MGH Center for Systems Biology

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Nature. 2017;547(7663):355-359 - PMID: 28678782 - PMCID: PMC5896562 - DOI: 10.1038/nature23000

Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M

Macrophages Facilitate Electrical Conduction in the Heart

Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, Sanborn AL, Johnstone SE, Bascom GD, Bochkov ID, Huang X, Shamim MS, Shin J, Turner D, Ye Z, Omer AD, Robinson JT, Schlick T, Bernstein BE, Casellas R, Lander ES, Aiden EL

Cohesin Loss Eliminates All Loop Domains.

Cell. 2017;171(2):305-320.e24 - PMID: 28985562 - PMCID: PMC5846482 - DOI: 10.1016/j.cell.2017.09.026

Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.

Cell. 2017;171(7):1611-1624.e24 - PMID: 29198524 - PMCID: PMC5878932 - DOI: 10.1016/j.cell.2017.10.044

Miller MA, Weissleder R

Imaging of anticancer drug action in single cells

Nat Rev Cancer. 2017;17(7):399–414 - PMID: 28642603 - PMCID: PMC7552440 - DOI: 10.1038/nrc.2017.41

Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichandran H, Mylvaganam R, Mount C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje M, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A, Suvà ML

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.

Science. 2017;355(6332):ePub - PMID: 28360267 - PMCID: PMC5519096 - DOI: 10.1126/science.aai8478

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK

Origins of lymphatic and distant metastases in human colorectal cancer.

Science. 2017;357(6346):55-60 - PMID: 28684519 - PMCID: PMC5536201 - DOI: 10.1126/science.aai8515

Flavahan WA, Gaskell E, Bernstein BE

Epigenetic plasticity and the hallmarks of cancer.

Science. 2017;357(6348):ePub - PMID: 28729483 - PMCID: PMC5940341 - DOI: 10.1126/science.aal2380

Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils

Science. 2017;358:eaal5081 - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081

Najm FJ, Strand C, Donovan KF, Hegde M, Sanson KR, Vaimberg EW, Sullender ME, Hartenian E, Kalani Z, Fusi N, Listgarten J, Younger ST, Bernstein BE, Root DE, Doench JG

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

Nat Biotechnol. 2017;36(2):179-189 - PMID: 29251726 - PMCID: PMC5800952 - DOI: 10.1038/nbt.4048

Pfirschke C, Siwicki M, Liao HW, Pittet MJ

Tumor Microenvironment: No Effector T Cells without Dendritic Cells.

Cancer Cell. 2017;31(5):614-615 - PMID: 28486102 - DOI: 10.1016/j.ccell.2017.04.007

Kleppe M, Koche R, Zou L, van Galen P, Hill CE, Dong L, De Groote S, Papalexi E, Hanasoge Somasundara AV, Cordner K, Keller M, Farnoud N, Medina J, McGovern E, Reyes J, Roberts J, Witkins M, Rapaport F, Teruya-Feldstein J, Qi J, Rampal R, Bernstein BE, Bradner JE, Levine RL

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell. 2017;33(1):29-43.e7 - PMID: 29249691 - PMCID: PMC5760343 - DOI: 10.1016/j.ccell.2017.11.009

Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, Tang CY, Mulder WJ, Murrough JW, Hoffmann U, Nahrendorf M, Shin LM, Fayad ZA, Pitman RK

Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study.

Lancet. 2017;389(10071):834-845 - PMID: 28088338 - PMCID: PMC7864285 - DOI: 10.1016/S0140-6736(16)31714-7

Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M

Cellular uptake of nanoparticles: journey inside the cell.

Chem Soc Rev. 2017;46(14):4218-4244 - PMID: 28585944 - PMCID: PMC5593313 - DOI: 10.1039/c6cs00636a

van der Valk FM, Kuijk C, Verweij SL, Stiekema LC, Kaiser Y, Zeerleder S, Nahrendorf M, Voermans C, Stroes ES

Increased haematopoietic activity in patients with atherosclerosis.

Eur Heart J. 2017;38(6):425-432 - PMID: 27357356 - DOI: 10.1093/eurheartj/ehw246

Frodermann V, Nahrendorf M

Neutrophil-macrophage cross-talk in acute myocardial infarction.

Eur Heart J. 2017;38(3):198-200 - PMID: 28158564 - PMCID: PMC5837392 - DOI: 10.1093/eurheartj/ehw085

Nahrendorf M, Swirski FK

Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis.

Eur Heart J. 2017;38(20):1594-1596 - PMID: 28329093 - DOI: 10.1093/eurheartj/ehx098

Hoyer FF, Nahrendorf M

Neutrophil contributions to ischaemic heart disease.

Eur Heart J. 2017;38(7):465-472 - PMID: 28363210 - DOI: 10.1093/eurheartj/ehx017

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R

IRF3 and type I interferons fuel a fatal response to myocardial infarction

Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428

Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL

Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.

Blood. 2017;130(1):73-83 - PMID: 28438754 - PMCID: PMC5501149 - DOI: 10.1182/blood-2016-12-759423

Frenk NE, Spring L, Muzikansky A, Vadvala HV, Gurski JM, Henderson LE, Mino-Kenudson M, Ly A, Bardia A, Finkelstein D, Engelman J, Mueller PR, Juric D, Weissleder R

High-Content Biopsies Facilitate Molecular Analyses and Do Not Increase Complication Rates in Patients With Advanced Solid Tumors.

JCO Precis Oncol. 2017;1:1-9 - PMID: 35172508 - DOI: 10.1200/PO.17.00081

Kakkar A, Traverso G, Farokhzad OC, Weissleder R, Langer R

Evolution of macromolecular complexity in drug delivery systems.

Nat Rev Chem. 2017;1(8):ePub - PMID: 31286060 - PMCID: PMC6613785 - DOI: 10.1038/s41570-017-0063

Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK

Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study.

J Am Coll Cardiol. 2017;69(20):2502-2513 - PMID: 28521888 - DOI: 10.1016/j.jacc.2017.03.556

Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN

Unraveling Vascular Inflammation: From Immunology to Imaging.

J Am Coll Cardiol. 2017;70(11):1403-1412 - PMID: 28882238 - PMCID: PMC5658004 - DOI: 10.1016/j.jacc.2017.07.750

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.

Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064

Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.

Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Nat Commun. 2017;8:15142 - PMID: 28485378 - PMCID: PMC5436068 - DOI: 10.1038/ncomms15142

Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R

Nano-palladium is a cellular catalyst for in vivo chemistry

Nat Commun. 2017;8:15906 - PMID: 28699627 - PMCID: PMC5510178 - DOI: 10.1038/ncomms15906

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL

PD-L1 is an activation-independent marker of brown adipocytes.

Nat Commun. 2017;8(1):647 - PMID: 28935898 - PMCID: PMC5608754 - DOI: 10.1038/s41467-017-00799-8

Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC

Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts.

Nat Commun. 2017;8(1):765 - PMID: 29018244 - PMCID: PMC5635127 - DOI: 10.1038/s41467-017-00779-y

Castro CM

Good to the last "emulsified" drop.

Sci Transl Med. 2017;9(373):ePub - PMID: 28100835 - DOI: 10.1126/scitranslmed.aal4993

Miller MA

Richer data with personalized GEMs.

Sci Transl Med. 2017;9(381):ePub - PMID: 28298424 - DOI: 10.1126/scitranslmed.aam9865

King KR

Squeeze-E squeeze-E.

Sci Transl Med. 2017;9(382):ePub - PMID: 28330860 - DOI: 10.1126/scitranslmed.aan0766

Miller MA

Nanoparticles improve economic mileage for CARs.

Sci Transl Med. 2017;9(387):ePub - PMID: 28446684 - DOI: 10.1126/scitranslmed.aan2784

King KR

Stunning neutrophils changes the forecast: No more showers.

Sci Transl Med. 2017;9(388):ePub - PMID: 28469035 - DOI: 10.1126/scitranslmed.aan3775

Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604

Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226

Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

Sci Transl Med. 2017;9(392):eaal0225 - PMID: 28566423 - PMCID: PMC6681815 - DOI: 10.1126/scitranslmed.aal0225

Miller MA

Driver mutations take the wheel in invasive yet nonmalignant disease.

Sci Transl Med. 2017;9(393):ePub - PMID: 28592567 - DOI: 10.1126/scitranslmed.aan8194

Miller MA

Nanotransfection brings progress that’s more than skin-deep

Sci Transl Med. 2017;9(405):eaao4216

Miller MA

Counting on carbon quantum dots to clear infection

Sci Transl Med. 2017;9(399):eaao0969

Miller MA

It’s what’s inside that counts for nanoparticle vaccines

Sci Transl Med. 2017;9(417):eaar2438 - DOI: 10.1126/scitranslmed.aar2438

Miller MA

Less is more for anticancer therapy combinations

Sci Transl Med. 2017;9 (411):aap8166 - DOI: 10.1126/scitranslmed.aap8166

Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.

Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682

Seo KJ, Qiang Y, Bilgin I, Kar S, Vinegoni C, Weissleder R, Fang H

Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh.

ACS Nano. 2017;11(4):4365-4372 - PMID: 28391679 - DOI: 10.1021/acsnano.7b01995

Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H

Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.

ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318

Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR

Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection.

ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083

Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H

Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.

ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - PMCID: PMC6296367 - DOI: 10.1021/acsnano.7b06074

Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion.

Circ Res. 2017;121(1):31-42 - PMID: 28428204 - PMCID: PMC5488735 - DOI: 10.1161/CIRCRESAHA.117.310694

Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.

J Exp Med. 2017;214(11):3293-3310 - PMID: 28978634 - PMCID: PMC5679174 - DOI: 10.1084/jem.20170689

Swirski FK, Nahrendorf M

Inflammation: Old, caffeinated, and healthy.

Nat Rev Cardiol. 2017;14(4):194-196 - PMID: 28250451 - DOI: 10.1038/nrcardio.2017.22

Swirski FK

Inflammation and CVD in 2017: From clonal haematopoiesis to the CANTOS trial.

Nat Rev Cardiol. 2017;15(2):79-80 - PMID: 29263444 - DOI: 10.1038/nrcardio.2017.208

Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR

Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.

Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341

Miller MA, Weissleder R

Imaging the pharmacology of nanomaterials by intravital microscopy: Towards understanding their biological behavior.

Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023

Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM

Applying nanomedicine in maladaptive inflammation and angiogenesis.

Adv Drug Deliv Rev. 2017;119:143-158 - PMID: 28506745 - PMCID: PMC5682240 - DOI: 10.1016/j.addr.2017.05.009

Miller MA, Weissleder R

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior

Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023

Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES

Systematic dissection of genomic features determining transcription factor binding and enhancer function.

Proc Natl Acad Sci U S A. 2017;114(7):E1291-E1300 - PMID: 28137873 - PMCID: PMC5321001 - DOI: 10.1073/pnas.1621150114

Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.

Proc Natl Acad Sci U S A. 2017;114(37):E7776-E7785 - PMID: 28839093 - PMCID: PMC5604023 - DOI: 10.1073/pnas.1707381114

He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M

Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

Proc Natl Acad Sci U S A. 2017;114(45):E9559-E9568 - PMID: 29078380 - PMCID: PMC5692581 - DOI: 10.1073/pnas.1712670114

Chaudhury A, Noiret L, Higgins JM

White blood cell population dynamics for risk stratification of acute coronary syndrome.

Proc Natl Acad Sci U S A. 2017;114(46):12344-12349 - PMID: 29087321 - PMCID: PMC5699055 - DOI: 10.1073/pnas.1709228114

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA

Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.

Proc Natl Acad Sci U S A. 2017;114(46):E9989-E9998 - PMID: 29089413 - PMCID: PMC5699061 - DOI: 10.1073/pnas.1710964114

Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I

Stress granule-associated protein G3BP2 regulates breast tumor initiation.

Proc Natl Acad Sci U S A. 2017;114(5):1033-1038 - PMID: 28096337 - PMCID: PMC5293063 - DOI: 10.1073/pnas.1525387114

Song KA, Niederst MJ, Lochmann TL, Hata AN, Kitai H, Ham J, Floros KV, Hicks MA, Hu H, Mulvey HE, Drier Y, Heisey DAR, Hughes MT, Patel NU, Lockerman E, Garcia AR, Gillepsie S, Archibald HL, Gomez-Caraballo M, Nulton TJ, Windle B, Piotrowska Z, Sahingur SE, Taylor SM, Dozmorov MG, Sequist LV, Bernstein BE, Ebi H, Engelman JA, Faber AC

Epithelial-to-mesenchymal transition antagonizes response to targeted therapies in lung cancer by suppressing BIM.

Clin Cancer Res. 2017;24(1):197-208 - PMID: 29051323 - PMCID: PMC5959009 - DOI: 10.1158/1078-0432.CCR-17-1577

Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK

Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma.

Clin Cancer Res. 2017;23(19):5959-5969 - PMID: 28600474 - PMCID: PMC5856249 - DOI: 10.1158/1078-0432.CCR-17-0256

Mikula H, Stapleton S, Kohler RH, Vinegoni C, Weissleder R

Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.

Theranostics. 2017;7(5):1257-1265 - PMID: 28435463 - PMCID: PMC5399591 - DOI: 10.7150/thno.18238

Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.

J Clin Invest. 2017;127(6):2433-2437 - PMID: 28481220 - PMCID: PMC5451245 - DOI: 10.1172/JCI92030

Park CO, Fu X, Jiang X, Pan Y, Teague JE, Collins N, Tian T, O'Malley JT, Emerson RO, Kim JH, Jung Y, Watanabe R, Fuhlbrigge RC, Carbone FR, Gebhardt T, Clark RA, Lin CP, Kupper TS

Staged development of long lived TCRαβ Th17 resident memory T cell population to Candida albicans after skin infection.

J Allergy Clin Immunol. 2017;142(2):647-662 - PMID: 29128674 - PMCID: PMC5943196 - DOI: 10.1016/j.jaci.2017.09.042

Harada T, Ohguchi H, Grondin Y, Kikuchi S, Sagawa M, Tai YT, Mazitschek R, Hideshima T, Anderson KC

HDAC3 regulates DNMT1 expression in multiple myeloma: Therapeutic implications.

Leukemia. 2017;31(12):2670-2677 - PMID: 28490812 - PMCID: PMC5681897 - DOI: 10.1038/leu.2017.144

Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Păunescu TG

Characterization and Correction of Olfactory Deficits in Kidney Disease.

J Am Soc Nephrol. 2017;28(11):3395-3403 - PMID: 28775001 - PMCID: PMC5661283 - DOI: 10.1681/ASN.2016121308

Battistone MA, Nair AV, Barton CR, Liberman RN, Peralta MA, Capen DE, Brown D, Breton S

Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells.

J Am Soc Nephrol. 2017;29(2):545-556 - PMID: 29222395 - PMCID: PMC5791049 - DOI: 10.1681/ASN.2017060643

She A, Kurtser I, Reis SA, Hennig K, Lai J, Lang A, Zhao WN, Mazitschek R, Dickerson BC, Herz J, Haggarty SJ

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.

Cell Chem Biol. 2017;24(7):892-906.e5 - PMID: 28712747 - PMCID: PMC5695697 - DOI: 10.1016/j.chembiol.2017.06.010

Shah N, Wang P, Wongvipat J, Karthaus WR, Abida W, Armenia J, Rockowitz S, Drier Y, Bernstein BE, Long HW, Freedman ML, Arora VK, Zheng D, Sawyers CL

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.

eLife. 2017;6:ePub - PMID: 28891793 - PMCID: PMC5593504 - DOI: 10.7554/eLife.27861

Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI

PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4⁺ TILs in the Presence of PD-L1⁺ TAMs.

Cancer Res. 2017;77(22):6365-6374 - PMID: 28947422 - PMCID: PMC5690870 - DOI: 10.1158/0008-5472.CAN-16-3453

Miller MA, Arlauckas S, Weissleder R

Prediction of Anti-cancer Nanotherapy Efficacy by Imaging

Nanotheranostics. 2017;1(3):296-312 - PMID: 29071194 - PMCID: PMC5646731 - DOI: 10.7150/ntno.20564

Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

Cell Rep. 2017;21(3):784-797 - PMID: 29045844 - PMCID: PMC5687286 - DOI: 10.1016/j.celrep.2017.09.066

Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R

Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.

Nat Protoc. 2017;12(7):1472-1497 - PMID: 28686582 - PMCID: PMC5928516 - DOI: 10.1038/nprot.2017.043

Pulli B, Wojtkiewicz G, Iwamoto Y, Ali M, Zeller MW, Bure L, Wang C, Choi Y, Masia R, Guimaraes AR, Corey KE, Chen JW

Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease.

Radiology. 2017;284(2):390-400 - PMID: 28358240 - PMCID: PMC5548451 - DOI: 10.1148/radiol.2017160588

Bourgeois S, Bounoure L, Mouro-Chanteloup I, Colin Y, Brown D, Wagner CA

The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells.

Kidney Int. 2017;93(2):390-402 - PMID: 29054531 - PMCID: PMC6166241 - DOI: 10.1016/j.kint.2017.07.027

Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F

The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction.

EMBO Mol Med. 2017;9(9):1279-1293 - PMID: 28774883 - PMCID: PMC5582413 - DOI: 10.15252/emmm.201707565

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ

Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Mucosal Immunol. 2017;11(3):703-715 - PMID: 29139475 - PMCID: PMC5953762 - DOI: 10.1038/mi.2017.91

Wilk K, Yeh SA, Mortensen LJ, Ghaffarigarakani S, Lombardo CM, Bassir SH, Aldawood ZA, Lin CP, Intini G

Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration.

Stem Cell Reports. 2017;8(4):933-946 - PMID: 28366454 - PMCID: PMC5390237 - DOI: 10.1016/j.stemcr.2017.03.002

Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.

Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024

Brown D, Sands JM, Reckelhoff JF

APS: The Times They Are A-Changin'.

Physiology (Bethesda). 2017;32(6):400-401 - PMID: 28978629 - DOI: 10.1152/physiol.00025.2017

Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H

Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System

ACS Photonics. 2017;5(2):487-494 - PMID: 29805987 - PMCID: PMC5966285 - DOI: 10.1021/acsphotonics.7b00992

Im H, Lee K, Weissleder R, Lee H, Castro CM

Novel nanosensing technologies for exosome detection and profiling.

Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e

Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H

Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.

Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h

Fenn AM, Swirski FK

Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them.

Arterioscler Thromb Vasc Biol. 2017;37(2):173-175 - PMID: 28122772 - DOI: 10.1161/ATVBAHA.116.308768

Huang P, Almeciga-Pinto I, Jarpe M, van Duzer JH, Mazitschek R, Yang M, Jones SS, Quayle SN

Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models.

Oncotarget. 2017;8(2):2694-2707 - PMID: 27926524 - PMCID: PMC5356834 - DOI: 10.18632/oncotarget.13738

Hideshima T, Mazitschek R, Qi J, Mimura N, Tseng JC, Kung AL, Bradner JE, Anderson KC

HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.

Oncotarget. 2017;8(46):80109-80123 - PMID: 29113288 - PMCID: PMC5655183 - DOI: 10.18632/oncotarget.19019

Hideshima T, Mazitschek R, Qi J, Mimura N, Tseng JC, Kung AL, Bradner JE, Anderson KC

HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.

Oncotarget. 2017;8(46):80109-80123 - PMID: 29113288 - PMCID: PMC5655183 - DOI: 10.18632/oncotarget.19019

Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J

FOXO protects against age-progressive axonal degeneration.

Aging Cell. 2017;17(1):ePub - PMID: 29178390 - PMCID: PMC5771393 - DOI: 10.1111/acel.12701

Hong S, Park KS, Weissleder R, Castro CM, Lee H

Facile silicification of plastic surface for bioassays.

Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k

Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R

Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b

Kim DE, Kim JY, Schellingerhout D, Ryu JH, Lee SK, Jeon S, Lee JS, Kim J, Jang HJ, Park JE, Kim EJ, Kwon IC, Ahn CH, Nahrendorf M, Kim K

Quantitative Imaging of Cerebral Thromboemboli In Vivo: The Effects of Tissue-Type Plasminogen Activator.

Stroke. 2017;48(5):1376-1385 - PMID: 28432262 - DOI: 10.1161/STROKEAHA.117.016511

Tokarz D, Martins JS, Petit ET, Lin CP, Demay MB, Liu ES

Hormonal regulation of osteocyte perilacunar and canalicular remodeling in the Hyp mouse model of XLH.

J Bone Miner Res. 2017;33(3):499-509 - PMID: 29083055 - PMCID: PMC6005377 - DOI: 10.1002/jbmr.3327

Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Păunescu TG, Brown D, Lu HAJ

Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking.

J Cell Sci. 2017;130(17):2914-2925 - PMID: 28754689 - PMCID: PMC5612225 - DOI: 10.1242/jcs.204842

Vandoorne K, Nahrendorf M

Multiparametric Imaging of Organ System Interfaces.

Circ Cardiovasc Imaging. 2017;10(4):ePub - PMID: 28360260 - PMCID: PMC5419074 - DOI: 10.1161/CIRCIMAGING.116.005613

Stein-Merlob AF, Hara T, McCarthy JR, Mauskapf A, Hamilton JA, Ntziachristos V, Libby P, Jaffer FA

Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging.

Circ Cardiovasc Imaging. 2017;10(5):ePub - PMID: 28487316 - PMCID: PMC5509162 - DOI: 10.1161/CIRCIMAGING.116.005813

Global Cardiovascular Magnetic Resonance Registry (GCMR) Investigators, Kwong RY, Petersen SE, Schulz-Menger J, Arai AE, Bingham SE, Chen Y, Choi YL, Cury RC, Ferreira VM, Flamm SD, Steel K, Bandettini WP, Martin ET, Nallamshetty L, Neubauer S, Raman SV, Schelbert EB, Valeti US, Cao JJ, Reichek N, Young AA, Fexon L, Pivovarov M, Ferrari VA, Simonetti OP

The global cardiovascular magnetic resonance registry (GCMR) of the society for cardiovascular magnetic resonance (SCMR): its goals, rationale, data infrastructure, and current developments.

J Cardiovasc Magn Reson. 2017;19(1):23 - PMID: 28187739 - PMCID: PMC5303267 - DOI: 10.1186/s12968-016-0321-7

Minami Y, Wang Z, Aguirre AD, Ong DS, Kim CJ, Uemura S, Soeda T, Lee H, Fujimoto J, Jang IK

Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study.

J Am Heart Assoc. 2017;6(11):e006241 - PMID: 29092845 - PMCID: PMC5721742 - DOI: 10.1161/JAHA.117.006241

Chousterman BG, Swirski FK, Weber GF

Cytokine storm and sepsis disease pathogenesis.

Semin Immunopathol. 2017;39(5):517-528 - PMID: 28555385 - DOI: 10.1007/s00281-017-0639-8

Pai SI, Jack Lee J, Carey TE, Westra WH, Ferrone S, Moore C, Mosunjac MB, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium

HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers.

Oral Oncol. 2017;77:92-97 - PMID: 29362132 - PMCID: PMC5786382 - DOI: 10.1016/j.oraloncology.2017.12.014

Canali S, Wang CY, Zumbrennen-Bullough KB, Bayer A, Babitt JL

Bmp2 controls iron homeostasis in mice independent of Bmp6.

Am J Hematol. 2017;92(11):1204-1213 - PMID: 28815688 - PMCID: PMC5986189 - DOI: 10.1002/ajh.24888

Conrad C, Dorzweiler K, Miller MA, Lauffenburger DA, Strik H, Bartsch JW

Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis.

Fluids Barriers CNS. 2017;14(1):22 - PMID: 28806983 - PMCID: PMC5556623 - DOI: 10.1186/s12987-017-0070-5

Pai SI, Faquin WC

Programmed cell death ligand 1 as a biomarker in head and neck cancer.

Cancer Cytopathol. 2017;125(7):529-533 - PMID: 28472542 - PMCID: PMC5690557 - DOI: 10.1002/cncy.21872

Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy.

Pain. 2017;158(6):1126-1137 - PMID: 28267067 - PMCID: PMC5435512 - DOI: 10.1097/j.pain.0000000000000893

Vunnam S, Reddy A, Mazitschek R, Lukens AK, Wirth DF, Li L, Naumov P, O'Connor MJ, Al-Tel TH

Intramolecular Diaza-Diels-Alder Protocol: A Novel Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks.

Chemistry. 2017;23(17):4137-4148 - PMID: 27997727 - DOI: 10.1002/chem.201605231

Vunnam S, Mazitschek R, Kariem NM, Reddy A, Rabeh W, Li L, O'Connor MJ, Al-Tel TH

Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines.

Chemistry. 2017;23(57):14182-14192 - PMID: 28770556 - DOI: 10.1002/chem.201702495

Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R

Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing

Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524

Oza AM, Tinker AV, Oaknin A, Shapira-Frommer R, McNeish IA, Swisher EM, Ray-Coquard I, Bell-McGuinn K, Coleman RL, O'Malley DM, Leary A, Chen LM, Provencher D, Ma L, Brenton JD, Konecny GE, Castro CM, Giordano H, Maloney L, Goble S, Lin KK, Sun J, Raponi M, Rolfe L, Kristeleit RS

Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.

Gynecol Oncol. 2017;147(2):267-275 - PMID: 28882436 - DOI: 10.1016/j.ygyno.2017.08.022

Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, Karmacharya R

Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.

ACS Chem Biol. 2017;12(8):2139-2148 - PMID: 28628306 - PMCID: PMC6747705 - DOI: 10.1021/acschembio.6b01014

Beam AL, Kartoun U, Pai JK, Chatterjee AK, Fitzgerald TP, Shaw SY, Kohane IS

Predictive Modeling of Physician-Patient Dynamics That Influence Sleep Medication Prescriptions and Clinical Decision-Making.

Sci Rep. 2017;7:42282 - PMID: 28181568 - PMCID: PMC5299453 - DOI: 10.1038/srep42282

Turcotte R, Alt C, Runnels JM, Ito K, Wu JW, Zaher W, Mortensen LJ, Silberstein L, Côté DC, Kung AL, Ito K, Lin CP

Image-guided transplantation of single cells in the bone marrow of live animals.

Sci Rep. 2017;7(1):3875 - PMID: 28634334 - PMCID: PMC5478633 - DOI: 10.1038/s41598-017-02896-6

Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G

Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.

Sci Rep. 2017;7(1):13012 - PMID: 29026145 - PMCID: PMC5638901 - DOI: 10.1038/s41598-017-13046-3

Bozhko D, Osborn EA, Rosenthal A, Verjans JW, Hara T, Kellnberger S, Wissmeyer G, Ovsepian SV, McCarthy JR, Mauskapf A, Stein AF, Jaffer FA, Ntziachristos V

Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo.

Eur Heart J Cardiovasc Imaging. 2017;18(11):1253-1261 - PMID: 28031233 - PMCID: PMC5837649 - DOI: 10.1093/ehjci/jew222

Nairz M, Theurl I, Swirski FK, Weiss G

"Pumping iron" - how macrophages handle iron at the systemic, microenvironmental, and cellular levels.

Pflugers Arch. 2017;469(3-4):397-418 - PMID: 28251312 - PMCID: PMC5362662 - DOI: 10.1007/s00424-017-1944-8

Stiekema LCA, Schnitzler JG, Nahrendorf M, Stroes ESG

The maturation of a 'neural-hematopoietic' inflammatory axis in cardiovascular disease.

Curr Opin Lipidol. 2017;28(6):507-512 - PMID: 28877089 - DOI: 10.1097/MOL.0000000000000457

Park YJ, Battistone MA, Kim B, Breton S

Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis.

Biol Reprod. 2017;96(2):366-375 - PMID: 28203710 - PMCID: PMC6213081 - DOI: 10.1095/biolreprod.116.144857

Tokarz D, Cisek R, Wein MN, Turcotte R, Haase C, Yeh SA, Bharadwaj S, Raphael AP, Paudel H, Alt C, Liu TM, Kronenberg HM, Lin CP

Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy.

PLoS ONE. 2017;12(10):e0186846 - PMID: 29065178 - PMCID: PMC5655444 - DOI: 10.1371/journal.pone.0186846

Arystarkhova E, Bouley R, Liu YB, Sweadner KJ

Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport.

PLoS ONE. 2017;12(11):e0188006 - PMID: 29155857 - PMCID: PMC5695786 - DOI: 10.1371/journal.pone.0188006

Menezes TP, Hill E, de Alencar Moura A, Lobo MDP, Monteiro-Moreira ACO, Breton S, Machado-Neves M

Pattern of protein expression in the epididymis of Oligoryzomys nigripes (Cricetidae, Sigmodontinae).

Cell Tissue Res. 2017;372(1):135-147 - PMID: 29119327 - DOI: 10.1007/s00441-017-2714-9

Cheung PW, Ueberdiek L, Day J, Bouley R, Brown D

Protein phosphatase 2C (PP2C) is responsible for VP-induced dephosphorylation of AQP2 serine 261.

Am J Physiol Renal Physiol. 2017;313(2):F404-F413 - PMID: 28381458 - PMCID: PMC5582913 - DOI: 10.1152/ajprenal.00004.2017

Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HJ

Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.

Am J Physiol Renal Physiol. 2017;313(4):F1026-F1037 - PMID: 28701310 - PMCID: PMC5668581 - DOI: 10.1152/ajprenal.00038.2017

Noiret L, Slater A, Higgins JM

Determinants of red blood cell alloantibody detection duration: analysis of multiply alloimmunized patients supports peritransfusion factors.

Transfusion. 2017;57(8):1930-1937 - PMID: 28639314 - DOI: 10.1111/trf.14157

Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Oh KS, Loeffler JS, Shih HA

Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas.

J Neurosurg. 2017;128(4):1123-1132 - PMID: 28621619 - DOI: 10.3171/2016.11.JNS16913

Li YX, Gautam V, Brüstle A, Cockburn IA, Daria VR, Gillespie C, Gaus K, Alt C, Lee WM

Flexible polygon-mirror based laser scanning microscope platform for multiphoton in-vivo imaging.

J Biophotonics. 2017;10(11):1526-1537 - PMID: 28164461 - DOI: 10.1002/jbio.201600289

Randino R, Gazzerro P, Mazitschek R, Rodriquez M

Synthesis and biological evaluation of Santacruzamate-A based analogues.

Bioorg Med Chem. 2017;25(24):6486-6491 - PMID: 29100734 - DOI: 10.1016/j.bmc.2017.10.026

Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM

Integrating nanomedicine and imaging.

Philos Trans A Math Phys Eng Sci. 2017;375(2107):ePub - PMID: 29038380 - PMCID: PMC5647268 - DOI: 10.1098/rsta.2017.0110

Dorsey ER, Yvonne Chan YF, McConnell MV, Shaw SY, Trister AD, Friend SH

The Use of Smartphones for Health Research.

Acad Med. 2017;92(2):157-160 - PMID: 27119325 - DOI: 10.1097/ACM.0000000000001205

Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL

Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates.

J Cancer. 2017;8(19):3916-3932 - PMID: 29187866 - PMCID: PMC5705993 - DOI: 10.7150/jca.20779

Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C

Motion characterization scheme to minimize motion artifacts in intravital microscopy.

J Biomed Opt. 2017;22(3):36005 - PMID: 28253383 - PMCID: PMC5333764 - DOI: 10.1117/1.JBO.22.3.036005

Pera V, Tan X, Runnels J, Sardesai N, Lin CP, Niedre M

Diffuse fluorescence fiber probe for in vivo detection of circulating cells.

J Biomed Opt. 2017;22(3):37004 - PMID: 28290598 - PMCID: PMC5348644 - DOI: 10.1117/1.JBO.22.3.037004

Hartmann C, Patil R, Lin CP, Niedre MJ

Fluorescence detection, enumeration and characterization of single circulating cells in vivo technology, applications and future prospects.

Phys Med Biol. 2017;:ePub - PMID: 29115281 - DOI: 10.1088/1361-6560/aa98f9

Hartmann C, Patil R, Lin CP, Niedre M

Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.

Phys Med Biol. 2017;63(1):01TR01 - PMID: 29240559 - PMCID: PMC5753400 - DOI: 10.1088/1361-6560/aa98f9

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The Discovery of Water Channels (Aquaporins).

Ann Nutr Metab. 2017;70 Suppl 1:37-42 - PMID: 28614812 - DOI: 10.1159/000463061

Lu X, Galarneau MM, Higgins JM, Wood DK

A microfluidic platform to study the effects of vascular architecture and oxygen gradients on sickle blood flow.

Microcirculation. 2017;24(5):ePub - PMID: 28129479 - PMCID: PMC5505799 - DOI: 10.1111/micc.12357

Je KH, Ryu WS, Lee SK, Kim EJ, Kim JY, Jang HJ, Park JE, Nahrendorf M, Schellingerhout D, Kim DE

Green-channel autofluorescence imaging: A novel and sensitive technique to delineate infarcts.

J Neurosci Methods. 2017;279:22-32 - PMID: 28104485 - DOI: 10.1016/j.jneumeth.2017.01.007

Hassanzadeh E, Glazer DI, Dunne RM, Fennessy FM, Harisinghani MG, Tempany CM

Prostate imaging reporting and data system version 2 (PI-RADS v2): a pictorial review.

Abdom Radiol. 2017;42(1):278-289 - PMID: 27522352 - PMCID: PMC5247306 - DOI: 10.1007/s00261-016-0871-z

Hedgire SS, Kudrimoti S, Oliveira IS, Nadkarni N, McDermott S, Hahn PF, Mino-Kenudson M, Harisinghani MG

Extranodal lymphomas of abdomen and pelvis: imaging findings and differential diagnosis.

Abdom Radiol. 2017;42(4):1096-1112 - PMID: 27866240 - DOI: 10.1007/s00261-016-0964-8

Vieson MD, Gojmerac AM, Khan D, Dai R, van Duzer JH, Mazitschek R, Caudell DL, Liao X, Luo XM, Reilly CM

Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice.

Histol Histopathol. 2017;32(12):1317-1332 - PMID: 28245046 - DOI: 10.14670/HH-11-885

Yamamoto E, Xing L, Higuma T, Minami Y, Bryniarski K, Zanchin T, Wang Z, Aguirre AD, Lee H, Jang IK

Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography.

Coron Artery Dis. 2017;28(7):557-563 - PMID: 28704243 - DOI: 10.1097/MCA.0000000000000534

Dev S, Babitt JL

Overview of iron metabolism in health and disease.

Hemodial Int. 2017;21 Suppl 1:S6-S20 - PMID: 28296010 - PMCID: PMC5977983 - DOI: 10.1111/hdi.12542

Shon SM, Jang HJ, Schellingerhout D, Kim JY, Ryu WS, Lee SK, Kim J, Park JY, Oh JH, Kang JW, Je KH, Park JE, Kim K, Kwon IC, Lee J, Nahrendorf M, Park JH, Kim DE

Cytokine Response to Diet and Exercise Affects Atheromatous Matrix Metalloproteinase-2/9 Activity in Mice.

Circ J. 2017;81(10):1528-1536 - PMID: 28883215 - DOI: 10.1253/circj.CJ-16-1196

Conrad C, Miller MA, Bartsch JW, Schlomann U, Lauffenburger DA

Simultaneous Detection of Metalloprotease Activities in Complex Biological Samples Using the PrAMA (Proteolytic Activity Matrix Assay) Method.

Methods Mol Biol. 2017;1574:243-253 - PMID: 28315256 - DOI: 10.1007/978-1-4939-6850-3_18

Im H, Yang K, Lee H, Castro CM

Characterization of Extracellular Vesicles by Surface Plasmon Resonance.

Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653 - DOI: 10.1007/978-1-4939-7253-1_11

Christensen HL, Păunescu TG, Matchkov V, Barbuskaite D, Brown D, Damkier HH, Praetorius J

The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.

Physiol Rep. 2017;5(1):ePub - PMID: 28053225 - PMCID: PMC5256157 - DOI: 10.14814/phy2.13072

Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K

Deep-learning based hologram classification for molecular diagnostics

bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559

Mohan S, Pai SI, Bhattacharyya N

Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity.

Laryngoscope. 2017;127(6):1334-1338 - PMID: 28150306 - PMCID: PMC7388729 - DOI: 10.1002/lary.26443

Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR, Head and Neck Cancer Specialized Program of Research Excellence (SPORE) Human Immunodeficiency Virus (HIV) Supplement Consortium

Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.

Cancer. 2017;124(1):84-94 - PMID: 29053175 - PMCID: PMC5785080 - DOI: 10.1002/cncr.31063

Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM, Head and Neck Cancer SPORE HIV supplement consortium

Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma.

Head Neck. 2017;39(12):2433-2443 - PMID: 28945296 - PMCID: PMC5808949 - DOI: 10.1002/hed.24911

Pai SI, Wirth LJ

Checkpoint cluster: biomarkers of response.

Emerg Top Life Sci. 2017;1(5):501-508 - PMID: 33525795 - DOI: 10.1042/ETLS20170077

Hwang KL, Hwang WL, Bussière MR, Shih HA

The role of radiotherapy in the management of high-grade meningiomas.

Chin Clin Oncol. 2017;6(Suppl 1):S5 - PMID: 28758409 - DOI: 10.21037/cco.2017.06.09