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Rodriguez-Castellanos VE, Quintana JM, Martin JM, Goemans MA, Banla LI, Ng TSC, Weissleder R, Miller MA

Radiation-Triggered Payload Release Enhances Bispecific Antibody Efficacy.
Cancer Res. 2025;:ePub - PMID: 41066595 - DOI: 10.1158/0008-5472.CAN-25-0517

Obuchi W, Zargani-Piccardi A, Leandro K, Rufino-Ramos D, Di Lanni E, Frederick DM, Maalouf K, Nieland L, Xiao T, Repiton P, Vaine CA, Kleinstiver BP, Bragg DC, Lee H, Miller MA, Breakefield XO, Breyne K

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.
J Extracell Vesicles. 2025;14(6):e70094 - PMID: 40527733 - PMCID: PMC12173531 - DOI: 10.1002/jev2.70094

Quintana JM*, Jiang F*, Kang M, Valladolid Onecha V, Könik A, Qin L, Rodriguez VE, Hu H, Borges N, Khurana I, Banla LI, Le Fur M, Caravan P, Schuemann J, Bertolet A, Weissleder R, Miller MA, Ng TSC

Localized In Vivo Prodrug Activation Using Radionuclides.
J Nucl Med. 2025;66(1):91-97 - PMID: 39753366 - PMCID: PMC11705795 - DOI: 10.2967/jnumed.124.268559

Simpson GG, Quintana JM, Carrothers JE, Jiang F, Walker SA, Cho C, Weissleder R, Miller MA, Ng TSC

Fluorescent PSMA-Targeted Radiotheranostic Compounds for Multiscale Imaging.
Bioconjug Chem. 2025;36(7):1448-1460 - PMID: 40574660 - PMCID: PMC12365983 - DOI: 10.1021/acs.bioconjchem.5c00139

Zhao P, Kundu J, Blanton D, Rezaeeyazdi M, Oudin MJ, Miller MA, Meyer AS, Bencherif SA, Baranov PY, Young MJ, Carrier RL

Human Retinal Progenitor Cell (hRPC) Migration in Three-Dimensional (3D) Environments of Varying Stiffness and Composition.
J Tissue Eng Regen Med. 2025;2025:9963972 - PMID: 41195017 - PMCID: PMC12585844 - DOI: 10.1155/term/9963972

Di Ianni E, Jeon J, Hu H, Quintana JM, Lee C, Haidar EA, Mohammadi S, Zargani-Piccardi A, Mahamdeh M, Hernández IC, Ng TSC, Breyne K, Lee H, Breakefield XO, Miller MA

Enhanced mRNA delivery using ultrasound-delivered click reactive anchors.
bioRxiv. 2025;:ePub - PMID: 39975219 - PMCID: PMC11838329 - DOI: 10.1101/2025.01.28.635330

Song J, Cho MH, Cho H, Song Y, Lee SW, Nam HC, Yoon TH, Shin JC, Hong JS, Kim Y, Ekanayake E, Jeon J, You DG, Im SG, Choi GS, Park JS, Carter BC, Balaj L, Seo AN, Miller MA, Park SY, Kang T, Castro CM, Lee H

Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE.
Nat Biotechnol. 2024;43(9):1485-1495 - PMID: 39375445 - DOI: 10.1038/s41587-024-02426-6

Kang M, Quintana J, Hu H, Teixeira VC, Olberg S, Banla LI, Rodriguez V, Hwang WL, Schuemann J, Parangi S, Weissleder R, Miller MA

Sustained and Localized Drug Depot Release using Radiation-Activated Scintillating Nanoparticles.
Adv Mater. 2024;36(23):e2312326 - PMID: 38389502 - PMCID: PMC11161319 - DOI: 10.1002/adma.202312326

Quintana JM, Kang M, Hu H, Ng TSC, Wojtkiewicz GR, Scott E, Parangi S, Schuemann J, Weissleder R, Miller MA

Extended Pharmacokinetics Improve Site-Specific Prodrug Activation Using Radiation.
ACS Cent Sci. 2024;10(7):1371-1382 - PMID: 39071065 - PMCID: PMC11273447 - DOI: 10.1021/acscentsci.4c00354

Jeng-Miller KW, Miller MA, Heier JS

Ocular Effects of MEK Inhibitor Therapy: Literature Review, Clinical Presentation, and Best Practices for Mitigation.
Oncologist. 2024;29(5):e616-e621 - PMID: 38527005 - PMCID: PMC11067803 - DOI: 10.1093/oncolo/oyae014

Quintana JM, Carlson JCT, Scott E, Ng TSC, Miller MA, Weissleder R

Scission-Enhanced Molecular Imaging (SEMI).
Bioconjug Chem. 2024;35(10):1543-52 - PMID: 39255972 - PMCID: PMC11488501 - DOI: 10.1021/acs.bioconjchem.4c00337

Quintana JM, Jiang F, Kang M, Valladolid Onecha V, Könik A, Qin L, Rodriguez VE, Hu H, Borges N, Khurana I, Banla LI, Le Fur M, Caravan P, Schuemann J, Bertolet A, Weissleder R, Miller MA, Ng TSC

Localized in vivo prodrug activation using radionuclides.
bioRxiv. 2024;:ePub - PMID: 39211146 - PMCID: PMC11361159 - DOI: 10.1101/2024.08.02.606075

Hu H, Ng TSC, Kang M, Scott E, Li R, Quintana JM, Matvey D, Vantaku VR, Weissleder R, Parangi S, Miller MA

Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response.
Clin Cancer Res. 2023;29(17):3457-3470 - PMID: 37289199 - PMCID: PMC10527034 - DOI: 10.1158/1078-0432.CCR-22-2976

Dosta P, Puigmal N, Cryer AM, Rodríguez AL, Scott E, Weissleder R, Miller MA, Artzi N

Polymeric microneedles enable simultaneous delivery of cancer immunomodulatory drugs and detection of skin biomarkers.
Theranostics. 2023;13(1):1-15 - PMID: 36593949 - PMCID: PMC9800729 - DOI: 10.7150/thno.73966

Lugani S*, Halabi EA*, Oh J, Kohler R, Peterson H, Breakefield XO, Chiocca EAA, Miller MA, Garris C, Weissleder R

Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma.
Adv Mater. 2022;35(7):e2208782 - PMID: 36427266 - PMCID: PMC10197197 - DOI: 10.1002/adma.202208782

Villalba JA, Hilburn CF, Garlin MA, Elliott GA, Li Y, Kunitoki K, Poli S, Alba GA, Madrigal E, Taso M, Price MC, Aviles AJ, Araujo-Medina M, Bonanno L, Boyraz B, Champion SN, Harris CK, Helland TL, Hutchison B, Jobbagy S, Marshall MS, Shepherd DJ, Barth JL, Hung YP, Ly A, Hariri LP, Turbett SE, Pierce VM, Branda JA, Rosenberg ES, Mendez-Pena J, Chebib I, Rosales IA, Smith RN, Miller MA, Rosas IO, Hardin CC, Baden LR, Medoff BD, Colvin RB, Little BP, Stone JR, Mino-Kenudson M, Shih AR

Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and ARDS.
Am J Respir Crit Care Med. 2022;206(7):857-873 - PMID: 35671465 - PMCID: PMC9799276 - DOI: 10.1164/rccm.202109-2150OC

Ng TSC, Hu H, Kronister S, Lee C, Li R, Gerosa L, Stopka SA, Burgenske DM, Khurana I, Regan MS, Vallabhaneni S, Putta N, Scott E, Matvey D, Giobbie-Hurder A, Kohler RH, Sarkaria JN, Parangi S, Sorger PK, Agar NYR, Jacene HA, Sullivan RJ, Buchbinder E, Mikula H, Weissleder R, Miller MA

Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Sci Adv. 2022;8(17):eabl6339 - PMID: 35486732 - PMCID: PMC9054019 - DOI: 10.1126/sciadv.abl6339

Hu H, Quintana J, Weissleder R, Parangi S, Miller M

Deciphering albumin-directed drug delivery by imaging.
Adv Drug Deliv Rev. 2022;185:114237 - PMID: 35364124 - PMCID: PMC9117484 - DOI: 10.1016/j.addr.2022.114237

Ng TSC, Allen HH, Rashidian M, Miller MA

Probing immune infiltration dynamics in cancer by in-vivo imaging.
Curr Opin Chem Biol. 2022;67:102117 - PMID: 35219177 - PMCID: PMC9118268 - DOI: 10.1016/j.cbpa.2022.102117

Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X

New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium.
Clin Pharmacol Ther. 2022;112(3):540-561 - PMID: 35488474 - PMCID: PMC9398938 - DOI: 10.1002/cpt.2627

Cook L, Sengelmann M, Winkler B, Nagl C, Koch S, Schlomann U, Slater EP, Miller MA, von Strandmann EP, Dorsam B, Preuber C, Bartsch JW

ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9.
Int J Mol Sci. 2022;23(4):ePub - PMID: 35216088 - PMCID: PMC8875419 - DOI: 10.3390/ijms23041976

Quintana JM, Arboleda D, Hu H, Scott E, Luthria G, Pai S, Parangi S, Weissleder R, Miller MA

Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release.
Bioconjug Chem. 2022;33(8):1474-1484 - PMID: 35833631 - PMCID: PMC9390333 - DOI: 10.1021/acs.bioconjchem.2c00174

Matvey DO, Ng TSC, Miller MA

Confocal Imaging of Single-Cell Signaling in Orthotopic Models of Ovarian Cancer.
Methods Mol Biol. 2022;2424:295-315 - PMID: 34918302 - DOI: 10.1007/978-1-0716-1956-8_19

Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer
Nat Nanotechnol. 2021;16(7):830-839 - PMID: 33958764 - PMCID: PMC8491539 - DOI: 10.1038/s41565-021-00897-1

Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G

p53 dynamics vary between tissues and are linked with radiation sensitivity
Nat Commun. 2021;12(1):898 - PMID: 33563973 - PMCID: PMC7873198 - DOI: 10.1038/s41467-021-21145-z

Arlauckas S, Oh N, Li R, Weissleder R, Miller MA

Macrophage imaging and subset analysis using single-cell RNA sequencing.
Nanotheranostics. 2021;5(1):36-56 - PMID: 33391974 - PMCID: PMC7738942 - DOI: 10.7150/ntno.50185

Luthria G, Lauffenburger D, Miller MA

Cell-Cell Communication Networks in Tissue: Toward Quantitatively Linking Structure with Function.
Curr Opin Syst Biol. 2021;27:ePub - PMID: 34693081 - PMCID: PMC8530179 - DOI: 10.1016/j.coisb.2021.05.002

Li R, Ng TSC, Garlin MA, Weissleder R*, Miller MA*

Understanding the In Vivo Fate of Advanced Materials by Imaging
Adv Funct Mater. 2020;30(37):ePub - PMID: 38545084 - PMCID: PMC10972611 - DOI: 10.1002/adfm.201910369

Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA

In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
Nat Commun. 2020;11:3521 - PMID: 32665556 - PMCID: PMC7360550 - DOI: 10.1038/s41467-020-17147-y

Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA

Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy.
Sci Adv. 2020;6(21):ePub - PMID: 32937338 - PMCID: PMC7244320 - DOI: 10.1126/sciadv.aaz8521

Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Cell Syst. 2020;11(5):478-494.e9 - PMID: 33113355 - PMCID: PMC8009031 - DOI: 10.1016/j.cels.2020.10.002

Ng TSC, Gunda V, Li R, Prytyskach M, Iwamoto Y, Kohler RH, Parangi S, Weissleder R, Miller MA

Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer
Radiology. 2020;298(1):123-132 - PMID: 33107799 - PMCID: PMC7771993 - DOI: 10.1148/radiol.2020201791

Baskaran JP, Weldy A, Guarin J, Munoz G, Shpilker PH, Kotlik M, Subbiah N, Wishart A, Peng Y, Miller MA, Cowen L, Oudin MJ

Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer.
APL Bioeng. 2020;4(2):026105 - PMID: 32455252 - PMCID: PMC7202897 - DOI: 10.1063/1.5143779

Ng TSC, Garlin MA, Weissleder R, Miller MA

Understanding the EPR effect through image-guided systems pharmacology
Theranostics. 2019;:ePub

Li R, Attari A, Prytyskach M, Garlin MA, Weissleder R, Miller MA

Single‐Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics
Cytometry A. 2019;97(5):528-539 - PMID: 31423731 - PMCID: PMC7028488 - DOI: 10.1002/cyto.a.23872

Ahrens CC, Chiswick EL, Ravindra KC, Miller MA, Ramseier J, Isaacson KB, Lauffenburger DA, Griffith LG

Development and Application of the Metalloprotease Activity Multi-plexed Bead-based Immunoassay (MAMBI).
Biochemistry. 2019;58(38):3938-3942 - PMID: 31474112 - DOI: 10.1021/acs.biochem.9b00584

Miller MA

Gold photothermal therapy: A positive for negative margins
Sci Transl Med. 2018;10(423):eaar7512 - DOI: 10.1126/scitranslmed.aar7512

Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.
ACS Nano. 2018;12(12):12814-12826 - PMID: 30550257 - PMCID: PMC6307086 - DOI: 10.1021/acsnano.8b07954

Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet M, Nahrendorf M, Weissleder R, Miller MA

Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.
ACS Nano. 2018;12(12):12015-12029 - PMID: 30508377 - PMCID: PMC6482841 - DOI: 10.1021/acsnano.8b04338

Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ

Site occupancy calibration of taxane pharmacology in live cells and tissues
Proc Natl Acad Sci U S A. 2018;115(48):E11406-E11414 - PMID: 30429313 - PMCID: PMC6275538 - DOI: 10.1073/pnas.1800047115

Ng EX, Sun G, Wei SC, Miller MA, Dasgupta R, Lam PYP, Chen CH

Ultrafast Single-Cell Level Enzymatic Tumor Profiling.
Anal Chem. 2018;91(2):1277-1285 - PMID: 30362713 - DOI: 10.1021/acs.analchem.8b02576

Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL

ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.
J Cancer. 2018;9(14):2559-2570 - PMID: 30026855 - PMCID: PMC6036891 - DOI: 10.7150/jca.24601

Miller MA, Weissleder R

Imaging of anticancer drug action in single cells
Nat Rev Cancer. 2017;17(7):399–414 - PMID: 28642603 - PMCID: PMC7552440 - DOI: 10.1038/nrc.2017.41

Miller MA

Less is more for anticancer therapy combinations
Sci Transl Med. 2017;9 (411):aap8166 - DOI: 10.1126/scitranslmed.aap8166

Miller MA

It’s what’s inside that counts for nanoparticle vaccines
Sci Transl Med. 2017;9(417):eaar2438 - DOI: 10.1126/scitranslmed.aar2438

Miller MA

Counting on carbon quantum dots to clear infection
Sci Transl Med. 2017;9(399):eaao0969

Miller MA

Nanotransfection brings progress that’s more than skin-deep
Sci Transl Med. 2017;9(405):eaao4216

Miller MA

Driver mutations take the wheel in invasive yet nonmalignant disease.
Sci Transl Med. 2017;9(393):ePub - PMID: 28592567 - DOI: 10.1126/scitranslmed.aan8194

Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
Sci Transl Med. 2017;9(392):eaal0225 - PMID: 28566423 - PMCID: PMC6681815 - DOI: 10.1126/scitranslmed.aal0225

Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604

Miller MA

Nanoparticles improve economic mileage for CARs.
Sci Transl Med. 2017;9(387):ePub - PMID: 28446684 - DOI: 10.1126/scitranslmed.aan2784

Miller MA

Richer data with personalized GEMs.
Sci Transl Med. 2017;9(381):ePub - PMID: 28298424 - DOI: 10.1126/scitranslmed.aam9865

Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R

Nano-palladium is a cellular catalyst for in vivo chemistry
Nat Commun. 2017;8:15906 - PMID: 28699627 - PMCID: PMC5510178 - DOI: 10.1038/ncomms15906

Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

Miller MA, Weissleder R

Imaging the pharmacology of nanomaterials by intravital microscopy: Towards understanding their biological behavior.
Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023

Miller MA, Weissleder R

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior
Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023

Miller MA, Arlauckas S, Weissleder R

Prediction of Anti-cancer Nanotherapy Efficacy by Imaging
Nanotheranostics. 2017;1(3):296-312 - PMID: 29071194 - PMCID: PMC5646731 - DOI: 10.7150/ntno.20564

Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R

Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b

Conrad C, Dorzweiler K, Miller MA, Lauffenburger DA, Strik H, Bartsch JW

Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis.
Fluids Barriers CNS. 2017;14(1):22 - PMID: 28806983 - PMCID: PMC5556623 - DOI: 10.1186/s12987-017-0070-5

Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL

Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates.
J Cancer. 2017;8(19):3916-3932 - PMID: 29187866 - PMCID: PMC5705993 - DOI: 10.7150/jca.20779

Conrad C, Miller MA, Bartsch JW, Schlomann U, Lauffenburger DA

Simultaneous Detection of Metalloprotease Activities in Complex Biological Samples Using the PrAMA (Proteolytic Activity Matrix Assay) Method.
Methods Mol Biol. 2017;1574:243-253 - PMID: 28315256 - DOI: 10.1007/978-1-4939-6850-3_18

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Cancer Discov. 2016;6(4):382-99 - PMID: 26984351 - PMCID: PMC5087317 - DOI: 10.1158/2159-8290.CD-15-0933

Miller MA, Sullivan RJ, Lauffenburger DA

Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.
Clin Cancer Res. 2016;23(3):623-629 - PMID: 27895032 - PMCID: PMC5290119 - DOI: 10.1158/1078-0432.CCR-16-0869

Ng EX, Miller MA, Jing T, Chen CH

Single cell multiplexed assay for proteolytic activity using droplet microfluidics.
Biosens Bioelectron. 2016;81:408-14 - PMID: 26995287 - DOI: 10.1016/j.bios.2016.03.002

Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB

MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer.
Mol Cancer Ther. 2016;16(1):143-155 - PMID: 27811011 - PMCID: PMC5359014 - DOI: 10.1158/1535-7163.MCT-16-0413

Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB

MenaINV mediates synergistic crosstalk between signaling pathways driving chemotaxis and haptotaxis.
Mol Biol Cell. 2016;27(20):3085-3094 - PMID: 27559126 - PMCID: PMC5063616 - DOI: 10.1091/mbc.E16-04-0212

Moss ML, Miller MA, Vujanovic N, Yoneyama T, Rasmussen FH

Fluorescent substrates for ADAM15 useful for assaying and high throughput screening.
Anal Biochem. 2016;514:42-47 - PMID: 27637923 - DOI: 10.1016/j.ab.2016.09.010

Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamal N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R

Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
Sci Transl Med. 2015;7:314 - PMID: 26582898 - PMCID: PMC5462466 - DOI: 10.1126/scitranslmed.aac6522

Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW

ADAM8 as a drug target in pancreatic cancer.
Nat Commun. 2015;6:6175 - PMID: 25629724 - PMCID: PMC5014123 - DOI: 10.1038/ncomms7175

Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Nat Commun. 2015;6:8692 - PMID: 26503691 - PMCID: PMC4711745 - DOI: 10.1038/ncomms9692

Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH

Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array.
Lab Chip. 2015;15(4):1153-9 - PMID: 25553996 - DOI: 10.1039/c4lc01162g

Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R

Advances in measuring single-cell pharmacokinetics and pharmacology in vivo.
Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011

Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.
Sci Rep. 2015;5:15150 - PMID: 26477568 - PMCID: PMC4609913 - DOI: 10.1038/srep15150

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R

Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318

Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R

Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.
Sci Rep. 2014;4:4782 - PMID: 24759210 - PMCID: PMC3998017 - DOI: 10.1038/srep04782

Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R

Platinum Compounds for High-Resolution In Vivo Cancer Imaging.
ChemMedChem. 2014;9(6):1131-5 - PMID: 24504646 - PMCID: PMC4037345 - DOI: 10.1002/cmdc.201300502

Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A

Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Proc Natl Acad Sci U S A. 2013;110(24):9776-81 - PMID: 23720309 - PMCID: PMC3683718 - DOI: 10.1073/pnas.1307478110

Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Proc Natl Acad Sci U S A. 2013;110(22):E2074-83 - PMID: 23674691 - PMCID: PMC3670354 - DOI: 10.1073/pnas.1222387110

Meyer AS, Miller MA, Gertler FB, Lauffenburger DA

The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells.
Sci Signal. 2013;6(287):ra66 - PMID: 23921085 - PMCID: PMC3947921 - DOI: 10.1126/scisignal.2004155

Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J

Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.
J Am Chem Soc. 2012;135(5):1645-8 - PMID: 23157326 - PMCID: PMC3566300 - DOI: 10.1021/ja307866z

Miller M, Hafner M, Sontag E, Davidsohn N, Subramanian S, Purnick PE, Lauffenburger D, Weiss R

Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity.
PLoS Comput Biol. 2012;8(7):e1002579 - PMID: 22829755 - PMCID: PMC3400602 - DOI: 10.1371/journal.pcbi.1002579

Miller MA, Feng XJ, Li G, Rabitz HA

Identifying biological network structure, predicting network behavior, and classifying network state with High Dimensional Model Representation (HDMR).
PLoS ONE. 2012;7(6):e37664 - PMID: 22723838 - PMCID: PMC3377689 - DOI: 10.1371/journal.pone.0037664

Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J

Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator.
J Am Chem Soc. 2011;133(27):10368-71 - PMID: 21671557 - PMCID: PMC3165005 - DOI: 10.1021/ja2036628

Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
J Biol Chem. 2011;286(47):40443-51 - PMID: 21956108 - PMCID: PMC3220463 - DOI: 10.1074/jbc.M111.280495

Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA

Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities.
Integr Biol (Camb). 2010;3(4):422-38 - PMID: 21180771 - PMCID: PMC3173501 - DOI: 10.1039/c0ib00083c

Miller M, Feng X, Li G, Rabitz H

Nonlinear bionetwork structure inference using the random sampling-high dimensional model representation (RS-HDMR) algorithm.
Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6412-5 - PMID: 19964421 - DOI: 10.1109/IEMBS.2009.5333798
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