Translational Program of Excellence in Nanotechnology (TPEN)

The overall goal of this NHLBI funded Program (PI: R. Weissleder) is to create and support a highly multidisciplinary team of expert chemists, biologists, engineers and physicians to develop and rapidly translate new nanotechnologies to better diagnose and treat heart, lung and blood disorders. The current team includes investigators from the Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), Harvard Medical School (HMS), Harvard School of Engineering and Applied Sciences (SEAS), Massachusetts Institute of Technology (MIT) and the Broad Institute of Harvard and MIT.

Specific applications of nanotechnology in this application include molecular imaging and sensing, drug delivery, targeted therapies and nanosensors. Powerful chemical biology approaches are being used to functionalize nanomaterials and to test their biosafety at unprecedented throughputs.

There are currently five innovative and applied Research Projects.

• Project 1 (Dr. Hilderbrand): Novel nanomaterials
• Project 2 (Drs. Shaw and Pittet): Nanoparticle libraries for the discovery of cell-specific imaging probes for cardiovascular disease and therapy
• Project 3 (Dr. Nahrendorf): Development of macrophage targeted 18F-PET nanoparticles for imaging of vascular inflammation
• Project 4 (Drs. Libby and McCarthy): Theranostic nanotechnology approach to the management of cardiac transplantation complications
• Project 5 (Drs. Weissleder and Lee): Rapid detection of infection using nanosensors

NHLBI Inter-PEN Quarterly Newsletter

• Vol 5, Issue 2, July 2011
• Vol 5, Issue 1, March 2011
• Vol 4, Issue 1, February 2010
• Vol 3, Issue 4, November 2009
• Vol 3, Issue 3, August 2009
• Vol 3, Issue 2, May 2009
• Vol 3, Issue 1, February 2009
• Vol 2, Issue 4, November 2008
• Vol 2, Issue 3, August 2008
• Vol 2, Issue 2, May 2008
• Vol 2, Issue 1, February 2008
• Vol 1, Issue 4, November 2007
• Vol 1, Issue 3, August 2007
• Vol 1, Issue 2, May 2007
• Vol 1, Issue 1, February 2007

The PENs and their PIs

Center for Translational Cardiovascular Nanomedicine Emory University Georgia Institute of Technology University of California, Davis P.I. – Gang Bao, Ph.D. CoE Distinguished Professor The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology
Integrated Nanosystems for Diagnosis and Therapy Washington University in Saint Louis Texas A&M University University of California, Santa Barbara University of California, Berkeley University of Texas, Southwestern Medical Center at Dallas Co-P.I. – Michael J. Welch, Ph.D
Professor of Radiology Department of Radiology Washington University School of Medicine Co-P.I. – Karen L. Wooley, Ph.D W. T. Doherty-Welch Professor Department of Chemistry Texas A&M University
Translational Nanomedical Therapies for Cardiac and Vascular Diseases Mount Sinai School of Medicine Massachusetts Institute of Technology Brigham and Women’s Hospital Columbia University New York University Co-P.I. – Zahi Fayad, Ph.D.
Director,Translational and Molecular Imaging Institute Professor of Radiology and Medicine (Cardiology) Director and Founder of the Eva and Morris Feld Imaging Science Laboratories Director of Cardiovascular Imaging Research Mount Sinai School of Medicine Co-P.I. – Robert Langer, Ph.D. David H. Koch Institute Professor Department of Chemical Engineering Massachusetts Institute of Technology

Links

• NHLBI Programs of Excellence in Nanotechnology