Overview

The MGH Center for Systems Biology (CSB) was established in 2007 as one of the five thematic interdisciplinary Centers at MGH. The Center is directed by Professor Ralph Weissleder, and is located on two floors in the new Simches Research Building.

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The mission of the Center is to analyze at a systems level how biological molecules, proteins and cells interact in both healthy and diseased states.

Through a multidisciplinary approach that combines clinical insight with powerful technologies, CSB faculty pursue systems-level research that is at once fundamental, and yet immediately linked to the diagnosis and treatment of human disease. While these approaches are generalizable to many diseases, the Center has particular strengths in complex human conditions such as cancer, cardiovascular disease, diabetes, autoimmune disease, and renal disease. This goal is enabled by particular faculty expertise in genomics, chemical biology, physiology, bioimaging, and nanotechnology.

The Center is a major node for the Harvard-wide Program in Systems Biology, and has active links with the Broad Institute of Harvard and MIT, clinical departments at MGH, and the other MGH thematic centers.

Upcoming Events (more...)

Recent Publications (more...)

Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R
Chemical phylogenetics of histone deacetylases.
Nat Chem Biol. 2010;:ePub - PMID: 20139990
Ozsolak F, Goren A, Gymrek MA, Guttman M, Regev A, Bernstein BE, Milos PM
Digital transcriptome profiling from attomole-level RNA samples.
Genome Res. 2010;:ePub - PMID: 20133332
Tsigkou O, Pomerantseva I, Spencer JA, Redondo PA, Hart AR, O'Doherty E, Lin Y, Friedrich CC, Daheron L, Lin CP, Sundback CA, Vacanti JP, Neville C
Regenerative Medicine Special Feature: Engineered vascularized bone grafts.
P Natl Acad Sci U S A. 2010;:ePub - PMID: 20133604

Recent News (more...)

2010-02-02: "Diagnostic Magnetic Resonance – Miniature System Could Have Huge Public Health Impact" - an article about CSB work in NIBIB eAdvances online magazine. (pdf)
2009-11-09: Nature Nanotechnology Feature article describes CSB work on TB detection using magnetic nanoparticles, microfluidics and nuclear magnetic resonance. (pdf)
2009-10-12: Dr. Ralph Weissleder has been elected as a new member of the U.S. National Academies Institute of Medicine (IOM). This is one of the highest honors in the fields of health and medicine.
2009-09-30: Sylvie Breton, PhD was among the first 42 recipients of Transformative R01 Awards, a new program designed to give recipients resources and flexibility to pursue high-risk projects that have the potential to overturn current scientific assumptions.
2009-09-09: F1000 Medicine features the Science article ‘Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites’.

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