Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Cell Metab. 2024;36(4):857-876.e10 - PMID: 38569472 - DOI: 10.1016/j.cmet.2024.02.007
Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers.
Adv Mater. 2024;36(21):e2311467 - PMID: 38241649 - DOI: 10.1002/adma.202311467
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation.
Cell Chem Biol. 2024;31(6):1162-1175.e10 - PMID: 38320555 - DOI: 10.1016/j.chembiol.2024.01.003
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology.
STAR Protoc. 2024;5(2):103129 - PMID: 38857155 - PMCID: PMC11193044 - DOI: 10.1016/j.xpro.2024.103129
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes.
Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
7
CSV