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Guan D, Men Y, Bartlett A, Hernández MAS, Xu J, Yi X, Li HS, Kong D, Mazitschek R, Ozcan U

Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Cell Metab. 2024;36(4):857-876.e10 - PMID: 38569472 - DOI: 10.1016/j.cmet.2024.02.007

Carrow KP, Hamilton HL, Hopps MP, Li Y, Qiao B, Payne NC, Thompson MP, Zhang X, Magassa A, Fattah M, Agarwal S, Vincent MP, Buyanova M, Bertin PA, Mazitschek R, Olvera de la Cruz M, Johnson DA, Johnson JA, Gianneschi NC

Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers.
Adv Mater. 2024;36(21):e2311467 - PMID: 38241649 - PMCID: PMC11257647 - DOI: 10.1002/adma.202311467

Hammel FA, Payne NC, Marando VM, Mazitschek R, Walker S

Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity.
J Am Chem Soc. 2024;146(38):26320-26330 - PMID: 39276112 - PMCID: PMC11440498 - DOI: 10.1021/jacs.4c08656

Antolin AA, Aye Y, Bar-Peled L, De Vita E, Dudkina N, Jewett MC, Kiely-Collins H, Mazitschek R, Zhang ZJ

What is chemical biology?
Cell Chem Biol. 2024;31(9):1562-1565 - PMID: 39303695 - DOI: 10.1016/j.chembiol.2024.08.011

Ichikawa S, Payne NC, Xu W, Chang CF, Vallavoju N, Frome S, Flaxman HA, Mazitschek R, Woo CM

The cyclimids: Degron-inspired cereblon binders for targeted protein degradation.
Cell Chem Biol. 2024;31(6):1162-1175.e10 - PMID: 38320555 - PMCID: PMC12136240 - DOI: 10.1016/j.chembiol.2024.01.003

Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Sci Rep. 2024;14(1):9064 - PMID: 38643236 - PMCID: PMC11032351 - DOI: 10.1038/s41598-024-59110-7

Payne NC, Ichikawa S, Woo CM, Mazitschek R

Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology.
STAR Protoc. 2024;5(2):103129 - PMID: 38857155 - PMCID: PMC11193044 - DOI: 10.1016/j.xpro.2024.103129

Xie X, Zhang O, Yeo MJR, Lee C, Harry SA, Paul L, Li Y, Payne NC, Nam E, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N, Liau BB

KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes.
bioRxiv. 2024;:ePub - PMID: 38798357 - PMCID: PMC11118371 - DOI: 10.1101/2024.05.14.593970

Yeo MJ, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N

Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
bioRxiv. 2024;:ePub - PMID: 38798619 - PMCID: PMC11118476 - DOI: 10.1101/2024.05.14.593897
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