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Chen ACY, Jaiswal S, Martinez D, Yerinde C, Ji K, Miranda V, Fung ME, Weiss SA, Zschummel M, Taguchi K, Garris CS, Mempel TR, Hacohen N, Sen DR
The aged tumor microenvironment limits T cell control of cancer.
Nat Immunol. 2024;25(6):1033-1045 - PMID: 38745085 - PMCID: PMC11500459 - DOI: 10.1038/s41590-024-01828-7
Enbergs N*, Halabi EA*, Goubet AG, Schleyer K, Fredrich IR, Kohler RH, Garris CS, Pittet MJ, Weissleder R
Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype.
Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026
Das R, Ge X, Fei F, Parvanian S, Weissleder R*, Garris CS*
Lipid Nanoparticle-mRNA Engineered Dendritic Cell Based Adoptive Cell Therapy Enhances Cancer Immune Response.
Small Methods. 2024;:e2400633 - PMID: 39039995 - DOI: 10.1002/smtd.202400633
Kim HS, Halabi EA, Enbergs N, Kohler RH, Fei F, Garris CS, Weissleder R
A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation.
Theranostics. 2024;14(7):2934-2945 - PMID: 38773971 - PMCID: PMC11103498 - DOI: 10.7150/thno.95267
Sarkar B, Arlauckas SP, Cuccarese MF, Garris CS, Weissleder R, Rodell CB
Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype
Frontiers in Immunology (molecular innate immunity section). 2024;15:1331480 - PMID: 38545103 - PMCID: PMC10965546 - DOI: 10.3389/fimmu.2024.1331480
Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF
Non-cell-autonomous cancer progression from chromosomal instability.
Nature. 2023;620(7976):1080-1088 - PMID: 37612508 - PMCID: PMC10468402 - DOI: 10.1038/s41586-023-06464-z
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ
A neutrophil response linked to tumor control in immunotherapy.
Cell. 2023;186(7):1448-1464.e20 - PMID: 37001504 - PMCID: PMC10132778 - DOI: 10.1016/j.cell.2023.02.032
Pittet MJ, Di Pilato M, Garris C, Mempel TR
Dendritic cells as shepherds of T cell immunity in cancer.
Immunity. 2023;56(10):2218-2230 - PMID: 37708889 - PMCID: PMC10591862 - DOI: 10.1016/j.immuni.2023.08.014
Fredrich IR*, Halabi EA*, Kohler RH, Ge X, Garris CS, Weissleder R
Highly Active Myeloid Therapy for Cancer.
ACS Nano. 2023;17(20):20666-20679 - PMID: 37824733 - PMCID: PMC10941024 - DOI: 10.1021/acsnano.3c08034
Das R*, Halabi EA*, Fredrich IR, Oh J, Peterson HM, Ge X, Scott E, Kohler RH, Garris CS, Weissleder R
Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery.
Adv Sci (Weinh). 2023;10(33):e2303576 - PMID: 37814359 - PMCID: PMC10667837 - DOI: 10.1002/advs.202303576
Lugani S*, Halabi EA*, Oh J, Kohler R, Peterson H, Breakefield XO, Chiocca EAA, Miller MA, Garris C, Weissleder R
Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma.
Adv Mater. 2022;35(7):e2208782 - PMID: 36427266 - PMCID: PMC10197197 - DOI: 10.1002/adma.202208782
Garris CS, Wong JL, Ravetch JV, Knorr DA
Dendritic cell targeting with Fc-enhanced CD40 antibody agonists induces durable antitumor immunity in humanized mouse models of bladder cancer.
Sci Transl Med. 2021;13(594):eabd1346 - PMID: 34011627 - PMCID: PMC8325152 - DOI: 10.1126/scitranslmed.abd1346
Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):eabi7083 - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083
Deyell M, Garris CS, Laughney AM
Cancer metastasis as a non-healing wound.
Br J Cancer. 2021;124(9):1491-1502 - PMID: 33731858 - PMCID: PMC8076293 - DOI: 10.1038/s41416-021-01309-w
Algazi AP, Twitty CG, Tsai KK, Le M, Pierce R, Browning E, Hermiz R, Canton DA, Bannavong D, Oglesby A, Francisco M, Fong L, Pittet MJ, Arlauckas SP, Garris C, Levine LP, Bifulco C, Ballesteros-Merino C, Bhatia S, Gargosky S, Andtbacka RHI, Fox BA, Rosenblum MD, Daud AI
Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.
Clin Cancer Res. 2020;26(12):2827-2837 - PMID: 32376655 - PMCID: PMC9354653 - DOI: 10.1158/1078-0432.CCR-19-2217
Garris CS, Luke JJ
Dendritic Cells, the T-cell-inflamed Tumor Microenvironment, and Immunotherapy Treatment Response.
Clin Cancer Res. 2020;26(15):3901-3907 - PMID: 32332013 - PMCID: PMC7607412 - DOI: 10.1158/1078-0432.CCR-19-1321
Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010
Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R
Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy
Theranostics. 2019;9(26):8426-8436 - PMID: 31879528 - PMCID: PMC6924259 - DOI: 10.7150/thno.35434
Lan YY, Heather JM, Eisenhaure T, Garris CS, Lieb D, Raychowdhury R, Hacohen N
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation.
Aging Cell. 2019;18(2):e12901 - PMID: 30706626 - PMCID: PMC6413746 - DOI: 10.1111/acel.12901
Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ
LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects.
Cell Stress. 2019;3(11):348-360 - PMID: 31799501 - PMCID: PMC6859426 - DOI: 10.15698/cst2019.11.204
Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Nat Biomed Eng. 2018;2:578-588 - PMID: 31015631 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8
Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Theranostics. 2018;8(21):5842-5854 - PMID: 30613266 - PMCID: PMC6299430 - DOI: 10.7150/thno.26888
Pittet MJ, Garris CS, Arlauckas SP, Weissleder R
Recording the wild lives of immune cells.
Sci Immunol. 2018;3(27):ePub - PMID: 30194240 - PMCID: PMC6771424 - DOI: 10.1126/sciimmunol.aaq0491
Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils
Science. 2017;358:eaal5081 - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081
Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293
Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ
In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604
Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ
SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions
Science. 2016;352(6282):242-246 - PMID: 26989197 - PMCID: PMC4960636 - DOI: 10.1126/science.aaf1328
Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865 - DOI: 10.1016/j.immuni.2015.11.024
Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ
PF4 Promotes Platelet Production and Lung Cancer Growth.
Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031
Tsai HC, Huang Y, Garris CS, Moreno MA, Griffin CW, Han MH
Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation.
JCI Insight. 2016;1(9):e86462 - PMID: 27699272 - PMCID: PMC5033897 - DOI: 10.1172/jci.insight.86462
Garris CS, Pittet MJ
ER Stress in Dendritic Cells Promotes Cancer.
Cell. 2015;161(7):1492-3 - PMID: 26091029 - DOI: 10.1016/j.cell.2015.06.006
Pfirschke C, Garris C, Pittet MJ
Common TLR5 Mutations Control Cancer Progression.
Cancer Cell. 2015;27(1):1-3 - PMID: 25584886 - DOI: 10.1016/j.ccell.2014.12.008
Garris CS, Blaho VA, Hla T, Han MH
Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.
Immunology. 2014;142(3):347-53 - PMID: 24597601 - PMCID: PMC4080950 - DOI: 10.1111/imm.12272
Garris C, Pittet MJ
Therapeutically reeducating macrophages to treat GBM.
Nature Med. 2013;19(10):1207-1208 - PMID: 24100977 - DOI: 10.1038/nm.3355
Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Nat Immunol. 2013;14(11):1166-72 - PMID: 24076635 - PMCID: PMC4014310 - DOI: 10.1038/ni.2730
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
J Exp Med. 2012;209(7):1325-34 - PMID: 22734047 - PMCID: PMC3405500 - DOI: 10.1084/jem.20101974
Misaghi S, Garris CS, Sun Y, Nguyen A, Zhang J, Sebrell A, Senger K, Yan D, Lorenzo MN, Heldens S, Lee WP, Xu M, Wu J, DeForge L, Sai T, Dixit VM, Zarrin AA
Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells.
J Immunol. 2010;185(1):166-73 - PMID: 20511552 - DOI: 10.4049/jimmunol.1000515
Hackney JA, Misaghi S, Senger K, Garris C, Sun Y, Lorenzo MN, Zarrin AA
DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination.
Adv Immunol. 2009;101:163-89 - PMID: 19231595 - DOI: 10.1016/S0065-2776(08)01005-5
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