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Halabi EA, Gessner I, Yang K, Kim JJ, Jana R, Peterson HM, Spitzberg J, Weissleder R

Magnetic Silica-Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor-Associated Proteins.
Angew Chem Int Ed Engl. 2024;63(24):e202318870 - PMID: 38578432 - PMCID: PMC11998990 - DOI: 10.1002/anie.202318870

Di Ianni E, Jeon J, Mohammadi S, Hu H, Quintana JM, Lee C, Haidar EA, Goemans M, Zargani-Piccardi A, Mahamdeh M, Hernández IC, Rodriguez VE, Zhou Y, Aguirre A, Yuan S, Ng TSC, Breyne K, Lee H, Breakefield XO, Miller MA

Enhanced-mRNA Delivery Using Ultrasound-Delivered Anchors for Bioorthogonal Ligation.
Angew Chem Int Ed Engl. 2026;65(10):e23437 - PMID: 41568620 - PMCID: PMC13052994 - DOI: 10.1002/anie.202523437

Lee H*, Yoon TJ*, Weissleder R

Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.
Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791

Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R

Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition.
Angew Chem Int Ed Engl. 2009;48(38):7013-6 - PMID: 19697389 - PMCID: PMC2790075 - DOI: 10.1002/anie.200903233

Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.
Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120

Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R

Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method.
Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579

Yoon TJ*, Lee H*, Shao H, Weissleder R

Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101

Budin G, Yang KS, Reiner T, Weissleder R

Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification.
Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273

Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R

Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.
Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670

Karver MR, Weissleder R, Hilderbrand SA

Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging.
Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389

Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H

Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors.
Angew Chem Int Ed Engl. 2004;43(2):224-8 - PMID: 14695616 - DOI: 10.1002/anie.200352582

Huwe A, Mazitschek R, Giannis A

Small molecules as inhibitors of cyclin-dependent kinases.
Angew Chem Int Ed Engl. 2003;42(19):2122-38 - PMID: 12761741 - DOI: 10.1002/anie.200200540

Stahl P, Kissau L, Mazitschek R, Giannis A, Waldmann H

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors.
Angew Chem Int Ed Engl. 2002;41(7):1174-8 - PMID: 12491250 - DOI: 10.1002/1521-3773(20020402)41:7<1174::aid-anie1174>3.0.co;2-v

Stieber F, Mazitschek R, Soric N, Giannis A, Waldmann H

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.
Angew Chem Int Ed Engl. 2002;41(24):4757-61 - PMID: 12481350 - DOI: 10.1002/anie.200290040

Mazitschek R, Mülbaier M, Giannis A

IBX-mediated oxidation of primary alcohols and aldehydes to form carboxylic acids.
Angew Chem Int Ed Engl. 2002;41(21):4059-61 - PMID: 12412081 - DOI: 10.1002/1521-3773(20021104)41:21<4059::AID-ANIE4059>3.0.CO;2-R

Baumhof P, Mazitschek R, Giannis A

A Mild and Effective Method for the Transesterification of Carboxylic Acid Esters P.B. and R.M. are grateful to the Land Baden-Württemberg for a scholarship from the Landesgraduiertenförderung.
Angew Chem Int Ed Engl. 2001;40(19):3672-3674 - PMID: 11592218 - DOI: 10.1002/1521-3773(20011001)40:19<3672::aid-anie3672>3.0.co;2-y

Wernert N, Stanjek A, Kiriakidis S, Hügel A, Jha HC, Mazitschek R, Giannis A

Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin.
Angew Chem Int Ed Engl. 1999;38(21):3228-3231 - PMID: 10556911 - DOI: 10.1002/(sici)1521-3773(19991102)38:21<3228::aid-anie3228>3.0.co;2-8

Hendricks JA, Keliher EJ, Wan D, Hilderbrand SA, Weissleder R, Mazitschek R

Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.
Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957

Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R

Bioorthogonal Imaging of Aurora Kinase A in Live Cells.
Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994

Budin G*, Chung HJ*, Lee H, Weissleder R

A Magnetic Gram Stain for Bacterial Detection.
Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982

Josephson L, Perez JM, Weissleder R

Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.
Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H

Choudhary A, Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law B, Mazitschek R

A singular system with precise dosing and spatiotemporal control of CRISPR-Cas9.
Angew Chem Int Ed Engl. 2019;58(19):6285-6289 - PMID: 30834641 - PMCID: PMC7067309 - DOI: 10.1002/anie.201900788

Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R

Ultra-fast cycling for multiplexed cellular fluorescence imaging.
Angew Chem Int Ed Engl. 2020;59(17):6839-6846 - PMID: 32004403 - PMCID: PMC11853113 - DOI: 10.1002/anie.201915153

Miller MA

It’s what’s inside that counts for nanoparticle vaccines
Sci Transl Med. 2017;9(417):eaar2438 - DOI: 10.1126/scitranslmed.aar2438

Miller MA

Less is more for anticancer therapy combinations
Sci Transl Med. 2017;9 (411):aap8166 - DOI: 10.1126/scitranslmed.aap8166

Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682

Miller MA

Gold photothermal therapy: A positive for negative margins
Sci Transl Med. 2018;10(423):eaar7512 - DOI: 10.1126/scitranslmed.aar7512

Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.
Sci Transl Med. 2019;11(506):ePub - PMID: 31434756 - PMCID: PMC7328283 - DOI: 10.1126/scitranslmed.aaw7736

Naxerova K

A new function for polycomb in immune evasion
Sci Transl Med. 2019;11(514):eaaz3718 - DOI: 10.1126/scitranslmed.aaz3718

Harisinghani MG, O’Shea A, Weissleder R

Advances in clinical MRI technology
Sci Transl Med. 2019;11 (523):eaba2591 - PMID: 31852796 - DOI: 10.1126/scitranslmed.aba2591

Naxerova K

Tumor mutations are not alone in the plasma
Sci Transl Med. 2019;11(522):eaaz9767 - DOI: 10.1126/scitranslmed.aaz9767

Naxerova K

Interrogating CD8+ T cell reactivity on a genome-wide scale
Sci Transl Med. 2019;11(506):eaaz0302 - DOI: 10.1126/scitranslmed.aaz0302

Naxerova K

From micrographs to microsatellites in one bold step
Sci Transl Med. 2019;11(498):eaax9570 - DOI: 10.1126/scitranslmed.aax9570

Naxerova K

Somatic mutations are improving their bad rap
Sci Transl Med. 2019;11(490):eaax4871 - DOI: 10.1126/scitranslmed.aax4871

Weissleder R, Lee H, Ko J, Pittet MJ

COVID-19 diagnostics in context
Sci Transl Med. 2020;12(546):eabc1931 - PMID: 32493791 - DOI: 10.1126/scitranslmed.abc1931

Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R

CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis
Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746

Panizzi P, Krohn-Grimberghe M, Keliher E, Ye YX, Grune J, Frodermann V, Sun Y, Muse CG, Bushey K, Iwamoto Y, van Leent MMT, Meerwaldt A, Toner YC, Munitz J, Maier A, Soultanidis G, Calcagno C, Pérez-Medina C, Carlucci G, Riddell KP, Barney S, Horne G, Anderson B, Maddur-Appajaiah A, Verhamme IM, Bock PE, Wojtkiewicz GR, Courties G, Swirski FK, Church WR, Walz PH, Tillson DM, Mulder WJM, Nahrendorf M

Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis.
Sci Transl Med. 2020;12(568):ePub - PMID: 33148623 - PMCID: PMC7818516 - DOI: 10.1126/scitranslmed.aay2104

van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R

Prosaposin mediates inflammation in atherosclerosis.
Sci Transl Med. 2021;13(584):eabe1433 - PMID: 33692130 - PMCID: PMC8209679 - DOI: 10.1126/scitranslmed.abe1433

Garris CS, Wong JL, Ravetch JV, Knorr DA

Dendritic cell targeting with Fc-enhanced CD40 antibody agonists induces durable antitumor immunity in humanized mouse models of bladder cancer.
Sci Transl Med. 2021;13(594):eabd1346 - PMID: 34011627 - PMCID: PMC8325152 - DOI: 10.1126/scitranslmed.abd1346

Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H

A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid
Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover

Weissleder R

Leveraging technology to address current and future world issues.
Sci Transl Med. 2022;14(666):eabq0606 - PMID: 36223448 - DOI: 10.1126/scitranslmed.abq0606 - Cover

Mohammadian M, Efthimiou N, Gabriel K, Brusaferri L, Cooper-Hohn J, Kim M, Murphy JP, Alshelh Z, Grmek G, Schnieders JH, Chane CA, Carmichael TG, Yang D, Schubert JJ, Turkheimer FE, Cazuza RA, Grace PM, Catana C, Stufflebeam SM, Edwards RR, Napadow V, Sullivan K, Nahrendorf M, Price TJ, Gilman JM, Loggia ML

Elevated translocator protein in skull bone marrow is linked to human chronic pain.
Sci Transl Med. 2026;18(865):eaed8729 - PMID: 42685155 - DOI: 10.1126/scitranslmed.aed8729

Ullal AV*, Peterson V*, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R

Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361

Kobzik L, Swirski FK

MARCOing Monocytes for Elimination.
Sci Transl Med. 2014;6(219):219fs4 - PMID: 24431109 - PMCID: PMC4374341 - DOI: 10.1126/scitranslmed.3008448

Mulder WJ, Jaffer FA, Fayad ZA, Nahrendorf M

Imaging and Nanomedicine in Inflammatory Atherosclerosis.
Sci Transl Med. 2014;6(239):239sr1 - PMID: 24898749 - PMCID: PMC4110972 - DOI: 10.1126/scitranslmed.3005101

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R

Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318

Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Sci Transl Med. 2015;7(288):288ra77 - PMID: 25995223 - PMCID: PMC4675670 - DOI: 10.1126/scitranslmed.aaa3575

Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamal N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R

Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
Sci Transl Med. 2015;7:314 - PMID: 26582898 - PMCID: PMC5462466 - DOI: 10.1126/scitranslmed.aac6522

Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Sci Transl Med. 2016;8:342 - PMID: 27280687 - PMCID: PMC5125383 - DOI: 10.1126/scitranslmed.aaf1435

Weissleder R, Schwaiger MC, Gambhir SS, Hricak H

Imaging approaches to optimize molecular therapies
Sci Transl Med. 2016;8(355):355ps16 - PMID: 27605550 - DOI: 10.1126/scitranslmed.aaf3936
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