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Lee H*, Yoon TJ*, Figueiredo JL, Swirski FK, Weissleder R

Rapid detection and profiling of cancer cells in fine-needle aspirates.
Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106

Yoo B, Gredler R, Vozhilla N, Su Z, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher P, Sarkar D

Identification of genes conferring resistance to 5-fluorouracil.
Proc Natl Acad Sci U S A. 2009;106(31):12938-43 - PMID: 19622726 - PMCID: PMC2722317 - DOI: 10.1073/pnas.0901451106

Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA

Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.
Proc Natl Acad Sci U S A. 2009;106(35):14932-6 - PMID: 19706423 - PMCID: PMC2736449 - DOI: 10.1073/pnas.0902408106

Evans C, Potma E, Puoris'haag M, C

Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy.
Proc Natl Acad Sci U S A. 2005;102:16807-12 - PMID: 16263923 - PMCID: PMC1283840 - DOI: 10.1073/pnas.0508282102

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L

Sickle cell vasoocclusion and rescue in a microfluidic device.
Proc Natl Acad Sci U S A. 2007;104(51):20496-500 - PMID: 18077341 - PMCID: PMC2154459 - DOI: 10.1073/pnas.0707122105

Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proc Natl Acad Sci U S A. 2010;107(4):1565-70 - PMID: 20080688 - PMCID: PMC2824379 - DOI: 10.1073/pnas.0908682107

Tsigkou O, Pomerantseva I, Spencer JA, Redondo PA, Hart AR, O'Doherty E, Lin Y, Friedrich CC, Daheron L, Lin CP, Sundback CA, Vacanti JP, Neville C

Regenerative Medicine Special Feature: Engineered vascularized bone grafts.
Proc Natl Acad Sci U S A. 2010;107(8):3311-6 - PMID: 20133604 - PMCID: PMC2840421 - DOI: 10.1073/pnas.0905445107

Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922 - DOI: 10.1073/pnas.0911929107

Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R

Hybrid PET-optical imaging using targeted probes
Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107

Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, Deangelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Proc Natl Acad Sci U S A. 2010;107(28):12617-22 - PMID: 20616024 - PMCID: PMC2906581 - DOI: 10.1073/pnas.1006774107

Higgins JM, Mahadevan L

Physiological and pathological population dynamics of circulating human red blood cells.
Proc Natl Acad Sci U S A. 2010;107(47):20587-92 - PMID: 21059904 - PMCID: PMC2996693 - DOI: 10.1073/pnas.1012747107

Gao X, Eladari D, Leviel F, Tew BY, Miro-Julia

Deletion of hensin/DMBT1 blocks conversion of {beta}- to {alpha}-intercalated cells and induces distal renal tubular acidosis.
Proc Natl Acad Sci U S A. 2010;107(50):21872-7 - PMID: 21098262 - PMCID: PMC3003085 - DOI: 10.1073/pnas.1010364107

Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.
Proc Natl Acad Sci U S A. 2010;108(2):492-7 - PMID: 21183721 - PMCID: PMC3021060 - DOI: 10.1073/pnas.1016789108

Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR

Measuring single-cell density.
Proc Natl Acad Sci U S A. 2011;108(27):10992-10996 - PMID: 21690360 - PMCID: PMC3131325 - DOI: 10.1073/pnas.1104651108

Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
Proc Natl Acad Sci U S A. 2011;108(36):14908-13 - PMID: 21737748 - PMCID: PMC3169118 - DOI: 10.1073/pnas.1109023108

Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.
Proc Natl Acad Sci U S A. 2011;108(36):14902-7 - PMID: 21746931 - PMCID: PMC3169132 - DOI: 10.1073/pnas.1108892108

Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R

Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog.
Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108

Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ

Origins of tumor-associated macrophages and neutrophils.
Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109

Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R

Reactive polymer enables efficient in vivo bioorthogonal chemistry.
Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109

Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M

Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109

Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R

Imaging inflammation of the pancreatic islets in type 1 diabetes.
Proc Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109 - DOI: 10.1073/pnas.0404307101

Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R

Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Proc Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472 - DOI: 10.1073/pnas.0401137101

Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
Proc Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311 - DOI: 10.1073/pnas.0408197102

Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.

Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
Proc Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291 - DOI: 10.1073/pnas.0503920102

Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.

Volumetric tomography of fluorescent proteins through small animals in vivo
Proc Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905 - DOI: 10.1073/pnas.0504628102

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA

Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Proc Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678 - DOI: 10.1073/pnas.0601273103

Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103

Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A.

Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
Proc Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940 - DOI: 10.1073/pnas.0605496103

Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP

The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.
Proc Natl Acad Sci U S A. 2005;102(38):13616-21 - PMID: 16174750 - PMCID: PMC1224669 - DOI: 10.1073/pnas.0506769102

Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R.

In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
Proc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104

Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K

Mast cells are an essential hematopoietic component for polyp development.
Proc Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408 - DOI: 10.1073/pnas.0704620104

Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R

Perturbational profiling of nanomaterial biologic activity.
Proc Natl Acad Sci U S A. 2008;105:7387-7392 - PMID: 18492802 - PMCID: PMC2396702 - DOI: 10.1073/pnas.0802878105

Gold L, Brown D, He Y, Shtatland T, Singer B, Wu Y

From oligonucleotide shapes to genomic SELEX: novel biological regulatory loops.
Proc Natl Acad Sci U S A. 1997;94:59-64 - PMID: 8990161 - PMCID: PMC19236 - DOI: 10.1073/pnas.94.1.59

Hahn C, Ross K, Warrington I, Mazitschek R, Kanegai C, Wright R, Kung A, Golub T, Stegmaier K

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.
Proc Natl Acad Sci U S A. 2008;105(28):9751-6 - PMID: 18607002 - PMCID: PMC2474517 - DOI: 10.1073/pnas.0710413105

Shaw S, Wang J

Chirality of DNA trefoils: implications in intramolecular synapsis of distant DNA segments.
Proc Natl Acad Sci U S A. 1997;94(5):1692-7 - PMID: 9050840 - PMCID: PMC19978 - DOI: 10.1073/pnas.94.5.1692

Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R

Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
Proc Natl Acad Sci U S A. 2008;105 (47):18584-18589 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105

Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V

Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
Proc Natl Acad Sci U S A. 2008;105(49)::19126-19131 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105

Okazaki M, Ferrandon S, Vilardaga J, Bouxsein M, Potts J, Gardella T

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.
Proc Natl Acad Sci U S A. 2008;105(43):16525-30 - PMID: 18946036 - PMCID: PMC2571912 - DOI: 10.1073/pnas.0808750105

Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Bronson R, Chen J, Weissleder R, Housman D, Charest A.

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesis
Proc Natl Acad Sci U S A. 0;:ePub

Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Proc Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331 - DOI: 10.1073/pnas.0813314106

Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.
Proc Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771 - DOI: 10.1073/pnas.0806647106

Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium
PLoS Biol. 2012;10(9):e1001393 - PMID: 23055830 - PMCID: PMC3463506 - DOI: 10.1371/journal.pbio.1001393

Pucci F, Pittet MJ

Molecular Pathways: Tumor-derived microvesicles and their interactions with immune cells in vivo.
Clin Cancer Res. 2013;19(10):2598-604 - PMID: 23426276 - PMCID: PMC3655093 - DOI: 10.1158/1078-0432.CCR-12-0962

Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Desphande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes CH, Engelman JA, Bardeesy N

Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Clin Cancer Res. 2014;21(2):396-404 - PMID: 25348516 - PMCID: PMC4447091 - DOI: 10.1158/1078-0432.CCR-14-1591

Gainor JF, Shaw AT, Sequist LV, Fu X, Azzoli CG, Piotrowska Z, Huynh TG, Zhao L, Fulton L, Schultz K, Howe E, Farago AF, Sullivan RJ, Stone JR, Digumarthy S, Moran T, Hata AN, Yagi Y, Yeap BY, Engelman JA, Mino-Kenudson M

EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer (NSCLC): A Retrospective Analysis.
Clin Cancer Res. 2016;22(18):4585-93 - PMID: 27225694 - PMCID: PMC5026567 - DOI: 10.1158/1078-0432.CCR-15-3101

Miller MA, Sullivan RJ, Lauffenburger DA

Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.
Clin Cancer Res. 2016;23(3):623-629 - PMID: 27895032 - PMCID: PMC5290119 - DOI: 10.1158/1078-0432.CCR-16-0869

Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O

The progress and promise of molecular imaging probes in oncologic drug development.
Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226 - DOI: 10.1158/1078-0432.CCR-05-1302

Ayyoub M, Zippelius A, Pittet M, Rimoldi D, Valmori D, Cerottini J, Romero P, Lejeune F, Lienard D, Speiser D

Activation of human melanoma reactive CD8+ T cells by vaccination with an immunogenic peptide analog derived from Melan-A/melanoma antigen recognized by T cells-1.
Clin Cancer Res. 2003;9:669-77 - PMID: 12576434

Pittet M, Speiser D, Lienard D, Valmori D, Guillaume P, Dutoit V, Rimoldi D, Lejeune F, Cerottini J, Romero P

Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.
Clin Cancer Res. 2001;7:796s-803s - PMID: 11300475

Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK

Regression of drug-resistant lung cancer by the combination of rosiglitazone and Carboplatin.
Clin Cancer Res. 2008;14(20):6478-86 - PMID: 18927287 - PMCID: PMC2696122 - DOI: 10.1158/1078-0432.CCR-08-1128
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