Hakho Lee


PI Bio

Lee, Hakho, PhD

Phone: 617-726-1653
Email: hlee@mgh.harvard.edu


Hakho Lee, Ph.D. is Associate Professor in Radiology at Harvard Medical School, and Director of the Biomedical Engineering Program at the Center for Systems Biology (CSB), Massachusetts General Hospital (MGH). He received his Ph.D. in Physics from Harvard University (Advisor: Robert M. Westervelt), and completed his post-doctoral training at MGH under Dr. Weissleder. Dr. Lee has extensive experience in nanomaterials, biophysics, microfluidics, and electrical engineering. His research focuses on developing new biosensor technologies, and has been leading the Biomedical Engineering Program at CSB.

Selected Publications (from total of 93)

Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H
Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis.
ACS Nano. 2018;:ePub - PMID: 29533646 - DOI: 10.1021/acsnano.7b08965
Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Sci Adv. 2018;4(3):eaar2766 - PMID: 29532035 - PMCID: PMC5842038 - DOI: 10.1126/sciadv.aar2766
Lin HY, Yang KS, Curley C, Lee H, Welch MW, Wolpin BM, Weissleder R, Im H, Castro C
Bead Enhancement of EV Analysis
bioRxiv. 2018;:ePub - DOI: 10.1101/269423
Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H
New Technologies for Analysis of Extracellular Vesicles.
Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - DOI: 10.1021/acs.chemrev.7b00534
Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R
Multiplexed Profiling of Single Extracellular Vesicles.
ACS Nano. 2017;12(1):494-503 - PMID: 29286635 - DOI: 10.1021/acsnano.7b07060
Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - DOI: 10.1021/acsnano.7b06074
Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H
Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System
ACS Photonics. 2017;:ePub - DOI: 10.1021/acsphotonics.7b00992
Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H
Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.
Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h
Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR
Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection.
ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - DOI: 10.1021/acsnano.7b05083
Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K
Deep-learning based hologram classification for molecular diagnostics
bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559
Im H, Yang K, Lee H, Castro CM
Characterization of Extracellular Vesicles by Surface Plasmon Resonance.
Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653 - DOI: 10.1007/978-1-4939-7253-1_11
Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318
Im H, Lee K, Weissleder R, Lee H, Castro CM
Novel nanosensing technologies for exosome detection and profiling.
Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.
Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341
Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226