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Guan D, Men Y, Bartlett A, Hernández MAS, Xu J, Yi X, Li HS, Kong D, Mazitschek R, Ozcan U
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Cell Metab. 2024;36(4):857-876.e10 - PMID: 38569472 - DOI: 10.1016/j.cmet.2024.02.007
Carrow KP, Hamilton HL, Hopps MP, Li Y, Qiao B, Payne NC, Thompson MP, Zhang X, Magassa A, Fattah M, Agarwal S, Vincent MP, Buyanova M, Bertin PA, Mazitschek R, Olvera de la Cruz M, Johnson DA, Johnson JA, Gianneschi NC
Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers.
Adv Mater. 2024;:e2311467 - PMID: 38241649 - DOI: 10.1002/adma.202311467
Ichikawa S, Payne NC, Xu W, Chang CF, Vallavoju N, Frome S, Flaxman HA, Mazitschek R, Woo CM
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation.
Cell Chem Biol. 2024;:ePub - PMID: 38320555 - DOI: 10.1016/j.chembiol.2024.01.003
Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Sci Rep. 2024;14(1):9064 - PMID: 38643236 - PMCID: PMC11032351 - DOI: 10.1038/s41598-024-59110-7
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