Nahrendorf, Matthias, MD, PhD
My current research interests focus on imaging of molecular processes during the healing phase after myocardial infarction. Imaging targets are innate immune cells. Monocytes and macrophages are key players with a central role in disease, including the development of heart failure. We use the entire spectrum of modalities, including MRI, nuclear and optical imaging techniques. Multimodal imaging, as well as hybrid approaches to fuse molecular data with anatomical information are aspects of particular interest. These technologies are embedded in a biologically driven research program that aims at systematic understanding of inflammation at a basic level while keeping a rigorous translational perspective. In addition, I serve as the Director of the Mouse Imaging Program at the Center for Systems Biology. In this function, I oversee the scientific and administrative aspects of a broad molecular imaging facility that comprises all modalities, lead and mentor a team of post doctoral researchers and technicians and support collaborative imaging projects with outside researchers focussing on cardiovascular disease and cancer.
Reply to 'Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies'.
Sleep modulates haematopoiesis and protects against atherosclerosis
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
Uremic Toxins Activate Macrophages.
Smad3 Cranks Up the Appetite of Infarct Macrophages.
Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.
Clonal and diverse: revisiting cardiac endothelial cells after myocardial infarction.
Novel functions of macrophages in the heart: insights into electrical conduction, stress, and diastolic dysfunction.
Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis.
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.
Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Interferon-ɣ regulates cardiac myeloid cells in myocardial infarction.
A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart.