About TPEN

Translational Program of Excellence in Nanotechnology (TPEN)

The overall goal of this NHLBI funded Program (PI: R. Weissleder) is to create and support a highly multidisciplinary team of expert chemists, biologists, engineers and physicians to develop and rapidly translate new nanotechnologies to better diagnose and treat heart, lung and blood disorders. The current team includes investigators from the Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), Harvard Medical School (HMS), Harvard School of Engineering and Applied Sciences (SEAS), Massachusetts Institute of Technology (MIT) and the Broad Institute of Harvard and MIT.


Specific applications of nanotechnology in this application include molecular imaging and sensing, drug delivery, targeted therapies and nanosensors. Powerful chemical biology approaches are being used to functionalize nanomaterials and to test their biosafety at unprecedented throughputs.

There are currently five innovative and applied Research Projects.

NHLBI Inter-PEN Quarterly Newsletter

The PENs and their PIs

Center for Translational Cardiovascular Nanomedicine

Emory University
Georgia Institute of Technology
University of California, Davis
P.I. - Gang Bao, Ph.D.
CoE Distinguished Professor
The Wallace H. Coulter Department of Biomedical Engineering
Georgia Institute of Technology

Gang Bao, PhD
Integrated Nanosystems for Diagnosis and Therapy

Washington University in Saint Louis
Texas A&M University
University of California, Santa Barbara
University of California, Berkeley
University of Texas, Southwestern Medical Center at Dallas
Co-P.I. - Michael J. Welch, Ph.D

Michael J. Welch, PhD

Professor of Radiology
Department of Radiology
Washington University School of Medicine
Co-P.I. - Karen L. Wooley, Ph.D
W. T. Doherty-Welch Professor
Department of Chemistry
Texas A&M University

Karen Wooley, PhD
Translational Nanomedical Therapies for Cardiac and Vascular Diseases

Mount Sinai School of Medicine
Massachusetts Institute of Technology
Brigham and Women's Hospital
Columbia University
New York University
Co-P.I. - Zahi Fayad, Ph.D.

Zahi Fayad, PhD

Director,Translational and Molecular Imaging Institute
Professor of Radiology and Medicine (Cardiology)
Director and Founder of the Eva and Morris Feld Imaging Science Laboratories
Director of Cardiovascular Imaging Research
Mount Sinai School of Medicine
Co-P.I. - Robert Langer, Ph.D.
David H. Koch Institute Professor
Department of Chemical Engineering
Massachusetts Institute of Technology

Robert Langer, PhD