI: 10.1126/sciadv.adx0632

Deutsch-Williams RJ, Xie Y, Rabinowitz Z, Goemans M, Wirapati P, Vinegoni C, Carlson JCT, Pittet M, Weissleder R

Targeting cancer-­ associated fibroblasts for real-­ time intraoperative tumor identification with a spray-­on fluorescent probe
Sci Adv. 2025;11(47):eaeb5810 - PMID: 41259533 - PMCID: PMC12629203 - DOI: 10.1126/sciadv.aeb5810

Szafraniec HM, Bull F, Higgins JM, Stone HA, Krüger T, Pearce P, Wood DK

Suspension physics govern the multiscale dynamics of blood flow in sickle cell disease.
Sci Adv. 2026;12(1):eadx3842 - PMID: 41477838 - PMCID: PMC12757044 - DOI: 10.1126/sciadv.adx3842

Yang J, Zhao Y, Jeang WJ, Pabel S, Wong BM, Manan R, Nahrendorf M, Langer R, Anderson DG

A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness.
Sci Adv. 2026;12(26):eaee3894 - PMID: 42341113 - PMCID: PMC13292947 - DOI: 10.1126/sciadv.aee3894

Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM

Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2

Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Nat Commun. 2022;13(1):4976 - PMID: 36008486 - PMCID: PMC9403976 - DOI: 10.1038/s41467-022-32630-4

Che M, Chaturvedi A, Munro SA, Pitzen SP, Ling A, Zhang W, Mentzer J, Ku SY, Puca L, Zhu Y, Bergman AM, Severson TM, Forster C, Liu Y, Hildebrand J, Daniel M, Wang TY, Selth LA, Hickey T, Zoubeidi A, Gleave M, Bareja R, Sboner A, Tilley W, Carroll JS, Tan W, Kohli M, Yang R, Hsieh AC, Murugan P, Zwart W, Beltran H, Huang RS, Dehm SM

Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Nat Commun. 2021;12(1):6377 - PMID: 34737261 - PMCID: PMC8568894 - DOI: 10.1038/s41467-021-26612-1

Momin N, Palmeri JR, Lutz EA, Jailkhani N, Mak H, Tabet A, Chinn MM, Kang BH, Spanoudaki V, Hynes RO, Wittrup KD

Maximizing response to intratumoral immunotherapy in mice by tuning local retention.
Nat Commun. 2022;13(1):109 - PMID: 35013154 - PMCID: PMC8748612 - DOI: 10.1038/s41467-021-27390-6

Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles.
Nat Commun. 2023;14(1):771 - PMID: 36774352 - PMCID: PMC9922247 - DOI: 10.1038/s41467-023-36321-6

Spitzberg JD, Ferguson S, Yang KS, Peterson HM, Carlson JCT, Weissleder R

Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact.
Nat Commun. 2023;14(1):1239 - PMID: 36870999 - PMCID: PMC9985597 - DOI: 10.1038/s41467-023-36932-z

De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
Nat Commun. 2023;14(1):5850 - PMID: 37730674 - PMCID: PMC10511721 - DOI: 10.1038/s41467-023-40923-5

Stollmann A, Garcia-Guirado J, Hong JS, Rüedi P, Im H, Lee H, Ortega Arroyo J, Quidant R

Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform.
Nat Commun. 2024;15(1):4109 - PMID: 38750038 - PMCID: PMC11096335 - DOI: 10.1038/s41467-024-48132-4

Diez I, Ortiz-Terán L, Ng TSC, Albers MW, Marshall G, Orwig W, Kim CM, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs HIL, Sepulcre J

Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging.
Nat Commun. 2024;15(1):4809 - PMID: 38844444 - PMCID: PMC11156945 - DOI: 10.1038/s41467-024-48462-3

Lee CY, Kim H, Degani I, Lee H, Sandoval A, Nam Y, Pascavis M, Park HG, Randall T, Ly A, Castro CM, Lee H

Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing.
Nat Commun. 2024;15(1):6271 - PMID: 39054353 - PMCID: PMC11272939 - DOI: 10.1038/s41467-024-50588-3

Foy BH, Carlson JCT, Aguirre AD, Higgins JM

Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.
Nat Commun. 2025;16(1):1113 - PMID: 39875373 - PMCID: PMC11775293 - DOI: 10.1038/s41467-025-56251-9

Chung JY, Hong YK, Jeon E, Yang S, Park A, Weissleder R, Chong YP, Chung HJ

Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis.
Nat Commun. 2025;16(1):5532 - PMID: 40595501 - PMCID: PMC12215473 - DOI: 10.1038/s41467-025-60684-7

Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Nat Commun. 2013;4:1504 - PMID: 23422672 - PMCID: PMC3579506 - DOI: 10.1038/ncomms2506

Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H*, Weissleder R*

Magnetic barcode assay for genetic detection of pathogens
Nat Commun. 2013;4:1752 - PMID: 23612293 - PMCID: PMC3635151 - DOI: 10.1038/ncomms2745

Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.
Nat Commun. 2013;4:2189 - PMID: 23877263 - PMCID: PMC3740589 - DOI: 10.1038/ncomms3189

Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.
Nat Commun. 2013;4:2532 - PMID: 24113571 - PMCID: PMC3826633 - DOI: 10.1038/ncomms3532

Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Fisher EA, Fayad ZA, Mulder WJ

A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.
Nat Commun. 2014;5:3065 - PMID: 24445279 - PMCID: PMC4001802 - DOI: 10.1038/ncomms4065

Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R

In vivo imaging of specific drug-target binding at subcellular resolution.
Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946

Lee SK, Mortensen LJ, Lin CP, Tung CH

An authentic imaging probe to track cell fate from beginning to end.
Nat Commun. 2014;5:5216 - PMID: 25323442 - PMCID: PMC4852472 - DOI: 10.1038/ncomms6216

Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B

Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Nat Commun. 2014;5:5662 - PMID: 25489927 - PMCID: PMC4261930 - DOI: 10.1038/ncomms6662

Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H*, Weissleder R*

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Nat Commun. 2015;6:6999 - PMID: 25959588 - PMCID: PMC4430127 - DOI: 10.1038/ncomms7999

Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Nat Commun. 2015;6:7029 - PMID: 25967391 - PMCID: PMC4435621 - DOI: 10.1038/ncomms8029

Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Nat Commun. 2015;6:8692 - PMID: 26503691 - PMCID: PMC4711745 - DOI: 10.1038/ncomms9692

Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M

Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.
Nat Commun. 2015;6:8803 - PMID: 26541940 - PMCID: PMC4638135 - DOI: 10.1038/ncomms9803

Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S

Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666

Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R

Real-time high dynamic range laser scanning microscopy.
Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995 - DOI: 10.1038/ncomms11077

Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C

ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Nat Commun. 2016;7:12313 - PMID: 27460411 - PMCID: PMC4974469 - DOI: 10.1038/ncomms12313

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064

Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW

ADAM8 as a drug target in pancreatic cancer.
Nat Commun. 2015;6:6175 - PMID: 25629724 - PMCID: PMC5014123 - DOI: 10.1038/ncomms7175

Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
Nat Commun. 2017;8:15142 - PMID: 28485378 - PMCID: PMC5436068 - DOI: 10.1038/ncomms15142
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