Hakho Lee

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PI Bio

Lee, Hakho, PhD

Hakho_lee
Phone: 617-726-1653
Email: hlee@mgh.harvard.edu

Research

Hakho Lee, Ph.D. is Associate Professor in Radiology at Harvard Medical School, and Director of the Biomedical Engineering Program at the Center for Systems Biology (CSB), Massachusetts General Hospital (MGH). He received his Ph.D. in Physics from Harvard University (Advisor: Robert M. Westervelt), and completed his post-doctoral training at MGH under Dr. Weissleder. Dr. Lee has extensive experience in nanomaterials, biophysics, microfluidics, and electrical engineering. His research focuses on developing new biosensor technologies, and has been leading the Biomedical Engineering Program at CSB.

Selected Publications (from total of 89)

Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R
Multiplexed Profiling of Single Extracellular Vesicles.
ACS Nano. 2017;:ePub - PMID: 29286635 - DOI: 10.1021/acsnano.7b07060
Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - DOI: 10.1021/acsnano.7b06074
Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H
Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System
ACS Photonics. 2017;:ePub - DOI: 10.1021/acsphotonics.7b00992
Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H
Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.
Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h
Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR
Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection.
ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - DOI: 10.1021/acsnano.7b05083
Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K
Deep-learning based hologram classification for molecular diagnostics
bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559
Im H, Yang K, Lee H, Castro CM
Characterization of Extracellular Vesicles by Surface Plasmon Resonance.
Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653 - DOI: 10.1007/978-1-4939-7253-1_11
Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318
Im H, Lee K, Weissleder R, Lee H, Castro CM
Novel nanosensing technologies for exosome detection and profiling.
Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.
Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341
Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - DOI: 10.1126/scitranslmed.aal3226
Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024
Hong S, Park KS, Weissleder R, Castro CM, Lee H
Facile silicification of plastic surface for bioassays.
Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k
Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R
Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing
Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524
Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R
Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood.
Nanomedicine. 2016;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428 - DOI: 10.1016/j.nano.2016.12.006
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