Weissleder, Ralph, MD, PhD
Dr. Weissleder is the Thrall Professor of Radiology and Professor of Systems Biology at Harvard Medical School, Director of the Center for Systems Biology at Massachusetts General Hospital (MGH), and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Department of Systems Biology at HMS and the Harvard Cancer Center. Dr. Weissleder’s research interests include the development of novel high resolution molecular imaging systems, tools for early disease detection, new and more advanced nanomaterials for imaging, and modeling methods for systems analysis. Increasingly, his work has been focused on reconciling the gap that exists between traditional cell biology and human biology. His work on imaging, nanomaterials and miniaturized sensing technologies has led to a number of new technologies and advanced clinical trials. He is a cofounder of T2Biosystems and Lumicell. Dr. Weissleder is currently the principal investigator of several National Institute of Health grants and consortia. He has published over 800 publications in peer reviewed journals and has authored several textbooks. He has received the J. Taylor International Prize in Medicine, the Millennium Pharmaceuticals Innovator Award, the Society for Molecular Imaging Lifetime Achievement Award and is a member of the German National Academy of Sciences (Leopoldina) and of the US National Academies of Medicine. In 2014 Dr. Weissleder was named by Thomson Reuters as one of the “The World’s Most Influential Scientific Minds”.
SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions
Science. 2016;352(6282):242-246 - PMID: 26989197
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Imaging the pharmacology of nanomaterials by intravital microscopy: Towards understanding their biological behavior.
Adv Drug Deliv Rev. 2016;:ePub - PMID: 27266447
Integrated Magneto-Electrochemical Sensor for Exosome Analysis.
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Real-time high dynamic range laser scanning microscopy.
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications
Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity.
Glucagon-like peptide-1 receptor activation attenuates platelet aggregation and thrombosis.
Diabetes. 2016;65(6):1714-23 - PMID: 26936963
Fluorescent vinblastine probes for live cell imaging
Chem Commun. 2016;:ePub - PMID: 27439765
Digital diffraction detection of protein markers for avian influenza.
Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography.
Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement
IEEE J Sel Top Quantum Electron. 2016;22 (3):6801607 - PMID: 27440991
Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries.
ACS Comb Sci. 2016;18(6):271-8 - PMID: 27124678
Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group.