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Yeo MJR, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N

UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Nature. 2025;639(8053):232-240 - PMID: 39939761 - PMCID: PMC11882444 - DOI: 10.1038/s41586-024-08532-4

Xie X, Zhang O, Yeo MJR, Lee C, Tao R, Harry SA, Payne NC, Nam E, Paul L, Li Y, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N, Liau BB

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.
Nature. 2025;639(8053):241-249 - PMID: 39939763 - PMCID: PMC11882451 - DOI: 10.1038/s41586-024-08533-3

Zhu Q, Fischer G, Cheng SS, Payne NC, Peter D, Mody AC, Arce-Solano S, Shen D, Lin Z, Mazitschek R, Kessler D, Woo CM

Enzyme-Activated Sugar-Coated Bifunctional Degraders.
J Am Chem Soc. 2025;147(38):34672-34680 - PMID: 40937862 - DOI: 10.1021/jacs.5c09843

Amako Y, Ichikawa S, Lloyd HC, Payne NC, Lin Z, Boghossian AS, Rees MG, Ronan MM, Roth JA, Zhu Q, Budnik B, Mazitschek R, Woo CM

The contribution of cyclic imide stereoisomers on cereblon-dependent activity.
Chem Sci. 2025;16(25):11519-11529 - PMID: 40443985 - PMCID: PMC12117711 - DOI: 10.1039/d5sc01371b

Bopp S, Fagbami L, Deik A, Taccheri C, Pant A, Luth M, Chen D, Tye MA, Ullah I, Kreuzer J, Morris R, Haas W, Winzeler EA, Clish C, Lukens AK, Mazitschek R, Wirth DF

Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors.
Cell Chem Biol. 2025;32(10):1293-1302.e5 - PMID: 41061700 - DOI: 10.1016/j.chembiol.2025.09.007

Lloyd HC, Li Y, Payne NC, Zhao Z, Xu W, Kroupova A, Zollman D, Long T, Kabir F, Chen M, Freeman R, Feng EY, Xi SY, Hsu YC, Ciulli A, Mazitschek R, Woo CM

A method for the detection and enrichment of endogenous cereblon substrates.
Cell Chem Biol. 2025;32(8):1028-1041.e13 - PMID: 40782806 - PMCID: PMC12360616 - DOI: 10.1016/j.chembiol.2025.07.002

Stopka SA, Bodineau C, Baquer G, Lin JR, Hossain MA, Martinez CJ, Regan MS, Ruiz D, Fletcher SM, Pourquié O, Lutsenko S, Payne CN, Agar JN, Mazitschek R, McDannold NJ, Sorger PK, Santagata S, Agar NYR

Spatial Profiling of Elements through Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging.
Anal Chem. 2025;97(45):25334-25345 - PMID: 41201007 - DOI: 10.1021/acs.analchem.5c05632

Merz ML, Shoba VM, Pergu R, Severance ZC, Munkanatta Godage DNP, Deb A, Kwok HS, Singh P, Singh S, Allen JB, Tian W, Gosavi PM, Chaudhary SK, Anokhina V, Weisberg EL, Payne NC, He Y, Osadchey R, Shekhar M, Mazitschek R, Rees MG, Roth JA, Cui Q, Griffin JD, Liau BB, Choudhary A

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.
bioRxiv. 2025;:ePub - PMID: 40661463 - PMCID: PMC12259158 - DOI: 10.1101/2025.06.13.659082

Lloyd HC, Li Y, Payne N, Zhao Z, Xu W, Kroupova A, Zollman D, Long T, Kabir F, Chen M, Freeman R, Feng EY, Xi S, Hsu YC, Ciulli A, Mazitschek R, Woo CM

A method for the detection and enrichment of endogenous cereblon substrates.
bioRxiv. 2025;:ePub - PMID: 40196695 - PMCID: PMC11974815 - DOI: 10.1101/2025.03.24.645063
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