Weissleder, Ralph, MD, PhD
Dr. Weissleder is the Thrall Professor of Radiology and Professor of Systems Biology at Harvard Medical School, Director of the Center for Systems Biology at Massachusetts General Hospital (MGH), Attending Clinician (Interventional Radiology) at MGH, senior faculty in the HMS Department of Systems Biology, a member of the Harvard Cancer Center as well as the Harvard Stem Cell Institute (HSCI). Dr. Weissleder obtained his postdoctoral and residency training at MGH (1986-91) and has been on faculty at HMS since 1991. He has published over >750 publications in peer reviewed journals and has authored several textbooks. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award, the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award among others. In 2009 he was elected member of the US National Academies Institute of Medicine. His lab has been a driving force in studying human biology, especially cancer and inflammatory diseases. He has developed systematic ways to explore disease biology using in vivo imaging and has been instrumental in translating several discoveries into new drugs. In 2014 Dr. Weissleder was named by Thomson Reuters as one of the “The World’s Most Influential Scientific Minds”.
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis.
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
JAMA. 2015;313(2):135-136 - PMID: 25585320
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy
Nat Methods. 2015;:ePub - PMID: 25867850
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.
Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo.
Acoustic Purification of Extracellular Microvesicles.
Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Noninvasive imaging of immune responses.
Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
On chip analysis of CNS lymphoma in cerebrospinal fluid.
Nano-plasmonic exosome diagnostics.
Expert Rev Mol Diagn. 2015;:1-9 - PMID: 25936957
Statins Improve the Resolution of Established Murine Venous Thrombosis: Reductions in Thrombus Burden and Vein Wall Scarring.
Single cell resolution in vivo imaging of DNA damage following PARP inhibition