Durable and controlled depletion of neutrophils in mice.
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
Detecting sample swaps in diverse NGS data types using linkage disequilibrium.
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.
p53 dynamics vary between tissues and are linked with radiation sensitivity
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Magnetic barcode assay for genetic detection of pathogens
Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.
A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.
In vivo imaging of specific drug-target binding at subcellular resolution.
An authentic imaging probe to track cell fate from beginning to end.
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Real-time high dynamic range laser scanning microscopy.
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
ADAM8 as a drug target in pancreatic cancer.
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
Atomic layer lithography of wafer-scale nanogap arrays for extreme confinement of electromagnetic waves.
Nat Commun. 2013;4:2361 - PMID: 23999053 - DOI: 10.1038/ncomms3361
Nano-palladium is a cellular catalyst for in vivo chemistry
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Maximizing response to intratumoral immunotherapy in mice by tuning local retention.
T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles.
Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact.
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform.
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging.
Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing.
Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.
Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis.
Digital transcriptome profiling from attomole-level RNA samples.
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.
Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.
Sleep exerts lasting effects on hematopoietic stem cell function and diversity.
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
Cardiac macrophages promote diastolic dysfunction.