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Rufer N, Zippelius A, Batard P, Pittet M, Kurth I, Corthesy P, Cerottini J, Leyvraz S, Roosnek E, Nabholz M, Romero P
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
Blood. 2003;102:1779-87 - PMID: 12750165 - DOI: 10.1182/blood-2003-02-0420
Kerre T, De Smet G, De Smedt M, Zippelius A, Pittet M, Langerak A, De Bosscher J, Offner F, Vandekerckhove B, Plum J
Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.
Blood. 2002;99:1620-6 - PMID: 11861276 - DOI: 10.1182/blood.v99.5.1620
Roccaro AM, Sacco A, Thompson B, Leleu X, Azab AK, Azab F, Runnels J, Jia X, Ngo HT, Melhem MR, Lin CP, Ribatti D, Rollins BJ, Witzig TE, Anderson KC, Ghobrial IM
microRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.
Blood. 2009;113(26):6669-80 - PMID: 19401561 - PMCID: PMC2710922 - DOI: 10.1182/blood-2009-01-198408
Azab AK, Azab F, Blotta S, Pitsillides CM, Thompson B, Runnels JM, Roccaro AM, Ngo HT, Melhem MR, Sacco A, Jia X, Anderson KC, Lin CP, Rollins BJ, Ghobrial IM
Rho-A and Rac-1 GTPases play major and differential roles in SDF1-induced cell adhesion and chemotaxis in multiple myeloma.
Blood. 2009;114(3):619-29 - PMID: 19443661 - PMCID: PMC2713475 - DOI: 10.1182/blood-2009-01-199281
Azab A, Runnels J, Pitsillides C, Moreau A, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson A, Alt C, Burwick N, Roccaro A, Ngo H, Farag M, Melhem M, Sacco A, Munshi N, Hideshima T, Rollins B, Anderson K, Kung A, Lin CP, Ghobrial I
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood. 2009;113:4341-51 - PMID: 19139079 - PMCID: PMC2676090 - DOI: 10.1182/blood-2008-10-186668
Kunstfeld R, Hirakawa S, Hong Y-K, Schacht V, Lange-Asschenfeldt B, Velasco P, Lin CP, Fiebiger E, Wu Y, Hicklin D, Bohlen P, Detmar M
VEGF-A overexpression leads to lymphatic vessel enlargement and persistent skin inflammation
Blood. 2004;104:1048-57
Higgins JM, Sloan SR
Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.
Blood. 2008;112(6):2546-53 - PMID: 18535200 - DOI: 10.1182/blood-2008-03-146415
Higgins JM, Sloan SR
Response: Other factors may contribute to differences between sickle cell and non-sickle cell patients.
Blood. 2010;115(21):4315-6 - PMID: 20508172
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, Lopez-Otin C, Grgurevic L, Hong CC, Stirnberg M, Gutschow M, Vukicevic S, Babitt JL, Lin HY
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.
Blood. 2011;118(3):747-56 - PMID: 21622652 - PMCID: PMC3142910 - DOI: 10.1182/blood-2011-04-348698
Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic disease in rats.
Blood. 2011;118(18):4977-84 - PMID: 21730356 - PMCID: PMC3208302 - DOI: 10.1182/blood-2011-03-345066
Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA
Differential niche and Wnt requirements during acute myeloid leukemia progression.
Blood. 2011;118(10):2849-56 - PMID: 21765021 - PMCID: PMC3172801 - DOI: 10.1182/blood-2011-03-345165
Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM
Engineered cell homing.
Blood. 2011;118(25):e184-91 - PMID: 22034631 - PMCID: PMC3242725 - DOI: 10.1182/blood-2010-10-311464
Maiso P, Liu Y, Morgan B, Azab A, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A, Ngo H, Azab F, Quang P, Rodig SJ, Lin CP, Roccaro A, Rommel C, Ghobrial IM
Defining the role of TORC1 and TORC2 in multiple myeloma.
Blood. 2011;118(26):6860-70 - PMID: 22045983 - PMCID: PMC3245208 - DOI: 10.1182/blood-2011-03-342394
Azab AK, Quang P, Azab F, Pitsillides C, Thompson B, Chonghaile T, Patton JT, Maiso P, Monrose V, Sacco A, Ngo HT, Flores LM, Lin CP, Magnani JL, Kung AL, Letai A, Carrasco R, Roccaro AM, Ghobrial IM
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Blood. 2011;119(6):1468-78 - PMID: 22096244 - PMCID: PMC3286211 - DOI: 10.1182/blood-2011-07-368050
Santo L, Hideshima T, Kung AL, Tseng JC, Tamang D, Yang M, Jarpe M, van Duzer JH, Mazitschek R, Ogier WC, Cirstea D, Rodig S, Eda H, Scullen T, Canavese M, Bradner J, Anderson KC, Jones SS, Raje N
Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.
Blood. 2012;119(11):2579-89 - PMID: 22262760 - PMCID: PMC3337713 - DOI: 10.1182/blood-2011-10-387365
Mosley AJ, Meekings KN, McCarthy C, Shepherd D, Cerundolo V, Mazitschek R, Tanaka Y, Taylor GP, Bangham CR
Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection.
Blood. 2006;108(12):3801-7 - PMID: 16912225 - DOI: 10.1182/blood-2006-03-013235
Azab AK, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, Thompson B, Maiso P, Sun JD, Hart CP, Roccaro AM, Sacco A, Ngo HT, Lin CP, Kung AL, Carrasco RD, Vanderkerken K, Ghobrial IM
Hypoxia promotes dissemination of multiple myeloma through acquisition of endothelial to mesenchymal transition-like features.
Blood. 2012;119(24):5782-94 - PMID: 22394600 - PMCID: PMC3382938 - DOI: 10.1182/blood-2011-09-380410
Cohen KS, Cheng S, Larson MG, Cupples LA, McCabe EL, Wang YA, Ngwa JS, Martin RP, Klein RJ, Hashmi B, Ge Y, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ
Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors.
Blood. 2013;121(8):e50-6 - PMID: 23287867 - PMCID: PMC3578962 - DOI: 10.1182/blood-2012-05-424846
Levy O, Zhao W, Mortensen LJ, Leblanc S, Tsang K, Fu M, Phillips JA, Sagar V, Anandakumaran P, Ngai J, Cui CH, Eimon P, Angel M, Lin CP, Yanik MF, Karp JM
mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation.
Blood. 2013;122(14):e23-e32 - PMID: 23980067 - PMCID: PMC3790516 - DOI: 10.1182/blood-2013-04-495119
Meynard D, Babitt JL, Lin HY
The liver: conductor of systemic iron regulation.
Blood. 2013;123(2):168-76 - PMID: 24200681 - PMCID: PMC3888285 - DOI: 10.1182/blood-2013-06-427757
Babitt JL, Lin HY
BuMPing iron with modified heparins.
Blood. 2014;123(10):1440-1 - PMID: 24627550 - PMCID: PMC3945857 - DOI: 10.1182/blood-2014-01-549519
Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS
CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD.
Blood. 2003;101(10):4033-41 - PMID: 12576324 - DOI: 10.1182/blood-2002-01-0324
Da Silva N, Bharti A, Shelley CS
hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter.
Blood. 2002;100(10):3536-44 - PMID: 12411317 - DOI: 10.1182/blood.V100.10.3536
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Del Toro R, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Blood. 2014;124(19):2937-47 - PMID: 25202142 - PMCID: PMC4224192 - DOI: 10.1182/blood-2014-08-593426
Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression.
Blood. 2015;126(16):1930-9 - PMID: 26320100 - PMCID: PMC4608240 - DOI: 10.1182/blood-2015-06-649087
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
Cancer Cell. 2002;1:269-77 - PMID: 12086863 - DOI: 10.1016/s1535-6108(02)00046-6
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer Cell. 2006;9(6):485-95 - PMID: 16730237 - DOI: 10.1016/j.ccr.2006.04.022
Wurdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM
miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells.
Cancer Cell. 2008;14(5):382-393 - PMID: 18977327 - PMCID: PMC2597164 - DOI: 10.1016/j.ccr.2008.10.005
Rheinbay E, Louis DN, Bernstein BE, Suvà ML
A Tell-Tail Sign of Chromatin: Histone Mutations Drive Pediatric Glioblastoma.
Cancer Cell. 2012;21(3):329-331 - PMID: 22439930 - DOI: 10.1016/j.ccr.2012.03.001
Abdel-Wahab O, Adli M, Lafave LM, Gao J, Hricik T, Shih AH, Pandey S, Patel JP, Chung YR, Koche R, Perna F, Zhao X, Taylor JE, Park CY, Carroll M, Melnick A, Nimer SD, Jaffe JD, Aifantis I, Bernstein BE, Levine RL
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression.
Cancer Cell. 2012;22(2):180-93 - PMID: 22897849 - PMCID: PMC3422511 - DOI: 10.1016/j.ccr.2012.06.032
Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling.
Cancer Cell. 2013;24(1):45-58 - PMID: 23770013 - PMCID: PMC3746037 - DOI: 10.1016/j.ccr.2013.05.004
Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.
Cancer Cell. 2014;26(5):668-81 - PMID: 25453903 - PMCID: PMC4492343 - DOI: 10.1016/j.ccell.2014.10.004
Pfirschke C, Garris C, Pittet MJ
Common TLR5 Mutations Control Cancer Progression.
Cancer Cell. 2015;27(1):1-3 - PMID: 25584886 - DOI: 10.1016/j.ccell.2014.12.008
Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO, Lander ES, Haber DA, Bernstein BE
Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network.
Cell Stem Cell. 2010;6(6):591-602 - PMID: 20569696 - PMCID: PMC2897075 - DOI: 10.1016/j.stem.2010.03.016
Koche RP, Smith ZD, Adli M, Gu H, Ku M, Gnirke A, Bernstein BE, Meissner A
Reprogramming factor expression initiates widespread targeted chromatin remodeling.
Cell Stem Cell. 2011;8(1):96-105 - PMID: 21211784 - PMCID: PMC3220622 - DOI: 10.1016/j.stem.2010.12.001
Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT
Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration.
Cell Stem Cell. 2012;10(3):259-72 - PMID: 22385654 - PMCID: PMC3652251 - DOI: 10.1016/j.stem.2012.02.003
Silberstein LE, Lin CP
A new image of the hematopoietic stem cell vascular niche.
Cell Stem Cell. 2013;13(5):514-6 - PMID: 24209758 - PMCID: PMC4148778 - DOI: 10.1016/j.stem.2013.10.012
Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008
Devaraj NK, Weissleder R
Biomedical Applications of Tetrazine Cycloadditions.
Accounts Chem Res. 2011;44(9):816-27 - PMID: 21627112 - PMCID: PMC3166440 - DOI: 10.1021/ar200037t
Tassa C, Shaw SY, Weissleder R
Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy.
Accounts Chem Res. 2011;44(10):842-52 - PMID: 21661727 - PMCID: PMC3182289 - DOI: 10.1021/ar200084x
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Nat Cell Biol. 2006;8(2):124-36 - PMID: 16415858 - DOI: 10.1038/ncb1348
Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA
Programming human pluripotent stem cells into white and brown adipocytes.
Nat Cell Biol. 2012;14(2):209-19 - PMID: 22246346 - PMCID: PMC3385947 - DOI: 10.1038/ncb2411
Jaffer F, Libby P, Weissleder R.
Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
J Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517 - DOI: 10.1016/j.jacc.2006.01.029
Nahrendorf M, Hu K, Hiller K, Galuppo P, Fraccarollo D, Schweizer G, Haase A, Ertl G, Bauer W, Bauersachs J
Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study.
J Am Coll Cardiol. 2002;40(9):1695-700 - PMID: 12427425 - DOI: 10.1016/s0735-1097(02)02375-6
Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schar M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging.
J Am Coll Cardiol. 2008;52:483-91 - PMID: 18672170 - PMCID: PMC2628468 - DOI: 10.1016/j.jacc.2008.03.063
Jaffer FA
Assessing niacin as an atherosclerosis therapeutic agent valuable insights provided by high-resolution vascular magnetic resonance imaging.
J Am Coll Cardiol. 2009;54(19):1795-6 - PMID: 19874993 - DOI: 10.1016/j.jacc.2009.07.026
Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089
Jaffer FA, Calfon MA, Rosenthal A, Mallas G, Razansky RN, Mauskapf A, Weissleder R, Libby P, Ntziachristos V
Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury.
J Am Coll Cardiol. 2011;57(25):2516-26 - PMID: 21679853 - PMCID: PMC3123768 - DOI: 10.1016/j.jacc.2011.02.036
Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MPV, Niessen HWM, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M
PET/MRI of Inflammation in Myocardial Infarction
J Am Coll Cardiol. 2012;59:153-163 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066
Swirski FK, Nahrendorf M
Macrophage - stem cell crosstalk after myocardial infarction.
J Am Coll Cardiol. 2013;62(20):1902-4 - PMID: 23973700 - DOI: 10.1016/j.jacc.2013.07.058
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