MGH Center for Systems Biology

Piccirillo G M, Binda E, Fiocco R, Vescovi L, Shah K

Brain cancer stem cells.

J Mol Med. 2009;87(11):1087-95 - PMID: 19784875 - DOI: 10.1007/s00109-009-0535-3

Alvarez de la Rosa D, Paunescu TG, Els WJ, Helman SI, Canessa CM

Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells.

J Gen Physiol. 2004;124(4):395-407 - PMID: 15452200 - PMCID: PMC2233909 - DOI: 10.1085/jgp.200409120

Li C, Breton S, Morrison R, Cannon CL, Emma F, Sanchez-Olea R, Bear C, Strange K

Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes.

J Gen Physiol. 1998;112(6):727-36 - PMID: 9834142 - PMCID: PMC2229450 - DOI: 10.1085/jgp.112.6.727

Xu Y, Ashline D, Liu L, Tassa C, Shaw SY, Ravid K, Layne MD, Reinhold V, Robbins PW

The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis.

J Lipid Res. 2014;56(2):266-76 - PMID: 25528754 - PMCID: PMC4306681 - DOI: 10.1194/jlr.M053017

Pojoga LH, Romero JR, Yao TM, Loutraris P, Ricchiuti V, Coutinho P, Guo C, Lapointe N, Stone JR, Adler GK, Williams GH

Caveolin-1 Ablation Reduces the Adverse Cardiovascular Effects of N-{omega}-Nitro-L-Arginine Methyl Ester and Angiotensin II.

Endocrinology. 2010;151(3):1236-46 - PMID: 20097717 - PMCID: PMC2840694 - DOI: 10.1210/en.2009-0514

Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, Weinstein LS, Chen M, Marshansky V, Frohlich LF, Bastepe M

Transgenic Overexpression of the Extra-Large Gs{alpha} Variant XL{alpha}s Enhances Gs{alpha}-Mediated Responses in the Mouse Renal Proximal Tubule in Vivo.

Endocrinology. 2011;152(4):1222-33 - PMID: 21303955 - PMCID: PMC3060637 - DOI: 10.1210/en.2010-1034

Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R

Visualizing Microtubule-Dependent Vasopressin Type 2 Receptor Trafficking Using a New High-Affinity Fluorescent Vasopressin Ligand.

Endocrinology. 2011;152(10):3893-904 - PMID: 21828182 - PMCID: PMC3176653 - DOI: 10.1210/en.2011-1049

Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A

Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis.

Endocrinology. 2005;146(8):3614-21 - PMID: 15890774 - PMCID: PMC1351303 - DOI: 10.1210/en.2004-1676

Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A

ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.

Endocrinology. 2014;155(9):3661-73 - PMID: 24971615 - PMCID: PMC4138574 - DOI: 10.1210/en.2014-1341

Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer A, Pietrangelo A, Babitt JL

Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.

Endocrinology. 2016;157(3):1146-62 - PMID: 26735394 - PMCID: PMC4769363 - DOI: 10.1210/en.2015-1747

Canali S, Vecchi C, Garuti C, Montosi G, Babitt JL, Pietrangelo A

The SMAD pathway is required for hepcidin response during endoplasmic reticulum stress.

Endocrinology. 2016;157(10):3935-3945 - PMID: 27483343 - PMCID: PMC5045507 - DOI: 10.1210/en.2016-1258

Hilderbrand S, Lippard S

Cobalt chemistry with mixed aminotroponiminate salicylaldiminate ligands: synthesis, characterization, and nitric oxide reactivity.

Inorg Chem. 2004;43:4674-82 - PMID: 15257596 - DOI: 10.1021/ic049776h

Hilderbrand S, Lippard S

Nitric oxide reactivity of fluorophore coordinated carboxylate-bridged diiron(II) and dicobalt(II) complexes.

Inorg Chem. 2004;43:5294-301 - PMID: 15310207 - DOI: 10.1021/ic049649l

Nolan E, Burdette S, Harvey J, Hilderbrand S, Lippard S

Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform.

Inorg Chem. 2004;43:2624-35 - PMID: 15074981 - DOI: 10.1021/ic035158+

Sheth RA, Upadhyay R, Stangenberg L, Sheth R, Weissleder R, Mahmood U

Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model.

Gynecol Oncol. 2009;112(3):616-22 - PMID: 19135233 - PMCID: PMC2664404 - DOI: 10.1016/j.ygyno.2008.11.018

Brown D, Breton S, Ausiello DA, Marshansky V

Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology.

Traffic. 2009;10(3):275-84 - PMID: 19170982 - PMCID: PMC2896909 - DOI: 10.1111/j.1600-0854.2008.00867.x

Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S

Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.

J Biol Chem. 2005;280(9):8452-63 - PMID: 15591047 - DOI: 10.1074/jbc.M412750200

Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D

Heat shock protein 70 interacts with aquaporin-2 (AQP2) and regulates its trafficking.

J Biol Chem. 2007;282(39):28721-32 - PMID: 17636261 - DOI: 10.1074/jbc.M611101200

Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S

Role of NHERF1, CFTR and cAMP in the regulation of aquaporin 9

J Biol Chem. 2008;283:2986-96 - PMID: 18055461 - DOI: 10.1074/jbc.M704678200

Johnson E, Lee Y, Sander T, Rabkin E, Schoen F, Kaushal S, Bischoff J

NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.

J Biol Chem. 2003;278:1686-92 - PMID: 12427739 - PMCID: PMC2813494 - DOI: 10.1074/jbc.M210250200

Shah K, Vervoort J, de Vries S

Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation.

J Biol Chem. 2001;276(44):41263-9 - PMID: 11509554 - DOI: 10.1074/jbc.M102381200

Xia Y, Yu P, Sidis Y, Beppu H, Bloch K, Schneyer A, Lin H

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.

J Biol Chem. 2007;282(25):18129-40 - PMID: 17472960 - DOI: 10.1074/jbc.M701679200

Babitt J, Zhang Y, Samad T, Xia Y, Tang J, Campagna J, Schneyer A, Woolf C, Lin HY

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.

J Biol Chem. 2005;280(33):29820-7 - PMID: 15975920 - DOI: 10.1074/jbc.M503511200

del Re E, Sidis Y, Fabrizio D, Lin HY, Schneyer A

Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system.

J Biol Chem. 2004;279(51):53126-35 - PMID: 15475360 - DOI: 10.1074/jbc.M408090200

del Re E, Babitt J, Pirani A, Schneyer A, Lin HY

In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2.

J Biol Chem. 2004;279(21):22765-72 - PMID: 14996829 - DOI: 10.1074/jbc.M401350200

Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D

Acute hypertonicity alters aquaporin-2 trafficking and induces a MAP kinase-dependent accumulation at the plasma membrane of renal epithelial cells.

J Biol Chem. 2008;283(39):26643-61 - PMID: 18664568 - PMCID: PMC2546545 - DOI: 10.1074/jbc.M801071200

Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski N, Lewis T, Maglathin R, McLean T, Bochkarev A, Plotnikov A, Vedadi M, Arrowsmith C

Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.

J Biol Chem. 2008;283(17):11355-63 - PMID: 18285338 - PMCID: PMC2431080 - DOI: 10.1074/jbc.M707362200

Kawada J, Zou P, Mazitschek R, Bradner JE, Cohen JI

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.

J Biol Chem. 2009;284(25):17102-9 - PMID: 19386607 - PMCID: PMC2719348 - DOI: 10.1074/jbc.M809090200

Tharp A, Laha M, Panizzi P, Thompson M, Fuentes-Prior P, Bock P

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and Kringle 5 of the substrate.

J Biol Chem. 2009;284(29):19511-21 - PMID: 19473980 - PMCID: PMC2740577 - DOI: 10.1074/jbc.M109.005512

Wiles KG, Panizzi P, Kroh HK, Bock PE

Skizzle is a novel plasminogen and plasmin binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation.

J Biol Chem. 2010;285(27):21153-64 - PMID: 20435890 - PMCID: PMC2898333 - DOI: 10.1074/jbc.M110.107730

Maenz DD, Chenu C, Breton S, Berteloot A

pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.

J Biol Chem. 1992;267(3):1510-6 - PMID: 1346136

Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D

The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.

J Biol Chem. 2000;275(24):18219-24 - PMID: 10748165 - DOI: 10.1074/jbc.M909857199

Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S

Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.

J Biol Chem. 2003;278(49):49523-9 - PMID: 14512417 - PMCID: PMC3652382 - DOI: 10.1074/jbc.M309543200

van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM

Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.

J Biol Chem. 2002;278(2):1101-7 - PMID: 12374804 - DOI: 10.1074/jbc.M207339200

Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W

Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.

J Biol Chem. 2011;286(36):31308-19 - PMID: 21775438 - PMCID: PMC3173057 - DOI: 10.1074/jbc.M111.246124

Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ

DRAGON, a bone morphogenetic protein co-receptor.

J Biol Chem. 2005;280(14):14122-9 - PMID: 15671031 - DOI: 10.1074/jbc.M410034200

Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V

Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.

J Biol Chem. 2001;276(21):18540-50 - PMID: 11278939 - DOI: 10.1074/jbc.M011577200

Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Gruber G, Marshansky V

The N-terminus of a-Subunit Isoforms is Involved in Signaling between V-ATPase and Cytohesin-2.

J Biol Chem. 2013;288(8):5896-913 - PMID: 23288846 - PMCID: PMC3581410 - DOI: 10.1074/jbc.M112.409169

Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

J Biol Chem. 2013;288(39):27849-60 - PMID: 23935101 - PMCID: PMC3784700 - DOI: 10.1074/jbc.M112.445098

Zumbrennen-Bullough K, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D, Babitt JL

MicroRNA-130a is upregulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.

J Biol Chem. 2014;289(34):23796-808 - PMID: 25002578 - PMCID: PMC4156078 - DOI: 10.1074/jbc.M114.577387

Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.

J Biol Chem. 2011;286(47):40443-51 - PMID: 21956108 - PMCID: PMC3220463 - DOI: 10.1074/jbc.M111.280495

Otu HH*, Naxerova K*, Ho K, Can H, Nesbitt N, Libermann TA, Karp SJ

Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns.

J Biol Chem. 2007;282(15):11197-204 - PMID: 17227769 - DOI: 10.1074/jbc.M608441200

Chen S, Reynolds F, Yu L, Weissleder R, Josephson L

A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles

J Mater Chem. 2009;19:6387-6392

Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R

Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.

Exp Neurol. 1997;143(1):61-9 - PMID: 9000446 - DOI: 10.1006/exnr.1996.6350

Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R

MR imaging of slow axonal transport in vivo.

Exp Neurol. 1993;123(2):235-42 - PMID: 8405287 - DOI: 10.1006/exnr.1993.1156

Sinnott JA, Dai W, Liao KP, Shaw SY, Ananthakrishnan AN, Gainer VS, Karlson EW, Churchill S, Szolovits P, Murphy S, Kohane I, Plenge R, Cai T

Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.

Hum Genet. 2014;133(11):1369-82 - PMID: 25062868 - PMCID: PMC4185241 - DOI: 10.1007/s00439-014-1466-9

Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM

RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.

Mol Biol Cell. 2000;11(9):3155-68 - PMID: 10982407 - PMCID: PMC14982 - DOI: 10.1091/mbc.11.9.3155

Cabrero JR, Serrador JM, Barreiro O, Mittelbrunn M, Naranjo-Suárez S, Martín-Cófreces N, Vicente-Manzanares M, Mazitschek R, Bradner JE, Avila J, Valenzuela-Fernández A, Sánchez-Madrid F

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.

Mol Biol Cell. 2006;17(8):3435-45 - PMID: 16738306 - PMCID: PMC1525231 - DOI: 10.1091/mbc.E06-01-0008

Guan Y, Meurer M, Raghavan S, Rebane A, Lindquist JR, Santos S, Kats I, Davidson MW, Mazitschek R, Hughes TE, Drobizhev M, Knop M, Shah JV

Live Cell Multi-Photon Fluorescence Correlation Spectroscopy with an Improved Large Stokes Shift Fluorescent Protein.

Mol Biol Cell. 2015;26(11):2054-66 - PMID: 25877871 - PMCID: PMC4472016 - DOI: 10.1091/mbc.E14-10-1473

Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB

MenaINV mediates synergistic crosstalk between signaling pathways driving chemotaxis and haptotaxis.

Mol Biol Cell. 2016;27(20):3085-3094 - PMID: 27559126 - PMCID: PMC5063616 - DOI: 10.1091/mbc.E16-04-0212