Reset

Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA

Reply to Edemir: Physiological regulation and single-cell RNA sequencing.
Proc Natl Acad Sci U S A. 2018;115(3):E351-E352 - PMID: 29311339 - PMCID: PMC5777009 - DOI: 10.1073/pnas.1720333115

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M

Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Proc Natl Acad Sci U S A. 2018;115(15):3912-3917 - PMID: 29581255 - PMCID: PMC5899492 - DOI: 10.1073/pnas.1801524115

Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT, Barker FG, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DP

Genotype-targeted local therapy of glioma.
Proc Natl Acad Sci U S A. 2018;115(36):E8388-E8394 - PMID: 30082399 - PMCID: PMC6130372 - DOI: 10.1073/pnas.1805751115

Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.
Proc Natl Acad Sci U S A. 2018;115(45):E10672-E10681 - PMID: 30348759 - PMCID: PMC6233093 - DOI: 10.1073/pnas.1810580115

Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ

Site occupancy calibration of taxane pharmacology in live cells and tissues
Proc Natl Acad Sci U S A. 2018;115(48):E11406-E11414 - PMID: 30429313 - PMCID: PMC6275538 - DOI: 10.1073/pnas.1800047115

Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - PMCID: PMC6561160 - DOI: 10.1073/pnas.1819889116

Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ

A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor
Proc Natl Acad Sci U S A. 2019;116(23):11444-11453 - PMID: 31101720 - PMCID: PMC6561274 - DOI: 10.1073/pnas.1702372116

Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116

Babitt JL

Ironing out pulmonary arterial hypertension.
Proc Natl Acad Sci U S A. 2019;116(26):12604-12606 - PMID: 31171658 - PMCID: PMC6601273 - DOI: 10.1073/pnas.1908298116

Heyde A, Reiter JG, Naxerova K, Nowak MA

Consecutive seeding and transfer of genetic diversity in metastasis.
Proc Natl Acad Sci U S A. 2019;116(28):14129-14137 - PMID: 31239334 - PMCID: PMC6628640 - DOI: 10.1073/pnas.1819408116

Di Caprio G*, Schonbrun E*, Gonçalves BP, Valdez JM, Wood DK, Higgins JM

High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension.
Proc Natl Acad Sci U S A. 2019;116(50):25236-25242 - PMID: 31767751 - PMCID: PMC6911208 - DOI: 10.1073/pnas.1914056116

Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Proc Natl Acad Sci U S A. 2020;117(16):8900-8911 - PMID: 32253314 - PMCID: PMC7183223 - DOI: 10.1073/pnas.1913788117

Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
Proc Natl Acad Sci U S A. 2020;117(38):23684-23694 - PMID: 32907939 - PMCID: PMC7519254 - DOI: 10.1073/pnas.2002806117

Zaidman NA, Tomilin VN, Hassanzadeh Khayyat N, Damarla M, Tidmore J, Capen DE, Brown D, Pochynyuk OM, Pluznick JL

Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
Proc Natl Acad Sci U S A. 2020;117(42):26470-26481 - PMID: 33004624 - PMCID: PMC7584995 - DOI: 10.1073/pnas.2007620117

Zhang Y, Kohrn BF, Yang M, Nachmanson D, Soong TR, Lee IH, Tao Y, Clevers H, Swisher EM, Brentnall TA, Loeb LA, Kennedy SR, Salk JJ, Naxerova K, Risques RA

PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.
Proc Natl Acad Sci U S A. 2021;118(31):ePub - PMID: 34330826 - PMCID: PMC8346827 - DOI: 10.1073/pnas.2023373118

Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz GR, Schmidt S, Chau C, Narsimhan R, Kullenberg EG, Zhu C, Linnoila J, Yao Z, Chen JW

d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation.
Proc Natl Acad Sci U S A. 2021;118(44):ePub - PMID: 34702739 - PMCID: PMC8673064 - DOI: 10.1073/pnas.2107663118

Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK

Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118

Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B

Implantable microenvironments to attract hematopoietic stem/cancer cells.
Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109

Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110

Liu Y, Shoji-Kawata S, Sumpter RM, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Proc Natl Acad Sci U S A. 2013;110(51):20364-71 - PMID: 24277826 - PMCID: PMC3870705 - DOI: 10.1073/pnas.1319661110

Peterson VM*, Castro CM*, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R

Ascites analysis by a microfluidic chip allows tumor-cell profiling
Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110

Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos JA, Weng Z, White KP, Hardison RC

Defining functional DNA elements in the human genome.
Proc Natl Acad Sci U S A. 2014;111(17):6131-6138 - PMID: 24753594 - PMCID: PMC4035993 - DOI: 10.1073/pnas.1318948111

Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.
Proc Natl Acad Sci U S A. 2014;111(18):6696-701 - PMID: 24753589 - PMCID: PMC4020091 - DOI: 10.1073/pnas.1405634111

Stangenberg L, Burzyn D, Binstadt BA, Weissleder R, Mahmood U, Benoist C, Mathis D

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
Proc Natl Acad Sci U S A. 2014;111(31):11419-24 - PMID: 25049388 - PMCID: PMC4128122 - DOI: 10.1073/pnas.1410854111

Aguirre AD, Vinegoni C, Sebas M, Weissleder R

Intravital imaging of cardiac function at the single-cell level.
Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111

Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos J, Weng Z, White KP, Hardison RC

Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease.
Proc Natl Acad Sci U S A. 2014;111(33):E3366 - PMID: 25275169 - PMCID: PMC4143047 - DOI: 10.1073/pnas.1410434111

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
Proc Natl Acad Sci U S A. 2014;111(46):E4946-53 - PMID: 25369933 - PMCID: PMC4246292 - DOI: 10.1073/pnas.1407079111

Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C

Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Proc Natl Acad Sci U S A. 2015;112(5):1511-6 - PMID: 25605891 - PMCID: PMC4321317 - DOI: 10.1073/pnas.1423769112

Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C Mathis D, Weissleder R

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
Proc Natl Acad Sci U S A. 2015;112(7):2139-44 - PMID: 25650428 - PMCID: PMC4343112 - DOI: 10.1073/pnas.1424993112

Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H*

Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112

Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL

Noninvasive imaging of immune responses.
Proc Natl Acad Sci U S A. 2015;112(19):6146-51 - PMID: 25902531 - PMCID: PMC4434737 - DOI: 10.1073/pnas.1502609112

Di Caprio G, Stokes C, Higgins JM, Schonbrun E

Single-cell measurement of red blood cell oxygen affinity.
Proc Natl Acad Sci U S A. 2015;112(32):9984-9 - PMID: 26216973 - PMCID: PMC4538663 - DOI: 10.1073/pnas.1509252112

Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK

AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer.
Proc Natl Acad Sci U S A. 2015;112(32):E4418-27 - PMID: 26216943 - PMCID: PMC4538667 - DOI: 10.1073/pnas.1510604112

Weissleder R, Nahrendorf M

Advancing biomedical imaging
Proc Natl Acad Sci U S A. 2015;112(47):14424-8 - PMID: 26598657 - PMCID: PMC4664297 - DOI: 10.1073/pnas.1508524112

Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Proc Natl Acad Sci U S A. 2016;113(7):1871-6 - PMID: 26831087 - PMCID: PMC4763742 - DOI: 10.1073/pnas.1511380113

Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT

Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.
Proc Natl Acad Sci U S A. 2016;113(34):9527-32 - PMID: 27512047 - PMCID: PMC5003247 - DOI: 10.1073/pnas.1610435113

Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, Richardson PG, Carrasco RD, Wiest O, Schreiber SL, Anderson KC, Bradner JE

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Proc Natl Acad Sci U S A. 2016;113(46):13162-13167 - PMID: 27799547 - PMCID: PMC5135369 - DOI: 10.1073/pnas.1608067113

Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Proc Natl Acad Sci U S A. 2016;113(46):13227-13232 - PMID: 27799546 - PMCID: PMC5135308 - DOI: 10.1073/pnas.1609397113

Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ

Immune cell screening of a nanoparticle library improves atherosclerosis therapy.
Proc Natl Acad Sci U S A. 2016;113(44):E6731-E6740 - PMID: 27791119 - PMCID: PMC5098679 - DOI: 10.1073/pnas.1609629113

Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES

Systematic dissection of genomic features determining transcription factor binding and enhancer function.
Proc Natl Acad Sci U S A. 2017;114(7):E1291-E1300 - PMID: 28137873 - PMCID: PMC5321001 - DOI: 10.1073/pnas.1621150114

Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Proc Natl Acad Sci U S A. 2013;110(22):E2074-83 - PMID: 23674691 - PMCID: PMC3670354 - DOI: 10.1073/pnas.1222387110

Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A

Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Proc Natl Acad Sci U S A. 2013;110(24):9776-81 - PMID: 23720309 - PMCID: PMC3683718 - DOI: 10.1073/pnas.1307478110

Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.
Proc Natl Acad Sci U S A. 2017;114(37):E7776-E7785 - PMID: 28839093 - PMCID: PMC5604023 - DOI: 10.1073/pnas.1707381114

Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, Dong X, Speranza MC, Neagu MR, Iorgulescu JB, Huang RY, Youssef G, Reardon DA, Sharpe AH, Freeman GJ, Suvà ML, Xu L, Jain RK

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models.
Proc Natl Acad Sci U S A. 2023;120(6):e2219199120 - PMID: 36724255 - PMCID: PMC9963691 - DOI: 10.1073/pnas.2219199120

Qiang Y, Sissoko A, Liu ZL, Dong T, Zheng F, Kong F, Higgins JM, Karniadakis GE, Buffet PA, Suresh S, Dao M

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease.
Proc Natl Acad Sci U S A. 2023;120(6):e2217607120 - PMID: 36730189 - PMCID: PMC9963977 - DOI: 10.1073/pnas.2217607120

Lutz EA, Agarwal Y, Momin N, Cowles SC, Palmeri JR, Duong E, Hornet V, Sheen A, Lax BM, Rothschilds AM, Irvine DJ, Spranger S, Wittrup KD

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies.
Proc Natl Acad Sci U S A. 2022;119(36):e2205983119 - PMID: 36037341 - PMCID: PMC9457244 - DOI: 10.1073/pnas.2205983119

Aldawood ZA, Mancinelli L, Geng X, Yeh SA, Di Carlo R, C Leite T, Gustafson J, Wilk K, Yozgatian J, Garakani S, Bassir SH, Cunningham ML, Lin CP, Intini G

Expansion of the sagittal suture induces proliferation of skeletal stem cells and sustains endogenous calvarial bone regeneration.
Proc Natl Acad Sci U S A. 2023;120(16):e2120826120 - PMID: 37040407 - PMCID: PMC10120053 - DOI: 10.1073/pnas.2120826120

Butcher R, Ragains J, Li W, Ruvkun G, Clardy J, Mak H

Biosynthesis of the Caenorhabditis elegans dauer pheromone.
Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

Kroh H, Panizzi P, Bock P

Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin.
Proc Natl Acad Sci U S A. 2009;106(19):7786-91 - PMID: 19416890 - PMCID: PMC2683071 - DOI: 10.1073/pnas.0811750106
3245 CSV HTML