About
John Higgins' Lab
I study the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time. The research combines medical insight, dynamic systems theory, and experiments utilizing microfluidics, video processing, flow cytometry, simulation, and large-scale analysis of medical databases in pursuit of two goals: (1) advancing fundamental understanding of the dynamics of human pathophysiology, and (2) improving patient diagnosis, monitoring, and treatment.
Recent Publications (more...)
Statistical dynamics of flowing red blood cells by morphological image processing.
PLoS Comput Biol. 2009;5(2):e1000288 - PMID: 19214200 - PMCID: PMC2631282
Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.
Blood. 2008;112(6):2546-53 - PMID: 18535200
Sickle cell vasoocclusion and rescue in a microfluidic device.
P Natl Acad Sci U S A. 2007;104(51):20496-500 - PMID: 18077341 - PMCID: PMC2154459
Recent News (more...)
2009-11-09: Nature Nanotechnology Feature article describes CSB work on TB detection using magnetic nanoparticles, microfluidics and nuclear magnetic resonance. (pdf)
2009-10-12: Dr. Ralph Weissleder has been elected as a new member of the U.S. National Academies Institute of Medicine (IOM). This is one of the highest honors in the fields of health and medicine.
2009-09-30: Sylvie Breton, PhD was among the first 42 recipients of Transformative R01 Awards, a new program designed to give recipients resources and flexibility to pursue high-risk projects that have the potential to overturn current scientific assumptions.
2009-09-09: F1000 Medicine features the Science article ‘Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites’.
2009-09-03: CSB welcomes John Higgins, MD. His Lab will study the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.