Garris, Christopher, PhD
Assistant ProfessorPublications
Das R, Ge X, Fei F, Parvanian S, Weissleder R*, Garris CS* Lipid Nanoparticle-mRNA Engineered Dendritic Cell Based Adoptive Cell Therapy Enhances Cancer Immune Response. Small Methods. 2024;:e2400633 - PMID: 39039995 - DOI: 10.1002/smtd.202400633
Kim HS, Halabi EA, Enbergs N, Kohler RH, Fei F, Garris CS, Weissleder R A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation. Theranostics. 2024;14(7):2934-2945 - PMID: 38773971 - PMCID: PMC11103498 - DOI: 10.7150/thno.95267
Chen ACY, Jaiswal S, Martinez D, Yerinde C, Ji K, Miranda V, Fung ME, Weiss SA, Zschummel M, Taguchi K, Garris CS, Mempel TR, Hacohen N, Sen DR The aged tumor microenvironment limits T cell control of cancer. Nat Immunol. 2024;25(6):1033-1045 - PMID: 38745085 - DOI: 10.1038/s41590-024-01828-7
Sarkar B, Arlauckas SP, Cuccarese MF, Garris CS, Weissleder R, Rodell CB Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype. Frontiers in Immunology (molecular innate immunity section). 2024;15:1331480 - PMID: 38545103 - PMCID: PMC10965546 - DOI: 10.3389/fimmu.2024.1331480
Enbergs N*, Halabi EA*, Goubet AG, Schleyer K, Fredrich IR, Kohler RH, Garris CS, Pittet MJ, Weissleder R Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype. Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026
Fredrich IR*, Halabi EA*, Kohler RH, Ge X, Garris CS, Weissleder R Highly Active Myeloid Therapy for Cancer. ACS Nano. 2023;17(20):20666-20679 - PMID: 37824733 - PMCID: PMC10941024 - DOI: 10.1021/acsnano.3c08034
Das R*, Halabi EA*, Fredrich IR, Oh J, Peterson HM, Ge X, Scott E, Kohler RH, Garris CS, Weissleder R Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery. Adv Sci (Weinh). 2023;10(33):e2303576 - PMID: 37814359 - PMCID: PMC10667837 - DOI: 10.1002/advs.202303576
Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF Non-cell-autonomous cancer progression from chromosomal instability. Nature. 2023;620(7976):1080-1088 - PMID: 37612508 - PMCID: PMC10468402 - DOI: 10.1038/s41586-023-06464-z
Pittet MJ, Di Pilato M, Garris C, Mempel TR Dendritic cells as shepherds of T cell immunity in cancer. Immunity. 2023;56(10):2218-2230 - PMID: 37708889 - PMCID: PMC10591862 - DOI: 10.1016/j.immuni.2023.08.014
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ A neutrophil response linked to tumor control in immunotherapy. Cell. 2023;186(7):1448-1464.e20 - PMID: 37001504 - PMCID: PMC10132778 - DOI: 10.1016/j.cell.2023.02.032
Lugani S*, Halabi EA*, Oh J, Kohler R, Peterson H, Breakefield XO, Chiocca EAA, Miller MA, Garris C, Weissleder R Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2022;35(7):e2208782 - PMID: 36427266 - PMCID: PMC10197197 - DOI: 10.1002/adma.202208782
Algazi AP, Twitty CG, Tsai KK, Le M, Pierce R, Browning E, Hermiz R, Canton DA, Bannavong D, Oglesby A, Francisco M, Fong L, Pittet MJ, Arlauckas SP, Garris C, Levine LP, Bifulco C, Ballesteros-Merino C, Bhatia S, Gargosky S, Andtbacka RHI, Fox BA, Rosenblum MD, Daud AI Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. Clin Cancer Res. 2020;26(12):2827-2837 - PMID: 32376655 - PMCID: PMC9354653 - DOI: 10.1158/1078-0432.CCR-19-2217
Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024
Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. Theranostics. 2018;8(21):5842-5854 - PMID: 30613266 - PMCID: PMC6299430 - DOI: 10.7150/thno.26888
Pittet MJ, Garris CS, Arlauckas SP, Weissleder R Recording the wild lives of immune cells. Sci Immunol. 2018;3(27):ePub - PMID: 30194240 - PMCID: PMC6771424 - DOI: 10.1126/sciimmunol.aaq0491
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018;2:578-588 - PMID: 31015631 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8
Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017;358:eaal5081 - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081
Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy. Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604
Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293
Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031
Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions. Science. 2016;352(6282):242-246 - PMID: 26989197 - PMCID: PMC4960636 - DOI: 10.1126/science.aaf1328
Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865 - DOI: 10.1016/j.immuni.2015.11.024
Garris CS, Pittet MJ ER Stress in Dendritic Cells Promotes Cancer. Cell. 2015;161(7):1492-3 - PMID: 26091029 - DOI: 10.1016/j.cell.2015.06.006
Pfirschke C, Garris C, Pittet MJ Common TLR5 Mutations Control Cancer Progression. Cancer Cell. 2015;27(1):1-3 - PMID: 25584886 - DOI: 10.1016/j.ccell.2014.12.008
Garris C, Pittet MJ Therapeutically reeducating macrophages to treat GBM. Nature Med. 2013;19(10):1207-1208 - PMID: 24100977 - DOI: 10.1038/nm.3355