Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Dissecting direct reprogramming through integrative genomic analysis.
Direct measurement of local oxygen concentration in the bone marrow of live animals.
ABCB5 is a limbal stem cell gene required for corneal development and repair.
Genetic and epigenetic fine mapping of causal autoimmune disease variants.
Dissecting neural differentiation regulatory networks through epigenetic footprinting.
Integrative analysis of 111 reference human epigenomes.
Insulator dysfunction and oncogene activation in IDH mutant gliomas.
Distinct bone marrow blood vessels differentially regulate haematopoiesis.
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
Nature. 2019;566(7742):115-119 - PMID: 30700910 - PMCID: PMC6367023 - DOI: 10.1038/s41586-018-0849-9
Sleep modulates haematopoiesis and protects against atherosclerosis
Nature. 2019;566(7744):383-387 - PMID: 30760925 - PMCID: PMC6442744 - DOI: 10.1038/s41586-019-0948-2
Resolving medulloblastoma cellular architecture by single-cell genomics.
Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST.
Nature. 2019;:ePub - PMID: 31618758 - DOI: 10.1038/s41586-019-1668-3
An acute immune response underlies the benefit of cardiac stem-cell therapy.
Nature. 2019;577(7790):405-409 - PMID: 31775156 - PMCID: PMC6962570 - DOI: 10.1038/s41586-019-1802-2
Platelets have a dangerous hold over immune cells in cardiovascular disease.
Nature. 2020;577(7790):323-324 - PMID: 31937950 - DOI: 10.1038/d41586-019-03732-9
Live-animal imaging of native haematopoietic stem and progenitor cells.
Nature. 2020;578(7794):278-283 - PMID: 32025033 - PMCID: PMC7021587 - DOI: 10.1038/s41586-020-1971-z
Expanded encyclopaedias of DNA elements in the human and mouse genomes.
Nature. 2020;583(7818):699-710 - PMID: 32728249 - PMCID: PMC7410828 - DOI: 10.1038/s41586-020-2493-4
Perspectives on ENCODE.
Nature. 2020;583(7818):693-698 - PMID: 32728248 - PMCID: PMC7410827 - DOI: 10.1038/s41586-020-2449-8
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Nature. 2021;592(7854):428-432 - PMID: 33790465 - PMCID: PMC8923613 - DOI: 10.1038/s41586-021-03417-2
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Nature. 2021;595(7866):309-314 - PMID: 33953401 - PMCID: PMC9166167 - DOI: 10.1038/s41586-021-03520-4
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6
Mutation fingerprints encode cellular histories.
Nature. 2021;597(7876):334-336 - PMID: 34433973 - DOI: 10.1038/d41586-021-02269-0
Mutational clocks tick differently across species.
Nature. 2022;604(7906):435-436 - PMID: 35418556 - DOI: 10.1038/d41586-022-00976-w
Brain motor and fear circuits regulate leukocytes during acute stress.
Nature. 2022;607(7919):578-584 - PMID: 35636458 - PMCID: PMC9798885 - DOI: 10.1038/s41586-022-04890-z
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Nature. 2022;608(7921):174-180 - PMID: 35732739 - DOI: 10.1038/s41586-022-04817-8
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA.
Targeting TBK1 to overcome resistance to cancer immunotherapy.
Nature. 2023;615(7950):158-167 - PMID: 36634707 - PMCID: PMC10171827 - DOI: 10.1038/s41586-023-05704-6
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.
Nature. 2022;605(7910):532-538 - PMID: 35508657 - PMCID: PMC9815755 - DOI: 10.1038/s41586-022-04682-5
Non-cell-autonomous cancer progression from chromosomal instability.
Nature. 2023;620(7976):1080-1088 - PMID: 37612508 - PMCID: PMC10468402 - DOI: 10.1038/s41586-023-06464-z
Resilient anatomy and local plasticity of naive and stress haematopoiesis.
Nature. 2024;627(8005):839-846 - PMID: 38509363 - PMCID: PMC10972750 - DOI: 10.1038/s41586-024-07186-6
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.
Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia
The mammalian epigenome.
Cell. 2007;128(4):669-81 - PMID: 17320505 - DOI: 10.1016/j.cell.2007.01.033
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Cell. 2006;125(2):315-26 - PMID: 16630819 - DOI: 10.1016/j.cell.2006.02.041
Genomic maps and comparative analysis of histone modifications in human and mouse.
Cell. 2005;120(2):169-81 - PMID: 15680324 - DOI: 10.1016/j.cell.2005.01.001
Signaling network model of chromatin.
Cell. 2002;111(6):771-8 - PMID: 12526804 - DOI: 10.1016/s0092-8674(02)01196-0
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha.
Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains.
Systems Biology: What's the Next Challenge?
Cell. 2011;144:6
Intravital imaging.
Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells.
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Cell. 2012;149(7):1474-87 - PMID: 22726435 - DOI: 10.1016/j.cell.2012.04.035
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism.
Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues.
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.