Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Direct measurement of local oxygen concentration in the bone marrow of live animals.
Dissecting direct reprogramming through integrative genomic analysis.
Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.
Dedifferentiation of committed epithelial cells into stem cells in vivo.
Charting a dynamic DNA methylation landscape of the human genome.
Live-animal imaging of native haematopoietic stem and progenitor cells.
Nature. 2020;578(7794):278-283 - PMID: 32025033 - PMCID: PMC7021587 - DOI: 10.1038/s41586-020-1971-z
Mutation fingerprints encode cellular histories.
Nature. 2021;597(7876):334-336 - PMID: 34433973 - DOI: 10.1038/d41586-021-02269-0
Brain motor and fear circuits regulate leukocytes during acute stress.
Nature. 2022;607(7919):578-584 - PMID: 35636458 - PMCID: PMC9798885 - DOI: 10.1038/s41586-022-04890-z
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
Nature. 2019;566(7742):115-119 - PMID: 30700910 - PMCID: PMC6367023 - DOI: 10.1038/s41586-018-0849-9
Sleep modulates haematopoiesis and protects against atherosclerosis
Nature. 2019;566(7744):383-387 - PMID: 30760925 - PMCID: PMC6442744 - DOI: 10.1038/s41586-019-0948-2
Platelets have a dangerous hold over immune cells in cardiovascular disease.
Nature. 2020;577(7790):323-324 - PMID: 31937950 - DOI: 10.1038/d41586-019-03732-9
Perspectives on ENCODE.
Nature. 2020;583(7818):693-698 - PMID: 32728248 - PMCID: PMC7410827 - DOI: 10.1038/s41586-020-2449-8
Expanded encyclopaedias of DNA elements in the human and mouse genomes.
Nature. 2020;583(7818):699-710 - PMID: 32728249 - PMCID: PMC7410828 - DOI: 10.1038/s41586-020-2493-4
Mutational clocks tick differently across species.
Nature. 2022;604(7906):435-436 - PMID: 35418556 - DOI: 10.1038/d41586-022-00976-w
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Nature. 2022;608(7921):174-180 - PMID: 35732739 - PMCID: PMC12591363 - DOI: 10.1038/s41586-022-04817-8
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Nature. 2021;592(7854):428-432 - PMID: 33790465 - PMCID: PMC8923613 - DOI: 10.1038/s41586-021-03417-2
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6
An acute immune response underlies the benefit of cardiac stem-cell therapy.
Nature. 2019;577(7790):405-409 - PMID: 31775156 - PMCID: PMC6962570 - DOI: 10.1038/s41586-019-1802-2
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Nature. 2021;595(7866):309-314 - PMID: 33953401 - PMCID: PMC9166167 - DOI: 10.1038/s41586-021-03520-4
Resolving medulloblastoma cellular architecture by single-cell genomics.
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA.
Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST.
Nature. 2019;:ePub - PMID: 31618758 - DOI: 10.1038/s41586-019-1668-3
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541
Imaging in the era of molecular oncology
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
In vivo imaging of T(reg) cells providing immune privilege to the haematopoietic stem-cell niche.
An integrated encyclopedia of DNA elements in the human genome.
Mapping and analysis of chromatin state dynamics in nine human cell types.
Initial genome sequencing and analysis of multiple myeloma.
Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.
HDAC2 negatively regulates memory formation and synaptic plasticity.
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.
Myocardial infarction accelerates atherosclerosis
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
Epigenetic memory in induced pluripotent stem cells.
Systems Biology: What's the Next Challenge?
Cell. 2011;144:6
Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains.
Intravital imaging.
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Cell. 2012;149(7):1474-87 - PMID: 22726435 - DOI: 10.1016/j.cell.2012.04.035
Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells.
Signaling network model of chromatin.
Cell. 2002;111(6):771-8 - PMID: 12526804 - DOI: 10.1016/s0092-8674(02)01196-0
Genomic maps and comparative analysis of histone modifications in human and mouse.
Cell. 2005;120(2):169-81 - PMID: 15680324 - DOI: 10.1016/j.cell.2005.01.001
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Cell. 2006;125(2):315-26 - PMID: 16630819 - DOI: 10.1016/j.cell.2006.02.041