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Chandrasekhar A, Padrós-Valls R, Pallarès-López R, Palanques-Tost E, Houstis N, Sundt TM, Lee HS, Sodini CG, Aguirre AD
Tissue perfusion pressure enables continuous hemodynamic evaluation and risk prediction in the intensive care unit.
Nat Med. 2023;29(8):1998-2006 - PMID: 37550417 - DOI: 10.1038/s41591-023-02474-6
Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu A, Ma X, Gwee J, Tiwari P, Du PP, Sindurakar P, Tian J, Mehta A, Schneider AM, Yizhak K, Sade-Feldman M, LaSalle T, Sharova T, Xie H, Liu S, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A, Spetz JKE, Qin X, Sarosiek KA, Zhang G, Kim JW, Su MY, Cicerchia AM, Rasmussen MQ, Klempner SJ, Juric D, Pai SI, Miller DM, Giobbie-Hurder A, Chen JH, Pelka K, Frederick DT, Stinson S, Ivanova E, Aref AR, Paweletz CP, Barbie DA, Sen DR, Fisher DE, Corcoran RB, Hacohen N, Sorger PK, Flaherty KT, Boland GM, Manguso RT, Jenkins RW
Targeting TBK1 to overcome resistance to cancer immunotherapy.
Nature. 2023;615(7950):158-167 - PMID: 36634707 - PMCID: PMC10171827 - DOI: 10.1038/s41586-023-05704-6
Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF
Non-cell-autonomous cancer progression from chromosomal instability.
Nature. 2023;620(7976):1080-1088 - PMID: 37612508 - PMCID: PMC10468402 - DOI: 10.1038/s41586-023-06464-z
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ
A neutrophil response linked to tumor control in immunotherapy.
Cell. 2023;186(7):1448-1464.e20 - PMID: 37001504 - PMCID: PMC10132778 - DOI: 10.1016/j.cell.2023.02.032
Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M
Recruited macrophages elicit atrial fibrillation.
Science. 2023;381(6654):231-239 - PMID: 37440641 - PMCID: PMC10448807 - DOI: 10.1126/science.abq3061
Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J, Tarussio D, Benedetti F, Tissot S, Kandalaft L, Varrone M, Ciriello G, McKee TA, Monnier Y, Mermod M, Blaum EM, Gushterova I, Gonye ALK, Hacohen N, Getz G, Mempel TR, Klein AM, Weissleder R, Faquin WC, Sadow PM, Lin D, Pai SI, Sade-Feldman M, Pittet MJ
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers.
Science. 2023;381(6657):515-524 - PMID: 37535729 - PMCID: PMC10755760 - DOI: 10.1126/science.ade2292
Zagorulya M, Yim L, Morgan DM, Edwards A, Torres-Mejia E, Momin N, McCreery CV, Zamora IL, Horton BL, Fox JG, Wittrup KD, Love JC, Spranger S
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.
Immunity. 2023;56(2):386-405.e10 - PMID: 36736322 - PMCID: PMC10880816 - DOI: 10.1016/j.immuni.2023.01.010
Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK
Monocytes re-enter the bone marrow during fasting and alter the host response to infection.
Immunity. 2023;56(4):783-796.e7 - PMID: 36827982 - PMCID: PMC10101885 - DOI: 10.1016/j.immuni.2023.01.024
Kiss MG, Mindur JE, Yates AG, Lee D, Fullard JF, Anzai A, Poller WC, Christie KA, Iwamoto Y, Roudko V, Downey J, Chan CT, Huynh P, Janssen H, Ntranos A, Hoffmann JD, Jacob W, Goswami S, Singh S, Leppert D, Kuhle J, Kim-Schulze S, Nahrendorf M, Kleinstiver BP, Probert F, Roussos P, Swirski FK, McAlpine CS
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
Immunity. 2023;56(7):1502-1514.e8 - PMID: 37160117 - PMCID: PMC10524830 - DOI: 10.1016/j.immuni.2023.04.013
Pittet MJ, Di Pilato M, Garris C, Mempel TR
Dendritic cells as shepherds of T cell immunity in cancer.
Immunity. 2023;56(10):2218-2230 - PMID: 37708889 - PMCID: PMC10591862 - DOI: 10.1016/j.immuni.2023.08.014
Bianchi A, De Castro Silva I, Deshpande NU, Singh S, Mehra S, Garrido VT, Guo X, Nivelo LA, Kolonias DS, Saigh SJ, Wieder E, Rafie CI, Dosch AR, Zhou Z, Umland O, Amirian H, Ogobuiro IC, Zhang J, Ban Y, Shiau C, Nagathihalli NS, Montgomery EA, Hwang WL, Brambilla R, Komanduri K, Villarino AV, Toska E, Stanger BZ, Gabrilovich DI, Merchant NB, Datta J
Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer.
Cancer Discov. 2023;13(6):1428-1453 - PMID: 36946782 - PMCID: PMC10259764 - DOI: 10.1158/2159-8290.CD-22-1046
Küçükköse E, Laoukili J, Gorelick AN, Degner S, Lacle M, van den Bent L, Peters NA, Verheem A, Hung WT, Frenkel NC, Wassenaar E, Lansu N, Lenos KJ, Vermeulen L, Koopman M, Roodhart JML, Kops GJPL, Borel Rinkes IHM, Hagendoorn J, Naxerova K, Kranenburg O
Lymphatic invasion of plakoglobin-dependent tumor cell clusters drives formation of polyclonal lung metastases in colon cancer.
Gastroenterology. 2023;165(2):429-444.e15 - PMID: 36906044 - DOI: 10.1053/j.gastro.2023.02.047
Cephas AT, Hwang WL, Maitra A, Parnas O, DelGiorno KE
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease.
Gut. 2023;72(6):1211-1219 - PMID: 36997301 - PMCID: PMC10988578 - DOI: 10.1136/gutjnl-2022-329313
Bapat A, Schloss MJ, Yamazoe M, Grune J, Hulsmans M, Milan DJ, Nahrendorf M, Ellinor PT
A Mouse Model of Atrial Fibrillation in Sepsis.
Circulation. 2023;147(13):1047-1049 - PMID: 36972346 - PMCID: PMC10057612 - DOI: 10.1161/CIRCULATIONAHA.122.060317
Janizek JD, Dincer AB, Celik S, Chen H, Chen W, Naxerova K, Lee SI
Uncovering expression signatures of synergistic drug responses via ensembles of explainable machine-learning models.
Nat Biomed Eng. 2023;7(6):811-829 - PMID: 37127711 - DOI: 10.1038/s41551-023-01034-0
Pryce KD, Serafini RA, Ramakrishnan A, Nicolais A, Giosan IM, Polizu C, Torres-Berrío A, Vuppala S, Kronman H, Ruiz A, Gaspari S, Peña CJ, Sakloth F, Mitsi V, van Duzer J, Mazitschek R, Jarpe M, Shen L, Nestler EJ, Zachariou V
Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury.
Nat Neurosci. 2023;26(7):1229-1244 - PMID: 37291337 - PMCID: PMC10752505 - DOI: 10.1038/s41593-023-01350-3
Mazzitelli JA, Pulous FE, Smyth LCD, Kaya Z, Rustenhoven J, Moskowitz MA, Kipnis J, Nahrendorf M
Skull bone marrow channels as immune gateways to the central nervous system.
Nat Neurosci. 2023;26(12):2052-2062 - PMID: 37996526 - PMCID: PMC10894464 - DOI: 10.1038/s41593-023-01487-1
Rhee C, Scadden EW, Wong LP, Schiroli G, Mazzola MC, Chea PL, Kato H, Hoyer FF, Mistry M, Lee BK, Kim J, Nahrendorf M, Mansour M, Sykes DB, Sadreyev R, Scadden DT
Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors.
Blood. 2023;142(7):658-674 - PMID: 37267513 - PMCID: PMC10447620 - DOI: 10.1182/blood.2023020257
Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M
T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles.
Nat Commun. 2023;14(1):771 - PMID: 36774352 - PMCID: PMC9922247 - DOI: 10.1038/s41467-023-36321-6
Spitzberg JD, Ferguson S, Yang KS, Peterson HM, Carlson JCT, Weissleder R
Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact.
Nat Commun. 2023;14(1):1239 - PMID: 36870999 - PMCID: PMC9985597 - DOI: 10.1038/s41467-023-36932-z
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
Nat Commun. 2023;14(1):5850 - PMID: 37730674 - PMCID: PMC10511721 - DOI: 10.1038/s41467-023-40923-5
Halabi EA, Weissleder R
Light-Deactivated Fluorescent Probes (FLASH-Off) for Multiplexed Imaging.
J Am Chem Soc. 2023;:ePub - PMID: 37018018 - DOI: 10.1021/jacs.3c00170
Chin LK, Yang JY, Chousterman B, Jung S, Kim DG, Kim DH, Lee S, Castro CM, Weissleder R, Park SG, Im H
Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection.
ACS Nano. 2023;17(4):3610-3619 - PMID: 36745820 - PMCID: PMC10150330 - DOI: 10.1021/acsnano.2c10371
Fredrich IR*, Halabi EA*, Kohler RH, Ge X, Garris CS, Weissleder R
Highly Active Myeloid Therapy for Cancer.
ACS Nano. 2023;17(20):20666-20679 - PMID: 37824733 - PMCID: PMC10941024 - DOI: 10.1021/acsnano.3c08034
Kim K, Lee B, Park JH, Park JH, Lee KJ, Kwak TJ, Son T, Shin YB, Im H, Kim MG
Rapid PCR kit: lateral flow paper strip with Joule heater for SARS-CoV-2 detection.
Mater Horiz. 2023;10(5):1697-1704 - PMID: 36843375 - DOI: 10.1039/d2mh01267g
Levy D, Moskowitz MA
Meningeal Mechanisms and the Migraine Connection.
Annu Rev Neurosci. 2023;46:39-58 - PMID: 36913712 - DOI: 10.1146/annurev-neuro-080422-105509
Leming MJ, Bron EE, Bruffaerts R, Ou Y, Iglesias JE, Gollub RL, Im H
Challenges of implementing computer-aided diagnostic models for neuroimages in a clinical setting.
NPJ Digit Med. 2023;6(1):129 - PMID: 37443276 - PMCID: PMC10345121 - DOI: 10.1038/s41746-023-00868-x
Jeong MH, Son T, Tae YK, Park CH, Lee HS, Chung MJ, Park JY, Castro CM, Weissleder R, Jo JH, Bang S, Im H
Plasmon-Enhanced Single Extracellular Vesicle Analysis for Cholangiocarcinoma Diagnosis.
Adv Sci (Weinh). 2023;10(8):e2205148 - PMID: 36698298 - PMCID: PMC10015870 - DOI: 10.1002/advs.202205148
Roh YH, Lee CY, Lee S, Kim H, Ly A, Castro CM, Cheon J, Lee JH, Lee H
CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids.
Adv Sci (Weinh). 2023;10(10):e2206872 - PMID: 36725305 - PMCID: PMC10074104 - DOI: 10.1002/advs.202206872
Hong JS, Son T, Castro CM, Im H
CRISPR/Cas13a-Based MicroRNA Detection in Tumor-Derived Extracellular Vesicles.
Adv Sci (Weinh). 2023;10(24):e2301766 - PMID: 37340600 - PMCID: PMC10460892 - DOI: 10.1002/advs.202301766
Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Cheon J, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H
Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection.
Adv Sci (Weinh). 2023;10(27):e2301930 - PMID: 37485618 - PMCID: PMC10520636 - DOI: 10.1002/advs.202301930
Das R*, Halabi EA*, Fredrich IR, Oh J, Peterson HM, Ge X, Scott E, Kohler RH, Garris CS, Weissleder R
Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery.
Adv Sci (Weinh). 2023;10(33):e2303576 - PMID: 37814359 - PMCID: PMC10667837 - DOI: 10.1002/advs.202303576
Korolj A, Kohler RH, Scott E, Halabi EA, Lucas K, Carlson JCT, Weissleder R
Perfusion Window Chambers Enable Interventional Analyses of Tumor Microenvironments.
Adv Sci (Weinh). 2023;10(34):e2304886 - PMID: 37870204 - PMCID: PMC10700240 - DOI: 10.1002/advs.202304886
Batool SM, Yekula A, Khanna P, Hsia T, Gamblin AS, Ekanayake E, Escobedo AK, You DG, Castro CM, Im H, Kilic T, Garlin MA, Skog J, Dinulescu DM, Dudley J, Agrawal N, Cheng J, Abtin F, Aberle DR, Chia D, Elashoff D, Grognan T, Krysan K, Oh SS, Strom C, Tu M, Wei F, Xian RR, Skates SJ, Zhang DY, Trinh T, Watson M, Aft R, Rawal S, Agarwal A, Kesmodel SB, Yang C, Shen C, Hochberg FH, Wong DTW, Patel AA, Papadopoulos N, Bettegowda C, Cote RJ, Srivastava S, Lee H, Carter BS, Balaj L
The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring.
Cell Rep Med. 2023;4(10):101198 - PMID: 37716353 - PMCID: PMC10591039 - DOI: 10.1016/j.xcrm.2023.101198
Batool SM, Hsia T, Beecroft A, Lewis B, Ekanayake E, Rosenfeld Y, Escobedo AK, Gamblin AS, Rawal S, Cote RJ, Watson M, Wong DTW, Patel AA, Skog J, Papadopoulos N, Bettegowda C, Castro CM, Lee H, Srivastava S, Carter BS, Balaj L
Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer.
Cell Rep Med. 2023;4(10):101196 - PMID: 37725979 - PMCID: PMC10591035 - DOI: 10.1016/j.xcrm.2023.101196
Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK
Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention.
Nat Rev Cardiol. 2023;21(5):348 - PMID: 38110566 - DOI: 10.1038/s41569-023-00982-z
Pai SI, Matheus HR, Guastaldi FPS
Effects of periodontitis on cancer outcomes in the era of immunotherapy.
Lancet Healthy Longev. 2023;4(4):e166-e175 - PMID: 37003275 - PMCID: PMC10148268 - DOI: 10.1016/S2666-7568(23)00021-1
Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, Dong X, Speranza MC, Neagu MR, Iorgulescu JB, Huang RY, Youssef G, Reardon DA, Sharpe AH, Freeman GJ, Suvà ML, Xu L, Jain RK
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models.
Proc Natl Acad Sci U S A. 2023;120(6):e2219199120 - PMID: 36724255 - PMCID: PMC9963691 - DOI: 10.1073/pnas.2219199120
Qiang Y, Sissoko A, Liu ZL, Dong T, Zheng F, Kong F, Higgins JM, Karniadakis GE, Buffet PA, Suresh S, Dao M
Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease.
Proc Natl Acad Sci U S A. 2023;120(6):e2217607120 - PMID: 36730189 - PMCID: PMC9963977 - DOI: 10.1073/pnas.2217607120
Aldawood ZA, Mancinelli L, Geng X, Yeh SA, Di Carlo R, C Leite T, Gustafson J, Wilk K, Yozgatian J, Garakani S, Bassir SH, Cunningham ML, Lin CP, Intini G
Expansion of the sagittal suture induces proliferation of skeletal stem cells and sustains endogenous calvarial bone regeneration.
Proc Natl Acad Sci U S A. 2023;120(16):e2120826120 - PMID: 37040407 - PMCID: PMC10120053 - DOI: 10.1073/pnas.2120826120
Ansah IB, Leming M, Lee SH, Yang JY, Mun C, Noh K, An T, Lee S, Kim DH, Kim M, Im H, Park SG
Label-free detection and discrimination of respiratory pathogens based on electrochemical synthesis of biomaterials-mediated plasmonic composites and machine learning analysis.
Biosens Bioelectron. 2023;227:115178 - PMID: 36867960 - PMCID: PMC10165532 - DOI: 10.1016/j.bios.2023.115178
Kwak TJ, Son T, Hong JS, Winter UA, Jeong MH, McLean C, Weissleder R, Lee H, Castro CM, Im H
Electrokinetically enhanced label-free plasmonic sensing for rapid detection of tumor-derived extracellular vesicles.
Biosens Bioelectron. 2023;237:115422 - PMID: 37301179 - PMCID: PMC10527155 - DOI: 10.1016/j.bios.2023.115422
Hu H, Ng TSC, Kang M, Scott E, Li R, Quintana JM, Matvey D, Vantaku VR, Weissleder R, Parangi S, Miller MA
Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response.
Clin Cancer Res. 2023;29(17):3457-3470 - PMID: 37289199 - PMCID: PMC10527034 - DOI: 10.1158/1078-0432.CCR-22-2976
Clifton GT, Rothenberg M, Ascierto PA, Begley G, Cecchini M, Eder JP, Ghiringhelli F, Italiano A, Kochetkova M, Li R, Mechta-Grigoriou F, Pai SI, Provenzano P, Puré E, Ribas A, Schalper KA, Fridman WH
Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop.
J Immunother Cancer. 2023;11(6):ePub - PMID: 37290925 - PMCID: PMC10254706 - DOI: 10.1136/jitc-2023-006773
Gupta S, Hanna PE, Ouyang T, Yamada KS, Sawtell R, Wang Q, Katz-Agranov N, Feghali L, Krasner CN, Bouberhan S, Castro CM, Sise ME
Kidney Function in Patients with Ovarian Cancer Treated with Poly (ADP-ribose) polymerase (PARP) Inhibitors.
J Natl Cancer Inst. 2023;115(7):831-837 - PMID: 37074956 - PMCID: PMC10323894 - DOI: 10.1093/jnci/djad070
Kurata K, Bott AJ, Tye MA, Yamamoto L, Samur MK, Tai YT, Dunford J, Johansson C, Senbabaoglu F, Philpott M, Palmer C, Ramasamy K, Gooding S, Smilova M, Gaeta G, Guo M, Christianson JC, Payne NC, Singh K, Karagoz K, Stokes ME, Ortiz M, Hagner P, Thakurta A, Cribbs A, Mazitschek R, Hideshima T, Anderson KC, Oppermann U
Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.
Blood Cancer J. 2023;13(1):12 - PMID: 36631435 - PMCID: PMC9834298 - DOI: 10.1038/s41408-023-00787-w
Dosta P, Puigmal N, Cryer AM, Rodríguez AL, Scott E, Weissleder R, Miller MA, Artzi N
Polymeric microneedles enable simultaneous delivery of cancer immunomodulatory drugs and detection of skin biomarkers.
Theranostics. 2023;13(1):1-15 - PMID: 36593949 - PMCID: PMC9800729 - DOI: 10.7150/thno.73966
Conedera FM, Runnels JM, Stein JV, Alt C*, Enzmann V*, Lin CP*
Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration.
J Neuroinflammation. 2023;20(1):206 - PMID: 37689689 - PMCID: PMC10492418 - DOI: 10.1186/s12974-023-02867-x
Maier A, Toner YC, Munitz J, Sullivan NAT, Sakurai K, Meerwaldt AE, Brechbühl EES, Prévot G, van Elsas Y, Maas RJF, Ranzenigo A, Soultanidis G, Rashidian M, Pérez-Medina C, Heo GS, Gropler RJ, Liu Y, Reiner T, Nahrendorf M, Swirski FK, Strijkers GJ, Teunissen AJP, Calcagno C, Fayad ZA, Mulder WJM, van Leent MMT
Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models.
JACC Basic Transl Sci. 2023;8(7):801-816 - PMID: 37547068 - PMCID: PMC10401290 - DOI: 10.1016/j.jacbts.2022.12.014
Armstrong JF, Campo B, Alexander SPH, Arendse LB, Cheng X, Davenport AP, Faccenda E, Fidock DA, Godinez-Macias KP, Harding SD, Kato N, Lee MCS, Luth MR, Mazitschek R, Mittal N, Niles JC, Okombo J, Ottilie S, Pasaje CFA, Probst AS, Rawat M, Rocamora F, Sakata-Kato T, Southan C, Spedding M, Tye MA, Yang T, Zhao N, Davies JA
Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR Review X.
Br J Pharmacol. 2023;180(15):1899-1929 - PMID: 37197802 - DOI: 10.1111/bph.16144
Yue H, Nowak RP, Overwijn D, Payne NC, Fischinger S, Atyeo C, Lam EC, St Denis K, Brais LK, Konishi Y, Sklavenitis-Pistofidis R, Baden LR, Nilles EJ, Karlson EW, Yu XG, Li JZ, Woolley AE, Ghobrial IM, Meyerhardt JA, Balazs AB, Alter G, Mazitschek R, Fischer ES
Diagnostic TR-FRET assays for detection of antibodies in patient samples.
Cell Rep Methods. 2023;3(3):100421 - PMID: 37056371 - PMCID: PMC10088089 - DOI: 10.1016/j.crmeth.2023.100421
Jeong MH, Im H*, Dahl JB*
Non-contact microfluidic analysis of the stiffness of single large extracellular vesicles from IDH1-mutated glioblastoma cells.
Adv Mater Technol. 2023;8(7):ePub - PMID: 37649709 - PMCID: PMC10465107 - DOI: 10.1002/admt.202201412
Shah VS, Hou J, Vinarsky V, Xu J, Surve M, Lin CP, Rajagopal J
Autofluorescence imaging permits label free cell type assignment in unmodified airway and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs).
eLife. 2023;12:ePub - PMID: 36994985 - PMCID: PMC10154029 - DOI: 10.7554/eLife.84375
Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK
Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.
eLife. 2023;12:ePub - PMID: 37737220 - PMCID: PMC10695565 - DOI: 10.7554/eLife.85023
Adamson RJ, Payne NC, Bartual SG, Mazitschek R, Bullock AN
Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.
Free Radic Biol Med. 2023;204:215-225 - PMID: 37156295 - PMCID: PMC10564622 - DOI: 10.1016/j.freeradbiomed.2023.04.021
Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F
Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.
Biol Res. 2023;56(1):8 - PMID: 36869357 - PMCID: PMC9983216 - DOI: 10.1186/s40659-023-00419-4
Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F
Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.
Biol Res. 2023;56(1):24 - PMID: 37165417 - PMCID: PMC10173557 - DOI: 10.1186/s40659-023-00433-6
Foy B, Stefely J, Bendapudi PK, Hasserjian RP, Al-Samkari H, Louissaint A, Fitzpatrick M, Hutchison B, Mow C, Collins J, Patel H, Patel C, Patel N, Ho S, Kaufman RM, Dzik W', Higgins JM, Makar RS
Computer vision quantitation of erythrocyte shape abnormalities provides diagnostic, prognostic, and mechanistic insight.
Blood Adv. 2023;7(16):4621-4630 - PMID: 37146262 - PMCID: PMC10448422 - DOI: 10.1182/bloodadvances.2022008967
Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy S, Boitano A, Nahrendorf M, Scadden DT
Clearing and replacing tissue-resident myeloid cells with an anti-CD45-antibody-drug conjugate.
Blood Adv. 2023;7(22):6964-6973 - PMID: 37748049 - PMCID: PMC10690556 - DOI: 10.1182/bloodadvances.2023010561
Linnoila J, Jalali Motlagh N, Jachimiec G, Lin CJ, Küllenberg E, Wojtkiewicz G, Tanzi R, Chen JW
Optimizing animal models of autoimmune encephalitis using active immunization.
Front Immunol. 2023;14:1177672 - PMID: 37520559 - PMCID: PMC10374403 - DOI: 10.3389/fimmu.2023.1177672
Hwang WL, Su J, Shiau C, Wang PL, Guo JA, Lester NA, Barth JL, Hoffman HI, Aguirre A, Hong TS, Wo JY, Ting D, Zheng L, Mino-Kenudson M, Jacks T
Molecular Mechanisms of Intratumoral Nerve Recruitment and Perineural Invasion Elucidated with Spatial Transcriptomics and CRISPR Activation.
Int J Radiat Oncol Biol Phys. 2023;117(2S):S21 - PMID: 37784453 - DOI: 10.1016/j.ijrobp.2023.06.244
Holzschuh JC, Mix M, Ruf J, Hölscher T, Kotzerke J, Vrachimis A, Doolan P, Ilhan H, Marinescu IM, Spohn SKB, Fechter T, Kuhn D, Bronsert P, Gratzke C, Grosu R, Kamran SC, Heidari P, Ng TSC, Könik A, Grosu AL, Zamboglou C
Deep Learning based Automated Delineation of the Intraprostatic Gross Tumour Volume in PSMA-PET for Patients with Primary Prostate Cancer.
Radiother Oncol. 2023;188:109774 - PMID: 37394103 - PMCID: PMC10862258 - DOI: 10.1016/j.radonc.2023.109774
Hsia T, Small JL, Yekula A, Batool SM, Escobedo AK, Ekanayake E, You DG, Lee H, Carter BS, Balaj L
Systematic Review of Photodynamic Therapy in Gliomas.
Cancers (Basel). 2023;15(15):ePub - PMID: 37568734 - PMCID: PMC10417382 - DOI: 10.3390/cancers15153918
Michelson D, Chin WW, Dworkin RH, Freeman R, Herrmann DN, Mazitschek R, Pop-Busui R, Shaibani A, Vornov J, Jones M, Jarpe M, Hader B, Viera T, Hylan M, Kachmar T, Jones S
A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy.
Pain Rep. 2023;8(6):e1114 - PMID: 37899940 - PMCID: PMC10611336 - DOI: 10.1097/PR9.0000000000001114
Zeller MWG, Wang C, Keliher EJ, Wojtkiewicz GR, Aguirre A, Maresca K, Su C, Buckbinder L, Wang J, Nahrendorf M, Chen JW
Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction.
Int J Mol Sci. 2023;24(6):ePub - PMID: 36982778 - PMCID: PMC10057533 - DOI: 10.3390/ijms24065704
Keung EZ, Krause KJ, Maxwell J, Morris CD, Crago AM, Houdek MT, Kane J, Lewis V, Callegaro D, Miller B, Lazar AJ, Gladdy R, Raut CP, Fabbri N, Al-Refaie W, Fairweather M, Wong SL, Roland CL
ASO Visual Abstract: Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas-A Systematic Review of the Literature.
Ann Surg Oncol. 2023;30(2):970-971 - PMID: 36323987 - DOI: 10.1245/s10434-022-12754-z
Kim H, Lee S, Lee KW, Kim ES, Kim HM, Im H, Yoon HC, Ko JG, Kim E
Indolizine-based fluorescent compounds array for noninvasive monitoring of glucose in bio-fluids using on-device machine learning
Dyes Pigm. 2023;215:2023 - DOI: 10.1016/j.dyepig.2023.111287
Hegemann N, Sang P, Kim JH, Koçana C, Momin N, Klages J, Kucherenko MM, Knosalla C, O'Brien B, Simmons S, Nahrendorf M, Kuebler WM, Grune J
Ultrasonographic assessment of pulmonary and central venous congestion in experimental heart failure.
Am J Physiol Heart Circ Physiol. 2023;326(2):H433-H440 - PMID: 38099848 - DOI: 10.1152/ajpheart.00735.2023
Gilbert L, Oaknin A, Matulonis UA, Mantia-Smaldone GM, Lim PC, Castro CM, Provencher D, Memarzadeh S, Method M, Wang J, Moore KN, O'Malley DM
Safety and efficacy of mirvetuximab soravtansine, a folate receptor alpha (FRα))-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer.
Gynecol Oncol. 2023;170:241-247 - PMID: 36736157 - DOI: 10.1016/j.ygyno.2023.01.020
Silberman JN, Bercow AS, Gockley AA, Eisenhauer EL, Sisodia R, Randall T, Del Carmen MG, Goodman A, Castro CM, Melamed A, Bregar AJ
Trends in the use of neoadjuvant chemotherapy for low-grade serous ovarian cancer in the United States.
Gynecol Oncol. 2023;175:60-65 - PMID: 37327540 - DOI: 10.1016/j.ygyno.2023.06.001
Yang KS, O'Shea A, Zelga P, Liss AS, Del Castillo CF, Weissleder R
Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma.
Sci Rep. 2023;13(1):10969 - PMID: 37414831 - PMCID: PMC10325992 - DOI: 10.1038/s41598-023-37966-5
Bagramyan A, Lin CP
Miniaturized microscope for non-invasive imaging of leukocyte-endothelial interaction in human microcirculation.
Sci Rep. 2023;13(1):17881 - PMID: 37857684 - PMCID: PMC10587353 - DOI: 10.1038/s41598-023-45018-1
Hsia T, You DG, Politis MG, Batool SM, Ekanayake E, Lee H, Carter BS, Balaj L
Rigorous Comparison of Extracellular Vesicle Processing to Enhance Downstream Analysis for Glioblastoma Characterization.
Adv Biol (Weinh). 2023;8(1):e2300233 - PMID: 37670402 - DOI: 10.1002/adbi.202300233
Leming M, Das S, Im H
Adversarial confound regression and uncertainty measurements to classify heterogeneous clinical MRI in Mass General Brigham.
PLoS ONE. 2023;18(3):e0277572 - PMID: 36862751 - PMCID: PMC9980829 - DOI: 10.1371/journal.pone.0277572
Yoon BC, Pomerantz SR, Mercaldo ND, Goyal S, L'Italien EM, Lev MH, Buch KA, Buchbinder BR, Chen JW, Conklin J, Gupta R, Hunter GJ, Kamalian SC, Kelly HR, Rapalino O, Rincon SP, Romero JM, He J, Schaefer PW, Do S, González RG
Incorporating algorithmic uncertainty into a clinical machine deep learning algorithm for urgent head CTs.
PLoS ONE. 2023;18(3):e0281900 - PMID: 36913348 - PMCID: PMC10010506 - DOI: 10.1371/journal.pone.0281900
Song TH, Cao M, Min J, Im H, Lee H, Lee K
Deep learning-based phenotyping of breast cancer cells using lens-free digital in-line holography.
Biophys J. 2023;122(3S1):285a - PMID: 36783413 - DOI: 10.1016/j.bpj.2022.11.1619
Yekula A, Hsia T, Kitchen RR, Chakrabortty SK, Yu W, Batool MS, Lewis B, Szeglowski AJ, Weissleder R, Lee H, Chi AS, Batchelor T, Carter BS, Breakefield XO, Skog J, Balaj L
Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR amplified recurrent glioblastoma patients.
Neurooncol Adv. 2023;:ePub - DOI: 10.1093/noajnl/vdad104
Yekula A, Hsia T, Kitchen RR, Chakrabortty SK, Yu W, Batool SM, Lewis B, Szeglowski AJ, Weissleder R, Lee H, Chi AS, Batchelor T, Carter BS, Breakefield XO, Skog J, Balaj L
Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients.
Neurooncol Adv. 2023;5(1):vdad104 - PMID: 37811539 - PMCID: PMC10559837 - DOI: 10.1093/noajnl/vdad104
Magudia K, Arleo EK, Porter KK, Ng TSC
A Practical Guide for Paid Family and Medical Leave in Radiology, From the AJR Special Series on DEI.
AJR Am J Roentgenol. 2023;221(5):575-581 - PMID: 37195791 - DOI: 10.2214/AJR.23.29327
Kitson SL, Watters W, Moody TS, Chappell T, Mazitschek R
Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-14 C-heptanoyl]-oxy)-benzoic acid methyl ester, [14 C]-SHP-141: a novel class I/II histone deacetylase (HDAC) inhibitor.
J Labelled Comp Radiopharm. 2023;66(7-8):172-179 - PMID: 37186406 - DOI: 10.1002/jlcr.4026
Haase C, Richter D, Lin CP
Laser Micromachining of Bone as a Tool for Studying Bone Marrow Biology.
Methods Mol Biol. 2023;2567:163-180 - PMID: 36255701 - PMCID: PMC10287113 - DOI: 10.1007/978-1-0716-2679-5_11
Jeong MH, Son T, Im H
Plasmon-Enhanced Characterization of Single Extracellular Vesicles.
Methods Mol Biol. 2023;2668:3-13 - PMID: 37140785 - PMCID: PMC10394726 - DOI: 10.1007/978-1-0716-3203-1_1
Silva AM, Ng TSC
Creating the freedom to thrive: Honoring the legacy of RSNA gold medalist, Deborah Levine, MD.
Clin Imaging. 2023;106:110031 - PMID: 38128405 - DOI: 10.1016/j.clinimag.2023.110031
Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H
Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer.
bioRxiv. 2023;:ePub - PMID: 36711872 - PMCID: PMC9882285 - DOI: 10.1101/2023.01.19.524549
Yin Z, Wu L, Zhang Y, Sun Y, Chen JW, Subudhi S, Ho W, Lee GY, Wang A, Gao X, Ren J, Zhu C, Zhang N, Ferraro GB, Muzikansky A, Zhang L, Stemmer-Rachamimov A, Mao J, Plotkin SR, Xu L
Co-Targeting IL-6 and EGFR signaling for the treatment of schwannomatosis and associated pain.
bioRxiv. 2023;:ePub - PMID: 36798353 - PMCID: PMC9934519 - DOI: 10.1101/2023.02.06.527377
Shiau C, Cao J, Gregory MT, Gong D, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Schurman N, Barth JL, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Fernandez-Del Castillo C, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL
Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis.
bioRxiv. 2023;:ePub - PMID: 37425692 - PMCID: PMC10327107 - DOI: 10.1101/2023.06.28.546848
Stollmann A, Garcia-Guirado J, Hong JS, Im H, Lee H, Arroyo JO, Quidant R
Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform.
arXiv. 2023;:ePub - PMID: 37608933 - PMCID: PMC10441434
Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy SL, Boitano AE, Nahrendorf M, Scadden DT
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer.
bioRxiv. 2023;:ePub - PMID: 37732224 - PMCID: PMC10508759 - DOI: 10.1101/2023.09.05.556397
Foy BH, Petherbridge R, Roth M, Mow C, Patel HR, Patel CH, Ho SN, Lam E, Karczewski KJ, Tozzo V, Higgins JM
Hematologic setpoints are a stable and patient-specific deep phenotype.
medRxiv. 2023;:ePub - PMID: 37808854 - PMCID: PMC10557837 - DOI: 10.1101/2023.09.26.23296146
Arroyo JO, Stollmann A, Garcia-Guirado J, Hong JS, Im H, Lee H, Quidant R
Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform.
Res Sq. 2023;:ePub - PMID: 37886549 - PMCID: PMC10602063 - DOI: 10.21203/rs.3.rs-3309306/v1
Landeros C, Oh J, Weissleder R, Lee H
Deep Learning Pipeline for Automated Cell Profiling from Cyclic Imaging.
Res Sq. 2023;:ePub - PMID: 38196620 - PMCID: PMC10775369 - DOI: 10.21203/rs.3.rs-3745061/v1
Alam R, Aguirre AD, Stultz CM
QTNet: Deep Learning for Estimating QT Intervals Using a Single Lead ECG.
Annu Int Conf IEEE Eng Med Biol Soc. 2023;2023:1-4 - PMID: 38261472 - DOI: 10.1109/EMBC40787.2023.10341204
Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans M, Lee IH, Mentkowski K, Grune J, Schloss MJ, Honold L, Iwamoto Y, Zheng Y, Bredella MA, Buckless C, Ghoshhajra B, Thondapu V, van der Laan AM, Piek JJ, Niessen HWM, Pallante F, Carnevale R, Perrotta S, Carnevale D, Iborra-Egea O, Muñoz-Guijosa C, Galvez-Monton C, Bayes-Genis A, Vidoudez C, Trauger SA, Scadden D, Swirski FK, Moskowitz MA, Naxerova K, Nahrendorf M
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.
Nat Cardiovasc Res. 2023;2(12):1277-1290 - PMID: 38344689 - PMCID: PMC10857823 - DOI: 10.1038/s44161-023-00388-7
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