Case 6-2024: A 21-Year-Old Man with Fatigue and Night Sweats.
N Engl J Med. 2024;390(8):747-756 - PMID: 38381678 - DOI: 10.1056/NEJMcpc2309498
Resilient anatomy and local plasticity of naive and stress haematopoiesis.
Nature. 2024;627(8005):839-846 - PMID: 38509363 - PMCID: PMC10972750 - DOI: 10.1038/s41586-024-07186-6
Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells.
Science. 2024;385(6714):eadn1629 - PMID: 39264994 - DOI: 10.1126/science.adn1629
Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE.
Nat Biotechnol. 2024;:ePub - PMID: 39375445 - DOI: 10.1038/s41587-024-02426-6
Spatial oncology: Translating contextual biology to the clinic.
Cancer Cell. 2024;42(10):1653-1675 - PMID: 39366372 - DOI: 10.1016/j.ccell.2024.09.001
Integrating priorities at the intersection of cancer and neuroscience.
Cancer Cell. 2024;:ePub - PMID: 39423816 - DOI: 10.1016/j.ccell.2024.09.014
Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment.
Nat Genet. 2024;:ePub - PMID: 39227743 - DOI: 10.1038/s41588-024-01890-9
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Cell Metab. 2024;36(4):857-876.e10 - PMID: 38569472 - DOI: 10.1016/j.cmet.2024.02.007
Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart.
Circulation. 2024;150(1):49-61 - PMID: 38506045 - PMCID: PMC11216864 - DOI: 10.1161/CIRCULATIONAHA.123.066433
Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers.
Sustained and Localized Drug Depot Release using Radiation-Activated Scintillating Nanoparticles.
The aged tumor microenvironment limits T cell control of cancer.
Nat Immunol. 2024;25(6):1033-1045 - PMID: 38745085 - PMCID: PMC11500459 - DOI: 10.1038/s41590-024-01828-7
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.
Cell Stem Cell. 2024;31(3):359-377.e10 - PMID: 38458178 - PMCID: PMC10957094 - DOI: 10.1016/j.stem.2024.02.004
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.
Nat Cancer. 2024;:ePub - PMID: 39406916 - DOI: 10.1038/s43018-024-00840-y
Phase-driven progress in nanophotonic biosensing.
Light Sci Appl. 2024;13(1):76 - PMID: 38494520 - PMCID: PMC10944832 - DOI: 10.1038/s41377-024-01415-3
Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform.
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging.
Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing.
Magnetic Silica-Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor-Associated Proteins.
Angew Chem Int Ed Engl. 2024;63(24):e202318870 - PMID: 38578432 - DOI: 10.1002/anie.202318870
Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity.
J Am Chem Soc. 2024;146(38):26320-26330 - PMID: 39276112 - PMCID: PMC11440498 - DOI: 10.1021/jacs.4c08656
Estimating Glycemia From HbA1c and CGM: Analysis of Accuracy and Sources of Discrepancy.
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Extracellular vesicle isolation and counting system (EVics) based on simultaneous tandem tangential flow filtration and large field-of-view light scattering.
J Extracell Vesicles. 2024;13(7):e12479 - PMID: 38978321 - PMCID: PMC11231039 - DOI: 10.1002/jev2.12479
Live Organoid Cyclic Imaging.
Adv Sci (Weinh). 2024;11(14):e2309289 - PMID: 38326078 - PMCID: PMC11005682 - DOI: 10.1002/advs.202309289
Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype.
Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026
Extended Pharmacokinetics Improve Site-Specific Prodrug Activation Using Radiation.
ACS Cent Sci. 2024;10(7):1371-1382 - PMID: 39071065 - PMCID: PMC11273447 - DOI: 10.1021/acscentsci.4c00354
A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation.
Lipid Nanoparticle-mRNA Engineered Dendritic Cell Based Adoptive Cell Therapy Enhances Cancer Immune Response.
Small Methods. 2024;:e2400633 - PMID: 39039995 - DOI: 10.1002/smtd.202400633
Novel lateral flow assay to detect H2O2 by utilizing self-biotinylation of G-quadruplex.
Biosens Bioelectron. 2024;267:116811 - PMID: 39378787 - DOI: 10.1016/j.bios.2024.116811
Macrophages coordinate immune response to laser-induced injury via extracellular traps.
J Neuroinflammation. 2024;21(1):68 - PMID: 38500151 - PMCID: PMC10949579 - DOI: 10.1186/s12974-024-03064-0
Upconverting Nanoparticle-based Enhanced Luminescence Lateral-Flow Assay for Urinary Biomarker Monitoring.
ACS Appl Mater Interfaces. 2024;16(29):38243-38251 - PMID: 38980927 - DOI: 10.1021/acsami.4c06117
Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis.
ACS Appl Mater Interfaces. 2024;16(29):37698-37706 - PMID: 38980897 - DOI: 10.1021/acsami.4c07434
PARP trapping is governed by the PARP inhibitor dissociation rate constant.
Cell Chem Biol. 2024;31(7):1373-1382.e10 - PMID: 38262416 - PMCID: PMC11259578 - DOI: 10.1016/j.chembiol.2023.12.019
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation.
Cell Chem Biol. 2024;31(6):1162-1175.e10 - PMID: 38320555 - DOI: 10.1016/j.chembiol.2024.01.003
What is chemical biology?
Cell Chem Biol. 2024;31(9):1562-1565 - PMID: 39303695 - DOI: 10.1016/j.chembiol.2024.08.011
Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI.
Int J Biomed Imaging. 2024;2024:9763364 - PMID: 38644981 - PMCID: PMC11032209 - DOI: 10.1155/2024/9763364
Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype
Frontiers in Immunology (molecular innate immunity section). 2024;15:1331480 - PMID: 38545103 - PMCID: PMC10965546 - DOI: 10.3389/fimmu.2024.1331480
The R's of Radiation Therapy: Do We Need More or Do We Move On?
Int J Radiat Oncol Biol Phys. 2024;119(3):734-736 - PMID: 38851274 - DOI: 10.1016/j.ijrobp.2024.02.008
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke.
Aging Dis. 2024;:ePub - PMID: 39325942 - DOI: 10.14336/AD.2023.1640
Tuning Into Immune Cell Responses of Chronic Stress With Intravital Microscopy.
Arterioscler Thromb Vasc Biol. 2024;:ePub - PMID: 39445423 - DOI: 10.1161/ATVBAHA.124.321865
Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGFβ depletion.
JCI Insight. 2024;:ePub - PMID: 39298276 - DOI: 10.1172/jci.insight.182766
Ocular Effects of MEK Inhibitor Therapy: Literature Review, Clinical Presentation, and Best Practices for Mitigation.
Oncologist. 2024;29(5):e616-e621 - PMID: 38527005 - PMCID: PMC11067803 - DOI: 10.1093/oncolo/oyae014
Probing the glioma micro-environment: analysis using biopsy in combination with ultra-fast cyclic immunolabeling.
Cellular calcium handling and electrophysiology are modulated by chronic physiological pacing in human induced pluripotent stem cell-derived cardiomyocytes.
Am J Physiol Heart Circ Physiol. 2024;327(5):H1244-H1254 - PMID: 39302711 - DOI: 10.1152/ajpheart.00536.2024
Scission-Enhanced Molecular Imaging (SEMI).
Bioconjug Chem. 2024;35(10):1543-52 - PMID: 39255972 - PMCID: PMC11488501 - DOI: 10.1021/acs.bioconjchem.4c00337
Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer.
Gynecol Oncol. 2024;185:186-193 - PMID: 38447347 - DOI: 10.1016/j.ygyno.2024.01.045
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Deep learning pipeline for automated cell profiling from cyclic imaging
Timing of diuretic administration effects on urine volume in hospitalized patients.
Front Physiol. 2024;14:1208324 - PMID: 38321985 - PMCID: PMC10844419 - DOI: 10.3389/fphys.2023.1208324
Evaluating the added value of concurrent contrast-enhanced diagnostic CT for PSMA-PET/CT Interpretation.
Acad Radiol. 2024;:ePub - PMID: 39147641 - DOI: 10.1016/j.acra.2024.08.008
γ-Butyrolactone derivatives of MSA-2 are STING prodrugs
ChemMedChem. 2024;19(19):e202400416 - PMID: 38887174 - DOI: 10.1002/cmdc.202400416
CRISPR/Cas13a-assisted amplification-free miRNA biosensor via dark-field imaging and magnetic gold nanoparticles.
Barriers and facilitators of retention in care after cervical cancer screening: patients' and healthcare providers' perspectives.
BMC Womens Health. 2024;24(1):516 - PMID: 39272088 - PMCID: PMC11401415 - DOI: 10.1186/s12905-024-03343-1
Hypofractionated Radiotherapy-Related Lymphopenia Is Associated With Worse Survival in Unresectable Intrahepatic Cholangiocarcinoma.
Am J Clin Oncol. 2024;47(8):373-382 - PMID: 38767086 - DOI: 10.1097/COC.0000000000001108
Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology.
SAGE Open Med. 2024;12:20503121241252265 - PMID: 38764539 - PMCID: PMC11100407 - DOI: 10.1177/20503121241252265
Basic Science of Neuroinflammation and Involvement of the Inflammatory Response in Disorders of the Nervous System.
Magn Reson Imaging Clin N Am. 2024;32(2):375-384 - PMID: 38555147 - PMCID: PMC10987041 - DOI: 10.1016/j.mric.2024.01.003
The diagnostic accuracy of serum and plasma microRNAs in detection of cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis.
Gynecol Oncol Rep. 2024;54:101424 - PMID: 38939506 - PMCID: PMC11208915 - DOI: 10.1016/j.gore.2024.101424
Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes.
Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology.
STAR Protoc. 2024;5(2):103129 - PMID: 38857155 - PMCID: PMC11193044 - DOI: 10.1016/j.xpro.2024.103129
Targeting myeloperoxidase to reduce neuroinflammation in X-linked dystonia parkinsonism.
Therapeutic Spp1 silencing in TREM2 + cardiac macrophages suppresses atrial fibrillation.
Localized in vivo prodrug activation using radionuclides.
Ex Vivo Machine Perfusion as a Platform for Lentiviral Gene Delivery in Rat Livers.
A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer.