About

Weissleder, Ralph, MD, PhD

Ralph_weissleder
Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder

Research

Ralph Weissleder serves as the Director of the Center for Systems Biology at MGH. He is a Professor at Harvard Medical School, Director of the Center for Molecular Imaging Research, and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Dana Farber Harvard Cancer Center, an Associate Member of the Broad Institute (Chemical Biology Program) and a member of the Harvard Stem Cell Institute (HSCI). He is a world leader in applying molecular imaging tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, development of nanomaterials for sensing and systems analysis. His research has been translational and several of his developments have led to advanced clinical trials.

Dr. Weissleder is currently the principal investigator of several RO1 NIH grants, a P50 Center grant, a U24 grant, and a UO1 consortium focusing on nanotechnology. He has published over 500 publications in peer reviewed journals. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.

Publications

Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
New Engl J Med. 2003;348:2491-9 - PMID: 12815134
Weissleder R, Ntziachristos V
Shedding light onto live molecular targets
Nat Med. 2003;9:123-8 - PMID: 12514725
Rudin M, Weissleder R
Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303
Zhao M, Josephson L, Tang Y, Weissleder R
Magnetic sensors for protease assays
Angew Chem Int Edit. 2003;42:1375-8 - PMID: 12671972
Tung CH, Weissleder R
Arginine containing peptides as delivery vectors
Adv Drug Deliv Rev. 2003;55:281-94 - PMID: 12564981
Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R
Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media
J Am Chem Soc. 2003;125:10192-3 - PMID: 12926940
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
Cancer Res. 2003;63:8122-5 - PMID: 14678964
Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr
Near-infrared fluorescent imaging of tumor apoptosis
Cancer Res. 2003;63:1936-42 - PMID: 12702586
Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
Cancer Res. 2003;63:6838-46 - PMID: 14583481
Shah K, Tang Y, Breakefield X, Weissleder R
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
Oncogene. 2003;22:6865-72 - PMID: 14534533
Hogemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP.
The transferrin receptor: a potential molecular imaging marker for human cancer.
Neoplasia. 2003;5(6):495-506 - PMID: 14965443 - PMCID: PMC1502574
Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L
Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy
Neoplasia. 2003;5:187-92 - PMID: 12869301 - PMCID: PMC1502408
Allport JR, Weissleder R
Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro
Neoplasia. 2003;5:205-17 - PMID: 12869304 - PMCID: PMC1502407
Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R
Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice
Radiology. 2003;226:214-20 - PMID: 12511693
Mahmood U, Weissleder R
Near-infrared optical imaging of proteases in cancer
Mol Cancer Ther. 2003;2:489-96 - PMID: 12748311
Moon, WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate
Bioconjugate Chem. 2003;14:539-45 - PMID: 12757377
Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L
Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells
Bioconjugate Chem. 2003;14:1115-21 - PMID: 14624624
Pham W, Lai WF, Weissleder R, Tung CH
High efficiency synthesis of a bioconjugatable near-infrared fluorochrome
Bioconjugate Chem. 2003;14:1048-51 - PMID: 13129411
Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R
In vivo tracking of neural progenitor cell migration to glioblastomas
Hum Gene Ther. 2003;14:1247-54 - PMID: 12952596
Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A Jr
Engineering of technetium-99m-binding artificial receptors for imaging gene expression
J Gene Med. 2003;5:1056-66 - PMID: 14661181
Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R
Novel Factor XIII Probes for Blood Coagulation Imaging
Chembiochem. 2003;4:897-899 - PMID: 12964167
Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U
Miniaturized multichannel near infrared endoscope for mouse imaging
Mol Imaging. 2003;2:350-7 - PMID: 14717334
Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD
A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI
Mol Imaging. 2003;2:324-32 - PMID: 14717331
Lin Y, Weissleder R, Tung CH
Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imaging
Mol Imaging. 2003;2:87-92 - PMID: 12964306
Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe
Mol Imaging. 2003;2:18-23 - PMID: 12926234
Graves EE, Ripoll J, Weissleder R, Ntziachristos V
A submillimeter resolution fluorescence molecular imaging system for small animal imaging
Med Phys. 2003;30:901-11 - PMID: 12772999
Funovics M, Weissleder R, Tung CH
Protease sensors for bioimaging
Anal Bioanal Chem. 2003;377:956-63 - PMID: 12955390
Bremer C, Ntziachristos V, Weissleder R
Optical-based molecular imaging: contrast agents and potential medical applications
Eur J Radiol. 2003;13:231-43 - PMID: 12598985
Ntziachristos V, Bremer C, Weissleder R
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging
Eur J Radiol. 2003;13:195-208 - PMID: 12541130
Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY
Neural stem cell biology may be well suited for improving brain tumor therapies
Cancer J. 2003;9:189-204 - PMID: 12952304

Investigator

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