Weissleder, Ralph, MD, PhD
Dr. Weissleder is the Thrall Professor of Radiology and Professor of Systems Biology at Harvard Medical School, Director of the Center for Systems Biology at Massachusetts General Hospital (MGH), and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Department of Systems Biology at HMS and the Harvard Cancer Center. Dr. Weissleder’s research interests include the development of novel high resolution molecular imaging systems, tools for early disease detection, new and more advanced nanomaterials for imaging, and modeling methods for systems analysis. Increasingly, his work has been focused on reconciling the gap that exists between traditional cell biology and human biology. His work on imaging, nanomaterials and miniaturized sensing technologies has led to a number of new technologies and advanced clinical trials. He is a cofounder of T2Biosystems and Lumicell. Dr. Weissleder is currently the principal investigator of several National Institute of Health grants and consortia. He has published over 800 publications in peer reviewed journals and has authored several textbooks. He has received the J. Taylor International Prize in Medicine, the Millennium Pharmaceuticals Innovator Award, the Society for Molecular Imaging Lifetime Achievement Award and is a member of the German National Academy of Sciences (Leopoldina) and of the US National Academies of Medicine. In 2014 Dr. Weissleder was named by Thomson Reuters as one of the “The World’s Most Influential Scientific Minds”.
Imaging of anticancer drug action in single cells
Electrical Conduction in the Heart
Osteoblasts remotely supply lung tumors with cancer-promoting
High-Content Biopsies Facilitate Molecular Analyses and Do Not Increase Complication Rates in Patients With Advanced Solid Tumors
JCO Precis Oncol. 2017;1:1-9
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh.
Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection.
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
Nano-palladium is a cellular catalyst for in vivo chemistry
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
PD-L1 is an activation-independent marker of brown adipocytes.
Imaging the emergence and natural progression of spontaneous autoimmune diabetes.
Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.
Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.
Preclinical investigation of gene-mediated cytotoxic immunotherapy and checkpoint blockade in glioblastoma.
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Facile silicification of plastic surface for bioassays.
Novel nanosensing technologies for exosome detection and profiling.
Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.
Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing
Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Motion characterization scheme to minimize motion artifacts in intravital microscopy.
Prediction of Anti-cancer Nanotherapy Efficacy by Imaging
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.
Deep-learning based hologram classification for molecular diagnostics