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Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes
Nat Biotechnol. 2022;:ePub - PMID: 35654978 - DOI: 10.1038/s41587-022-01339-6
Cheek DM, Naxerova K
Mapping the long road to cancer.
Cell. 2022;185(6):939-940 - PMID: 35263624 - DOI: 10.1016/j.cell.2022.02.020
Gorelick AN, Naxerova K
Mutational clocks tick differently across species.
Nature. 2022;604(7906):435-436 - PMID: 35418556 - DOI: 10.1038/d41586-022-00976-w
Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK
Brain motor and fear circuits regulate leukocytes during acute stress.
Nature. 2022;:ePub - PMID: 35636458 - DOI: 10.1038/s41586-022-04890-z
Chaffin M, Papangeli I, Simonson B, Akkad AD, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, Atwa O, Ye J, Bedi KC, Nahrendorf M, Kaushik VK, Stegmann CM, Margulies KB, Tucker NR, Ellinor PT
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Nature. 2022;:ePub - PMID: 35732739 - DOI: 10.1038/s41586-022-04817-8
Libby P, Nahrendorf M, Swirski FK
Mischief in the marrow: a root of cardiovascular evil.
Eur Heart J. 2022;43(19):1829-1831 - PMID: 35567561 - DOI: 10.1093/eurheartj/ehac149
Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.
Nat Immunol. 2022;23(4):605-618 - PMID: 35352063 - PMCID: PMC8989652 - DOI: 10.1038/s41590-022-01165-7
Cheon J, Qin J, Lee LP, Lee H
Advances in Biosensor Technologies for Infection Diagnostics.
Acc Chem Res. 2022;55(2):121-122 - PMID: 35038867 - DOI: 10.1021/acs.accounts.1c00647
Villalba JA, Hilburn CF, Garlin MA, Elliott GA, Li Y, Kunitoki K, Poli S, Alba GA, Madrigal E, Taso M, Price MC, Aviles AJ, Araujo-Medina M, Bonanno L, Boyraz B, Champion SN, Harris CK, Helland TL, Hutchison B, Jobbagy S, Marshall MS, Shepherd DJ, Barth JL, Hung YP, Ly A, Hariri LP, Turbett SE, Pierce VM, Branda JA, Rosenberg ES, Mendez-Pena J, Chebib I, Rosales IA, Smith RN, Miller MA, Rosas IO, Hardin CC, Baden LR, Medoff BD, Colvin RB, Little BP, Stone JR, Mino-Kenudson M, Shih AR
Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and ARDS.
Am J Respir Crit Care Med. 2022;:ePub - PMID: 35671465 - DOI: 10.1164/rccm.202109-2150OC
Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.
Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2
Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R
Integrated Analytical System for Clinical Single-Cell Analysis
Adv Sci (Weinh). 2022;:e2200415 - PMID: 35508767 - DOI: 10.1002/advs.202200415
Kim H, Sa JK, Kim J, Cho HJ, Oh HJ, Choi DH, Kang SH, Jeong DE, Nam DH, Lee H, Lee HW, Chung S
Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip.
Adv Sci (Weinh). 2022;:e2201785 - PMID: 35657027 - DOI: 10.1002/advs.202201785
Ko J, Lucas K, Kohler RH, Halabi EA, Wilkovitsch M, Carlson JCT, Weissleder R
In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy
Adv Sci. 2022;:ePub - DOI: https://doi.org/10.1002/advs.202200064
Tian T, Liang R, Erel-Akbaba G, Saad L, Obeid PJ, Gao J, Chiocca EA, Weissleder R, Tannous BA
Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles.
ACS Nano. 2022;16(2):1940-1953 - PMID: 35099172 - PMCID: PMC9020451 - DOI: 10.1021/acsnano.1c05505
Kilic T, Cho YK, Jeong N, Shin IS, Carter BS, Balaj L, Weissleder R, Lee H
Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles.
ACS Cent Sci. 2022;8(1):110-117 - PMID: 35111901 - PMCID: PMC8802188 - DOI: 10.1021/acscentsci.1c01193
Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK
Optical coherence tomography in coronary atherosclerosis assessment and intervention.
Nat Rev Cardiol. 2022;:ePub - PMID: 35449407 - DOI: 10.1038/s41569-022-00687-9
Ferguson S, Yang KS, Zelga P, Liss AS, Carlson JCT, Del Castillo CF, Weissleder R
Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer.
Sci Adv. 2022;8(16):eabm3453 - PMID: 35452280 - PMCID: PMC9032977 - DOI: 10.1126/sciadv.abm3453
Ng TSC, Hu H, Kronister S, Lee C, Li R, Gerosa L, Stopka SA, Burgenske DM, Khurana I, Regan MS, Vallabhaneni S, Putta N, Scott E, Matvey D, Giobbie-Hurder A, Kohler RH, Sarkaria JN, Parangi S, Sorger PK, Agar NYR, Jacene HA, Sullivan RJ, Buchbinder E, Mikula H, Weissleder R, Miller MA
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Sci Adv. 2022;8(17):eabl6339 - PMID: 35486732 - PMCID: PMC9054019 - DOI: 10.1126/sciadv.abl6339
Hu H, Quintana J, Weissleder R, Parangi S, Miller M
Deciphering albumin-directed drug delivery by imaging.
Adv Drug Deliv Rev. 2022;185:114237 - PMID: 35364124 - PMCID: PMC9117484 - DOI: 10.1016/j.addr.2022.114237
Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP
Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.
Nat Commun. 2022;13(1):393 - PMID: 35046411 - PMCID: PMC8770570 - DOI: 10.1038/s41467-022-27973-x
Ferguson S, Yang KS, Weissleder R
Single extracellular vesicle analysis for early cancer detection
Trends in Molecular Medicine. 2022;:ePub - PMID: 35624008 - DOI: 10.1016/j.molmed.2022.05.003
Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H
Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma.
Theranostics. 2022;12(5):1988-1998 - PMID: 35265194 - PMCID: PMC8899565 - DOI: 10.7150/thno.69094 - Cover
Andreou C, Weissleder R, Kircher MF
Multiplexed imaging in oncology
Nat Biomed Eng. 2022;6(5):527-540 - PMID: 35624151 - DOI: 10.1038/s41551-022-00891-5
Oh HK, Kim K, Park J, Im H, Maher S, Kim MG
Plasmon color-preserved gold nanoparticle clusters for high sensitivity detection of SARS-CoV-2 based on lateral flow immunoassay.
Biosens Bioelectron. 2022;205:114094 - PMID: 35202985 - PMCID: PMC8851749 - DOI: 10.1016/j.bios.2022.114094
Kim K, Son T, Hong JS, Kwak TJ, Jeong MH, Weissleder R, Im H
Physisorption of Affinity Ligands Facilitates Extracellular Vesicle Detection with Low Non-Specific Binding to Plasmonic Gold Substrates.
ACS Appl Mater Interfaces. 2022;:ePub - PMID: 35653580 - DOI: 10.1021/acsami.2c07317
Chin LK, Li H, Choi JH, Iwamoto Y, Oh J, Min J, Beak SK, Yoo D, Castro CM, Lee D, Im H
Hydrogel Stamping for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues.
ACS Appl Mater Interfaces. 2022;14(24):27613-27622 - PMID: 35671240 - DOI: 10.1021/acsami.2c05071
Man CH, Mercier FE, Liu N, Dong W, Stephanopoulos G, Jiang L, Jung Y, Lin CP, Leung AYH, Scadden DT
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
Blood. 2022;139(4):502-522 - PMID: 34610101 - PMCID: PMC8796654 - DOI: 10.1182/blood.2021011563
Ng TSC, Allen HH, Rashidian M, Miller MA
Probing immune infiltration dynamics in cancer by in-vivo imaging.
Curr Opin Chem Biol. 2022;67:102117 - PMID: 35219177 - PMCID: PMC9118268 - DOI: 10.1016/j.cbpa.2022.102117
Payne NC, Mazitschek R
Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors.
Cell Chem Biol. 2022;:ePub - PMID: 35298895 - DOI: 10.1016/j.chembiol.2022.03.002
Payne NC, Maksoud S, Tannous BA, Mazitschek R
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader.
Cell Chem Biol. 2022;:ePub - PMID: 35649410 - DOI: 10.1016/j.chembiol.2022.05.003
Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X
New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium.
Clin Pharmacol Ther. 2022;:ePub - PMID: 35488474 - DOI: 10.1002/cpt.2627
Szafraniec HM, Valdez JM, Iffrig E, Lam WA, Higgins JM, Pearce P, Wood DK
Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.
Lab Chip. 2022;22(8):1565-1575 - PMID: 35315465 - PMCID: PMC9004467 - DOI: 10.1039/d1lc01133b
Lucas K, Oh J, Hoelzl J, Weissleder R
Cellular point-of-care diagnostics using an inexpensive layer-stack microfluidic device.
Lab Chip. 2022;22:2145 - 2154 - PMID: 35514273 - DOI: 10.1039/d2lc00162d
Iyer V, Yang Z, Ko J, Weissleder R, Issadore D
Advancing microfluidic diagnostic chips into clinical use: a review of current challenges and opportunities.
Lab Chip. 2022;:ePub - PMID: 35674283 - DOI: 10.1039/d2lc00024e
Cook L, Sengelmann M, Winkler B, Nagl C, Koch S, Schlomann U, Slater EP, Miller MA, von Strandmann EP, Dorsam B, Preuber C, Bartsch JW
ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9.
Int J Mol Sci. 2022;23(4):ePub - PMID: 35216088 - PMCID: PMC8875419 - DOI: 10.3390/ijms23041976
Truslow JG, Goto S, Homilius M, Mow C, Higgins JM, MacRae CA, Deo RC
Cardiovascular Risk Assessment Using Artificial Intelligence-Enabled Event Adjudication and Hematologic Predictors.
Circ Cardiovasc Qual Outcomes. 2022;15(6):e008007 - PMID: 35477255 - DOI: 10.1161/CIRCOUTCOMES.121.008007
Ali M, Fulci G, Grigalavicius M, Pulli B, Li A, Wojtkiewicz GR, Wang C, Hsieh KL, Linnoila JJ, Theodossiou TA, Chen JW
Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy.
Neoplasia. 2022;26:100779 - PMID: 35247801 - PMCID: PMC8894277 - DOI: 10.1016/j.neo.2022.100779
Li JH, Forghani R, Bure L, Wojtkiewicz GR, Wu Y, Iwamoto Y, Ali M, Li A, Wang C, Jalali Motlagh N, Papadakis AI, Pusztaszeri MP, Spatz A, Curtin H, Cheng YS, Chen JW
Molecular immuno-imaging improves tumor detection in head and neck cancer.
FASEB J. 2022;36(1):e22092 - PMID: 34919761 - DOI: 10.1096/fj.202100864R
Leming M, Das S, Im H
Construction of a confounder-free clinical MRI dataset in the Mass General Brigham system for classification of Alzheimer's disease.
Artif Intell Med. 2022;129:102309 - PMID: 35659387 - DOI: 10.1016/j.artmed.2022.102309
Oh J, Yoo TY, Saal TM, Tsay L, Faquin WC, Carlson JCT, Deschler DG, Pai SI, Weissleder R
Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors.
Cancer Cytopathol. 2022;:ePub - PMID: 35666645 - DOI: 10.1002/cncy.22594
Diamant N, Reinertsen E, Song S, Aguirre AD, Stultz CM, Batra P
Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling.
PLoS Comput Biol. 2022;18(2):e1009862 - PMID: 35157695 - PMCID: PMC8880931 - DOI: 10.1371/journal.pcbi.1009862
Srinivasulu V, Srikanth G, Khanfar MA, Abu-Yousef IA, Majdalawieh AF, Mazitschek R, Setty SC, Sebastian A, Al-Tel TH
Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta.
J Org Chem. 2022;87(2):1377-1397 - PMID: 35014258 - DOI: 10.1021/acs.joc.1c02698
Raghu VK, Moonsamy P, Sundt TM, Ong CS, Singh S, Cheng A, Hou M, Denning L, Gleason TG, Aguirre AD, Lu MT
Deep learning to predict mortality after cardiothoracic surgery using preoperative chest radiographs.
Ann Thorac Surg. 2022;:ePub - PMID: 35609650 - DOI: 10.1016/j.athoracsur.2022.04.056
Perazzo A, Peng Z, Young YN, Feng Z, Wood DK, Higgins JM, Stone HA
The effect of rigid cells on blood viscosity: linking rheology and sickle cell anemia.
Soft Matter. 2022;18(3):554-565 - PMID: 34931640 - PMCID: PMC8925304 - DOI: 10.1039/d1sm01299a
Kim J, Oh J, Peterson HM, Carlson JCT, Pittet MJ, Weissleder R
TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells
Adv Biol (Weinh). 2022;:e2200030 - PMID: 35675910 - DOI: 10.1002/adbi.202200030
Park JH, Park EK, Cho YK, Shin IS, Lee H
Normalizing the Optical Signal Enables Robust Assays with Lateral Flow Biosensors.
ACS Omega. 2022;7(21):17723-17731 - PMID: 35664567 - PMCID: PMC9161384 - DOI: 10.1021/acsomega.2c00793
Bernstein L, Ramier A, Wu J, Aiello VD, Beland MJ, Lin CP, Yun SH
Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.
Biomed Opt Express. 2022;13(4):1939-1947 - PMID: 35519264 - PMCID: PMC9045918 - DOI: 10.1364/BOE.443654
Aguirre AD, Shelton KT
Remote monitoring in the use of extracorporeal membrane oxygenation and acute mechanical circulatory support.
Curr Opin Crit Care. 2022;28(3):308-314 - PMID: 35653252 - DOI: 10.1097/MCC.0000000000000949
Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H
Computational Optics for Point-of-Care Breast Cancer Profiling.
Methods Mol Biol. 2022;2393:153-162 - PMID: 34837178 - DOI: 10.1007/978-1-0716-1803-5_8
Matvey DO, Ng TSC, Miller MA
Confocal Imaging of Single-Cell Signaling in Orthotopic Models of Ovarian Cancer.
Methods Mol Biol. 2022;2424:295-315 - PMID: 34918302 - DOI: 10.1007/978-1-0716-1956-8_19
Wissmeyer G, Kassab MB, Kawamura Y, Aguirre AD, Jaffer FA
Intravital Microscopy in Atherosclerosis Research.
Methods Mol Biol. 2022;2419:645-658 - PMID: 35237994 - PMCID: PMC9052099 - DOI: 10.1007/978-1-0716-1924-7_40
Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann F, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Fei Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP Naxerova K, Swirski FK, Nahrendorf M
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
Nat Cardiovasc Res. 2022;1:28–44 - PMID: 35747128 - PMCID: PMC9216333 - DOI: 10.1038/s44161-021-00002-8
Spitzberg J, Ferguson S, Yang K, Peterson HM, Carlson JCT, Weissleder R
Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact
bioRxiv. 2022;:ePub - DOI: 10.1101/2022.06.17.496607
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