Overview

The MGH Center for Systems Biology (CSB) was established in 2007 as one of the five thematic interdisciplinary Centers at MGH. The Center is directed by Professor Ralph Weissleder, and is located on two floors in the new Simches Research Building.

Simches_1

The mission of the Center is to analyze at a systems level how biological molecules, proteins and cells interact in both healthy and diseased states.

Through a multidisciplinary approach that combines clinical insight with powerful technologies, CSB faculty pursue systems-level research that is at once fundamental, and yet immediately linked to the diagnosis and treatment of human disease. While these approaches are generalizable to many diseases, the Center has particular strengths in complex human conditions such as cancer, cardiovascular disease, diabetes, autoimmune disease, and renal disease. This goal is enabled by particular faculty expertise in genomics, chemical biology, physiology, bioimaging, and nanotechnology.

The Center is a major node for the Harvard-wide Program in Systems Biology, and has active links with the Broad Institute of Harvard and MIT, clinical departments at MGH, and the other MGH thematic centers.

Upcoming Events (more...)

Recent Publications (more...)

Lee H, Yoon TJ, Weissleder R
Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.
Angew Chem Int Edit. 2009;:ePub - PMID: 19554581
Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A
Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response.
Science. 2009;324(5932):1334-1338 - PMID: 19498172
Azab AK, Azab F, Blotta S, Pitsillides CM, Thompson B, Runnels JM, Roccaro AM, Ngo HT, Melhem MR, Sacco A, Jia X, Anderson KC, Lin CP, Rollins BJ, Ghobrial IM
Rho-A and Rac-1 GTPases play major and differential roles in SDF1-induced cell adhesion and chemotaxis in multiple myeloma.
Blood. 2009;:ePub - PMID: 19443661

Recent News (more...)

2009-06-12: Dr. Jenny (Hua) Lu was the recent recipient of a Claflin Distinguished Fellowship Award established to facilitate the academic careers of women in science at MGH.
2009-06-11: Dr. Jodie Babitt was awarded the prestigious Marcel Simon Award for excellence in research in hemochromatosis which is given every two years by the International BioIron Society for work on elucidating the key role of BMP6 in iron metabolism.
2009-06-10: Chemical & Engineering News has highlighted work by Dr. Jason McCarthy on the synthesis of targeted nanoagents for the detection of intravascular thrombi - Bioconjugate Chem. ("Specks Mark The Clot")
2009-06-08: The Office for Research Career Development has chosen Dr. Jayeeta Bhaumik as the Poster of Excellence prize recipient at the MGH 4th Annual Research Fellows Poster Celebration for her entry entitled "Multimodal Nanoagents for the Detection and Treatment of Atherosclerosis." Co-authors include Drs. McCarthy, Jaffer, and Weissleder.
2009-02-12: The Executive Committee on Research and the MGH Board of Trustees are pleased to award the 2009 Martin Research Prize for Excellence in Basic Research to Sylvie Breton's Lab. In recognition of outstanding research achievements published in 2008 - 'Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia' Winnie Wai Chi Shum, Nicolas Da Silva, Mary McKee, Peter J.S. Smith, Dennis Brown, and Sylvie Breton Cell 135: 1108-1117, 2008

About

Science

Information

Home