MGH Center for Systems Biology :: Laboratories :: Base

Carlson JCT, Sertic MM, Chen MY

Case 6-2024: A 21-Year-Old Man with Fatigue and Night Sweats.

N Engl J Med. 2024;390(8):747-756 - PMID: 38381678 - DOI: 10.1056/NEJMcpc2309498

Reynolds DE, Sun Y, Wang X, Vallapureddy P, Lim J, Pan M, Fernandez Del Castillo A, Carlson JCT, Sellmyer MA, Nasrallah M, Binder Z, O'Rourke DM, Ming GL, Song H, Ko J

Live Organoid Cyclic Imaging.

Adv Sci (Weinh). 2024;11(14):e2309289 - PMID: 38326078 - PMCID: PMC11005682 - DOI: 10.1002/advs.202309289

Spitzberg JD, Ferguson S, Yang KS, Peterson HM, Carlson JCT, Weissleder R

Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact.

Nat Commun. 2023;14(1):1239 - PMID: 36870999 - PMCID: PMC9985597 - DOI: 10.1038/s41467-023-36932-z

Korolj A, Kohler RH, Scott E, Halabi EA, Lucas K, Carlson JCT, Weissleder R

Perfusion Window Chambers Enable Interventional Analyses of Tumor Microenvironments.

Adv Sci (Weinh). 2023;10(34):e2304886 - PMID: 37870204 - PMCID: PMC10700240 - DOI: 10.1002/advs.202304886

Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT

Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes

Nat Biotechnol. 2022;40(11):1654-1662 - PMID: 35654978 - PMCID: PMC9669087 - DOI: 10.1038/s41587-022-01339-6

Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM

Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.

Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2

Ko J, Lucas K, Kohler RH, Halabi EA, Wilkovitsch M, Carlson JCT, Weissleder R

In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy

Adv Sci (Weinh). 2022;9(24):e2200064 - PMID: 35750648 - PMCID: PMC9405492 - DOI: 10.1002/advs.202200064

Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R

Integrated Analytical System for Clinical Single-Cell Analysis

Adv Sci (Weinh). 2022;9(20):e2200415 - PMID: 35508767 - PMCID: PMC9284190 - DOI: 10.1002/advs.202200415

Ferguson S, Yang KS, Zelga P, Liss AS, Carlson JCT, Del Castillo CF, Weissleder R

Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer.

Sci Adv. 2022;8(16):eabm3453 - PMID: 35452280 - PMCID: PMC9032977 - DOI: 10.1126/sciadv.abm3453

Oh J, Yoo TY, Saal TM, Tsay L, Faquin WC, Carlson JCT, Deschler DG, Pai SI, Weissleder R

Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors.

Cancer Cytopathol. 2022;130(8):581-594 - PMID: 35666645 - PMCID: PMC9542730 - DOI: 10.1002/cncy.22594

Kuba W, Sohr B, Keppel P, Svatunek D, Humhal V, Stöger B, Goldeck M, Carlson JCT, Mikula H

Oxidative Desymmetrization Enables the Concise Synthesis of a trans-Cyclooctene Linker for Bioorthogonal Bond-Cleavage.

Chemistry. 2022;29(3):e202203069 - PMID: 36250260 - PMCID: PMC10098836 - DOI: 10.1002/chem.202203069

Kim J, Oh J, Peterson HM, Carlson JCT, Pittet MJ, Weissleder R

TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells

Adv Biol (Weinh). 2022;6(8):e2200030 - PMID: 35675910 - PMCID: PMC9398996 - DOI: 10.1002/adbi.202200030

Spitzberg J, Ferguson S, Yang K, Peterson HM, Carlson JCT, Weissleder R

Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact

bioRxiv. 2022;:ePub - DOI: 10.1101/2022.06.17.496607

Finn KM, Sutphin PD, Carlson JCT, Raskin KA, Van Cott EM

Case 17-2021: An 82-Year-Old Woman with Pain, Swelling, and Ecchymosis of the Left Arm.

N Engl J Med. 2021;384(23):2242-2250 - PMID: 34107184 - DOI: 10.1056/NEJMcpc2100281

Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R

Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling

Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252

Foy BH, Sundt T, Carlson JCT, Aguirre AD, Higgins JM

White Blood Cell and Platelet Dynamics Define Human Inflammatory Recovery.

medRxiv. 2021;:ePub - PMID: 34189534 - PMCID: PMC8240689 - DOI: 10.1101/2021.06.19.21259181

Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JC, Fogerty AE, Waheed A, Goodarzi K, Bendapudi P, Bornikova L, Gupta S, Leaf D, Kuter DJ, Rosovsky RP

COVID and Coagulation: Bleeding and Thrombotic Manifestations of SARS-CoV2 Infection.

Blood. 2020;136(4):489-500 - PMID: 32492712 - PMCID: PMC7378457 - DOI: 10.1182/blood.2020006520

Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R

Ultra-fast cycling for multiplexed cellular fluorescence imaging.

Angew Chem Int Ed Engl. 2020;59(17):6839-6846 - PMID: 32004403 - DOI: 10.1002/anie.201915153

Wilkovitsch M, Haider M, Sohr B, Herrmann B, Klubnick J, Weissleder R, Carlson JCT*, Mikula H*

A Cleavable C₂-Symmetric trans-Cyclooctene Enables Fast and Complete Bioorthogonal Disassembly of Molecular Probes.

J Am Chem Soc. 2020;142(45):19132-19141 - PMID: 33119297 - PMCID: PMC7662912 - DOI: 10.1021/jacs.0c07922

Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R

Ultra-fast cycling for multiplexed cellular fluorescence imaging.

Angew Chem Weinheim Bergstr Ger. 2020;132(17):6906-6913 - PMID: 34366494 - PMCID: PMC8340598 - DOI: 10.1002/ange.201915153

Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R

Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification.

Adv Biosyst. 2020;4(12):e1900307 - PMID: 33274611 - PMCID: PMC8491538 - DOI: 10.1002/adbi.201900307

Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R

Single Extracellular Vesicle Protein Analysis Using Immuno- Droplet Digital Polymerase Chain Reaction Amplification

Adv Biosyst. 2020;:ePub - DOI: 10.1002/adbi.201900307

Marquard AN, Carlson JCT, Weissleder R

Expanding the scope of antibody rebridging with new pyridazinedione-TCO constructs.

Bioconjug Chem. 2020;31(6):1616-1623 - PMID: 32286045 - PMCID: PMC7788567 - DOI: 10.1021/acs.bioconjchem.0c00155

Foy BH, Carlson JCT, Reinertsen E, Padros I Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM

Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection.

JAMA Netw Open. 2020;3(9):e2022058 - PMID: 32965501 - PMCID: PMC7512057 - DOI: 10.1001/jamanetworkopen.2020.22058

Foy BH, Carlson JCT, Reinertsen E, Padros Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM

Elevated RDW is Associated with Increased Mortality Risk in COVID-19

medRxiv. 2020;:ePub - DOI: 10.1101/2020.05.05.20091702

Carlson JCT, Hogan C, Ivkovic A

Case 5-2019: A Woman with Delusional Thinking and Paresthesia of the Right Hand. Reply.

N Engl J Med. 2019;380(21):2082 - PMID: 31116941 - DOI: 10.1056/NEJMc1903635

Hogan C, Little BP, Carlson JCT, Freudenreich O, Ivkovic A, Baron JM

Case 5-2019: A 48-Year-Old Woman with Delusional Thinking and Paresthesia of the Right Hand.

N Engl J Med. 2019;380(7):665-674 - PMID: 30763197 - DOI: 10.1056/NEJMcpc1807495

Marquard AN, Carlson JCT, Weissleder R

Glass Chemistry to Analyze Human Cells under Adverse Conditions

ACS Omega. 2019;4:11515−11521 - PMID: 31460257 - PMCID: PMC6682085 - DOI: 10.1021/acsomega.9b01036

Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R

Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens

Nat Commun. 2018;9(1):4550 - PMID: 30382095 - PMCID: PMC6208406 - DOI: 10.1038/s41467-018-07002-6

Carlson J, Mikula H, Weissleder R

Unraveling tetrazine-triggered bioorthogonal elimination enables chemical tools for ultrafast release and universal cleavage.

J Am Chem Soc. 2018;140(10):3603-3612 - PMID: 29384666 - PMCID: PMC5857921 - DOI: 10.1021/jacs.7b11217

Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604

Meimetis LG, Giedt R, Mikyla H, Carlson J, Kohler R, Pirovich DB, Weissleder R

Fluorescent vinblastine probes for live cell imaging

Chem Commun. 2016;52(64):9953-6 - PMID: 27439765 - PMCID: PMC4970878 - DOI: 10.1039/c6cc04129a

Hong S, Carlson J, Lee H, Weissleder R

Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking.

Adv Healthc Mater. 2015;5(4):421-426 - PMID: 26688173 - PMCID: PMC4811597 - DOI: 10.1002/adhm.201500780

Meimetis LG, Boros E, Carlson JC, Ran C, Caravan P, Weissleder R

Bioorthogonal fluorophore linked DFO - Technology enabling facile chelator quantification and multimodal imaging of antibodies.

Bioconjug Chem. 2015;27(1):257-63 - PMID: 26684717 - PMCID: PMC4858350 - DOI: 10.1021/acs.bioconjchem.5b00630

Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R

Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging.

Angew Chem Int Ed Engl. 2014;53(29):7531-4 - PMID: 24915832 - PMCID: PMC4122131 - DOI: 10.1002/anie.201403890

Carlson JC, Meimetis LG, Hilderbrand SA, Weissleder R

BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes.

Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100