Hakho Lee

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Lee, Hakho, PhD

Hakho_lee
Phone: 617-726-1653
Email: hlee@mgh.harvard.edu

Research

Hakho Lee, Ph.D. is Associate Professor in Radiology at Harvard Medical School, and Director of the Biomedical Engineering Program at the Center for Systems Biology (CSB), Massachusetts General Hospital (MGH). He received his Ph.D. in Physics from Harvard University (Advisor: Robert M. Westervelt), and completed his post-doctoral training at MGH under Dr. Weissleder. Dr. Lee has extensive experience in nanomaterials, biophysics, microfluidics, and electrical engineering. His research focuses on developing new biosensor technologies, and has been leading the Biomedical Engineering Program at CSB.

Selected Publications (from total of 84)

Im H, Yang K, Lee H, Castro CM
Characterization of Extracellular Vesicles by Surface Plasmon Resonance.
Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653
Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
ACS Nano. 2017;:ePub - PMID: 28792732
Im H, Lee K, Weissleder R, Lee H, Castro CM
Novel nanosensing technologies for exosome detection and profiling.
Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.
Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678
Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469
Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095
Hong S, Park KS, Weissleder R, Castro CM, Lee H
Facile silicification of plastic surface for bioassays.
Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824
Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R
Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing
Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933
Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R
Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood.
Nanomedicine. 2016;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428
Jeun M, Park S, Lee H, Lee KH
Highly sensitive detection of protein biomarkers via nuclear magnetic resonance biosensor with magnetically engineered nanoferrite particles
Int J Nanomedicine. 2016;2016:11:5497–5503 - PMID: 27799772 - PMCID: PMC5085298
Park KS, Chung HJ, Khanam F, Lee H, Rashu R, Bhuiyan MT, Berger A, Harris JB, Calderwood SB, Ryan ET, Qadri F, Weissleder R, Charles RC
A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever.
Sci Rep. 2016;6:32878 - PMID: 27605393 - PMCID: PMC5015101
Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM
Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications
Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059
Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H
Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
Sci Adv. 2016;2(5):e1600300 - PMID: 28861468 - PMCID: PMC5565941
Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE
Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries.
ACS Comb Sci. 2016;18(6):271-8 - PMID: 27124678 - PMCID: PMC5321554
Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H
Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography.
Sci Rep. 2016;6:24681 - PMID: 27098438 - PMCID: PMC4838824
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