Weissleder Lab
My laboratory has currently three major areas of interest: 1) An NIH-funded program to develop nanoparticle and other scaffold based libraries to identify novel ligands for interrogation of cellular pathways and to use this information to develop an more comprehensive understanding of in vivo biology; 2) Analyzing the genes and gene products involved in the molecular pathogenesis of complex human diseases (esp. cancer, cardiovascular and diabetes) to identify novel imaging and therapeutic targets; 3) Development of novel miniaturized sensing technologies (chips) for real-time high-throughput analysis of problems in biology.
The lab develops and uses a variety of different tools and platforms for data acquisition. In particular, we aim at obtaining the following information using in vivo systems through bioimaging and parallel sensing:
- Quantitative measurements
- Systems, wide global measurements
- Integration of multiple, different data sets into models
- Dynamic, serial measurements
- Systems perturbations
- Integration of discovery and hypothesis driven research