MGH Center for Systems Biology

del Re E, Sidis Y, Fabrizio D, Lin HY, Schneyer A

Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system.

J Biol Chem. 2004;279(51):53126-35 - PMID: 15475360 - DOI: 10.1074/jbc.M408090200

del Re E, Babitt J, Pirani A, Schneyer A, Lin HY

In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2.

J Biol Chem. 2004;279(21):22765-72 - PMID: 14996829 - DOI: 10.1074/jbc.M401350200

Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D

Acute hypertonicity alters aquaporin-2 trafficking and induces a MAP kinase-dependent accumulation at the plasma membrane of renal epithelial cells.

J Biol Chem. 2008;283(39):26643-61 - PMID: 18664568 - PMCID: PMC2546545 - DOI: 10.1074/jbc.M801071200

Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski N, Lewis T, Maglathin R, McLean T, Bochkarev A, Plotnikov A, Vedadi M, Arrowsmith C

Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.

J Biol Chem. 2008;283(17):11355-63 - PMID: 18285338 - PMCID: PMC2431080 - DOI: 10.1074/jbc.M707362200

Kawada J, Zou P, Mazitschek R, Bradner JE, Cohen JI

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.

J Biol Chem. 2009;284(25):17102-9 - PMID: 19386607 - PMCID: PMC2719348 - DOI: 10.1074/jbc.M809090200

Tharp A, Laha M, Panizzi P, Thompson M, Fuentes-Prior P, Bock P

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and Kringle 5 of the substrate.

J Biol Chem. 2009;284(29):19511-21 - PMID: 19473980 - PMCID: PMC2740577 - DOI: 10.1074/jbc.M109.005512

Wiles KG, Panizzi P, Kroh HK, Bock PE

Skizzle is a novel plasminogen and plasmin binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation.

J Biol Chem. 2010;285(27):21153-64 - PMID: 20435890 - PMCID: PMC2898333 - DOI: 10.1074/jbc.M110.107730

Maenz DD, Chenu C, Breton S, Berteloot A

pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.

J Biol Chem. 1992;267(3):1510-6 - PMID: 1346136

Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D

The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.

J Biol Chem. 2000;275(24):18219-24 - PMID: 10748165 - DOI: 10.1074/jbc.M909857199

Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S

Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.

J Biol Chem. 2003;278(49):49523-9 - PMID: 14512417 - PMCID: PMC3652382 - DOI: 10.1074/jbc.M309543200

van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM

Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.

J Biol Chem. 2002;278(2):1101-7 - PMID: 12374804 - DOI: 10.1074/jbc.M207339200

Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W

Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.

J Biol Chem. 2011;286(36):31308-19 - PMID: 21775438 - PMCID: PMC3173057 - DOI: 10.1074/jbc.M111.246124

Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ

DRAGON, a bone morphogenetic protein co-receptor.

J Biol Chem. 2005;280(14):14122-9 - PMID: 15671031 - DOI: 10.1074/jbc.M410034200

Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V

Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.

J Biol Chem. 2001;276(21):18540-50 - PMID: 11278939 - DOI: 10.1074/jbc.M011577200

Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Gruber G, Marshansky V

The N-terminus of a-Subunit Isoforms is Involved in Signaling between V-ATPase and Cytohesin-2.

J Biol Chem. 2013;288(8):5896-913 - PMID: 23288846 - PMCID: PMC3581410 - DOI: 10.1074/jbc.M112.409169

Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

J Biol Chem. 2013;288(39):27849-60 - PMID: 23935101 - PMCID: PMC3784700 - DOI: 10.1074/jbc.M112.445098

Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.

J Biol Chem. 2011;286(47):40443-51 - PMID: 21956108 - PMCID: PMC3220463 - DOI: 10.1074/jbc.M111.280495

Otu HH*, Naxerova K*, Ho K, Can H, Nesbitt N, Libermann TA, Karp SJ

Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns.

J Biol Chem. 2007;282(15):11197-204 - PMID: 17227769 - DOI: 10.1074/jbc.M608441200

Chen S, Reynolds F, Yu L, Weissleder R, Josephson L

A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles

J Mater Chem. 2009;19:6387-6392

Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R

Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.

Exp Neurol. 1997;143(1):61-9 - PMID: 9000446 - DOI: 10.1006/exnr.1996.6350

Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R

MR imaging of slow axonal transport in vivo.

Exp Neurol. 1993;123(2):235-42 - PMID: 8405287 - DOI: 10.1006/exnr.1993.1156

Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM

RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.

Mol Biol Cell. 2000;11(9):3155-68 - PMID: 10982407 - PMCID: PMC14982 - DOI: 10.1091/mbc.11.9.3155

Cabrero JR, Serrador JM, Barreiro O, Mittelbrunn M, Naranjo-Suárez S, Martín-Cófreces N, Vicente-Manzanares M, Mazitschek R, Bradner JE, Avila J, Valenzuela-Fernández A, Sánchez-Madrid F

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.

Mol Biol Cell. 2006;17(8):3435-45 - PMID: 16738306 - PMCID: PMC1525231 - DOI: 10.1091/mbc.E06-01-0008

Merkulova M, Bakulina A, Thaker YR, Gruber G, Marshansky V

Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.

Biochim Biophys Acta. 2010;1797(8):1398-1409 - PMID: 20153292 - DOI: 10.1016/j.bbabio.2010.02.009

Moore A, Basilion JP, Chiocca EA, Weissleder R

Measuring transferrin receptor gene expression by NMR imaging.

Biochim Biophys Acta. 1998;1402(3):239-49 - PMID: 9606982 - DOI: 10.1016/s0167-4889(98)00002-0

Bogdanov A, Simonova M, Weissleder R

Design of metal-binding green fluorescent protein variants.

Biochim Biophys Acta. 1998;1397(1):56-64 - PMID: 9545533 - DOI: 10.1016/s0167-4781(97)00221-2

Bogdanov AA, Martin C, Weissleder R, Brady TJ

Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes.

Biochim Biophys Acta. 1994;1193(1):212-8 - PMID: 7518693 - DOI: 10.1016/0005-2736(94)90350-6

Da Silva N, Pietrement C, Brown D, Breton S

Segmental and cellular expression of aquaporins in the male excurrent duct.

Biochim Biophys Acta. 2006;1758(8):1025-33 - PMID: 16935257 - DOI: 10.1016/j.bbamem.2006.06.026

Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R

SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.

J Leukocyte biol. 2006;81(3):748-56 - PMID: 17178915 - DOI: 10.1189/jlb.1105664

Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DF

A colorimetric high throughput screen for the detection of heme crystallization inhibitors.

Antimicrob Agents Chemother. 2009;53(6):2564-8 - PMID: 19307367 - PMCID: PMC2687197 - DOI: 10.1128/AAC.01466-08

Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A

Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.

Antimicrob Agents Chemother. 1995;39(4):839-45 - PMID: 7785981 - PMCID: PMC162639 - DOI: 10.1128/aac.39.4.839

Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jimenez-Diaz MB, Magan N, Gomez V, Ferrer S, Santos Marti

Aminoindoles: a Novel Scaffold with Potent Activity against Plasmodium falciparum.

Antimicrob Agents Chemother. 2011;55(6):2612-22 - PMID: 21422215 - PMCID: PMC3101419 - DOI: 10.1128/AAC.01714-10

Shi S, Hoogaars WM, de Gorter DJ, van Heiningen SH, Lin HY, Hong CC, Kemaladewi DU, Aartsma-Rus A, Ten Dijke P, 't Hoen PA

BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model.

Neurobiol Dis. 2010;41(2):353-60 - PMID: 20940052 - PMCID: PMC3674857 - DOI: 10.1016/j.nbd.2010.10.003

Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J

Propranolol and the risk of hospitalized myopathy: Translating chemical genomics findings into population-level hypotheses.

Am Heart J. 2010;159(3):428-433 - PMID: 20211305 - DOI: 10.1016/j.ahj.2009.12.008

Huang X, Im H, Lee D, Kim H, Choi Y

Ferrocene Functionalized Single-Walled Carbon Nanotube Bundles. Hybrid Interdigitated Construction Film for l-Glutamate Detection

J Phys Chem C. 2007;111(3):1200-1206

Cortez-Retamozo V, Etzrodt M, Pittet MJ

Regulation of Macrophage and Dendritic Cell Responses by Their Lineage Precursors.

J Innate Immunity. 2012;4(5-6):411-23 - PMID: 22433183 - PMCID: PMC3498093 - DOI: 10.1159/000335733

Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE

Noninvasive imaging of apoptosis in cardiovascular disease.

Heart Fail Rev. 2008;13(2)::163-173 - PMID: 18074226 - PMCID: PMC2597223 - DOI: 10.1007/s10741-007-9068-4

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L

Statistical dynamics of flowing red blood cells by morphological image processing.

PLoS Comput Biol. 2009;5(2):e1000288 - PMID: 19214200 - PMCID: PMC2631282 - DOI: 10.1371/journal.pcbi.1000288

Miller M, Hafner M, Sontag E, Davidsohn N, Subramanian S, Purnick PE, Lauffenburger D, Weiss R

Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity.

PLoS Comput Biol. 2012;8(7):e1002579 - PMID: 22829755 - PMCID: PMC3400602 - DOI: 10.1371/journal.pcbi.1002579

Tung CH, Quinti L, Jaffer F, Weissleder R

A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets

Mol Pharmacol. 2005;2:92-95 - PMID: 15804182 - DOI: 10.1021/mp0499048

Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.

Mol Pharmacol. 2007;72(5):1137-45 - PMID: 17675586 - DOI: 10.1124/mol.107.038117

Kelly K*, Shaw SY*, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R.

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.

Integr Biol (Camb). 2009;1(4):311-317 - PMID: 20023731 - PMCID: PMC2748356 - DOI: 10.1039/b821775k

Taqueti VR, Jaffer FA

High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo.

Integr Biol (Camb). 2013;5(2):278-90 - PMID: 23135362 - PMCID: PMC3558556 - DOI: 10.1039/c2ib20194a

Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA

Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities.

Integr Biol (Camb). 2010;3(4):422-38 - PMID: 21180771 - PMCID: PMC3173501 - DOI: 10.1039/c0ib00083c

Ruan YC, Shum WW, Belleannée C, Da Silva N, Breton S

ATP secretion in the male reproductive tract: essential role of CFTR.

J Physiol. 2012;590(Pt 17):4209-22 - PMID: 22711960 - PMCID: PMC3473280 - DOI: 10.1113/jphysiol.2012.230581

Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model.

ACS Chem Biol. 2009;4(7):527-33 - PMID: 19572548 - PMCID: PMC2745594 - DOI: 10.1021/cb900084v

McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.

ACS Chem Biol. 2012;7(9):1520-8 - PMID: 22724584 - DOI: 10.1021/cb300235m

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ

Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.

ACS Chem Biol. 2013;8(12):2724-33 - PMID: 24168452 - PMCID: PMC3951132 - DOI: 10.1021/cb400352d

McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S

Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.

ACS Chem Biol. 2012;9(4):1061 - PMID: 22724584 - DOI: 10.1021/cb300235m

Bhaumik J, Weissleder R, McCarthy JR

Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers.

J Org Chem. 2009;74(16):5894-901 - PMID: 19610602 - PMCID: PMC2888918 - DOI: 10.1021/jo900832y