Publications

• Kaiser Y, Garris CS, Marinari E, Kim HS, Oh J, Pedard M, Halabi EA, Choi M, Parvanian S, Kohler R, Migliorini D, Weissleder R

  Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence. Nat Biomed Eng. 2025;:ePub - PMID: 41125869 - DOI: 10.1038/s41551-025-01533-2

• Kim HS, Simpson GG, Carrothers J, Nguyen YTM, Kohler R, Hong S, Cha S, Kim DH, Garris CS, Weissleder R

  A Myeloid Cell-Targeted Immunostimulant Cocktail (MyTai) Enhances Cancer Immunotherapy. ACS Nano. 2025;19(41):36451-36464 - PMID: 41061756 - DOI: 10.1021/acsnano.5c10081

• Kim HS, Simpson GG, Fei F, Garris C, Weissleder R

  Fluorinated Ribonucleocarbohydrate Nanoparticles Allow Ultraefficient mRNA Delivery and Protein Expression in Tumor-Associated Myeloid Cells. J Am Chem Soc. 2025;147(14):11766-11776 - PMID: 40135499 - PMCID: PMC11987029 - DOI: 10.1021/jacs.4c14474

• Qin T, Mattox AK, Campbell JS, Park JC, Shin KY, Li S, Sadow PM, Faquin WC, Micevic G, Daniels AJ, Haddad R, Garris CS, Pittet MJ, Mempel TR, ONeill A, Sartor MA, Pai SI

  Epigenetic therapy sensitizes anti-PD-1 refractory head and neck cancers to immunotherapy rechallenge. J Clin Invest. 2025;135(6):ePub - PMID: 40091844 - PMCID: PMC11910227 - DOI: 10.1172/JCI181671

• Parvanian S, Ge X, Garris CS

  Recent developments in myeloid immune modulation in cancer therapy. Trends Cancer. 2025;11(4):365-375 - PMID: 39794212 - DOI: 10.1016/j.trecan.2024.12.003

• Kartal B, Garris CS, Kim HS, Kohler RH, Carrothers J, Halabi EA, Iwamoto Y, Goubet AG, Xie Y, Wirapati P, Pittet MJ, Weissleder R

  Targeted SPP1 Inhibition of Tumor-Associated Myeloid Cells Effectively Decreases Tumor Sizes. Adv Sci (Weinh). 2024;12(4):e2410360 - PMID: 39639496 - PMCID: PMC11775521 - DOI: 10.1002/advs.202410360

• Das R, Ge X, Fei F, Parvanian S, Weissleder R*, Garris CS*

  Lipid Nanoparticle-mRNA Engineered Dendritic Cell Based Adoptive Cell Therapy Enhances Cancer Immune Response. Small Methods. 2024;9(1):e2400633 - PMID: 39039995 - PMCID: PMC11740962 - DOI: 10.1002/smtd.202400633

• Kim HS, Halabi EA, Enbergs N, Kohler RH, Fei F, Garris CS, Weissleder R

  A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation. Theranostics. 2024;14(7):2934-2945 - PMID: 38773971 - PMCID: PMC11103498 - DOI: 10.7150/thno.95267

• Chen ACY, Jaiswal S, Martinez D, Yerinde C, Ji K, Miranda V, Fung ME, Weiss SA, Zschummel M, Taguchi K, Garris CS, Mempel TR, Hacohen N, Sen DR

  The aged tumor microenvironment limits T cell control of cancer. Nat Immunol. 2024;25(6):1033-1045 - PMID: 38745085 - PMCID: PMC11500459 - DOI: 10.1038/s41590-024-01828-7

• Sarkar B, Arlauckas SP, Cuccarese MF, Garris CS, Weissleder R, Rodell CB

  Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype. Frontiers in Immunology (molecular innate immunity section). 2024;15:1331480 - PMID: 38545103 - PMCID: PMC10965546 - DOI: 10.3389/fimmu.2024.1331480

• Enbergs N*, Halabi EA*, Goubet AG, Schleyer K, Fredrich IR, Kohler RH, Garris CS, Pittet MJ, Weissleder R

  Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype. Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026

• Fredrich IR*, Halabi EA*, Kohler RH, Ge X, Garris CS, Weissleder R

  Highly Active Myeloid Therapy for Cancer. ACS Nano. 2023;17(20):20666-20679 - PMID: 37824733 - PMCID: PMC10941024 - DOI: 10.1021/acsnano.3c08034

• Das R*, Halabi EA*, Fredrich IR, Oh J, Peterson HM, Ge X, Scott E, Kohler RH, Garris CS, Weissleder R

  Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery. Adv Sci (Weinh). 2023;10(33):e2303576 - PMID: 37814359 - PMCID: PMC10667837 - DOI: 10.1002/advs.202303576

• Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF

  Non-cell-autonomous cancer progression from chromosomal instability. Nature. 2023;620(7976):1080-1088 - PMID: 37612508 - PMCID: PMC10468402 - DOI: 10.1038/s41586-023-06464-z

• Pittet MJ, Di Pilato M, Garris C, Mempel TR

  Dendritic cells as shepherds of T cell immunity in cancer. Immunity. 2023;56(10):2218-2230 - PMID: 37708889 - PMCID: PMC10591862 - DOI: 10.1016/j.immuni.2023.08.014

• Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ

  A neutrophil response linked to tumor control in immunotherapy. Cell. 2023;186(7):1448-1464.e20 - PMID: 37001504 - PMCID: PMC10132778 - DOI: 10.1016/j.cell.2023.02.032

• Lugani S*, Halabi EA*, Oh J, Kohler R, Peterson H, Breakefield XO, Chiocca EAA, Miller MA, Garris C, Weissleder R

  Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2022;35(7):e2208782 - PMID: 36427266 - PMCID: PMC10197197 - DOI: 10.1002/adma.202208782

• Algazi AP, Twitty CG, Tsai KK, Le M, Pierce R, Browning E, Hermiz R, Canton DA, Bannavong D, Oglesby A, Francisco M, Fong L, Pittet MJ, Arlauckas SP, Garris C, Levine LP, Bifulco C, Ballesteros-Merino C, Bhatia S, Gargosky S, Andtbacka RHI, Fox BA, Rosenblum MD, Daud AI

  Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. Clin Cancer Res. 2020;26(12):2827-2837 - PMID: 32376655 - PMCID: PMC9354653 - DOI: 10.1158/1078-0432.CCR-19-2217

• Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ

  Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024

• Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R

  Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. Theranostics. 2018;8(21):5842-5854 - PMID: 30613266 - PMCID: PMC6299430 - DOI: 10.7150/thno.26888

• Pittet MJ, Garris CS, Arlauckas SP, Weissleder R

  Recording the wild lives of immune cells. Sci Immunol. 2018;3(27):ePub - PMID: 30194240 - PMCID: PMC6771424 - DOI: 10.1126/sciimmunol.aaq0491

• Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R

  TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018;2:578-588 - PMID: 31015631 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8

• Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ

  Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017;358:eaal5081 - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081

• Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ

  In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy. Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604

• Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R

  Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

• Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ

  PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031

• Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ

  SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions. Science. 2016;352(6282):242-246 - PMID: 26989197 - PMCID: PMC4960636 - DOI: 10.1126/science.aaf1328

• Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ

  Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865 - DOI: 10.1016/j.immuni.2015.11.024

• Garris CS, Pittet MJ

  ER Stress in Dendritic Cells Promotes Cancer. Cell. 2015;161(7):1492-3 - PMID: 26091029 - DOI: 10.1016/j.cell.2015.06.006

• Pfirschke C, Garris C, Pittet MJ

  Common TLR5 Mutations Control Cancer Progression. Cancer Cell. 2015;27(1):1-3 - PMID: 25584886 - DOI: 10.1016/j.ccell.2014.12.008

• Garris C, Pittet MJ

  Therapeutically reeducating macrophages to treat GBM. Nature Med. 2013;19(10):1207-1208 - PMID: 24100977 - DOI: 10.1038/nm.3355