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Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R

Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
N Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749

Weissleder R

Scaling down imaging: molecular mapping of cancer in mice
Nat Rev Cancer. 2002;2:1-8 - PMID: 11902581 - DOI: 10.1038/nrc701

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149

Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES

Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140

Schreiber S, Bernstein B

Signaling network model of chromatin.
Cell. 2002;111(6):771-8 - PMID: 12526804 - DOI: 10.1016/s0092-8674(02)01196-0

Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Nat Biotechnol. 2000;18:410-4 - PMID: 10748521 - DOI: 10.1038/74464

Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Nat Biotechnol. 1999;17:375-8 - PMID: 10207887 - DOI: 10.1038/7933

Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R

Magnetic relaxation switches capable of sensing molecular interactions
Nat Biotechnol. 2002;20:816-20 - PMID: 12134166 - DOI: 10.1038/nbt720

Weissleder R

A clearer vision for in vivo imaging
Nat Biotechnol. 2001;19:316-7 - PMID: 11283581 - DOI: 10.1038/86684

Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
Cancer Cell. 2002;1:269-77 - PMID: 12086863 - DOI: 10.1016/s1535-6108(02)00046-6

Shaw S, Wang J

Knotting of a DNA chain during ring closure.
Science. 1993;260(5107):533-6 - PMID: 8475384 - DOI: 10.1126/science.8475384

Huang D, Swanson E, Lin C, Schuman J, Stinson W, Chang W, Hee M, Flotte T, Gregory K, Puliafito C

Optical coherence tomography.
Science. 1991;254:1178-81 - PMID: 1957169 - PMCID: PMC4638169 - DOI: 10.1126/science.1957169

Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D

The structure of haplotype blocks in the human genome.
Science. 2002;296(5576):2225-9 - PMID: 12029063 - DOI: 10.1126/science.1069424

Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D

Human genome sequence variation and the influence of gene history, mutation and recombination.
Nat Genet. 2002;32(1):135-42 - PMID: 12161752 - DOI: 10.1038/ng947

Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R

Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
Gastroenterology. 2002;122:406-14 - PMID: 11832455 - DOI: 10.1053/gast.2002.30990

Rudin M, Weissleder R

Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303 - DOI: 10.1038/nrd1007

Weissleder R, Ntziachristos V

Shedding light onto live molecular targets
Nature Med. 2003;9:123-8 - PMID: 12514725 - DOI: 10.1038/nm0103-123

Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP

In vivo magnetic resonance imaging of transgene expression
Nature Med. 2000;6:351-5 - PMID: 10700241 - DOI: 10.1038/73219

Ntziachristos V, Tung CH, Bremer C, Weissleder R

Fluorescence molecular tomography resolves protease activity in vivo
Nature Med. 2002;8:757-60 - PMID: 12091907 - DOI: 10.1038/nm729

Breton S, Smith PJ, Lui B, Brown D

Acidification of the male reproductive tract by a proton pumping (H+)-ATPase.
Nature Med. 1996;2(4):470-2 - PMID: 8597961 - DOI: 10.1038/nm0496-470

Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell R

Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy.
Nature Med. 2001;7:738-41 - PMID: 11385513 - DOI: 10.1038/89121

Kaushal S, Amiel G, Guleserian K, Shapira O, Perry T, Sutherland F, Rabkin E, Moran A, Schoen F, Atala A, Soker S, Bischoff J, Mayer J

Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo.
Nature Med. 2001;7:1035-40 - PMID: 11533707 - PMCID: PMC2818999 - DOI: 10.1038/nm0901-1035

Bremer C, Tung CH, Weissleder R

In vivo molecular target assessment of matrix metalloproteinase inhibition
Nature Med. 2001;7:743-8 - PMID: 11385514 - DOI: 10.1038/89126

Fukumoto Y, Libby P, Rabkin E, Hill C, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M

Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits.
Circulation. 2001;103:993-9 - PMID: 11181475 - DOI: 10.1161/01.cir.103.7.993

Aikawa M, Rabkin E, Okada Y, Voglic S, Clinton S, Brinckerhoff C, Sukhova G, Libby P

Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.
Circulation. 1998;97:2433-44 - PMID: 9641696 - DOI: 10.1161/01.cir.97.24.2433

Aikawa M, Rabkin E, Sugiyama S, Voglic S, Fukumoto Y, Furukawa Y, Shiomi M, Schoen F, Libby P

An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
Circulation. 2001;103:276-83 - PMID: 11208689 - DOI: 10.1161/01.cir.103.2.276

Rabkin E, Aikawa M, Stone J, Fukumoto Y, Libby P, Schoen F

Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves.
Circulation. 2001;104:2525-32 - PMID: 11714645 - DOI: 10.1161/hc4601.099489

Waller C, Hiller K, Kahler E, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer W

Serial magnetic resonance imaging of microvascular remodeling in the infarcted rat heart.
Circulation. 2001;103(11):1564-9 - PMID: 11257086 - DOI: 10.1161/01.cir.103.11.1564

Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R

In vivo imaging of proteolytic activity in atherosclerosis
Circulation. 2002;105:2766-71 - PMID: 12057992 - DOI: 10.1161/01.cir.0000017860.20619.23

Aikawa M, Voglic S, Sugiyama S, Rabkin E, Taubman M, Fallon J, Libby P

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma.
Circulation. 1999;100:1215-22 - PMID: 10484543 - DOI: 10.1161/01.cir.100.11.1215

Aikawa M, Sugiyama S, Hill C, Voglic S, Rabkin E, Fukumoto Y, Schoen F, Witztum J, Libby P

Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma.
Circulation. 2002;106:1390-6 - PMID: 12221058 - DOI: 10.1161/01.cir.0000028465.52694.9b

Lindsey M, Gannon J, Aikawa M, Schoen F, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell P, Lee R

Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.
Circulation. 2002;105:753-8 - PMID: 11839633 - DOI: 10.1161/hc0602.103674

Nakagawa T, Sukhova G, Rabkin E, Winters G, Schoen F, Libby P

Acute rejection accelerates graft coronary disease in transplanted rabbit hearts.
Circulation. 1995;92:987-93 - PMID: 7641383 - DOI: 10.1161/01.cir.92.4.987

Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D

Arthritis critically dependent on innate immune system players
Immunity. 2002;16:157-68 - PMID: 11869678 - DOI: 10.1016/s1074-7613(02)00275-3

Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS

CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD.
Blood. 2003;101(10):4033-41 - PMID: 12576324 - DOI: 10.1182/blood-2002-01-0324

Da Silva N, Bharti A, Shelley CS

hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter.
Blood. 2002;100(10):3536-44 - PMID: 12411317 - DOI: 10.1182/blood.V100.10.3536

Rufer N, Zippelius A, Batard P, Pittet M, Kurth I, Corthesy P, Cerottini J, Leyvraz S, Roosnek E, Nabholz M, Romero P

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
Blood. 2003;102:1779-87 - PMID: 12750165 - DOI: 10.1182/blood-2003-02-0420

Kerre T, De Smet G, De Smedt M, Zippelius A, Pittet M, Langerak A, De Bosscher J, Offner F, Vandekerckhove B, Plum J

Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.
Blood. 2002;99:1620-6 - PMID: 11861276 - DOI: 10.1182/blood.v99.5.1620

Nahrendorf M, Hu K, Hiller K, Galuppo P, Fraccarollo D, Schweizer G, Haase A, Ertl G, Bauer W, Bauersachs J

Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study.
J Am Coll Cardiol. 2002;40(9):1695-700 - PMID: 12427425 - DOI: 10.1016/s0735-1097(02)02375-6

Simonova M, Wall A, Weissleder R, Bogdanov A Jr

Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
Cancer Res. 2000;60:6656-62 - PMID: 11118049

Zhao M, Josephson L, Tang Y, Weissleder R

Magnetic sensors for protease assays
Angew Chem Int Ed Engl. 2003;42:1375-8 - PMID: 12671972 - DOI: 10.1002/anie.200390352

Mazitschek R, Mülbaier M, Giannis A

IBX-mediated oxidation of primary alcohols and aldehydes to form carboxylic acids.
Angew Chem Int Ed Engl. 2002;41(21):4059-61 - PMID: 12412081 - DOI: 10.1002/1521-3773(20021104)41:21<4059::AID-ANIE4059>3.0.CO;2-R

Stieber F, Mazitschek R, Soric N, Giannis A, Waldmann H

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.
Angew Chem Int Ed Engl. 2002;41(24):4757-61 - PMID: 12481350 - DOI: 10.1002/anie.200290040

Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr

Near-infrared fluorescent imaging of tumor apoptosis
Cancer Res. 2003;63:1936-42 - PMID: 12702586

Stahl P, Kissau L, Mazitschek R, Giannis A, Waldmann H

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors.
Angew Chem Int Ed Engl. 2002;41(7):1174-8 - PMID: 12491250 - DOI: 10.1002/1521-3773(20020402)41:7<1174::aid-anie1174>3.0.co;2-v

Pai SI, Wu GS, Ozören N, Wu L, Jen J, Sidransky D, El-Deiry WS

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
Cancer Res. 1998;58(16):3513-8 - PMID: 9721851

Pham W, Weissleder R, Tung CH

An azulene dimer as a near-infrared quencher
Angew Chem Int Ed Engl. 2002;41:3659-62, 3519 - PMID: 12370922 - DOI: 10.1002/1521-3773(20021004)41:19<3659::AID-ANIE3659>3.0.CO;2-Q

Wernert N, Stanjek A, Kiriakidis S, Hügel A, Jha HC, Mazitschek R, Giannis A

Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin.
Angew Chem Int Ed Engl. 1999;38(21):3228-3231 - PMID: 10556911 - DOI: 10.1002/(sici)1521-3773(19991102)38:21<3228::aid-anie3228>3.0.co;2-8

Josephson L, Perez JM, Weissleder R

Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.
Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H

Valmori D, Dutoit V, Lienard D, Rimoldi D, Pittet M, Champagne P, Ellefsen K, Sahin U, Speiser D, Lejeune F, Cerottini J, Romero P

Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.
Cancer Res. 2000;60:4499-506 - PMID: 10969798
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