Pittet Lab
My laboratory studies responses mediated by innate and adaptive immune cells. We look at how these cells interplay, respond to stimuli and exhibit regulatory or effector functions. Because in vitro readouts do not always recapitulate the complexity of in vivo environments, the discovery effort utilizes noninvasive, three-dimensional bioimaging technologies combined with novel cell trackers and molecular sensors. The modalities provide either real-time microscopic cellular resolution, quantitative whole organ information and/or have translational potential. Our goals are to develop approaches for comprehensive investigation of cell types in defined microenvironments, and to quantify and model information obtained by bioimaging. The laboratory collaborates with several immunology programs at Harvard Medical School, Massachusetts General Hospital and Massachusetts Institute of Technology.
In vivo imaging of immune cells at different scales. Imaging modalities include single photon emission computed tomography - X-ray computed tomography (SPECT-CT), fluorescence mediated tomography (FMT), microscopic fiber optics, and intravital multiphoton microscopy (IVM).