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Pai SI, Wasserman I, Ji YD, Gilman M, Hung YP, Faquin WC, Mino-Kenudson M, Muniappan A
Pulmonary manifestations of chronic HPV infection in patients with recurrent respiratory papillomatosis
Lancet Respir Med. 2022;10(10):997-1008 - PMID: 35863360 - PMCID: PMC10634185 - DOI: 10.1016/S2213-2600(22)00008-X
Gorelick AN, Naxerova K
Mutational clocks tick differently across species.
Nature. 2022;604(7906):435-436 - PMID: 35418556 - DOI: 10.1038/d41586-022-00976-w
Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK
Brain motor and fear circuits regulate leukocytes during acute stress.
Nature. 2022;607(7919):578-584 - PMID: 35636458 - PMCID: PMC9798885 - DOI: 10.1038/s41586-022-04890-z
Chaffin M, Papangeli I, Simonson B, Akkad AD, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, Atwa O, Ye J, Bedi KC, Nahrendorf M, Kaushik VK, Stegmann CM, Margulies KB, Tucker NR, Ellinor PT
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Nature. 2022;608(7921):174-180 - PMID: 35732739 - DOI: 10.1038/s41586-022-04817-8
Oliveira G, Stromhaug K, Cieri N, Iorgulescu JB, Klaeger S, Wolff JO, Rachimi S, Chea V, Krause K, Freeman SS, Zhang W, Li S, Braun DA, Neuberg D, Carr SA, Livak KJ, Frederick DT, Fritsch EF, Wind-Rotolo M, Hacohen N, Sade-Feldman M, Yoon CH, Keskin DB, Ott PA, Rodig SJ, Boland GM, Wu CJ
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.
Nature. 2022;605(7910):532-538 - PMID: 35508657 - PMCID: PMC9815755 - DOI: 10.1038/s41586-022-04682-5
Cheek DM, Naxerova K
Mapping the long road to cancer.
Cell. 2022;185(6):939-940 - PMID: 35263624 - DOI: 10.1016/j.cell.2022.02.020
Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes
Nat Biotechnol. 2022;40(11):1654-1662 - PMID: 35654978 - PMCID: PMC9669087 - DOI: 10.1038/s41587-022-01339-6
Haase C, Gustafsson K, Mei S, Yeh SC, Richter D, Milosevic J, Turcotte R, Kharchenko PV, Sykes DB, Scadden DT, Lin CP
Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging.
Nat Methods. 2022;19(12):1622-1633 - PMID: 36424441 - PMCID: PMC9718684 - DOI: 10.1038/s41592-022-01673-2
Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks T, Zheng L, Wen PY, Wang TC, Hwang WL
Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities.
Lancet Oncol. 2022;23(2):e62-e74 - PMID: 35114133 - PMCID: PMC9516432 - DOI: 10.1016/S1470-2045(21)00596-9
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - PMCID: PMC10290535 - DOI: 10.1038/s41588-022-01134-8 - Cover
Libby P, Nahrendorf M, Swirski FK
Mischief in the marrow: a root of cardiovascular evil.
Eur Heart J. 2022;43(19):1829-1831 - PMID: 35567561 - DOI: 10.1093/eurheartj/ehac149
Ferdosi S, Stukalov A, Hasan M, Tangeysh B, Brown TR, Wang T, Elgierari EM, Zhao X, Huang Y, Alavi A, Lee-McMullen B, Chu J, Figa M, Tao W, Wang J, Goldberg M, O'Brien ES, Xia H, Stolarczyk C, Weissleder R, Farias V, Batzoglou S, Siddiqui A, Farokhzad OC, Hornburg D
Enhanced competition at the nano-bio interface enables comprehensive characterization of protein corona dynamics and deep coverage of proteomes.
Adv Mater. 2022;34(44):e2206008 - PMID: 35986672 - DOI: 10.1002/adma.202206008
Lugani S*, Halabi EA*, Oh J, Kohler R, Peterson H, Breakefield XO, Chiocca EAA, Miller MA, Garris C, Weissleder R
Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma.
Adv Mater. 2022;35(7):e2208782 - PMID: 36427266 - PMCID: PMC10197197 - DOI: 10.1002/adma.202208782
Andreou C, Weissleder R, Kircher MF
Multiplexed imaging in oncology
Nat Biomed Eng. 2022;6(5):527-540 - PMID: 35624151 - DOI: 10.1038/s41551-022-00891-5
Senders ML, Calcagno C, Tawakol A, Nahrendorf M, Mulder WJM, Fayad ZA
PET/MR imaging of inflammation in atherosclerosis.
Nat Biomed Eng. 2022;7(3):202-220 - PMID: 36522465 - DOI: 10.1038/s41551-022-00970-7
Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.
Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2
Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.
Nat Immunol. 2022;23(4):605-618 - PMID: 35352063 - PMCID: PMC8989652 - DOI: 10.1038/s41590-022-01165-7
Man CH, Mercier FE, Liu N, Dong W, Stephanopoulos G, Jiang L, Jung Y, Lin CP, Leung AYH, Scadden DT
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
Blood. 2022;139(4):502-522 - PMID: 34610101 - PMCID: PMC8796654 - DOI: 10.1182/blood.2021011563
Miller P, Fell G, Foy B, Scherer A, Gibson CJ, Sperling AS, Burugula BB, Nakao T, Uddin MM, Warren H, Bry L, Pozdnyakova O, Frigault MJ, Bick AG, Neuberg D, Higgins JM, Mansour M, Natarajan P, Kim AS, Kitzman J, Ebert BL
Clonal Hematopoiesis of Indeterminate Potential and Risk of Death from COVID-19.
Blood. 2022;140(18):1993-1997 - PMID: 36096050 - PMCID: PMC9474399 - DOI: 10.1182/blood.2022018052
Cheon J, Qin J, Lee LP, Lee H
Advances in Biosensor Technologies for Infection Diagnostics.
Acc Chem Res. 2022;55(2):121-122 - PMID: 35038867 - DOI: 10.1021/acs.accounts.1c00647
Villalba JA, Hilburn CF, Garlin MA, Elliott GA, Li Y, Kunitoki K, Poli S, Alba GA, Madrigal E, Taso M, Price MC, Aviles AJ, Araujo-Medina M, Bonanno L, Boyraz B, Champion SN, Harris CK, Helland TL, Hutchison B, Jobbagy S, Marshall MS, Shepherd DJ, Barth JL, Hung YP, Ly A, Hariri LP, Turbett SE, Pierce VM, Branda JA, Rosenberg ES, Mendez-Pena J, Chebib I, Rosales IA, Smith RN, Miller MA, Rosas IO, Hardin CC, Baden LR, Medoff BD, Colvin RB, Little BP, Stone JR, Mino-Kenudson M, Shih AR
Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and ARDS.
Am J Respir Crit Care Med. 2022;206(7):857-873 - PMID: 35671465 - PMCID: PMC9799276 - DOI: 10.1164/rccm.202109-2150OC
Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP
Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.
Nat Commun. 2022;13(1):393 - PMID: 35046411 - PMCID: PMC8770570 - DOI: 10.1038/s41467-022-27973-x
Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2
Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Nat Commun. 2022;13(1):4976 - PMID: 36008486 - PMCID: PMC9403976 - DOI: 10.1038/s41467-022-32630-4
Momin N, Palmeri JR, Lutz EA, Jailkhani N, Mak H, Tabet A, Chinn MM, Kang BH, Spanoudaki V, Hynes RO, Wittrup KD
Maximizing response to intratumoral immunotherapy in mice by tuning local retention.
Nat Commun. 2022;13(1):109 - PMID: 35013154 - PMCID: PMC8748612 - DOI: 10.1038/s41467-021-27390-6
Weissleder R
Leveraging technology to address current and future world issues.
Sci Transl Med. 2022;14(666):eabq0606 - PMID: 36223448 - DOI: 10.1126/scitranslmed.abq0606 - Cover
Tian T, Liang R, Erel-Akbaba G, Saad L, Obeid PJ, Gao J, Chiocca EA, Weissleder R, Tannous BA
Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles.
ACS Nano. 2022;16(2):1940-1953 - PMID: 35099172 - PMCID: PMC9020451 - DOI: 10.1021/acsnano.1c05505
Hsia T, Yekula A, Batool SM, Rosenfeld YB, You DG, Weissleder R, Lee H, Carter BS, Balaj L
Glioblastoma-derived extracellular vesicle subpopulations following 5-aminolevulinic acid treatment bear diagnostic implications.
J Extracell Vesicles. 2022;11(11):e12278 - PMID: 36404434 - PMCID: PMC9676504 - DOI: 10.1002/jev2.12278
Patel NJ, Tozzo V, Higgins JM, Stone JH
The effects of daily prednisone and tocilizumab on hemoglobin A1c during the treatment of giant cell arteritis.
Arthritis Rheumatol. 2022;75(4):586-594 - PMID: 36383175 - DOI: 10.1002/art.42405
Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R
Integrated Analytical System for Clinical Single-Cell Analysis
Adv Sci (Weinh). 2022;9(20):e2200415 - PMID: 35508767 - PMCID: PMC9284190 - DOI: 10.1002/advs.202200415
Kim H, Sa JK, Kim J, Cho HJ, Oh HJ, Choi DH, Kang SH, Jeong DE, Nam DH, Lee H, Lee HW, Chung S
Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip.
Adv Sci (Weinh). 2022;9(22):e2201785 - PMID: 35657027 - PMCID: PMC9353479 - DOI: 10.1002/advs.202201785
Ko J, Lucas K, Kohler RH, Halabi EA, Wilkovitsch M, Carlson JCT, Weissleder R
In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy
Adv Sci (Weinh). 2022;9(24):e2200064 - PMID: 35750648 - PMCID: PMC9405492 - DOI: 10.1002/advs.202200064
Kilic T, Cho YK, Jeong N, Shin IS, Carter BS, Balaj L, Weissleder R, Lee H
Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles.
ACS Cent Sci. 2022;8(1):110-117 - PMID: 35111901 - PMCID: PMC8802188 - DOI: 10.1021/acscentsci.1c01193
McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti MZ, Wong LP, Yates AG, Poller WC, Mindur JE, Chan CT, Janssen H, Downey J, Singh S, Sadreyev RI, Nahrendorf M, Jeffrey KL, Scadden DT, Naxerova K, St-Onge MP, Swirski FK
Sleep exerts lasting effects on hematopoietic stem cell function and diversity.
J Exp Med. 2022;219(11):ePub - PMID: 36129517 - PMCID: PMC9499822 - DOI: 10.1084/jem.20220081
Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK
Optical coherence tomography in coronary atherosclerosis assessment and intervention.
Nat Rev Cardiol. 2022;19(10):684-703 - PMID: 35449407 - PMCID: PMC9982688 - DOI: 10.1038/s41569-022-00687-9
Ferguson S, Yang KS, Zelga P, Liss AS, Carlson JCT, Del Castillo CF, Weissleder R
Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer.
Sci Adv. 2022;8(16):eabm3453 - PMID: 35452280 - PMCID: PMC9032977 - DOI: 10.1126/sciadv.abm3453
Ng TSC, Hu H, Kronister S, Lee C, Li R, Gerosa L, Stopka SA, Burgenske DM, Khurana I, Regan MS, Vallabhaneni S, Putta N, Scott E, Matvey D, Giobbie-Hurder A, Kohler RH, Sarkaria JN, Parangi S, Sorger PK, Agar NYR, Jacene HA, Sullivan RJ, Buchbinder E, Mikula H, Weissleder R, Miller MA
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Sci Adv. 2022;8(17):eabl6339 - PMID: 35486732 - PMCID: PMC9054019 - DOI: 10.1126/sciadv.abl6339
Cho YK, Kim H, Bénard A, Woo HK, Czubayko F, David P, Hansen FJ, Lee JI, Park JH, Schneck E, Weber GF, Shin IK, Lee H
Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing
Sci Adv. 2022;8:eabq4022 - PMID: 36129990 - PMCID: PMC9491722 - DOI: 10.1126/sciadv.abq4022
Hu H, Quintana J, Weissleder R, Parangi S, Miller M
Deciphering albumin-directed drug delivery by imaging.
Adv Drug Deliv Rev. 2022;185:114237 - PMID: 35364124 - PMCID: PMC9117484 - DOI: 10.1016/j.addr.2022.114237
Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, Hsu KL, Kashatus DF, Ting DT, Chandel NS, Bardeesy N, Bauer TW, Adli M
ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer.
Dev Cell. 2022;57(11):1331-1346.e9 - PMID: 35508175 - DOI: 10.1016/j.devcel.2022.04.014
Lutz EA, Agarwal Y, Momin N, Cowles SC, Palmeri JR, Duong E, Hornet V, Sheen A, Lax BM, Rothschilds AM, Irvine DJ, Spranger S, Wittrup KD
Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies.
Proc Natl Acad Sci U S A. 2022;119(36):e2205983119 - PMID: 36037341 - PMCID: PMC9457244 - DOI: 10.1073/pnas.2205983119
Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H
Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma.
Theranostics. 2022;12(5):1988-1998 - PMID: 35265194 - PMCID: PMC8899565 - DOI: 10.7150/thno.69094 - Cover
Ferguson S, Yang KS, Weissleder R
Single extracellular vesicle analysis for early cancer detection
Trends in Molecular Medicine. 2022;28(8):681-692 - PMID: 35624008 - PMCID: PMC9339504 - DOI: 10.1016/j.molmed.2022.05.003
Liu T, Meng Z, Liu J, Li J, Zhang Y, Deng Z, Luo S, Wang M, Huang Q, Zhang S, Fendt P, Devouassoux J, Li D, McKenzie ANJ, Nahrendorf M, Libby P, Guo J, Shi GP
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.
Cardiovasc Res. 2022;119(4):1046-1061 - PMID: 36063432 - PMCID: PMC10153644 - DOI: 10.1093/cvr/cvac144
Oh HK, Kim K, Park J, Im H, Maher S, Kim MG
Plasmon color-preserved gold nanoparticle clusters for high sensitivity detection of SARS-CoV-2 based on lateral flow immunoassay.
Biosens Bioelectron. 2022;205:114094 - PMID: 35202985 - PMCID: PMC8851749 - DOI: 10.1016/j.bios.2022.114094
Kim K, Son T, Hong JS, Kwak TJ, Jeong MH, Weissleder R, Im H
Physisorption of Affinity Ligands Facilitates Extracellular Vesicle Detection with Low Non-Specific Binding to Plasmonic Gold Substrates.
ACS Appl Mater Interfaces. 2022;:ePub - PMID: 35653580 - PMCID: PMC9715849 - DOI: 10.1021/acsami.2c07317
Chin LK, Li H, Choi JH, Iwamoto Y, Oh J, Min J, Beak SK, Yoo D, Castro CM, Lee D, Im H
Hydrogel Stamping for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues.
ACS Appl Mater Interfaces. 2022;14(24):27613-27622 - PMID: 35671240 - DOI: 10.1021/acsami.2c05071
Ng TSC, Allen HH, Rashidian M, Miller MA
Probing immune infiltration dynamics in cancer by in-vivo imaging.
Curr Opin Chem Biol. 2022;67:102117 - PMID: 35219177 - PMCID: PMC9118268 - DOI: 10.1016/j.cbpa.2022.102117
Payne NC, Mazitschek R
Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors.
Cell Chem Biol. 2022;29(7):1140-1152.e5 - PMID: 35298895 - DOI: 10.1016/j.chembiol.2022.03.002
Payne NC, Maksoud S, Tannous BA, Mazitschek R
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader.
Cell Chem Biol. 2022;29(8):1333-1340.e5 - PMID: 35649410 - PMCID: PMC9391279 - DOI: 10.1016/j.chembiol.2022.05.003
Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X
New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium.
Clin Pharmacol Ther. 2022;112(3):540-561 - PMID: 35488474 - PMCID: PMC9398938 - DOI: 10.1002/cpt.2627
Szafraniec HM, Valdez JM, Iffrig E, Lam WA, Higgins JM, Pearce P, Wood DK
Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.
Lab Chip. 2022;22(8):1565-1575 - PMID: 35315465 - PMCID: PMC9004467 - DOI: 10.1039/d1lc01133b
Lucas K, Oh J, Hoelzl J, Weissleder R
Cellular point-of-care diagnostics using an inexpensive layer-stack microfluidic device.
Lab Chip. 2022;22:2145 - 2154 - PMID: 35514273 - PMCID: PMC9214713 - DOI: 10.1039/d2lc00162d
Iyer V, Yang Z, Ko J, Weissleder R, Issadore D
Advancing microfluidic diagnostic chips into clinical use: a review of current challenges and opportunities.
Lab Chip. 2022;22(17):3110-3121 - PMID: 35674283 - PMCID: PMC9798730 - DOI: 10.1039/d2lc00024e
Seldon CS, Meiyappan K, Hoffman H, Guo JA, Goel N, Hwang WL, Nguyen PL, Mahal BA, Alshalalfa M
Genomic alterations predictive of poor clinical outcomes in pan-cancer.
Oncotarget. 2022;13:1069-1077 - PMID: 36187555 - PMCID: PMC9518688 - DOI: 10.18632/oncotarget.28276
Bapat A, Li G, Xiao L, Yeri A, Hulsmans M, Grune J, Yamazoe M, Schloss MJ, Iwamoto Y, Tedeschi JG, Yang X, Nahrendorf M, Rosenzweig A, Ellinor PT, Das S, Milan D
Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation.
JCI Insight. 2022;7(19):ePub - PMID: 35998035 - PMCID: PMC9675459 - DOI: 10.1172/jci.insight.160885
Shiau C, Su J, Guo JA, Hong TS, Wo JY, Jagadeesh KA, Hwang WL
Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution.
Front Oncol. 2022;12:929950 - PMID: 36185212 - PMCID: PMC9524152 - DOI: 10.3389/fonc.2022.929950
Cook L, Sengelmann M, Winkler B, Nagl C, Koch S, Schlomann U, Slater EP, Miller MA, von Strandmann EP, Dorsam B, Preuber C, Bartsch JW
ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9.
Int J Mol Sci. 2022;23(4):ePub - PMID: 35216088 - PMCID: PMC8875419 - DOI: 10.3390/ijms23041976
Truslow JG, Goto S, Homilius M, Mow C, Higgins JM, MacRae CA, Deo RC
Cardiovascular Risk Assessment Using Artificial Intelligence-Enabled Event Adjudication and Hematologic Predictors.
Circ Cardiovasc Qual Outcomes. 2022;15(6):e008007 - PMID: 35477255 - PMCID: PMC9208816 - DOI: 10.1161/CIRCOUTCOMES.121.008007
Ali M, Fulci G, Grigalavicius M, Pulli B, Li A, Wojtkiewicz GR, Wang C, Hsieh KL, Linnoila JJ, Theodossiou TA, Chen JW
Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy.
Neoplasia. 2022;26:100779 - PMID: 35247801 - PMCID: PMC8894277 - DOI: 10.1016/j.neo.2022.100779
Li JH, Forghani R, Bure L, Wojtkiewicz GR, Wu Y, Iwamoto Y, Ali M, Li A, Wang C, Jalali Motlagh N, Papadakis AI, Pusztaszeri MP, Spatz A, Curtin H, Cheng YS, Chen JW
Molecular immuno-imaging improves tumor detection in head and neck cancer.
FASEB J. 2022;36(1):e22092 - PMID: 34919761 - PMCID: PMC9584652 - DOI: 10.1096/fj.202100864R
Keung EZ, Krause KJ, Maxwell J, Morris CD, Crago AM, Houdek MT, Kane J, Lewis V, Callegaro D, Miller B, Lazar AJ, Gladdy R, Raut CP, Fabbri N, Al-Refaie W, Fairweather M, Wong SL, Roland CL
Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas: A Systematic Review of the Literature.
Ann Surg Oncol. 2022;30(2):958-967 - PMID: 36307665 - DOI: 10.1245/s10434-022-12688-6
Park BJ, Mattox AK, Clayburgh D, Patel M, Bell RB, Yueh B, Leidner R, Xiao H, Couey M, Li S, Qin T, Sartor MA, Cairns B, MacDonough T, Halliwill K, Deschler D, Lin DT, Faquin WC, Sadow PM, Pai SI
Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck.
Oral Oncol. 2022;135:106183 - PMID: 36215771 - PMCID: PMC10283355 - DOI: 10.1016/j.oraloncology.2022.106183
Leming M, Das S, Im H
Construction of a confounder-free clinical MRI dataset in the Mass General Brigham system for classification of Alzheimer's disease.
Artif Intell Med. 2022;129:102309 - PMID: 35659387 - PMCID: PMC9295028 - DOI: 10.1016/j.artmed.2022.102309
Oh J, Yoo TY, Saal TM, Tsay L, Faquin WC, Carlson JCT, Deschler DG, Pai SI, Weissleder R
Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors.
Cancer Cytopathol. 2022;130(8):581-594 - PMID: 35666645 - PMCID: PMC9542730 - DOI: 10.1002/cncy.22594
Kuba W, Sohr B, Keppel P, Svatunek D, Humhal V, Stöger B, Goldeck M, Carlson JCT, Mikula H
Oxidative Desymmetrization Enables the Concise Synthesis of a trans-Cyclooctene Linker for Bioorthogonal Bond-Cleavage.
Chemistry. 2022;29(3):e202203069 - PMID: 36250260 - PMCID: PMC10098836 - DOI: 10.1002/chem.202203069
Jeong MH, Han H, Lagares D, Im H
Recent Advances in Molecular Diagnosis of Pulmonary Fibrosis for Precision Medicine
ACS Pharmacol Transl Sci. 2022;5(8):520-538 - PMID: 35983278 - PMCID: PMC9379941 - DOI: 10.1021/acsptsci.2c00028
Quintana JM, Arboleda D, Hu H, Scott E, Luthria G, Pai S, Parangi S, Weissleder R, Miller MA
Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release.
Bioconjug Chem. 2022;33(8):1474-1484 - PMID: 35833631 - PMCID: PMC9390333 - DOI: 10.1021/acs.bioconjchem.2c00174
Diamant N, Reinertsen E, Song S, Aguirre AD, Stultz CM, Batra P
Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling.
PLoS Comput Biol. 2022;18(2):e1009862 - PMID: 35157695 - PMCID: PMC8880931 - DOI: 10.1371/journal.pcbi.1009862
Srinivasulu V, Srikanth G, Khanfar MA, Abu-Yousef IA, Majdalawieh AF, Mazitschek R, Setty SC, Sebastian A, Al-Tel TH
Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta.
J Org Chem. 2022;87(2):1377-1397 - PMID: 35014258 - DOI: 10.1021/acs.joc.1c02698
Raghu VK, Moonsamy P, Sundt TM, Ong CS, Singh S, Cheng A, Hou M, Denning L, Gleason TG, Aguirre AD, Lu MT
Deep learning to predict mortality after cardiothoracic surgery using preoperative chest radiographs.
Ann Thorac Surg. 2022;115(1):257-264 - PMID: 35609650 - PMCID: PMC11373441 - DOI: 10.1016/j.athoracsur.2022.04.056
Kim J, Oh J, Peterson HM, Carlson JCT, Pittet MJ, Weissleder R
TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells
Adv Biol (Weinh). 2022;6(8):e2200030 - PMID: 35675910 - PMCID: PMC9398996 - DOI: 10.1002/adbi.202200030
Lucas K
Cycling, Fasting, Fishing, and Other Things: The Emerging World of Biocompatible Chemistries
Adv Biol (Weinh). 2022;7(1):e2200178 - PMID: 36047616 - PMCID: PMC10228596 - DOI: 10.1002/adbi.202200178
Chang JYH, Agarwal Y, Rodrigues KA, Momin N, Ni K, Read BJ, Moyer TJ, Mehta NK, Silva M, Suh H, Melo MB, Wittrup KD, Irvine DJ
Co-Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced-Humoral Immunity.
Adv Ther (Weinh). 2022;5(7):2100235 - PMID: 36311814 - PMCID: PMC9595138 - DOI: 10.1002/adtp.202100235
Lee SE, Jeong SE, Hong JS, Im H, Hwang SY, Oh JK, Kim SE
Gold-Nanoparticle-Coated Magnetic Beads for ALP-Enzyme-Based Electrochemical Immunosensing in Human Plasma.
Materials (Basel). 2022;15(19):ePub - PMID: 36234217 - PMCID: PMC9573121 - DOI: 10.3390/ma15196875
Perazzo A, Peng Z, Young YN, Feng Z, Wood DK, Higgins JM, Stone HA
The effect of rigid cells on blood viscosity: linking rheology and sickle cell anemia.
Soft Matter. 2022;18(3):554-565 - PMID: 34931640 - PMCID: PMC8925304 - DOI: 10.1039/d1sm01299a
Park JH, Park EK, Cho YK, Shin IS, Lee H
Normalizing the Optical Signal Enables Robust Assays with Lateral Flow Biosensors.
ACS Omega. 2022;7(21):17723-17731 - PMID: 35664567 - PMCID: PMC9161384 - DOI: 10.1021/acsomega.2c00793
Keppel P, Sohr B, Kuba W, Goldeck M, Skrinjar P, Carlson JCT, Mikula H
Tetrazine-Triggered Bioorthogonal Cleavage of trans-Cyclooctene-Caged Phenols Using a Minimal Self-Immolative Linker Strategy.
Chembiochem. 2022;23(20):e202200363 - PMID: 35921044 - PMCID: PMC9804162 - DOI: 10.1002/cbic.202200363
Bernstein L, Ramier A, Wu J, Aiello VD, Beland MJ, Lin CP, Yun SH
Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.
Biomed Opt Express. 2022;13(4):1939-1947 - PMID: 35519264 - PMCID: PMC9045918 - DOI: 10.1364/BOE.443654
Aguirre AD, Shelton KT
Remote monitoring in the use of extracorporeal membrane oxygenation and acute mechanical circulatory support.
Curr Opin Crit Care. 2022;28(3):308-314 - PMID: 35653252 - DOI: 10.1097/MCC.0000000000000949
Krause K, Schumacher LY, Sachdeva UM
Advances in Imaging to Aid Segmentectomy for Lung Cancer.
Surg Oncol Clin N Am. 2022;31(4):595-608 - PMID: 36243496 - DOI: 10.1016/j.soc.2022.06.003
Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H
Computational Optics for Point-of-Care Breast Cancer Profiling.
Methods Mol Biol. 2022;2393:153-162 - PMID: 34837178 - PMCID: PMC9283060 - DOI: 10.1007/978-1-0716-1803-5_8
Matvey DO, Ng TSC, Miller MA
Confocal Imaging of Single-Cell Signaling in Orthotopic Models of Ovarian Cancer.
Methods Mol Biol. 2022;2424:295-315 - PMID: 34918302 - DOI: 10.1007/978-1-0716-1956-8_19
Wissmeyer G, Kassab MB, Kawamura Y, Aguirre AD, Jaffer FA
Intravital Microscopy in Atherosclerosis Research.
Methods Mol Biol. 2022;2419:645-658 - PMID: 35237994 - PMCID: PMC9052099 - DOI: 10.1007/978-1-0716-1924-7_40
Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann F, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Fei Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP Naxerova K, Swirski FK, Nahrendorf M
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
Nat Cardiovasc Res. 2022;1:28–44 - PMID: 35747128 - PMCID: PMC9216333 - DOI: 10.1038/s44161-021-00002-8
Spitzberg J, Ferguson S, Yang K, Peterson HM, Carlson JCT, Weissleder R
Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact
bioRxiv. 2022;:ePub - DOI: 10.1101/2022.06.17.496607
Guo JA, Alshalalfa M, Kim DY, Hoffman HI, Shiau C, Su J, Hwang WL, Mahal BA
DNA repair and immune checkpoint blockade response.
Cancer Genet. 2022;264-265:1-4 - PMID: 35245846 - DOI: 10.1016/j.cancergen.2022.02.007
Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto I, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M
Neutrophils incite and macrophages avert electrical storm after myocardial infarction
Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w
Lutz EA, Jailkhani N, Momin N, Huang Y, Sheen A, Kang BH, Wittrup KD, Hynes RO
Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice.
PNAS Nexus. 2022;1(5):pgac244 - PMID: 36712341 - PMCID: PMC9802395 - DOI: 10.1093/pnasnexus/pgac244
Zhang LH, Tozzo V, Higgins JM, Ranganath R
Set Norm and Equivariant Skip Connections: Putting the Deep in Deep Sets.
Proc Mach Learn Res. 2022;162:26559-26574 - PMID: 37645424 - PMCID: PMC10465016
Pulous FE, Nahrendorf M
Aortic-intima-resident macrophages are guardians of arterial health.
Nat Cardiovasc Res. 2022;1(1):4-5 - PMID: 39196109 - DOI: 10.1038/s44161-021-00008-2
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