MGH Center for Systems Biology

Weissleder, Ralph, MD, PhD

Thrall Professor of Radiology
Professor of Systems Biology
Director, Center for Systems Biology

Phone: 617-726-8226

Dr. Weissleder has been the Director of CSB at Massachusetts General Hospital (MGH) since its inception in 2007. He is the Thrall Professor of Radiology and Professor of Systems Biology at Harvard Medical School, and Attending Clinician in Interventional Radiology at MGH. Dr. Weissleder is also a member of the Department of Systems Biology at HMS and the Harvard Cancer Center. He is also a member of MGH’s Executive Committee on Research (ECOR) and participates in several other Institutional Committees.

The Weissleder group develops molecular technologies for noninvasive imaging of cellular function, and uses these technologies to study basic human biology and create next generation diagnostics and therapeutics. Many important biological processes occur deep inside our body. Their study requires new technologies to understand function at the single cell level. To develop such technologies, he pursues fundamental advances in chemistry, molecular engineering, bioengineering and modeling. His work also takes advantage of imaging tissues and cells obtained by minimally invasive image guided interventions. His primary interests are in cancer and in inflammation. His work on imaging, nanomaterials and miniaturized sensing technologies has led to a number of new technologies and advanced clinical trials. He is a cofounder of T2Biosystems and Lumicell. Dr. Weissleder is currently the principal investigator of several National Institute of Health grants and consortia. He has published over 960 publications (h-index of 202) in peer reviewed journals and has authored several textbooks. He is one of the top 100 ranking scientists in the world according a world ranking list (PLOS Biology, August 12, 2019)

He is a member of the National Academy of Medicine, the American Academy of Arts and Sciences, the National Academy of Inventors and the German Academy of Sciences (Leopoldina). His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President’s Award, The Society for Molecular Imaging Lifetime Achievement Award, the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award, the 2008 RSNA Outstanding Researcher Award and gold medalist of the ESR. In 2014 Dr. Weissleder was named by Thomson Reuters as one of the “The World’s Most Influential Scientific Minds”.

Publications

Deutsch-Williams RJ, Schleyer KA, Das R, Carrothers JE, Kohler RH, Vinegoni C, Weissleder R FAP-Targeted Fluorescent Imaging Agents to Study Cancer-Associated Fibroblasts In Vivo. Bioconjug Chem. 2024;:ePub - PMID: 39667730 - DOI: 10.1021/acs.bioconjchem.4c00426
Kartal B, Garris CS, Kim HS, Kohler RH, Carrothers J, Halabi EA, Iwamoto Y, Goubet AG, Xie Y, Wirapati P, Pittet MJ, Weissleder R Targeted SPP1 Inhibition of Tumor-Associated Myeloid Cells Effectively Decreases Tumor Sizes. Adv Sci (Weinh). 2024;:e2410360 - PMID: 39639496 - DOI: 10.1002/advs.202410360
Landeros C, Oh J, Weissleder R, Lee H Deep learning pipeline for automated cell profiling from cyclic imaging. Sci Rep. 2024;14(1):23600 - PMID: 39384907 - PMCID: PMC11464789 - DOI: 10.1038/s41598-024-74597-w
Uygun K, von Reiterdank IF, Mojoudi M, Bento R, Taggart M, Dinicu A, Wojtkiewicz G, Coert J, van der Molen AM, Weissleder R, Parekkadan B Ex Vivo Machine Perfusion as a Platform for Lentiviral Gene Delivery in Rat Livers. Res Sq. 2024;:ePub - PMID: 39315250 - PMCID: PMC11419271 - DOI: 10.21203/rs.3.rs-4784505/v1
Quintana JM, Carlson JCT, Scott E, Ng TSC, Miller MA, Weissleder R Scission-Enhanced Molecular Imaging (SEMI). Bioconjug Chem. 2024;35(10):1543-52 - PMID: 39255972 - PMCID: PMC11488501 - DOI: 10.1021/acs.bioconjchem.4c00337
Shiau C, Cao J, Gong D, Gregory MT, Caldwell NJ, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Bae JW, Zhao R, Schurman N, Barth JL, Ganci ML, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Castillo CF, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment. Nat Genet. 2024;56(11):2466-2478 - PMID: 39227743 - DOI: 10.1038/s41588-024-01890-9
Quintana JM, Jiang F, Kang M, Valladolid Onecha V, Könik A, Qin L, Rodriguez VE, Hu H, Borges N, Khurana I, Banla LI, Le Fur M, Caravan P, Schuemann J, Bertolet A, Weissleder R, Miller MA, Ng TSC Localized in vivo prodrug activation using radionuclides. bioRxiv. 2024;:ePub - PMID: 39211146 - PMCID: PMC11361159 - DOI: 10.1101/2024.08.02.606075
Quintana JM, Kang M, Hu H, Ng TSC, Wojtkiewicz GR, Scott E, Parangi S, Schuemann J, Weissleder R, Miller MA Extended Pharmacokinetics Improve Site-Specific Prodrug Activation Using Radiation. ACS Cent Sci. 2024;10(7):1371-1382 - PMID: 39071065 - PMCID: PMC11273447 - DOI: 10.1021/acscentsci.4c00354
Das R, Ge X, Fei F, Parvanian S, Weissleder R*, Garris CS* Lipid Nanoparticle-mRNA Engineered Dendritic Cell Based Adoptive Cell Therapy Enhances Cancer Immune Response. Small Methods. 2024;:e2400633 - PMID: 39039995 - DOI: 10.1002/smtd.202400633
van Solinge TS, Oh J, Abels E, Koch P, Breakefield XO, Weissleder R, Broekman MLD Probing the glioma micro-environment: analysis using biopsy in combination with ultra-fast cyclic immunolabeling. Neoplasia. 2024;57:101051 - PMID: 39270598 - PMCID: PMC11415813 - DOI: 10.1016/j.neo.2024.101051
Schleyer K, Halabi EA, Weissleder R γ-Butyrolactone derivatives of MSA-2 are STING prodrugs. ChemMedChem. 2024;19(19):e202400416 - PMID: 38887174 - DOI: 10.1002/cmdc.202400416
Kim HS, Halabi EA, Enbergs N, Kohler RH, Fei F, Garris CS, Weissleder R A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation. Theranostics. 2024;14(7):2934-2945 - PMID: 38773971 - PMCID: PMC11103498 - DOI: 10.7150/thno.95267
Halabi EA, Gessner I, Yang K, Kim JJ, Jana R, Peterson HM, Spitzberg J, Weissleder R Magnetic Silica-Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor-Associated Proteins. Angew Chem Int Ed Engl. 2024;63(24):e202318870 - PMID: 38578432 - DOI: 10.1002/anie.202318870
Sarkar B, Arlauckas SP, Cuccarese MF, Garris CS, Weissleder R, Rodell CB Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype. Frontiers in Immunology (molecular innate immunity section). 2024;15:1331480 - PMID: 38545103 - PMCID: PMC10965546 - DOI: 10.3389/fimmu.2024.1331480
Kang M, Quintana J, Hu H, Teixeira VC, Olberg S, Banla LI, Rodriguez V, Hwang WL, Schuemann J, Parangi S, Weissleder R, Miller MA Sustained and Localized Drug Depot Release using Radiation-Activated Scintillating Nanoparticles. Adv Mater. 2024;36(23):e2312326 - PMID: 38389502 - PMCID: PMC11161319 - DOI: 10.1002/adma.202312326
Welsh, JA Goberdhan, DCI O'Driscoll, L Buzas, EI Blenkiron, C Bussolati, B Cai, H Di Vizio, D Driedonks, TAP Erdbrügger, U Falcon-Perez, JM Fu, QL Hill, AF Lenassi, M Lim, SK Mahoney, MG Mohanty, S Möller, A Nieuwland, R Ochiya, T Sahoo, S Torrecilhas, AC Zheng, L Zijlstra, A Abuelreich, S Bagabas, R Bergese, P Bridges, EM Brucale, M Burger, D Carney, RP Cocucci, E Crescitelli, R Hanser, E Harris, AL Haughey, NJ Hendrix, A Ivanov, AR Jovanovic-Talisman, T Kruh-Garcia, NA Ku'ulei-Lyn Faustino, V Kyburz, D Lässer, C Lennon, KM Lötvall, J Maddox, AL Martens-Uzunova, ES Mizenko, RR Newman, LA Ridolfi, A Rohde, E Rojalin, T Rowland, A Saftics, A Sandau, US Saugstad, JA Shekari, F Swift, S Ter-Ovanesyan, D Tosar, JP Useckaite, Z Valle, F Varga, Z van der Pol, E van Herwijnen, MJC Wauben, MHM Wehman, AM Williams, S Zendrini, A Zimmerman, AJ MISEV, Consortium Théry, C Witwer, KW Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024;2:e12404 - PMID: 38326288 - PMCID: PMC10850029 - DOI: 10.1002/jev2.12404
Enbergs N*, Halabi EA*, Goubet AG, Schleyer K, Fredrich IR, Kohler RH, Garris CS, Pittet MJ, Weissleder R Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype. Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026
Gopal AA, Fernandez B, Delano J, Weissleder R, Dubach JM PARP trapping is governed by the PARP inhibitor dissociation rate constant. Cell Chem Biol. 2024;31(7):1373-1382.e10 - PMID: 38262416 - PMCID: PMC11259578 - DOI: 10.1016/j.chembiol.2023.12.019
Landeros C, Oh J, Weissleder R, Lee H Deep Learning Pipeline for Automated Cell Profiling from Cyclic Imaging. Res Sq. 2023;:ePub - PMID: 38196620 - PMCID: PMC10775369 - DOI: 10.21203/rs.3.rs-3745061/v1
Korolj A, Kohler RH, Scott E, Halabi EA, Lucas K, Carlson JCT, Weissleder R Perfusion Window Chambers Enable Interventional Analyses of Tumor Microenvironments. Adv Sci (Weinh). 2023;10(34):e2304886 - PMID: 37870204 - PMCID: PMC10700240 - DOI: 10.1002/advs.202304886
Fredrich IR*, Halabi EA*, Kohler RH, Ge X, Garris CS, Weissleder R Highly Active Myeloid Therapy for Cancer. ACS Nano. 2023;17(20):20666-20679 - PMID: 37824733 - PMCID: PMC10941024 - DOI: 10.1021/acsnano.3c08034
Yekula A, Hsia T, Kitchen RR, Chakrabortty SK, Yu W, Batool SM, Lewis B, Szeglowski AJ, Weissleder R, Lee H, Chi AS, Batchelor T, Carter BS, Breakefield XO, Skog J, Balaj L Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients. Neurooncol Adv. 2023;5(1):vdad104 - PMID: 37811539 - PMCID: PMC10559837 - DOI: 10.1093/noajnl/vdad104
Das R*, Halabi EA*, Fredrich IR, Oh J, Peterson HM, Ge X, Scott E, Kohler RH, Garris CS, Weissleder R Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery. Adv Sci (Weinh). 2023;10(33):e2303576 - PMID: 37814359 - PMCID: PMC10667837 - DOI: 10.1002/advs.202303576
Yekula A, Hsia T, Kitchen RR, Chakrabortty SK, Yu W, Batool MS, Lewis B, Szeglowski AJ, Weissleder R, Lee H, Chi AS, Batchelor T, Carter BS, Breakefield XO, Skog J, Balaj L Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR amplified recurrent glioblastoma patients. Neurooncol Adv. 2023;:ePub - DOI: 10.1093/noajnl/vdad104
Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J, Tarussio D, Benedetti F, Tissot S, Kandalaft L, Varrone M, Ciriello G, McKee TA, Monnier Y, Mermod M, Blaum EM, Gushterova I, Gonye ALK, Hacohen N, Getz G, Mempel TR, Klein AM, Weissleder R, Faquin WC, Sadow PM, Lin D, Pai SI, Sade-Feldman M, Pittet MJ CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science. 2023;381(6657):515-524 - PMID: 37535729 - PMCID: PMC10755760 - DOI: 10.1126/science.ade2292
Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M Recruited macrophages elicit atrial fibrillation. Science. 2023;381(6654):231-239 - PMID: 37440641 - PMCID: PMC10448807 - DOI: 10.1126/science.abq3061
Shiau C, Cao J, Gregory MT, Gong D, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Schurman N, Barth JL, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Fernandez-Del Castillo C, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis. bioRxiv. 2023;:ePub - PMID: 37425692 - PMCID: PMC10327107 - DOI: 10.1101/2023.06.28.546848
Yang KS, O'Shea A, Zelga P, Liss AS, Del Castillo CF, Weissleder R Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma. Sci Rep. 2023;13(1):10969 - PMID: 37414831 - PMCID: PMC10325992 - DOI: 10.1038/s41598-023-37966-5
Kwak TJ, Son T, Hong JS, Winter UA, Jeong MH, McLean C, Weissleder R, Lee H, Castro CM, Im H Electrokinetically enhanced label-free plasmonic sensing for rapid detection of tumor-derived extracellular vesicles. Biosens Bioelectron. 2023;237:115422 - PMID: 37301179 - PMCID: PMC10527155 - DOI: 10.1016/j.bios.2023.115422
Hu H, Ng TSC, Kang M, Scott E, Li R, Quintana JM, Matvey D, Vantaku VR, Weissleder R, Parangi S, Miller MA Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response. Clin Cancer Res. 2023;29(17):3457-3470 - PMID: 37289199 - PMCID: PMC10527034 - DOI: 10.1158/1078-0432.CCR-22-2976
Halabi EA, Weissleder R Light-Deactivated Fluorescent Probes (FLASH-Off) for Multiplexed Imaging. J Am Chem Soc. 2023;:ePub - PMID: 37018018 - DOI: 10.1021/jacs.3c00170
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ A neutrophil response linked to tumor control in immunotherapy. Cell. 2023;186(7):1448-1464.e20 - PMID: 37001504 - PMCID: PMC10132778 - DOI: 10.1016/j.cell.2023.02.032
Spitzberg JD, Ferguson S, Yang KS, Peterson HM, Carlson JCT, Weissleder R Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact. Nat Commun. 2023;14(1):1239 - PMID: 36870999 - PMCID: PMC9985597 - DOI: 10.1038/s41467-023-36932-z
Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK Monocytes re-enter the bone marrow during fasting and alter the host response to infection. Immunity. 2023;56(4):783-796.e7 - PMID: 36827982 - PMCID: PMC10101885 - DOI: 10.1016/j.immuni.2023.01.024
Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles. Nat Commun. 2023;14(1):771 - PMID: 36774352 - PMCID: PMC9922247 - DOI: 10.1038/s41467-023-36321-6
Chin LK, Yang JY, Chousterman B, Jung S, Kim DG, Kim DH, Lee S, Castro CM, Weissleder R, Park SG, Im H Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection. ACS Nano. 2023;17(4):3610-3619 - PMID: 36745820 - PMCID: PMC10150330 - DOI: 10.1021/acsnano.2c10371
Jeong MH, Son T, Tae YK, Park CH, Lee HS, Chung MJ, Park JY, Castro CM, Weissleder R, Jo JH, Bang S, Im H Plasmon-Enhanced Single Extracellular Vesicle Analysis for Cholangiocarcinoma Diagnosis. Adv Sci (Weinh). 2023;10(8):e2205148 - PMID: 36698298 - PMCID: PMC10015870 - DOI: 10.1002/advs.202205148
Dosta P, Puigmal N, Cryer AM, Rodríguez AL, Scott E, Weissleder R, Miller MA, Artzi N Polymeric microneedles enable simultaneous delivery of cancer immunomodulatory drugs and detection of skin biomarkers. Theranostics. 2023;13(1):1-15 - PMID: 36593949 - PMCID: PMC9800729 - DOI: 10.7150/thno.73966
Hsia T, Yekula A, Batool SM, Rosenfeld YB, You DG, Weissleder R, Lee H, Carter BS, Balaj L Glioblastoma-derived extracellular vesicle subpopulations following 5-aminolevulinic acid treatment bear diagnostic implications. J Extracell Vesicles. 2022;11(11):e12278 - PMID: 36404434 - PMCID: PMC9676504 - DOI: 10.1002/jev2.12278
Lugani S*, Halabi EA*, Oh J, Kohler R, Peterson H, Breakefield XO, Chiocca EAA, Miller MA, Garris C, Weissleder R Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2022;35(7):e2208782 - PMID: 36427266 - PMCID: PMC10197197 - DOI: 10.1002/adma.202208782
Weissleder R Leveraging technology to address current and future world issues. Sci Transl Med. 2022;14(666):eabq0606 - PMID: 36223448 - DOI: 10.1126/scitranslmed.abq0606 - Cover
Ferdosi S, Stukalov A, Hasan M, Tangeysh B, Brown TR, Wang T, Elgierari EM, Zhao X, Huang Y, Alavi A, Lee-McMullen B, Chu J, Figa M, Tao W, Wang J, Goldberg M, O'Brien ES, Xia H, Stolarczyk C, Weissleder R, Farias V, Batzoglou S, Siddiqui A, Farokhzad OC, Hornburg D Enhanced competition at the nano-bio interface enables comprehensive characterization of protein corona dynamics and deep coverage of proteomes. Adv Mater. 2022;34(44):e2206008 - PMID: 35986672 - DOI: 10.1002/adma.202206008
Quintana JM, Arboleda D, Hu H, Scott E, Luthria G, Pai S, Parangi S, Weissleder R, Miller MA Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022;33(8):1474-1484 - PMID: 35833631 - PMCID: PMC9390333 - DOI: 10.1021/acs.bioconjchem.2c00174
Ko J, Lucas K, Kohler RH, Halabi EA, Wilkovitsch M, Carlson JCT, Weissleder R In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy. Adv Sci (Weinh). 2022;9(24):e2200064 - PMID: 35750648 - PMCID: PMC9405492 - DOI: 10.1002/advs.202200064
Spitzberg J, Ferguson S, Yang K, Peterson HM, Carlson JCT, Weissleder R Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact. bioRxiv. 2022;:ePub - DOI: 10.1101/2022.06.17.496607
Iyer V, Yang Z, Ko J, Weissleder R, Issadore D Advancing microfluidic diagnostic chips into clinical use: a review of current challenges and opportunities. Lab Chip. 2022;22(17):3110-3121 - PMID: 35674283 - PMCID: PMC9798730 - DOI: 10.1039/d2lc00024e
Kim J, Oh J, Peterson HM, Carlson JCT, Pittet MJ, Weissleder R TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Adv Biol (Weinh). 2022;6(8):e2200030 - PMID: 35675910 - PMCID: PMC9398996 - DOI: 10.1002/adbi.202200030
Oh J, Yoo TY, Saal TM, Tsay L, Faquin WC, Carlson JCT, Deschler DG, Pai SI, Weissleder R Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors. Cancer Cytopathol. 2022;130(8):581-594 - PMID: 35666645 - PMCID: PMC9542730 - DOI: 10.1002/cncy.22594
Kim K, Son T, Hong JS, Kwak TJ, Jeong MH, Weissleder R, Im H Physisorption of Affinity Ligands Facilitates Extracellular Vesicle Detection with Low Non-Specific Binding to Plasmonic Gold Substrates. ACS Appl Mater Interfaces. 2022;:ePub - PMID: 35653580 - PMCID: PMC9715849 - DOI: 10.1021/acsami.2c07317
Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes. Nat Biotechnol. 2022;40(11):1654-1662 - PMID: 35654978 - PMCID: PMC9669087 - DOI: 10.1038/s41587-022-01339-6
Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 2022;607(7919):578-584 - PMID: 35636458 - PMCID: PMC9798885 - DOI: 10.1038/s41586-022-04890-z
Andreou C, Weissleder R, Kircher MF Multiplexed imaging in oncology. Nat Biomed Eng. 2022;6(5):527-540 - PMID: 35624151 - DOI: 10.1038/s41551-022-00891-5
Ferguson S, Yang KS, Weissleder R Single extracellular vesicle analysis for early cancer detection. Trends in Molecular Medicine. 2022;28(8):681-692 - PMID: 35624008 - PMCID: PMC9339504 - DOI: 10.1016/j.molmed.2022.05.003
Lucas K, Oh J, Hoelzl J, Weissleder R Cellular point-of-care diagnostics using an inexpensive layer-stack microfluidic device. Lab Chip. 2022;22:2145 - 2154 - PMID: 35514273 - PMCID: PMC9214713 - DOI: 10.1039/d2lc00162d
Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R Integrated Analytical System for Clinical Single-Cell Analysis. Adv Sci (Weinh). 2022;9(20):e2200415 - PMID: 35508767 - PMCID: PMC9284190 - DOI: 10.1002/advs.202200415
Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis. Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2
Ng TSC, Hu H, Kronister S, Lee C, Li R, Gerosa L, Stopka SA, Burgenske DM, Khurana I, Regan MS, Vallabhaneni S, Putta N, Scott E, Matvey D, Giobbie-Hurder A, Kohler RH, Sarkaria JN, Parangi S, Sorger PK, Agar NYR, Jacene HA, Sullivan RJ, Buchbinder E, Mikula H, Weissleder R, Miller MA Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy. Sci Adv. 2022;8(17):eabl6339 - PMID: 35486732 - PMCID: PMC9054019 - DOI: 10.1126/sciadv.abl6339
Ferguson S, Yang KS, Zelga P, Liss AS, Carlson JCT, Del Castillo CF, Weissleder R Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer. Sci Adv. 2022;8(16):eabm3453 - PMID: 35452280 - PMCID: PMC9032977 - DOI: 10.1126/sciadv.abm3453
Hu H, Quintana J, Weissleder R, Parangi S, Miller M Deciphering albumin-directed drug delivery by imaging. Adv Drug Deliv Rev. 2022;185:114237 - PMID: 35364124 - PMCID: PMC9117484 - DOI: 10.1016/j.addr.2022.114237
Kilic T, Cho YK, Jeong N, Shin IS, Carter BS, Balaj L, Weissleder R, Lee H Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles. ACS Cent Sci. 2022;8(1):110-117 - PMID: 35111901 - PMCID: PMC8802188 - DOI: 10.1021/acscentsci.1c01193
Tian T, Liang R, Erel-Akbaba G, Saad L, Obeid PJ, Gao J, Chiocca EA, Weissleder R, Tannous BA Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles. ACS Nano. 2022;16(2):1940-1953 - PMID: 35099172 - PMCID: PMC9020451 - DOI: 10.1021/acsnano.1c05505
Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H Computational Optics for Point-of-Care Breast Cancer Profiling. Methods Mol Biol. 2022;2393:153-162 - PMID: 34837178 - PMCID: PMC9283060 - DOI: 10.1007/978-1-0716-1803-5_8
Gessner I, Park JH, Lin HY, Lee H, Weissleder R Magnetic Gold Nanoparticles with Idealized Coating for Enhanced Point-Of-Care Sensing. Adv Healthc Mater. 2021;11(2):e2102035 - PMID: 34747576 - PMCID: PMC8770610 - DOI: 10.1002/adhm.202102035
Taghdiri N, Calcagno DM, Fu Z, Huang K, Kohler RH, Weissleder R, Coleman TP, King KR Macrophage calcium reporter mice reveal immune cell communication in vitro and in vivo. Cell Rep Methods. 2021;1(8):ePub - PMID: 35079727 - PMCID: PMC8786215 - DOI: 10.1016/j.crmeth.2021.100132
Kilic T, Gessner I, Cho Y, Jeong N, Quintana J, Weissleder R, Lee H Zwitterionic polymer electroplating facilitates the preparation of electrode surface for biosensing. Adv Mater. 2021;34(8):e2107892 - PMID: 34890082 - PMCID: PMC8881349 - DOI: 10.1002/adma.202107892
Pfirschke C, Zilionis R, Engblom C, Messemaker M, Zou AE, Rickelt S, Gort-Freitas NA, Lin Y, Bill R, Siwicki M, Gungabeesoon J, Sprachman MM, Marquard AN, Rodell CB, Cuccarese MF, Quintana J, Ahmed MS, Kohler RH, Savova V, Weissleder R, Klein AM, Pittet MJ Macrophage-targeted therapy unlocks antitumoral crosstalk between IFN𝛾-secreting lymphocytes and IL12-producing dendritic cells. Cancer Immunol Res. 2021;10(1):40-55 - PMID: 34795032 - PMCID: PMC10132467 - DOI: 10.1158/2326-6066.CIR-21-0326
Yang A, Mitchell M, Di Capua J, Som A, Huang J, Weissleder R, Kalva S, Uppot R Microwave Ablation for Resolution of Persistent Biloma Following Hepatectomy and Cholecystectomy: Case Report. Cardiovasc Intervent Radiol. 2021;45(3):387-390 - PMID: 34741197 - PMCID: PMC8570770 - DOI: 10.1007/s00270-021-02999-8
Lee CY, Degani I, Cheong J, Weissleder R, Lee JH, Cheon J, Lee H Development of Integrated Systems for On-Site Infection Detection. Acc Chem Res. 2021;54(21):3991-4000 - PMID: 34677927 - PMCID: PMC9099220 - DOI: 10.1021/acs.accounts.1c00498
Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid. Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover
McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6
Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling. Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252
Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021;6(61):eabi7083 - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083
Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7
Koch PD, Quintana J, Ahmed M, Kohler RH, Weissleder R Small Molecule Imaging Agent For Mutant Kras G12C. Adv Ther (Weinh). 2021;4(5):ePub - PMID: 33997272 - PMCID: PMC8115719 - DOI: 10.1002/adtp.202000290
Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nat Nanotechnol. 2021;16(7):830-839 - PMID: 33958764 - PMCID: PMC8491539 - DOI: 10.1038/s41565-021-00897-1
Ko J*, Wang Y*, Sheng K, Weitz DA, Weissleder R Sequencing-Based Protein Analysis of Single Extracellular Vesicles. ACS Nano. 2021;15(3):5631-5638 - PMID: 33687214 - PMCID: PMC8742254 - DOI: 10.1021/acsnano.1c00782
Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G p53 dynamics vary between tissues and are linked with radiation sensitivity. Nat Commun. 2021;12(1):898 - PMID: 33563973 - PMCID: PMC7873198 - DOI: 10.1038/s41467-021-21145-z
Arlauckas S, Oh N, Li R, Weissleder R, Miller MA Macrophage imaging and subset analysis using single-cell RNA sequencing. Nanotheranostics. 2021;5(1):36-56 - PMID: 33391974 - PMCID: PMC7738942 - DOI: 10.7150/ntno.50185
Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R Ultra-fast cycling for multiplexed cellular fluorescence imaging. Angew Chem Weinheim Bergstr Ger. 2020;132(17):6906-6913 - PMID: 34366494 - PMCID: PMC8340598 - DOI: 10.1002/ange.201915153
Rodell CB, Baldwin P, Fernandez B, Weissleder R, Sridhar S, Dubach JM Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating in vitro and in vivo Encapsulated Drug Delivery. Adv Ther (Weinh). 2020;4(3):ePub - PMID: 33997266 - PMCID: PMC8114878 - DOI: 10.1002/adtp.202000125
Yang KS, Ciprani D, O'Shea A, Liss A, Yang R, Fletcher-Mercaldo S, Mino-Kenudson M, Castillo CF, Weissleder R Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN. Gastroenterology. 2020;160(4):1345-1358.e11 - PMID: 33301777 - PMCID: PMC7956058 - DOI: 10.1053/j.gastro.2020.11.046
Weissleder R The Magical World of Circulating Vesicles. Adv Biosyst. 2020;4(12):e2000475 - PMID: 33274610 - DOI: 10.1002/adbi.202000475
Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification. Adv Biosyst. 2020;4(12):e1900307 - PMID: 33274611 - PMCID: PMC8491538 - DOI: 10.1002/adbi.201900307
Chin LK*, Son T*, Hong JS, Liu AQ, Skog J, Castro CM, Weissleder R, Lee H*, Im H* Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research. ACS Nano. 2020;14(11):14528-14548 - PMID: 33119256 - PMCID: PMC8423498 - DOI: 10.1021/acsnano.0c07581
Wilkovitsch M, Haider M, Sohr B, Herrmann B, Klubnick J, Weissleder R, Carlson JCT*, Mikula H* A Cleavable C₂-Symmetric trans-Cyclooctene Enables Fast and Complete Bioorthogonal Disassembly of Molecular Probes. J Am Chem Soc. 2020;142(45):19132-19141 - PMID: 33119297 - PMCID: PMC7662912 - DOI: 10.1021/jacs.0c07922
Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells. Cell Syst. 2020;11(5):478-494.e9 - PMID: 33113355 - PMCID: PMC8009031 - DOI: 10.1016/j.cels.2020.10.002
Ng TSC, Gunda V, Li R, Prytyskach M, Iwamoto Y, Kohler RH, Parangi S, Weissleder R, Miller MA Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer. Radiology. 2020;298(1):123-132 - PMID: 33107799 - PMCID: PMC7771993 - DOI: 10.1148/radiol.2020201791
Yang KS, Lin HY, Curley C, Welch MW, Wolpin BM, Lee H, Weissleder R, Im H*, Castro CM* Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry. Adv Biosyst. 2020;4(12):e2000203 - PMID: 33103361 - PMCID: PMC7718389 - DOI: 10.1002/adbi.202000203
Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor ⁶⁴Cu-Macrin in Mice, Rabbits, and Pigs. Circ Cardiovasc Imaging. 2020;13(10):e010586 - PMID: 33076700 - PMCID: PMC7583675 - DOI: 10.1161/CIRCIMAGING.120.010586
Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, Messemaker M, Siwicki M, Gerhard GM, Kohl A, Meylan E, Weissleder R, Klein AM, Pittet MJ Tumor-Promoting Ly-6G⁺ SiglecF^high Cells Are Mature and Long-Lived Neutrophils. Cell Rep. 2020;32(12):108164 - PMID: 32966785 - PMCID: PMC7508173 - DOI: 10.1016/j.celrep.2020.108164
Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020;6(21):ePub - PMID: 32937338 - PMCID: PMC7244320 - DOI: 10.1126/sciadv.aaz8521
Pai SI, Faquin WC, Sadow PM, Pittet MJ, Weissleder R New Technology on the Horizon: Fast Analytical Screening Technique FNA (FAST-FNA) Enables Rapid, Multiplex Biomarker Analysis in Head and Neck Cancers. Cancer Cytopathol. 2020;128(11):782-791 - PMID: 32841527 - PMCID: PMC8276888 - DOI: 10.1002/cncy.22305
Fumene Feruglio P, Vinegoni C, Weissleder R Extended dynamic range imaging for noise mitigation in fluorescence anisotropy imaging. J Biomed Opt. 2020;25(8):ePub - PMID: 32820624 - PMCID: PMC7439791 - DOI: 10.1117/1.JBO.25.8.086003
Min J, Son T, Hong JS, Cheah PS Wegemann A, Murlidharan K, Weissleder R, Lee H, Im H Plasmon-Enhanced Biosensing for Multiplexed Profiling of Extracellular Vesicles. Adv Biosyst. 2020;2020:2000003 - PMID: 32815321 - PMCID: PMC7718316 - DOI: 10.1002/adbi.202000003 - Cover
Bachar Issa TH, Vinegoni C, Shaw A, Fumene Feruglio P, Weissleder R, Uminsky D Video-Rate Acquisition Fluorescence Microscopy via Generative Adversarial Networks. EasyChair. 2020;:ePub
Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746
Kilic T, Weissleder R, Lee H Molecular and immunological diagnostic tests of COVID-19 – current status and challenges. iScience. 2020;23(8):101406 - PMID: 32771976 - PMCID: PMC7381402 - DOI: 10.1016/j.isci.2020.101406
Koch PD, Pittet MJ, Weissleder R The chemical biology of IL-12 production via the non-canonical NFkB pathway. RSC Chemical Biology. 2020;1:166-176 - PMID: 34458756 - PMCID: PMC8341911 - DOI: 10.1039/d0cb00022a
Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020;11:3521 - PMID: 32665556 - PMCID: PMC7360550 - DOI: 10.1038/s41467-020-17147-y
Weissleder R, Lee H, Ko J, Pittet MJ COVID-19 diagnostics in context. Sci Transl Med. 2020;12(546):eabc1931 - PMID: 32493791 - DOI: 10.1126/scitranslmed.abc1931
Ferguson S, Weissleder R Modeling EV Kinetics for Use in Early Cancer Detection. Adv Biosyst. 2020;4(12):e1900305 - PMID: 32394646 - PMCID: PMC7658022 - DOI: 10.1002/adbi.201900305
Van Deun J, Jo A, Li H, Lin HY, Weissleder R, Im H, Lee H Integrated Dual-Mode Chromatography to Enrich Extracellular Vesicles from Plasma. Adv Biosyst. 2020;4(12):e1900310 - PMID: 32351054 - PMCID: PMC7606548 - DOI: 10.1002/adbi.201900310
Wang Y, Cao T, Ko J, Shen Y, Zong W, Sheng K, Cao W, Sun S, Cai L, Zhou YL, Zhang XX, Zong C, Weissleder R, Weitz D Dissolvable Polyacrylamide Beads for High-Throughput Droplet DNA Barcoding. Adv Sci. 2020;7(8):1903463 - PMID: 32328429 - PMCID: PMC7175265 - DOI: 10.1002/advs.201903463
Marquard AN, Carlson JCT, Weissleder R Expanding the scope of antibody rebridging with new pyridazinedione-TCO constructs. Bioconjug Chem. 2020;31(6):1616-1623 - PMID: 32286045 - PMCID: PMC7788567 - DOI: 10.1021/acs.bioconjchem.0c00155
Li R, Ng TSC, Garlin MA, Weissleder R*, Miller MA* Understanding the In Vivo Fate of Advanced Materials by Imaging. Adv Funct Mater. 2020;30(37):ePub - PMID: 38545084 - PMCID: PMC10972611 - DOI: 10.1002/adfm.201910369
Vinegoni C, Fumene Feruglio P, Courties G, Schmidt S, Hulsmans M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R Fluorescence microscopy tensor imaging representations for large-scale dataset analysis. Sci Rep. 2020;10(1):5632 - PMID: 32221334 - PMCID: PMC7101442 - DOI: 10.1038/s41598-020-62233-2
Weissleder R, Pittet MJ The expanding landscape of inflammatory cells affecting cancer therapy. Nat Biomed Eng. 2020;4(5):489-498 - PMID: 32203281 - PMCID: PMC7405944 - DOI: 10.1038/s41551-020-0524-y
Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R Single Extracellular Vesicle Protein Analysis Using Immuno- Droplet Digital Polymerase Chain Reaction Amplification. Adv Biosyst. 2020;:ePub - DOI: 10.1002/adbi.201900307
Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7
Weissleder R, Lee H Automated molecular-image cytometry and analysis in modern oncology. Nature Review Materials. 2020;:ePub - DOI: 10.1038/s41578-020-0180-6
Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - PMCID: PMC7254576 - DOI: 10.1016/j.jacc.2019.12.056
Herrmann K, Schwaiger M, Lewis JS, Solomon SB, McNeil BJ, Baumann M, Gambhir SS, Hricak H, Weissleder R Radiotheranostics: a roadmap for future development. Lancet Oncol. 2020;21(3):e146–56 - PMID: 32135118 - PMCID: PMC7367151 - DOI: 10.1016/S1470-2045(19)30821-6 - Cover
Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R Ultra-fast cycling for multiplexed cellular fluorescence imaging. Angew Chem Int Ed Engl. 2020;59(17):6839-6846 - PMID: 32004403 - DOI: 10.1002/anie.201915153
Raisbeck JC, Allen M, Weissleder R, Im H, Lee H Evolution Strategies Converges to Finite Differences. arXiv. 2020;:ePub
Calcagno DM, Ng RP, Toomu A, Zhang C, Huang K, Aguirre AD, Weissleder R, Daniels LB, Fu Z, King KR Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3. Sci Immunol. 2020;5(51):ePub - PMID: 32978242 - PMCID: PMC7808338 - DOI: 10.1126/sciimmunol.aaz1974
Koch PD, Rodell CB, Kohler RH, Pittet MJ, Weissleder R Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy. Cell Chem Biol. 2020;27(1):94-104.e5 - PMID: 31902676 - PMCID: PMC7422681 - DOI: 10.1016/j.chembiol.2019.12.007
Harisinghani MG, O’Shea A, Weissleder R Advances in clinical MRI technology. Sci Transl Med. 2019;11 (523):eaba2591 - PMID: 31852796 - DOI: 10.1126/scitranslmed.aba2591
Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L Large and small extracellular vesicles released by glioma cells in vitro and in vivo. J Extracell Vesicles. 2019;9(1):1689784 - PMID: 31839905 - PMCID: PMC6896449 - DOI: 10.1080/20013078.2019.1689784
Koch PD, Ahmed MS, Kohler RH, Li R, Weissleder R Imaging of Tie2 with a fluorescently labeled small molecule affinity ligand. ACS Chem Biol. 2019;15(1):151-157 - PMID: 31809013 - PMCID: PMC7808335 - DOI: 10.1021/acschembio.9b00724
Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects. Cell Stress. 2019;3(11):348-360 - PMID: 31799501 - PMCID: PMC6859426 - DOI: 10.15698/cst2019.11.204
Chin LY, Carroll C, Raigani S, Detelich DM, Tessier SN, Wojtkiewicz GR, Schmidt SP, Weissleder R, Yeh H, Uygun K, Parekkadan B Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs. PLoS ONE. 2019;14(12):e0225222 - PMID: 31790444 - PMCID: PMC6886851 - DOI: 10.1371/journal.pone.0225222
Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Sci Rep. 2019;9(1):17387 - PMID: 31758005 - PMCID: PMC6874653 - DOI: 10.1038/s41598-019-53554-y
Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010
Rodell CB, Koch PD, Weissleder R Screening for new macrophage therapeutics. Theranostics. 2019;9(25):7714-7729 - PMID: 31695796 - PMCID: PMC6831478 - DOI: 10.7150/thno.34421
Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy. Theranostics. 2019;9(26):8426-8436 - PMID: 31879528 - PMCID: PMC6924259 - DOI: 10.7150/thno.35434
Ng TSC, Garlin MA, Weissleder R, Miller MA Understanding the EPR effect through image-guided systems pharmacology. Theranostics. 2019;:ePub
Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187
Park SG, Xiao X, Min J, Mun CW, Jung HS, Giannini V, Weissleder R, Maier SA, Im H, Kim DH Self‐Assembly of Nanoparticle‐Spiked Pillar Arrays for Plasmonic Biosensing. Adv Funct Mater. 2019;29(43):1904257 - DOI: 10.1002/adfm.201904257
Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H Compact and Filter-Free Luminescence Biosensor for Mobile In-Vitro Diagnoses. ACS Nano. 2019;13(10):11698-11706 - PMID: 31461265 - PMCID: PMC7307311 - DOI: 10.1021/acsnano.9b05634
Li R, Attari A, Prytyskach M, Garlin MA, Weissleder R, Miller MA Single‐Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics. Cytometry A. 2019;97(5):528-539 - PMID: 31423731 - PMCID: PMC7028488 - DOI: 10.1002/cyto.a.23872
Marquard AN, Carlson JCT, Weissleder R Glass Chemistry to Analyze Human Cells under Adverse Conditions. ACS Omega. 2019;4:11515−11521 - PMID: 31460257 - PMCID: PMC6682085 - DOI: 10.1021/acsomega.9b01036
Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity. Cell Rep. 2019;27(13):3972-3987.e6 - PMID: 31242427 - PMCID: PMC6604862 - DOI: 10.1016/j.celrep.2019.05.089
Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proc Natl Acad Sci U S A. 2019;116(23):11444-11453 - PMID: 31101720 - PMCID: PMC6561274 - DOI: 10.1073/pnas.1702372116
Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - PMCID: PMC6528836 - DOI: 10.1016/j.celrep.2019.03.003
Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA Radiation-Induced Targeted Nanoparticle- Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019;13(4):4028-4040 - PMID: 30916923 - PMCID: PMC7104714 - DOI: 10.1021/acsnano.8b08177
He S*, Kahles F*, Rattik S*, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019;566(7742):115-119 - PMID: 30700910 - PMCID: PMC6367023 - DOI: 10.1038/s41586-018-0849-9
Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J Bioassay for monitoring the anti-aging effect of cord blood treatment. Theranostics. 2019;9(1):1-10 - PMID: 30662549 - PMCID: PMC6332798 - DOI: 10.7150/thno.30422
Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre A, Nahrendorf M, Weissleder R A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019;30(3):733-740 - PMID: 30615425 - PMCID: PMC6483069 - DOI: 10.1021/acs.bioconjchem.8b00882
Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019;21(5):606-615 - PMID: 30561734 - PMCID: PMC6502493 - DOI: 10.1093/neuonc/noy187
Vinegoni C, Feruglio PF, Weissleder R High dynamic range fluorescence imaging. IEEE J Sel Top Quantum Electron. 2018;25(1):ePub - PMID: 31598059 - PMCID: PMC6785194 - DOI: 10.1109/JSTQE.2018.2881608
Vinegoni C, Feruglio PF, Weissleder R High dynamic range fluorescence imaging. IEEE J Sel Top Quantum Electron. 2018;25(1):ePub - PMID: 31598059 - PMCID: PMC6785194 - DOI: 10.1109/JSTQE.2018.2881608
Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018;12(12):12814-12826 - PMID: 30550257 - PMCID: PMC6307086 - DOI: 10.1021/acsnano.8b07954
Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet M, Nahrendorf M, Weissleder R, Miller MA Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. ACS Nano. 2018;12(12):12015-12029 - PMID: 30508377 - PMCID: PMC6482841 - DOI: 10.1021/acsnano.8b04338
Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024
Kim SJ*, Wang C*, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018;8(1):17003 - PMID: 30451953 - PMCID: PMC6242900 - DOI: 10.1038/s41598-018-35274-x
Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018;115(48):E11406-E11414 - PMID: 30429313 - PMCID: PMC6275538 - DOI: 10.1073/pnas.1800047115
Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. Theranostics. 2018;8(21):5842-5854 - PMID: 30613266 - PMCID: PMC6299430 - DOI: 10.7150/thno.26888
Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells. JCI Insight. 2018;3(21):ePub - PMID: 30385729 - PMCID: PMC6238736 - DOI: 10.1172/jci.insight.122961
Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens. Nat Commun. 2018;9(1):4550 - PMID: 30382095 - PMCID: PMC6208406 - DOI: 10.1038/s41467-018-07002-6
Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types. Proc Natl Acad Sci U S A. 2018;115(45):E10672-E10681 - PMID: 30348759 - PMCID: PMC6233093 - DOI: 10.1073/pnas.1810580115
Hulsmans M, Aguirre AD, Bonner M, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018;123(11):1208-1219 - PMID: 30571465 - PMCID: PMC6309285 - DOI: 10.1161/CIRCRESAHA.118.313429
Pittet MJ, Garris CS, Arlauckas SP, Weissleder R Recording the wild lives of immune cells. Sci Immunol. 2018;3(27):ePub - PMID: 30194240 - PMCID: PMC6771424 - DOI: 10.1126/sciimmunol.aaq0491
Aganj I, Harisinghani MG, Weissleder R, Fischl B Unsupervised medical image segmentation based on the local center of mass. Sci Rep. 2018;8:13012 - PMID: 30158534 - PMCID: PMC6115387 - DOI: 10.1038/s41598-018-31333-5
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Santos Masson G, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018;21(9):1209-1217 - PMID: 30150661 - PMCID: PMC6148759 - DOI: 10.1038/s41593-018-0213-2
Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel J, Castro CM, Weissleder R, Lee H Computational Optics Enables Breast Cancer Profiling in Point-Of-Care Settings. ACS Nano. 2018;12(9):9081-9090 - PMID: 30113824 - PMCID: PMC6519708 - DOI: 10.1021/acsnano.8b03029
Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble M, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning. Nat Biomed Eng. 2018;2(9):666-674 - PMID: 30555750 - PMCID: PMC6291220 - DOI: 10.1038/s41551-018-0265-3
Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz GR, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson FE, Jung Y, Désogère P, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018;123(4):415-427 - PMID: 29980569 - PMCID: PMC6202141 - DOI: 10.1161/CIRCRESAHA.118.313302
Sahin A, Sanchez C, Bullain S, Waterman P, Weissleder R, Carter BS Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma. PLoS ONE. 2018;13(7):e0199414 - PMID: 29975720 - PMCID: PMC6033533 - DOI: 10.1371/journal.pone.0199414
Schoenberg SO, Attenberger UI, Solomon SB, Weissleder R Developing a Roadmap for Interventional Oncology. Oncologist. 2018;23(10):1162-1170 - PMID: 29959284 - PMCID: PMC6263130 - DOI: 10.1634/theoncologist.2017-0654
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018;2:578-588 - PMID: 31015631 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8
Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proc Natl Acad Sci U S A. 2018;115(15):3912-3917 - PMID: 29581255 - PMCID: PMC5899492 - DOI: 10.1073/pnas.1801524115
Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018;4(3):eaar2766 - PMID: 29532035 - PMCID: PMC5842038 - DOI: 10.1126/sciadv.aar2766
Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis. ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - PMCID: PMC6019292 - DOI: 10.1021/acsnano.7b08965
Lin HY, Yang KS, Curley C, Lee H, Welch MW, Wolpin BM, Weissleder R, Im H, Castro C Bead Enhancement of EV Analysis. bioRxiv. 2018;:ePub - DOI: 10.1101/269423
Vinegoni C, Feruglio PF, Gryczynski I, Mazitschek R, Weissleder R Fluorescence anisotropy imaging in drug discovery. Adv Drug Deliv Rev. 2018;151-152:262-288 - PMID: 29410158 - PMCID: PMC6072632 - DOI: 10.1016/j.addr.2018.01.019
Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H New Technologies for Analysis of Extracellular Vesicles. Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - PMCID: PMC6029891 - DOI: 10.1021/acs.chemrev.7b00534
Carlson J, Mikula H, Weissleder R Unraveling tetrazine-triggered bioorthogonal elimination enables chemical tools for ultrafast release and universal cleavage. J Am Chem Soc. 2018;140(10):3603-3612 - PMID: 29384666 - PMCID: PMC5857921 - DOI: 10.1021/jacs.7b11217
Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018;215(2):423-440 - PMID: 29339450 - PMCID: PMC5789416 - DOI: 10.1084/jem.20171274
Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018;12(1):494-503 - PMID: 29286635 - PMCID: PMC5898240 - DOI: 10.1021/acsnano.7b07060
Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen P, Chiocca EA, Lawler SE Preclinical investigation of gene-mediated cytotoxic immunotherapy and checkpoint blockade in glioblastoma. Neuro Oncol. 2018;20(2):225-235 - PMID: 29016938 - PMCID: PMC5777502 - DOI: 10.1093/neuonc/nox139
Frenk NE, Spring L, Muzikansky A, Vadvala HV, Gurski JM, Henderson LE, Mino-Kenudson M, Ly A, Bardia A, Finkelstein D, Engelman J, Mueller PR, Juric D, Weissleder R High-Content Biopsies Facilitate Molecular Analyses and Do Not Increase Complication Rates in Patients With Advanced Solid Tumors. JCO Precis Oncol. 2017;1:1-9 - PMID: 35172508 - DOI: 10.1200/PO.17.00081
Kakkar A, Traverso G, Farokhzad OC, Weissleder R, Langer R Evolution of macromolecular complexity in drug delivery systems. Nat Rev Chem. 2017;1(8):ePub - PMID: 31286060 - PMCID: PMC6613785 - DOI: 10.1038/s41570-017-0063
Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K Deep-learning based hologram classification for molecular diagnostics. bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559
Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017;358:eaal5081 - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081
Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b
Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System. ACS Photonics. 2017;5(2):487-494 - PMID: 29805987 - PMCID: PMC5966285 - DOI: 10.1021/acsphotonics.7b00992
Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H Nano-Magnetic System For Rapid Diagnosis Of Acute Infection. ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - PMCID: PMC6296367 - DOI: 10.1021/acsnano.7b06074
King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428
Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h
Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection. ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083
Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017;214(11):3293-3310 - PMID: 28978634 - PMCID: PMC5679174 - DOI: 10.1084/jem.20170689
Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL PD-L1 is an activation-independent marker of brown adipocytes. Nat Commun. 2017;8(1):647 - PMID: 28935898 - PMCID: PMC5608754 - DOI: 10.1038/s41467-017-00799-8
Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A. 2017;114(37):E7776-E7785 - PMID: 28839093 - PMCID: PMC5604023 - DOI: 10.1073/pnas.1707381114
Miller MA, Weissleder R Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023
Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318
Im H, Lee K, Weissleder R, Lee H, Castro CM Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e
Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HJ Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis. Am J Physiol Renal Physiol. 2017;313(4):F1026-F1037 - PMID: 28701310 - PMCID: PMC5668581 - DOI: 10.1152/ajprenal.00038.2017
Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun. 2017;8:15906 - PMID: 28699627 - PMCID: PMC5510178 - DOI: 10.1038/ncomms15906
Miller MA, Arlauckas S, Weissleder R Prediction of Anti-cancer Nanotherapy Efficacy by Imaging. Nanotheranostics. 2017;1(3):296-312 - PMID: 29071194 - PMCID: PMC5646731 - DOI: 10.7150/ntno.20564
Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging. Nat Protoc. 2017;12(7):1472-1497 - PMID: 28686582 - PMCID: PMC5928516 - DOI: 10.1038/nprot.2017.043
Miller MA, Weissleder R Imaging of anticancer drug action in single cells. Nat Rev Cancer. 2017;17(7):399–414 - PMID: 28642603 - PMCID: PMC7552440 - DOI: 10.1038/nrc.2017.41
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341
Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci Transl Med. 2017;9(392):eaal0225 - PMID: 28566423 - PMCID: PMC6681815 - DOI: 10.1126/scitranslmed.aal0225
Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226
Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024
Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy. Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604
Mikula H, Stapleton S, Kohler RH, Vinegoni C, Weissleder R Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging. Theranostics. 2017;7(5):1257-1265 - PMID: 28435463 - PMCID: PMC5399591 - DOI: 10.7150/thno.18238
Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050
Seo KJ, Qiang Y, Bilgin I, Kar S, Vinegoni C, Weissleder R, Fang H Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh. ACS Nano. 2017;11(4):4365-4372 - PMID: 28391679 - DOI: 10.1021/acsnano.7b01995
Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C Motion characterization scheme to minimize motion artifacts in intravital microscopy. J Biomed Opt. 2017;22(3):36005 - PMID: 28253383 - PMCID: PMC5333764 - DOI: 10.1117/1.JBO.22.3.036005
Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293
Hong S, Park KS, Weissleder R, Castro CM, Lee H Facile silicification of plastic surface for bioassays. Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k
Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064
Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524
Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood. Nanomedicine. 2016;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428 - DOI: 10.1016/j.nano.2016.12.006
Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031
Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep. 2016;6:32985 - PMID: 27609668 - PMCID: PMC5017129 - DOI: 10.1038/srep32985
Park KS, Chung HJ, Khanam F, Lee H, Rashu R, Bhuiyan MT, Berger A, Harris JB, Calderwood SB, Ryan ET, Qadri F, Weissleder R, Charles RC A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever. Sci Rep. 2016;6:32878 - PMID: 27605393 - PMCID: PMC5015101 - DOI: 10.1038/srep32878
Weissleder R, Schwaiger MC, Gambhir SS, Hricak H Imaging approaches to optimize molecular therapies. Sci Transl Med. 2016;8(355):355ps16 - PMID: 27605550 - DOI: 10.1126/scitranslmed.aaf3936
Hong S, Pirovich D, Kilcoyne A, Huang CH, Lee H, Weissleder R Supramolecular Metallo-Bioadhesive for Minimally Invasive Use. Adv Mater. 2016;28(39):8675-8680 - PMID: 27515068 - PMCID: PMC5144581 - DOI: 10.1002/adma.201602606
Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2016;36(9):1802-8 - PMID: 27470513 - PMCID: PMC5001901 - DOI: 10.1161/ATVBAHA.116.307519
Clardy SM, Kohler RH, Vinegoni C, Iwamoto Y, Keliher EJ, Weissleder R Two-photon imaging of pancreatic beta cells in real time in vivo. Technology. 2016;4(2):130-134
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure. Circ Res. 2016;119(7):853-64 - PMID: 27444755 - PMCID: PMC5378496 - DOI: 10.1161/CIRCRESAHA.116.309001
Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059 - DOI: 10.7150/thno.15534
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nature Med. 2016;22(8):945-951 - PMID: 27428900 - PMCID: PMC4957133 - DOI: 10.1038/nm.4146
Meimetis LG, Giedt R, Mikyla H, Carlson J, Kohler R, Pirovich DB, Weissleder R Fluorescent vinblastine probes for live cell imaging. Chem Commun. 2016;52(64):9953-6 - PMID: 27439765 - PMCID: PMC4970878 - DOI: 10.1039/c6cc04129a
Vinegoni C, Dubach JM, Feruglio PF, Weissleder R Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quant. 2016;22 (3):6801607 - PMID: 27440991 - PMCID: PMC4946648 - DOI: 10.1109/JSTQE.2015.2501384
Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016;8:342 - PMID: 27280687 - PMCID: PMC5125383 - DOI: 10.1126/scitranslmed.aaf1435
Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system. Sci Adv. 2016;2(5):e1600300 - PMID: 28861468 - PMCID: PMC5565941 - DOI: 10.1126/sciadv.1600300
Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries. ACS Comb Sci. 2016;18(6):271-8 - PMID: 27124678 - PMCID: PMC5321554 - DOI: 10.1021/acscombsci.5b00180
Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Sci Rep. 2016;6:24681 - PMID: 27098438 - PMCID: PMC4838824 - DOI: 10.1038/srep24681
Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R Real-time high dynamic range laser scanning microscopy. Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995 - DOI: 10.1038/ncomms11077
Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity. Cancer Res. 2016;76(10):2876-2881 - PMID: 27013191 - PMCID: PMC4873326 - DOI: 10.1158/0008-5472.CAN-15-3432
Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov. 2016;6(4):382-99 - PMID: 26984351 - PMCID: PMC5087317 - DOI: 10.1158/2159-8290.CD-15-0933
Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016;16(8):1340-5 - PMID: 26980325 - PMCID: PMC4829473 - DOI: 10.1039/c5lc01558h
Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions. Science. 2016;352(6282):242-246 - PMID: 26989197 - PMCID: PMC4960636 - DOI: 10.1126/science.aaf1328
King K, Grazette LP, Paltoo DN, McDevitt JT, Sia SK, Barrett PM, Apple FS, Gurbel PA, Weissleder R, Leeds H, Iturriaga EJ, Rao A, Adhikari B, Desvigne-Nickens P, Galis ZS, Libby P Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group. JACC Basic Transl Sci. 2016;1(1-2):73-86 - PMID: 26977455 - PMCID: PMC4787294 - DOI: 10.1016/j.jacbts.2016.01.008
Cameron-Vendrig A, Reheman A, Siraj MA, Xu XR, Wang Y, Lei X, Afroze T, Shikatani E, El-Mounayri O, Noyan H, Weissleder R, Ni H, Husain M Glucagon-like peptide-1 receptor activation attenuates platelet aggregation and thrombosis. Diabetes. 2016;65(6):1714-23 - PMID: 26936963 - DOI: 10.2337/db15-1141
Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666
Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865 - DOI: 10.1016/j.immuni.2015.11.024
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016;10(2):1802-1809 - PMID: 26808216 - PMCID: PMC4802494 - DOI: 10.1021/acsnano.5b07584
Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer. ACS Cent Sci. 2015;1(3):142-147 - PMID: 26955657 - PMCID: PMC4778250 - DOI: 10.1021/acscentsci.5b00121
Koo H, Choi M, Kim E, Hahn SK, Weissleder R, Yun SH Bioorthogonal Click Chemistry-Based Synthetic Cell Glue. Small. 2015;11(48):6458-66 - PMID: 26768353 - PMCID: PMC5556392 - DOI: 10.1002/smll.201502972
Hong S, Carlson J, Lee H, Weissleder R Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking. Adv Healthc Mater. 2015;5(4):421-426 - PMID: 26688173 - PMCID: PMC4811597 - DOI: 10.1002/adhm.201500780
Meimetis LG, Boros E, Carlson JC, Ran C, Caravan P, Weissleder R Bioorthogonal fluorophore linked DFO - Technology enabling facile chelator quantification and multimodal imaging of antibodies. Bioconjug Chem. 2015;27(1):257-63 - PMID: 26684717 - PMCID: PMC4858350 - DOI: 10.1021/acs.bioconjchem.5b00630
Kuijten MM, Hannah Degeling M, Chen JW, Wojtkiewicz G, Waterman P, Weissleder R, Azzi J, Nicolay K, Tannous BA Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging. Sci Rep. 2015;5:17220 - PMID: 26610702 - PMCID: PMC4661695 - DOI: 10.1038/srep17220
Weissleder R, Nahrendorf M Advancing biomedical imaging. Proc Natl Acad Sci U S A. 2015;112(47):14424-8 - PMID: 26598657 - PMCID: PMC4664297 - DOI: 10.1073/pnas.1508524112
Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamal N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle. Sci Transl Med. 2015;7:314 - PMID: 26582898 - PMCID: PMC5462466 - DOI: 10.1126/scitranslmed.aac6522
Ullal AV, Weissleder R Photocleavable DNA Barcoding Antibodies for Multiplexed Protein Analysis in Single Cells. Methods Mol Biol. 2015;1346:47-54 - PMID: 26542714 - DOI: 10.1007/978-1-4939-2987-0_4
Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015;6:8692 - PMID: 26503691 - PMCID: PMC4711745 - DOI: 10.1038/ncomms9692
Vinegoni C, Aguirre AD, Lee S, Weissleder R Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015;10(11):1802-1819 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119
Park KS, Charles RC, Ryan ET, Weissleder R*, Lee H* Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease. Chem Eur J. 2015;21(46):16359-63 - PMID: 26420633 - PMCID: PMC4816641 - DOI: 10.1002/chem.201502934
Ye YX, Calcagno C, Binderup T, Courties G, Keliher E, Wojtkiewicz GR, Iwamoto Y, Tang J, Perez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjær A, Mulder W, Nahrendorf M Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. Circ Res. 2015;117(10):835-45 - PMID: 26394773 - PMCID: PMC4619168 - DOI: 10.1161/CIRCRESAHA.115.307024
Whitley MJ, Weissleder R, Kirsch DG Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer. Semin Radiat Oncol. 2015;25(4):313-21 - PMID: 26384279 - PMCID: PMC4575408 - DOI: 10.1016/j.semradonc.2015.05.005
Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015;132(20):1880-90 - PMID: 26358260 - PMCID: PMC4651795 - DOI: 10.1161/CIRCULATIONAHA.115.016160
Clardy SM, James F. Mohan JF, Vinegoni C, Keliher EJ, Iwamoto Y, Benoist C, Mathis D, Weissleder R Rapid, high efficiency isolation of pancreatic ß-cells. Sci Rep. 2015;5:13681 - PMID: 26330153 - PMCID: PMC4557033 - DOI: 10.1038/srep13681
Lee H, Shin TH, Cheon J, Weissleder R Recent Developments in Magnetic Diagnostic Systems. Chem Rev. 2015;115(19):10690-724 - PMID: 26258867 - PMCID: PMC5791529 - DOI: 10.1021/cr500698d
He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. Circ Heart Fail. 2015;8(5):980-7 - PMID: 26232205 - PMCID: PMC4568849 - DOI: 10.1161/CIRCHEARTFAILURE.115.002334
Konishi M, Erdem SS, Weissleder R, Lichtman AH, McCarthy J, Libby P Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis. Circ Res. 2015;117(6):502-12 - PMID: 26199323 - PMCID: PMC4553143 - DOI: 10.1161/CIRCRESAHA.115.306364
Chung HJ, Pellegrini KL, Chung J, Wanigasuriya K, Jayawardene I, Lee K, Lee H, Vaidya VS, Weissleder R Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury. PLoS ONE. 2015;10(7):e0133417 - PMID: 26186708 - PMCID: PMC4506142 - DOI: 10.1371/journal.pone.0133417
Abazari A, Meimetis LG, Budin G, Bale SS, Weissleder R, Toner M Engineered Trehalose Permeable to Mammalian Cells. PLoS ONE. 2015;10(6):e0130323 - PMID: 26115179 - PMCID: PMC4482662 - DOI: 10.1371/journal.pone.0130323
Park YI, Im H, Weissleder R, Lee H Nanostar clustering improves the sensitivity of plasmonic assays. Bioconjug Chem. 2015;26(8):1470-1474 - PMID: 26102604 - PMCID: PMC5292976 - DOI: 10.1021/acs.bioconjchem.5b00343
Glenn DR#, Lee K#, Park H, Weissleder R, Yacoby A, Lukin MD, Lee H*, Walsworth RL*, Connolly CB* Single-cell magnetic imaging using a quantum diamond microscope. Nat Methods. 2015;12(8):736-738 - PMID: 26098019 - PMCID: PMC4521973 - DOI: 10.1038/nmeth.3449
Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus". Circulation. 2015;131(24):e531-2 - PMID: 26078375 - DOI: 10.1161/CIRCULATIONAHA.115.014802
Vinegoni C, Lee S, Aguirre AD, Weissleder R New techniques for motion-artifact-free in vivo cardiac microscopy. Front Physiol. 2015;6:147 - PMID: 26029116 - PMCID: PMC4428079 - DOI: 10.3389/fphys.2015.00147
Kim E, Yang K, Kohler R, Dubach JM, Mikula H, Weissleder R Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression. Bioconjug Chem. 2015;26(8):1513-1518 - PMID: 26017814 - PMCID: PMC4772718 - DOI: 10.1021/acs.bioconjchem.5b00152
Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R Advances in measuring single-cell pharmacokinetics and pharmacology in vivo. Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011
Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015;5(8):796-804 - PMID: 26000053 - PMCID: PMC4440438 - DOI: 10.7150/thno.11220
Yang KS, Kohler RH, Landon M, Giedt R, Weissleder R Single cell resolution in vivo imaging of DNA damage following PARP inhibition. Sci Rep. 2015;5:10129 - PMID: 25984718 - PMCID: PMC4434991 - DOI: 10.1038/srep10129
Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 2015;6:7029 - PMID: 25967391 - PMCID: PMC4435621 - DOI: 10.1038/ncomms8029
Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H*, Weissleder R* Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma. Nat Commun. 2015;6:6999 - PMID: 25959588 - PMCID: PMC4430127 - DOI: 10.1038/ncomms7999
Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008
Im H, Shao H, Weissleder R, Castro CM, Lee H Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn. 2015;15(6):725-33 - PMID: 25936957 - PMCID: PMC4675626 - DOI: 10.1586/14737159.2015.1041378
Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL Noninvasive imaging of immune responses. Proc Natl Acad Sci U S A. 2015;112(19):6146-51 - PMID: 25902531 - PMCID: PMC4434737 - DOI: 10.1073/pnas.1502609112
Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R*, Danuser G*, Mitchison TJ* In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015;12(6):577-585 - PMID: 25867850 - PMCID: PMC4579269 - DOI: 10.1038/nmeth.3363
Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H* Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112
Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015;212(4):497-512 - PMID: 25800955 - PMCID: PMC4387283 - DOI: 10.1084/jem.20141642
Nair AV, Keliher EJ, Core AB, Brown D, Weissleder R Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo. ACS Nano. 2015;9(4):3641-53 - PMID: 25790730 - PMCID: PMC4414893 - DOI: 10.1021/acsnano.5b00428
Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015;347(6227):1260-1265 - PMID: 25766237 - PMCID: PMC4376966 - DOI: 10.1126/science.aaa4268
Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis. Cell. 2015;160(6):1246-60 - PMID: 25748654 - PMCID: PMC4380877 - DOI: 10.1016/j.cell.2015.02.038
Kessinger CW, Kim JW, Henke PK, Thompson B, McCarthy JR, Hara T, Sillesen M, Margey RJ, Libby P, Weissleder R, Lin CP, Jaffer FA Statins Improve the Resolution of Established Murine Venous Thrombosis: Reductions in Thrombus Burden and Vein Wall Scarring. PLoS ONE. 2015;10(2):e0116621 - PMID: 25680183 - PMCID: PMC4334538 - DOI: 10.1371/journal.pone.0116621
Lee K, Shao H, Weissleder R, Lee H Acoustic Purification of Extracellular Microvesicles. ACS Nano. 2015;9(3):2321-7 - PMID: 25672598 - PMCID: PMC4373978 - DOI: 10.1021/nn506538f
Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C Mathis D, Weissleder R Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. Proc Natl Acad Sci U S A. 2015;112(7):2139-44 - PMID: 25650428 - PMCID: PMC4343112 - DOI: 10.1073/pnas.1424993112
Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C Population dynamics of islet-infiltrating cells in autoimmune diabetes. Proc Natl Acad Sci U S A. 2015;112(5):1511-6 - PMID: 25605891 - PMCID: PMC4321317 - DOI: 10.1073/pnas.1423769112
Langer R, Weissleder R Nanotechnology. JAMA. 2015;313(2):135-136 - PMID: 25585320 - DOI: 10.1001/jama.2014.16315
Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells. Circ Res. 2015;116(3):407-17 - PMID: 25362208 - PMCID: PMC4312511 - DOI: 10.1161/CIRCRESAHA.116.305207
Alieva M, Ritsma L, Giedt RJ, Weissleder R, van Rheenen J Imaging windows for long-term intravital imaging: general overview. Intravital. 2014;3:2: e29917
Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014;5:5662 - PMID: 25489927 - PMCID: PMC4261930 - DOI: 10.1038/ncomms6662
Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. eLife. 2014;3:e04631 - PMID: 25407682 - PMCID: PMC4270084 - DOI: 10.7554/eLife.04631
Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318
Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Desphande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes CH, Engelman JA, Bardeesy N Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Clin Cancer Res. 2014;21(2):396-404 - PMID: 25348516 - PMCID: PMC4447091 - DOI: 10.1158/1078-0432.CCR-14-1591
Giedt RJ, Sprachman M, Yang K, Weissleder R Imaging cellular distribution of Bcl inhibitors using small molecule drug conjugates. Bioconjug Chem. 2014;25(11):2081-2085 - PMID: 25333750 - PMCID: PMC4240345 - DOI: 10.1021/bc500433k
Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P Increased Microvascularization and Vessel Permeability Associate with Active Inflammation in Human Atheromata. Circ Cardiovasc Imaging. 2014;7(6):920-929 - PMID: 25170063 - PMCID: PMC4237630 - DOI: 10.1161/CIRCIMAGING.114.002113
Dubach JM, Vinegoni C, Weissleder R Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014;39(15):4482-4485 - PMID: 25078208 - PMCID: PMC4341989 - DOI: 10.1364/OL.39.004482
Hara T, Truelove J, Tawakol A, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA FDG-PET/CT Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus. Circulation. 2014;130(13):1044-52 - PMID: 25070665 - PMCID: PMC4174982 - DOI: 10.1161/CIRCULATIONAHA.114.008902
Aguirre AD, Vinegoni C, Sebas M, Weissleder R Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111
Stangenberg L, Burzyn D, Binstadt BA, Weissleder R, Mahmood U, Benoist C, Mathis D Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature. Proc Natl Acad Sci U S A. 2014;111(31):11419-24 - PMID: 25049388 - PMCID: PMC4128122 - DOI: 10.1073/pnas.1410854111
Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M Chronic variable stress activates hematopoietic stem cells. Nature Med. 2014;20(7):754-758 - PMID: 24952646 - PMCID: PMC4087061 - DOI: 10.1038/nm.3589
Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M Silencing of CCR2 in myocarditis. Eur Heart J. 2014;36(23):1478-88 - PMID: 24950695 - PMCID: PMC4465633 - DOI: 10.1093/eurheartj/ehu225
Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging. Angew Chem Int Ed Engl. 2014;53(29):7531-4 - PMID: 24915832 - PMCID: PMC4122131 - DOI: 10.1002/anie.201403890
Issadore D, Park YI, Shao H, Min C, Lee K, Liong M, Weissleder R*, Lee H* Magnetic sensing technology for molecular analyses. Lab Chip. 2014;14(14):2385-97 - PMID: 24887807 - PMCID: PMC4098149 - DOI: 10.1039/c4lc00314d
Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946
Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014;211(6):1243-56 - PMID: 24821911 - PMCID: PMC4042649 - DOI: 10.1084/jem.20131471
Sprachman M, Laughney A, Kohler R, Weissleder R In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor. Bioconjug Chem. 2014;25(6):1137-42 - PMID: 24806886 - PMCID: PMC4098115 - DOI: 10.1021/bc500154c
Zeglis BM, Emmetiere F, Pillarsetty N, Weissleder R, Lewis JS, Reiner T Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis. ChemistryOpen. 2014;3(2):48-53 - PMID: 24808990 - PMCID: PMC4000166 - DOI: 10.1002/open.201402000
Heidt T, Courties G, Dutta P, Sager H, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction. Circ Res. 2014;115(2):284-95 - PMID: 24786973 - PMCID: PMC4082439 - DOI: 10.1161/CIRCRESAHA.115.303567
Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep. 2014;4:4782 - PMID: 24759210 - PMCID: PMC3998017 - DOI: 10.1038/srep04782
Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci U S A. 2014;111(18):6696-701 - PMID: 24753589 - PMCID: PMC4020091 - DOI: 10.1073/pnas.1405634111
Im H*, Shao H*, Park YI, Peterson VM, Castro CM, Weissleder R*, Lee H* Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014;32(5):490-5 - PMID: 24752081 - PMCID: PMC4356947 - DOI: 10.1038/nbt.2886
Lee S, Vinegoni C, Sebas M, Weissleder R Automated motion artifact removal for intravital microscopy, without a priori information. Sci Rep. 2014;4:4507 - PMID: 24676021 - PMCID: PMC3968488 - DOI: 10.1038/srep04507
Kim E, Yang KS, Giedt RJ, Weissleder R Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun. 2014;50(34):4504-7 - PMID: 24663433 - PMCID: PMC4028821 - DOI: 10.1039/c4cc00144c
Winkler DA, Burden FR, Yan B, Weissleder R, Tassa C, Shaw S, Epa VC Modelling and predicting the biological effects of nanomaterials. SAR QSAR Environ Res. 2014;25(2):161-72 - PMID: 24625316 - DOI: 10.1080/1062936X.2013.874367
Hilgendorf I, Gerhardt L, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherrer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium. Circ Res. 2014;114(10):1611-22 - PMID: 24625784 - PMCID: PMC4017349 - DOI: 10.1161/CIRCRESAHA.114.303204
Keliher EJ, Klubnick JA Reiner T, Mazitschek R, Weissleder R Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes. ChemMedChem. 2014;9(7):1368-73 - PMID: 24596307 - PMCID: PMC4145401 - DOI: 10.1002/cmdc.201300506
Elman JS, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells. PLoS ONE. 2014;9(2):e89882 - PMID: 24587097 - PMCID: PMC3931832 - DOI: 10.1371/journal.pone.0089882
Thurber G, Reiner T, Yang K, Kohler R, Weissleder R Effect of Small Molecule Modification on Single Cell Pharmacokinetics of PARP Inhibitors. Mol Cancer Ther. 2014;13(4):986-95 - PMID: 24552776 - PMCID: PMC3981972 - DOI: 10.1158/1535-7163.MCT-13-0801
Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H*, Weissleder R* Magnetic Ligation Method for Quantitative Detection of MicroRNAs. Adv Healthc Mater. 2014;3(7):1015-9 - PMID: 24532323 - PMCID: PMC4107040 - DOI: 10.1002/adhm.201300672
Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R Platinum Compounds for High-Resolution In Vivo Cancer Imaging. ChemMedChem. 2014;9(6):1131-5 - PMID: 24504646 - PMCID: PMC4037345 - DOI: 10.1002/cmdc.201300502
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity. Circulation. 2014;129(16):1677-87 - PMID: 24488984 - PMCID: PMC3997655 - DOI: 10.1161/CIRCULATIONAHA.113.006381
Weissleder R, Nahrendorf M, Pittet MJ Imaging macrophages with nanoparticles. Nat Mater. 2014;13(2):125-38 - PMID: 24452356 - DOI: 10.1038/nmat3780
Ullal AV*, Peterson V*, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates. Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361
Vinegoni C, Lee S, Feruglio PF, Weissleder R Advanced Motion Compensation Methods for Intravital Optical Microscopy. IEEE J Sel Top Quant. 2014;20(2):ePub - PMID: 24273405 - PMCID: PMC3832946 - DOI: 10.1109/JSTQE.2013.2279314
Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari KI, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1. Cancer Res. 2013;74(3):738-50 - PMID: 24310399 - PMCID: PMC3928601 - DOI: 10.1158/0008-5472.CAN-13-2650
McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R, Harisinghani MG Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol. 2013;6(6):670-5 - PMID: 24466369 - PMCID: PMC3890701 - DOI: 10.1593/tlo.13400
Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2013;63(15):1556-66 - PMID: 24361318 - PMCID: PMC3992176 - DOI: 10.1016/j.jacc.2013.11.023
Coffey SE, Giedt RJ, Weissleder R Automated analysis of clonal cancer cells by intravital imaging. Intravital. 2013;2(3):ePub - PMID: 24349895 - PMCID: PMC3859690 - DOI: 10.4161/intv.26138
Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles. ACS Nano. 2013;7(12):11227-33 - PMID: 24295203 - PMCID: PMC3898036 - DOI: 10.1021/nn405016y
Peterson VM*, Castro CM*, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110
Kim E, Yang K, Weissleder R Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET. PLoS ONE. 2013;8 (11):e81275 - PMID: 24265843 - PMCID: PMC3827223 - DOI: 10.1371/journal.pone.0081275
Ghazani A, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008
Vinegoni C, Lee S, Feruglio PF, Marzola P, Nahrendorf M, Weissleder R Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging. Biomed Opt Express. 2013;4(10):2095-106 - PMID: 24156067 - PMCID: PMC3799669 - DOI: 10.1364/BOE.4.002095
Agasti SS, Laughney AM, Kohler RH, Weissleder R A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport. Chem Commun. 2013;49(94):11050-2 - PMID: 24135896 - PMCID: PMC3856557 - DOI: 10.1039/c3cc46089d
Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications. J Vis Exp. 2013;(79):e50772 - PMID: 24084440 - PMCID: PMC3924759 - DOI: 10.3791/50772
Chung J*, Issadore D*, Ullal A*, Lee K, Weissleder R*, Lee H* Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip. Biomicrofluidics. 2013;7(5):54107 - PMID: 24404070 - PMCID: PMC3790798 - DOI: 10.1063/1.4821923
Yoon TJ, Shao H, Weissleder R, Lee H Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles. Part. Part. Syst. Charact. 2013;30:667–671 - PMID: 24077230 - PMCID: PMC3783348 - DOI: 10.1002/ppsc.201300013
Yang* KS, Budin* G, Tassa C, Kister O, Weissleder R Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells. Angew Chem Int Ed Engl. 2013;52(40):10593-7 - PMID: 23960025 - PMCID: PMC3856564 - DOI: 10.1002/anie.201304096
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, Rooijen NV, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nature Med. 2013;19(9):1166-72 - PMID: 23933982 - PMCID: PMC3769444 - DOI: 10.1038/nm.3258
Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R Targeting cathepsin e in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia. 2013;15(7):684-93 - PMID: 23814481 - PMCID: PMC3689232 - DOI: 10.1593/neo.13276
Ueno T, Dutta P, Keliher E, Leuschner F, Majmudar M, Marinelli B, Iwamoto Y, Figueiredo JL, Christen T, Swirski FK, Libby P, Weissleder R, Nahrendorf M Nanoparticle PET-CT Detects Rejection and Immunomodulation in Cardiac Allografts. Circ Cardiovasc Imaging. 2013;6(4):568-73 - PMID: 23771986 - PMCID: PMC3734553 - DOI: 10.1161/CIRCIMAGING.113.000481
Carlson JC, Meimetis LG, Hilderbrand SA, Weissleder R BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes. Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100
Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry. J Nucl Med. 2013;54(8):1389-96 - PMID: 23708196 - PMCID: PMC4151562 - DOI: 10.2967/jnumed.112.115840
Chung HJ, Castro CM, Im H, Lee H*, Weissleder R* A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol. 2013;8(5):369-75 - PMID: 23644570 - PMCID: PMC3711657 - DOI: 10.1038/nnano.2013.70
Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice. Circulation. 2013;127(20):2038-2046 - PMID: 23616627 - PMCID: PMC3661714 - DOI: 10.1161/CIRCULATIONAHA.112.000116
Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H*, Weissleder R* Magnetic barcode assay for genetic detection of pathogens. Nat Commun. 2013;4:1752 - PMID: 23612293 - PMCID: PMC3635151 - DOI: 10.1038/ncomms2745
Shan G, Weissleder R, Hilderbrand SA Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal Therapy. Theranostics. 2013;3(4):267-74 - PMID: 23606913 - PMCID: PMC3630527 - DOI: 10.7150/thno.5226
Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, Chen EZ, Angarone M, Weissleder R, Khazaie K, Barrett TA Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis. Inflamm Bowel Dis. 2013;19(7):1339-1345 - PMID: 23591598 - PMCID: PMC4306589 - DOI: 10.1097/MIB.0b013e318281f3f8
Giedt RJ, Koch PD, Weissleder R Single Cell Analysis of Drug Distribution by Intravital Imaging. PLoS ONE. 2013;8(4):e60988 - PMID: 23593370 - PMCID: PMC3622689 - DOI: 10.1371/journal.pone.0060988
Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system. Nanomedicine (Lond). 2013;9(7):1009-17 - PMID: 23570873 - PMCID: PMC4330975 - DOI: 10.1016/j.nano.2013.03.011
Issadore D*, Chung HJ*, Chung J, Budin G, Weissleder R*, Lee H* μHall Chip for Sensitive Detection of Bacteria. Adv Healthc Mater. 2013;2(9):1224-8 - PMID: 23495188 - PMCID: PMC4340655 - DOI: 10.1002/adhm.201200380
Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013;4:1504 - PMID: 23422672 - PMCID: PMC3579506 - DOI: 10.1038/ncomms2506
Liu R, Rallo R, Weissleder R, Tassa C, Shaw S, Cohen Y Nano-SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries. Small. 2013;9(9-10):1842-52 - PMID: 23423856 - DOI: 10.1002/smll.201201903
Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ Angiotensin II Drives the Production of Tumor-Promoting Macrophages. Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015
Majmudar MD, Yoo J, Keliher E, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson D, Swirski FK, Weissleder R, Nahrendorf M Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques. Circ Res. 2013;112(5):755-61 - PMID: 23300273 - PMCID: PMC3586287 - DOI: 10.1161/CIRCRESAHA.111.300576
Keliher EJ, Reiner T, Thurber GM, Upadhyay R, Weissleder R Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells. ChemistryOpen. 2012;1(4):177-183 - PMID: 23997998 - PMCID: PMC3758109 - DOI: 10.1002/open.201200014
Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Mol Ther Nucleic Acids. 2012;1:e4 - PMID: 23344621 - PMCID: PMC3381593 - DOI: 10.1038/mtna.2011.3
Vinegoni C, Lee S, Gorbatov R, Weissleder R Motion compensation using a suctioning stabilizer for intravital microscopy. Intravital. 2012;1:115-121 - PMID: 24086796 - PMCID: PMC3786172 - DOI: 10.4161/intv.23017
Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, Macdonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism. Cell. 2012;151(6):1185-99 - PMID: 23217706 - PMCID: PMC3526953 - DOI: 10.1016/j.cell.2012.10.047
Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway. JACC Cardiovasc Imaging. 2012;5(11):1127-38 - PMID: 23153913 - PMCID: PMC3502014 - DOI: 10.1016/j.jcmg.2012.01.025
Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109
Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R*, Lee H* Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nature Med. 2012;18(12):1835-1840 - PMID: 23142818 - PMCID: PMC3518564 - DOI: 10.1038/nm.2994
Agasti SS, Liong M, Peterson VM, Lee H, Weissleder R Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell. J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w
Lee S, Vinegoni C, Feruglio PF, Weissleder R Improved intravital microscopy via synchronization of respiration and holder stabilization. J Biomed Opt. 2012;17(9):96018-1 - PMID: 23085919 - PMCID: PMC3449295 - DOI: 10.1117/1.JBO.17.9.096018
Epa VC, Burden FR, Tassa C, Weissleder R, Shaw SY, Winkler DA Modelling biological activities of nanoparticles. Nano Lett. 2012;12(11):5808-5812 - PMID: 23039907 - DOI: 10.1021/nl303144k
Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging. Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622 - DOI: 10.1161/ATVBAHA.112.251983
Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking. Small. 2012;9(2):222-7 - PMID: 22996932 - PMCID: PMC3552149 - DOI: 10.1002/smll.201201007
Lee S, Vinegoni C, Feruglio PF, Fexon L, Gorbatov R, Pivovarov M, Sbarbati A, Nahrendorf M, Weissleder R Real-time in vivo imaging of the beating mouse heart at microscopic resolution. Nat Commun. 2012;3:1054 - PMID: 22968700 - PMCID: PMC3622400 - DOI: 10.1038/ncomms2060
Lu X, Agasti SS, Vinegoni C, Waterman P, Depinho R, Weissleder R Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem. 2012;23(9):1945-51 - PMID: 22917215 - PMCID: PMC3775343 - DOI: 10.1021/bc300319c
Feruglio PF, Vinegoni C, Fexon L, Thurber G, Sbarbati A, Weissleder R Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. J Biophotonics. 2012;6(4):363-70 - PMID: 22887724 - PMCID: PMC3779878 - DOI: 10.1002/jbio.201200086
Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy. J Neurooncol. 2012;110(1):37-48 - PMID: 22875706 - PMCID: PMC4291475 - DOI: 10.1007/s11060-012-0948-7
Chung J*, Shao H*, Reiner T, Issadore D, Weissleder R, Lee H Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells. Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046
Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H Mechanism of Magnetic Relaxation Switching Sensing. ACS Nano. 2012;6(8):6821-8 - PMID: 22762250 - PMCID: PMC3429660 - DOI: 10.1021/nn301615b
Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab Chip. 2012;12(17):3103-10 - PMID: 22760641 - PMCID: PMC3411869 - DOI: 10.1039/c2lc40337d
Issadore D, Chung J*, Shao H*, Liong M, Ghazani AA, Castro CM, Weissleder R*, Lee H* Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector. Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747
Budin G*, Chung HJ*, Lee H, Weissleder R A Magnetic Gram Stain for Bacterial Detection. Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982
Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance. Neoplasia. 2012;14(5):388-95 - PMID: 22745585 - PMCID: PMC3384426 - DOI: 10.1596/neo.12696
Dutta P*, Courties G*, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AN, Niessen HWM, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M Myocardial infarction accelerates atherosclerosis. Nature. 2012;487(7407):325-9 - PMID: 22763456 - PMCID: PMC3401326 - DOI: 10.1038/nature11260
Hara T, Bhayana B, Thompson B, Kessinger CW, Khatri A, McCarthy JR, Weissleder R, Lin CP, Tearney GJ, Jaffer FA Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence. JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109
Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R Bioorthogonal Imaging of Aurora Kinase A in Live Cells. Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism. Cell. 2012;149(3):656-70 - PMID: 22541435 - PMCID: PMC3472002 - DOI: 10.1016/j.cell.2012.01.058
Vinegoni C, Feruglio PF, Razansky D, Gorbatov R, Ntziachristos V, Sbarbati A, Nahrendorf M, Weissleder R Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography. PLoS ONE. 2012;7(4):e34427 - PMID: 22509302 - PMCID: PMC3324534 - DOI: 10.1371/journal.pone.0034427
Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res. 2012;30(10):1666-73 - PMID: 22504929 - DOI: 10.1002/jor.22113
Earley S, Vinegoni C, Dunham J, Gorbatov R, Fumene Feruglio P, Weissleder R In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution. Cancer Res. 2012;72(12):2949-56 - PMID: 22505651 - PMCID: PMC3603290 - DOI: 10.1158/0008-5472.CAN-11-4096
Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier RJ, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb. Cell Rep. 2012;1(4):1-8 - PMID: 22545247 - PMCID: PMC3334310 - DOI: 10.1016/j.celrep.2012.02.009
Hendricks JA, Keliher EJ, Wan D, Hilderbrand SA, Weissleder R, Mazitschek R Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging. Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957
Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH, Vinegoni C, Weissleder R Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents. Neoplasia. 2012;14(3):169-177 - PMID: 22496617 - PMCID: PMC3323895 - DOI: 10.1593/neo.12414
Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target. Radiology. 2012;263(2):451-60 - PMID: 22438365 - PMCID: PMC3329272 - DOI: 10.1148/radiol.12111593
Peterson VM, Castro CM, Lee H, Weissleder R Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing. ACS Nano. 2012;6(4):3506-13 - PMID: 22424443 - PMCID: PMC3337350 - DOI: 10.1021/nn300536y
Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109
Niers JM*, Chen JW*, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA Single Reporter for Targeted Multimodal in Vivo Imaging. J Am Chem Soc. 2012;134(11):5149-56 - PMID: 22397453 - PMCID: PMC3310895 - DOI: 10.1021/ja209868g
Fu W, Wojtkiewicz G, Weissleder R, Benoist C, Mathis D Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol. 2012;13(4):361-8 - PMID: 22366893 - PMCID: PMC3309063 - DOI: 10.1038/ni.2233
McCarthy JR, Sazonova IY, Erdem SS, Hara T, Thompson BD, Patel P, Botnaru I, Lin CP, Reed GL, Weissleder R, Jaffer FA Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy. Nanomedicine (Lond). 2012;7(7):1017-28 - PMID: 22348271 - PMCID: PMC3360120 - DOI: 10.2217/nnm.11.179
Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA The neuropeptide neuromedin U promotes autoantibody-mediated arthritis. Arthritis Res Ther. 2012;14(1):R29 - PMID: 22314006 - PMCID: PMC3392824 - DOI: 10.1186/ar3732
Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109
Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H Magnetic Nanoparticles and microNMR for Diagnostic Applications. Theranostics. 2012;2(1):55-65 - PMID: 22272219 - PMCID: PMC3263516 - DOI: 10.7150/thno.3465
Rauch PJ*, Chudnovskiy A*, Robbins CS*, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK Innate Response Activator B Cells Protect Against Microbial Sepsis. Science. 2012;335(6068):597-601 - PMID: 22245738 - PMCID: PMC3279743 - DOI: 10.1126/science.1215173
Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012;209(1):123-37 - PMID: 22213805 - PMCID: PMC3260875 - DOI: 10.1084/jem.20111009
Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MPV, Niessen HWM, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M PET/MRI of Inflammation in Myocardial Infarction. J Am Coll Cardiol. 2012;59:153-163 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066
Karver MR, Weissleder R, Hilderbrand SA Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging. Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389
Thomas S, Waterman P, Chen S, Marinelli B, Seaman M, Rodig S, Ross RW, Josephson L, Weissleder R, Kelly KA Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. J Nanomedic Nanotechnol. 2011;2(4):112 - PMID: 22319675 - PMCID: PMC3273319 - DOI: 10.4172/2157-7439.1000112
Pittet MJ, Weissleder R Intravital imaging. Cell. 2011;147(5):983-91 - PMID: 22118457 - PMCID: PMC3824153 - DOI: 10.1016/j.cell.2011.11.004
Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers. Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670
Su HS, Nahrendorf M, Panizzi PR, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase. Radiology. 2011;262(1):181-90 - PMID: 22084204 - PMCID: PMC3244672 - DOI: 10.1148/radiol.11110040
Weissleder R, Castro C Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Nanomedicine (Lond). 2011;6(9):1495-8 - PMID: 22077461 - DOI: 10.2217/nnm.11.138
Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance. Bioconjug Chem. 2011;22(12):2390-4 - PMID: 22043803 - PMCID: PMC3263317 - DOI: 10.1021/bc200490r
Keliher E, Yoo J, Nahrendorf M, Lewis JS, Marinelli B, Newton A, Pittet M, Weissleder R 89Zr Labeled Dextran Nanoparticles Enable in vivo Macrophage Imaging. Bioconjug Chem. 2011;22(12):2383-9 - PMID: 22035047 - PMCID: PMC3244512 - DOI: 10.1021/bc200405d
Settles M, Etzrodt M, Kosanke K, Schiemann M, Zimmermann A, Meier R, Braren R, Huber A, Rummeny EJ, Weissleder R, Swirski FK, Wildgruber M Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles. PLoS ONE. 2011;6(10):e25197 - PMID: 21984904 - PMCID: PMC3184946 - DOI: 10.1371/journal.pone.0025197
Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011;29(11):1005-10 - PMID: 21983520 - PMCID: PMC3212614 - DOI: 10.1038/nbt.1989
Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells. ACS Nano. 2011;5(11):9216-24 - PMID: 21962084 - PMCID: PMC3297118 - DOI: 10.1021/nn203450p
Chung H, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles. ACS Nano. 2011;5(11):8834-41 - PMID: 21967150 - PMCID: PMC3222727 - DOI: 10.1021/nn2029692
Budin G, Yang KS, Reiner T, Weissleder R Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification. Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273
Karver M, Weissleder R, Hilderbrand SA Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation. Bioconjug Chem. 2011;22(11):2263-2270 - PMID: 21950520 - PMCID: PMC3254257 - DOI: 10.1021/bc200295y
Yoon TJ*, Lee H*, Shao H, Hilderbrand SA, Weissleder R Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles. Adv Mater. 2011;23(41):4793-7 - PMID: 21953810 - PMCID: PMC3224986 - DOI: 10.1002/adma.201102948
Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma. Mol Ther. 2011;20(1):37-45 - PMID: 21915104 - PMCID: PMC3255598 - DOI: 10.1038/mt.2011.187
Thurber GM, Weissleder R A Systems Approach for Tumor Pharmacokinetics. PLoS ONE. 2011;6(9):e24696 - PMID: 21935441 - PMCID: PMC3173470 - DOI: 10.1371/journal.pone.0024696
Zeglis BM, Mohindra P, Weissmann GI, Divilov V, Hilderbrand SA, Weissleder R, Lewis JS A Modular Strategy for the Construction of Radiometallated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry. Bioconjug Chem. 2011;22(10):2048-59 - PMID: 21877749 - PMCID: PMC3197258 - DOI: 10.1021/bc200288d
Panizzi P*, Nahrendorf M*, Jose-Luiz Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nature Med. 2011;17(9):1142-6 - PMID: 21857652 - PMCID: PMC3169740 - DOI: 10.1038/nm.2423
Liong M, Tassa C, Shaw SY, Lee H, Weissleder R Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization. Adv Mater. 2011;23(36):H254-7 - PMID: 21780311 - PMCID: PMC3584698 - DOI: 10.1002/adma.201101401
Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108
Hendricks JA, Keliher EJ, Marinelli B, Reiner T, Weissleder R, Mazitschek R In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA). J Med Chem. 2011;54(15):5576-82 - PMID: 21721525 - PMCID: PMC3150598 - DOI: 10.1021/jm200620f
Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics. Cancer Res. 2011;71(13):4608-16 - PMID: 21712408 - PMCID: PMC3129392 - DOI: 10.1158/0008-5472.CAN-11-0412
Jaffer FA, Calfon MA, Rosenthal A, Mallas G, Razansky RN, Mauskapf A, Weissleder R, Libby P, Ntziachristos V Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury. J Am Coll Cardiol. 2011;57(25):2516-26 - PMID: 21679853 - PMCID: PMC3123768 - DOI: 10.1016/j.jacc.2011.02.036
Tassa C, Shaw SY, Weissleder R Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy. Accounts Chem Res. 2011;44(10):842-52 - PMID: 21661727 - PMCID: PMC3182289 - DOI: 10.1021/ar200084x
Devaraj NK, Weissleder R Biomedical Applications of Tetrazine Cycloadditions. Accounts Chem Res. 2011;44(9):816-27 - PMID: 21627112 - PMCID: PMC3166440 - DOI: 10.1021/ar200037t
Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques. Sci Transl Med. 2011;3 (84) ra45):84ra45 - PMID: 21613624 - PMCID: PMC3112179 - DOI: 10.1126/scitranslmed.3001577
Yoon TJ*, Lee H*, Shao H, Weissleder R Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101
Buxton DB, Antman M, Danthi N, Dilsizian V, Fayad ZA, Garcia MJ, Jaff MR, Klimas M, Libby P, Nahrendorf M, Sinusas AJ, Wickline SA, Wu JC, Bonow RO, Weissleder R Report of the national heart, lung, and blood institute working group on the translation of cardiovascular molecular imaging. Circulation. 2011;123(19):2157-63 - PMID: 21576680 - PMCID: PMC3119488 - DOI: 10.1161/CIRCULATIONAHA.110.000943
Kleijn A*, Chen JW*, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clin Cancer Res. 2011;17(13):4484-93 - PMID: 21558403 - PMCID: PMC3131449 - DOI: 10.1158/1078-0432.CCR-11-0575
Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee H Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip. 2011;11(13):2282-7 - PMID: 21547317 - PMCID: PMC3115660 - DOI: 10.1039/c1lc20177h
Deliolanis NC, Wurdinger T, Pike L, Tannous BA, Breakefield XO, Weissleder R, Ntziachristos V In vivo tomographic imaging of red-shifted fluorescent proteins. Biomed Opt Express. 2011;2(4):887-900 - PMID: 21483611 - PMCID: PMC3072128 - DOI: 10.1364/BOE.2.000887
Shao F, Yuan H, Josephson L, Weissleder R, Hilderbrand SA Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores. Dyes Pigm. 2011;90(2):119-122 - PMID: 21475610 - PMCID: PMC3070263 - DOI: 10.1016/j.dyepig.2010.12.008
Haun JB, Yoon TJ, Lee H, Weissleder R Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance. Methods Mol Biol. 2011;726:33-49 - PMID: 21424441 - DOI: 10.1007/978-1-61779-052-2_3
Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R High-Yielding, Two-Step (18) F Labeling Strategy for (18) F-PARP1 Inhibitors. ChemMedChem. 2011;6(3):424-7 - PMID: 21360818 - PMCID: PMC3136544 - DOI: 10.1002/cmdc.201000426
Haun J, Devaraj NK, Marinelli B, Lee H, Weissleder R Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry. ACS Nano. 2011;5(4):3204-13 - PMID: 21351804 - PMCID: PMC3088084 - DOI: 10.1021/nn200333m
Haun JB*, Castro CM*, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples . Sci Transl Med. 2011;3(71):71ra16 - PMID: 21346169 - PMCID: PMC3086073 - DOI: 10.1126/scitranslmed.3002048
Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method. Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579
Kirsch DG, Grimm J, Guimaraes AR, Weissleder R In response to dr. Garbow and colleagues. Int J Radiat Oncol Biol Phys. 2011;79(3):959 - PMID: 21281902
Nahrendorf M, Keliher E, Marinelli B, Leuschner F, Robins CS, Gerszten RE, Pittet MJ, Swirski FK, Weissleder R Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography. Arterioscler Thromb Vasc Biol. 2011;31(4):750-7 - PMID: 21252070 - PMCID: PMC3060293 - DOI: 10.1161/ATVBAHA.110.221499
Quillard T, Croce K, Jaffer FA, Weissleder R, Libby P Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo. Thromb Haemostasis. 2011;105(5):828-36 - PMID: 21225096 - PMCID: PMC3087830 - DOI: 10.1160/TH10-09-0589
Niers JM, Chen JW, Weissleder R, Tannous BA Enhanced in Vivo Imaging of Metabolically Biotinylated Cell Surface Reporters. Anal Chem. 2011;83(3):994-9 - PMID: 21214190 - PMCID: PMC3059349 - DOI: 10.1021/ac102758m
Sun N, Yoon TJ, Lee H, Andress W, Weissleder R, Ham D Palm NMR and 1-Chip NMR. IEEE J Solid-ST Circ. 2011;46(1):342-352
Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY Dragon (Repulsive Guidance Molecule b) Inhibits IL-6 Expression in Macrophages. J Immunol. 2011;186(3):1369-76 - PMID: 21187450 - PMCID: PMC3670585 - DOI: 10.4049/jimmunol.1002047
Figueiredo JL, Nahrendorf M, Vinegoni C, Weissleder R Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury: Reply. World J Surg. 2011;35(3):694-5 - PMID: 20645091 - DOI: 10.1007/s00268-010-0728-5
Shao H, Yoon TJ, Liong M, Weissleder R, Lee H Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein J Nanotechnol. 2010;1:142154 - PMID: 21977404 - PMCID: PMC3045933 - DOI: 10.3762/bjnano.1.17
Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud. Curr Top Dev Biol. 2010;20(22):1993-2002 - PMID: 21055947 - PMCID: PMC2998074 - DOI: 10.1016/j.cub.2010.09.063
Reiner T, Earley S, Turetsky A, Weissleder R Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells. Chembiochem. 2010;11(17):2374-2377 - PMID: 20967817 - PMCID: PMC3034378 - DOI: 10.1002/cbic.201000477
Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis. Circulation. 2010;122(17):1707-15 - PMID: 20937980 - PMCID: PMC3003265 - DOI: 10.1161/CIRCULATIONAHA.109.891804
Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction. Circ Res. 2010;107(11):1364-73 - PMID: 20930148 - PMCID: PMC2992104 - DOI: 10.1161/CIRCRESAHA.110.227454
Thurber GM, Figueiredo JL, Weissleder R Detection limits of intraoperative near infrared imaging for tumor resection. J Surg Oncol. 2010;102(7):758-64 - PMID: 20872807 - PMCID: PMC3758114 - DOI: 10.1002/jso.21735
Condeelis J, Weissleder R In Vivo Imaging in Cancer. Cold Spring Harb Perspect Biol. 2010;2(12):a003848 - PMID: 20861158 - PMCID: PMC2982169 - DOI: 10.1101/cshperspect.a003848
Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A Quantitative Nanostructure-Activity Relationship Modeling. ACS Nano. 2010;4(10):5703-12 - PMID: 20857979 - PMCID: PMC2997621 - DOI: 10.1021/nn1013484
Liong M, Shao H, Haun JB, Lee H, Weissleder R Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications. Adv Mater. 2010;22(45):5168-72 - PMID: 20859943 - PMCID: PMC2993874 - DOI: 10.1002/adma.201002219
McCarthy JR, Bhaumik J, Karver MR, Sibel Erdem S, Weissleder R Targeted nanoagents for the detection of cancers. Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649 - DOI: 10.1016/j.molonc.2010.08.003
Fumene Feruglio P, Vinegoni C, Gros J, Sbarbati A, Weissleder R Block matching 3D random noise filtering for absorption optical projection tomography. Phys Med Biol. 2010;55(18):5401-5415 - PMID: 20736500 - PMCID: PMC2934766 - DOI: 10.1088/0031-9155/55/18/009
McCarthy JR, Korngold E, Weissleder R, Jaffer FA A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis. Small. 2010;6(18):2041-9 - PMID: 20721949 - PMCID: PMC3018665 - DOI: 10.1002/smll.201000596
Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis. Novel Detection by Dual-Target Fluorescence Molecular Imaging. Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475 - DOI: 10.1161/ATVBAHA.110.206342
Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010;5(9):660-5 - PMID: 20676091 - PMCID: PMC2934903 - DOI: 10.1038/nnano.2010.148
Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ Epigenetic memory in induced pluripotent stem cells. Nature. 2010;467(7313):285-90 - PMID: 20644535 - PMCID: PMC3150836 - DOI: 10.1038/nature09342
Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur Heart J. 2010;31(16):1975-84 - PMID: 20601388 - PMCID: PMC2921509 - DOI: 10.1093/eurheartj/ehq237
Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R Near-Infrared Fluorescent Probe for Imaging of Pancreatic B Cells. Bioconjug Chem. 2010;21:1362-1368 - PMID: 20583828 - PMCID: PMC2912453 - DOI: 10.1021/bc100184w
Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010;120(7):2627-34 - PMID: 20577051 - PMCID: PMC2898607 - DOI: 10.1172/JCI42304
Libby P, Nahrendorf M, Weissleder R Molecular imaging of atherosclerosis: a progress report. Tex Heart I J. 2010;37(3):324-7 - PMID: 20548813 - PMCID: PMC2879214
Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Aleman JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling. Cancer Res. 2010;70(13):5305-5315 - PMID: 20530665 - PMCID: PMC3204358 - DOI: 10.1158/0008-5472.CAN-09-3399
Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine-Norbornene Cycloaddition. J Am Chem Soc. 2010;132(23):7838-9 - PMID: 20481508 - PMCID: PMC2892974 - DOI: 10.1021/ja101677r
Libby P, DiCarli M, Weissleder R The Vascular Biology of Atherosclerosis and Imaging Targets. J Nucl Med. 2010;51 Suppl 1:33S-37S - PMID: 20395349 - DOI: 10.2967/jnumed.109.069633
Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS ONE. 2010;5(4):e10032 - PMID: 20386609 - PMCID: PMC2850367 - DOI: 10.1371/journal.pone.0010032
Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107
Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089
Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Opt Lett. 2010;35(7):1088-90 - PMID: 20364226 - PMCID: PMC2900933 - DOI: 10.1364/OL.35.001088
Haun JB, Yoon TJ, Lee H, Weissleder R Magnetic nanoparticle biosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(3):291-304 - PMID: 20336708 - DOI: 10.1002/wnan.84
van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors. Oncogene. 2010;29(22):3185-95 - PMID: 20305695 - PMCID: PMC3390229 - DOI: 10.1038/onc.2010.75
Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells. Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120
Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T Imaging Primary Lung Cancers in Mice to Study Radiation Biology. Int J Radiat Oncol Biol Phys. 2010;76(4):973-977 - PMID: 20206017 - PMCID: PMC2847457 - DOI: 10.1016/j.ijrobp.2009.11.038
Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922 - DOI: 10.1073/pnas.0911929107
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha. Cell. 2010;140(2):280-293 - PMID: 20141841 - PMCID: PMC2821045 - DOI: 10.1016/j.cell.2009.12.041
Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules. Stem Cells. 2010;28(4):832-41 - PMID: 20127797 - PMCID: PMC3021283 - DOI: 10.1002/stem.313
Hamilton AM, Rogers KA, Belisle AJ, Ronald JA, Rutt BK, Weissleder R, Boughner DR Early identification of aortic valve sclerosis using iron oxide enhanced MRI. J Magn Reson Imaging. 2010;31(1):110-6 - PMID: 20027578 - PMCID: PMC5638659 - DOI: 10.1002/jmri.22008
Rodriguez E, Nilges M, Weissleder R, Chen JW Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. J Am Chem Soc. 2010;132(1):168-77 - PMID: 19968300 - PMCID: PMC2802665 - DOI: 10.1021/ja905274f
Figueiredo JL, Siegel C, Nahrendorf M, Weissleder R Intraoperative Near-Infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury. World J Surg. 2010;34 (2):336-343 - PMID: 20033407 - PMCID: PMC2809822 - DOI: 10.1007/s00268-009-0332-8
Tassa C, Duffner JL, Lewis TA, Weissleder R, Schreiber SL, Koehler AN, Shaw SY Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles. Bioconjug Chem. 2010;21:14-19 - PMID: 20028085 - PMCID: PMC2902264 - DOI: 10.1021/bc900438a
Taboada E, Solanas R, Rodriguez E, Weissleder R, Roig A Supercritical-Fluid-Assisted One-Pot Synthesis of Biocompatible Core (γ-Fe2O3)/Shell(SiO2) Nanoparticles as High Relaxivity T2-Contrast Agents for Magnetic Resonance Imaging. Adv Funct Mater. 2009;19 :2319-2324
Chen S, Reynolds F, Yu L, Weissleder R, Josephson L A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles. J Mater Chem. 2009;19:6387-6392
Vinegoni C, Fexon L, Fumene Feruglio P, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R High throughput transmission optical projection tomography using low cost graphics processing unit. Opt Express. 2009;17(25):22320-22332 - PMID: 20052155 - PMCID: PMC2805020 - DOI: 10.1364/OE.17.022320
Tsai CC, Vinegoni C, Weissleder R Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide. Opt Express. 2009;17(24):21723-31 - PMID: 19997414 - PMCID: PMC2805120 - DOI: 10.1364/OE.17.021723
Thurber GM, Figueiredo JL, Weissleder R Multicolor Fluorescent Intravital Live Microscopy (FILM) for Surgical Tumor Resection in a Mouse Xenograft Model. PLoS ONE. 2009;4(11):e8053 - PMID: 19956597 - PMCID: PMC2779447 - DOI: 10.1371/journal.pone.0008053
Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L Molecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo: Potential for Midmyocardial Salvage in Acute Ischemia. Circ Cardiovasc Imaging. 2009;2(6):460-467 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678
Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure. Circ Cardiovasc Imaging. 2009;2(6):468-475 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779
Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L A Wortmannin-Cetuximab as a Double Drug. Bioconjug Chem. 2009;20 :2185-2189 - PMID: 19883074 - PMCID: PMC3386608 - DOI: 10.1021/bc900176a
Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R 18F-4V for PET-CT Imaging of VCAM-1 Expression in Atherosclerosis. J Am Coll Cardiol Img. 2009;2:1213-1222 - PMID: 19833312 - PMCID: PMC2773129 - DOI: 10.1016/j.jcmg.2009.04.016
Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation. J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134 - DOI: 10.1021/ja903922u
Duchrow T, Shtatland T, Guettler D, Pivovarov M, Kramer S, Weissleder R Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC Bioinformatics. 2009;10(1):317 - PMID: 19799796 - PMCID: PMC2768718 - DOI: 10.1186/1471-2105-10-317
Martinez-Boubeta C, Balcells L, Cristool R, Sanfeliu C, Rodriguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martinez B Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia. Nanomedicine. 2009;6(2):362-370 - PMID: 19800988 - DOI: 10.1016/j.nano.2009.09.003
Vinegoni C, Razansky D, Hilderbrand SA, Shao F, Ntziachristos V, Weissleder R Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles. Opt Lett. 2009;34(17):2566-8 - PMID: 19724491 - PMCID: PMC2749971 - DOI: 10.1364/OL.34.002566
Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila. J Vis Exp. 2009;(30):pii:1510 - PMID: 19696720 - PMCID: PMC2736679 - DOI: 10.3791/1510
Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition. Angew Chem Int Ed Engl. 2009;48(38):7013-6 - PMID: 19697389 - PMCID: PMC2790075 - DOI: 10.1002/anie.200903233
McCarthy JR, Bhaumik J, Merbouh N, Weissleder R High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins. Org Biomol Chem. 2009;7(17):3430-6 - PMID: 19675897 - PMCID: PMC2749955 - DOI: 10.1039/b908713c
Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques. Circulation. 2009;120(7):592-9 - PMID: 19652086 - PMCID: PMC2736635 - DOI: 10.1161/CIRCULATIONAHA.108.813998
Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheumatol. 2009;60:2314-2324 - PMID: 19644878 - PMCID: PMC3080016 - DOI: 10.1002/art.24704
Swirski* FK, Nahrendorf* M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites. Science. 2009;325 (5940):612-6 - PMID: 19644120 - PMCID: PMC2803111 - DOI: 10.1126/science.1175202
Lee H*, Yoon TJ*, Figueiredo JL, Swirski FK, Weissleder R Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106
Bhaumik J, Weissleder R, McCarthy JR Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers. J Org Chem. 2009;74(16):5894-901 - PMID: 19610602 - PMCID: PMC2888918 - DOI: 10.1021/jo900832y
Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors. Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086
Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun. 2009;(29):4444-6 - PMID: 19597620 - PMCID: PMC2754278 - DOI: 10.1039/b907375b
Hilderbrand SA, Shao F, Salthouse C, Mahmood U, Weissleder R Upconverting luminescent nanomaterials: application to in vivo bioimaging. Chem Commun. 2009;28:4188-90 - PMID: 19585016 - PMCID: PMC2748243 - DOI: 10.1039/b905927j
Rajendran R*, Ronald JA*, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections. Microsc Micoranal. 2009;15:338-44 - PMID: 19575834 - PMCID: PMC2802450 - DOI: 10.1017/S1431927609090813
Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clin Imaging. 2009;33(4):301-5 - PMID: 19559353 - DOI: 10.1016/j.clinimag.2009.01.013
Lee H*, Yoon TJ*, Weissleder R Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System. Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791
Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. Int J Radiat Oncol Biol Phys. 2009;74(4):1207-16 - PMID: 19545786 - PMCID: PMC2733223 - DOI: 10.1016/j.ijrobp.2009.02.052
Vonken EJ, Korosoglou G, Yu J, Schar M, Weissleder R, Stuber M On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA). Magn Reson Med. 2009;62(2):314-24 - PMID: 19526511 - PMCID: PMC2742771 - DOI: 10.1002/mrm.22027
Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009;19(15):4223-7 - PMID: 19523825 - PMCID: PMC2877487 - DOI: 10.1016/j.bmcl.2009.05.105
Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther. 2009;8(6):1666-1675 - PMID: 19509266 - PMCID: PMC2740925 - DOI: 10.1158/1535-7163.MCT-08-1012
McCarthy JR, Patel P, Botnaru I, Haghayeghi P, Weissleder R, Jaffer FA Multimodal Nanoagents for the Detection of Intravascular Thrombi. Bioconjug Chem. 2009;20(6):1251-5 - PMID: 19456115 - PMCID: PMC2733224 - DOI: 10.1021/bc9001163
Figueiredo JL, Nahrendorf M, Sosnovik DE, Weissleder R MRI of a Novel Murine Working Heart Transplant Model. Circ Heart Fail. 2009;2:272-274 - PMID: 19718275 - PMCID: PMC2733535 - DOI: 10.1161/CIRCHEARTFAILURE.109.852707
Daniel KD, Kim GY, Vassiliou CC, Galindo M, Guimaraes AR, Weissleder R, Charest A, Langer R, Cima MJ Implantable diagnostic device for cancer monitoring. Biosens Bioelectron. 2009;24(11):3252-7 - PMID: 19442510 - PMCID: PMC2738970 - DOI: 10.1016/j.bios.2009.04.010
Wildgruber M, Lee H, Chudnovskiy A, Yoon T, Etzrodt M, Pittet M, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski F Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS ONE. 2009;4(5):e5663 - PMID: 19461894 - PMCID: PMC2680949 - DOI: 10.1371/journal.pone.0005663
Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging. J Vis Exp. 2009;28:1389 - PMID: 19578329 - PMCID: PMC2794886 - DOI: 10.3791/1389
Sun N, Liu Y, Lee H, Weissleder R, Ham D CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance. IEEE J Solid-ST Circ. 2009;44:1629-1643
Bullain SS, Sahin A, Szentirmai O, Sanchez C, Lin N, Baratta E, Waterman P, Weissleder R, Mulligan RC, Carter BS Genetically engineered T cells to target EGFRvIII expressing glioblastoma. J Neuro-Oncol. 2009;94(3):373-82 - PMID: 19387557 - PMCID: PMC2730985 - DOI: 10.1007/s11060-009-9889-1
Swirski FK, Weissleder R, Pittet MJ Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29(10):1424-32 - PMID: 19372462 - PMCID: PMC2746262 - DOI: 10.1161/ATVBAHA.108.180521
Jaffer FA, Libby P, Weissleder R Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29(7):1017-24 - PMID: 19359659 - PMCID: PMC2733228 - DOI: 10.1161/ATVBAHA.108.165530
Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton A, Waterman P, Figueiredo JL, Kohler R, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009;11(5):459-468 - PMID: 19412430 - PMCID: PMC2672160 - DOI: 10.1593/neo.09356
Christen T*, Nahrendorf M*, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P Molecular Imaging of Innate Immune Cell Function in Transplant Rejection. Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888
Koh I, Hong R, Weissleder R, Josephson L Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions. Anal Chem. 2009;81(9):3618-22 - PMID: 19323458 - PMCID: PMC2690647 - DOI: 10.1021/ac802717c
Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease. Circulation. 2009;119(13):1785-94 - PMID: 19307473 - PMCID: PMC2717745 - DOI: 10.1161/CIRCULATIONAHA.108.827972
Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771 - DOI: 10.1073/pnas.0806647106
Tannous BA, Christensen AP, Pike L, Wurdinger T, Perry KF, Saydam O, Jacobs AH, Garcia-Anoveros J, Weissleder R, Sena-Esteves M, Corey DP, Breakefield XO Mutant Sodium Channel for Tumor Therapy. Mol Cancer Ther. 2009;17(5):810-9 - PMID: 19259066 - PMCID: PMC2751883 - DOI: 10.1038/mt.2009.33
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331 - DOI: 10.1073/pnas.0813314106
Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R Normalized Born ratio for fluorescence optical projection tomography. Opt Lett. 2009;34(3):319-21 - PMID: 19183644 - PMCID: PMC2771918 - DOI: 10.1364/ol.34.000319
Kelly K*, Shaw SY*, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integr Biol (Camb). 2009;1(4):311-317 - PMID: 20023731 - PMCID: PMC2748356 - DOI: 10.1039/b821775k
Devaraj NK*, Keliher EJ*, Thurber GM, Nahrendorf M, Weissleder R (18)F Labeled Nanoparticles for in Vivo PET-CT Imaging. Bioconjug Chem. 2009;20(2):397-401 - PMID: 19138113 - PMCID: PMC2644737 - DOI: 10.1021/bc8004649
Sheth RA, Upadhyay R, Stangenberg L, Sheth R, Weissleder R, Mahmood U Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model. Gynecol Oncol. 2009;112(3):616-22 - PMID: 19135233 - PMCID: PMC2664404 - DOI: 10.1016/j.ygyno.2008.11.018
Garanger E, Weissleder R, Josephson L A Multifunctional Single-Attachment-Point Reagent for Controlled Protein Biotinylation. Bioconjug Chem. 2009;20(1):170-173 - PMID: 19072220 - PMCID: PMC2692913 - DOI: 10.1021/bc800392t
Salthouse C, Weissleder R, Mahmood U Development of a Time Domain Fluorimeter (TDF) for Fluorescent Lifetime Multiplexing Analysis. 2008;3:204-211
Rusanescu G, Weissleder R, Aikawa E Notch signaling in cardiovascular disease and calcification. Curr Cardiol Review. 2008;4(3):148-56 - PMID: 19936191 - PMCID: PMC2780816 - DOI: 10.2174/157340308785160552
Salthouse CD, Weissleder R, Mahmood U Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis. IEEE T Biomed Circuits Syst. 2008;2(3):204-211 - PMID: 19830273 - PMCID: PMC2760943 - DOI: 10.1109/TBCAS.2008.2003195
McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2008;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831 - DOI: 10.1016/j.neuroimage.2008.12.022
Salthouse C, Hilderbrand S, Weissleder R, Mahmood U Design and demonstration of a small-animal up-conversion imager. Opt Express. 2008;16 (26):21731-7 - PMID: 19104605 - PMCID: PMC2717740 - DOI: 10.1364/oe.16.021731
Jeong JH, Wang Z, Guimaraes AS, Ouyang X, Figueiredo JL, Ding Z, Jiang S, Guney I, Kang GH, Shin E, Hahn WC, Loda MF, Abate-Shen C, Weissleder R, Chin L BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. PLoS ONE. 2008;3(12):e3949 - PMID: 19079609 - PMCID: PMC2597248 - DOI: 10.1371/journal.pone.0003949
Devaraj N, Weissleder R, Hilderbrand S Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging. Bioconjug Chem. 2008;19(12):2297-2299 - PMID: 19053305 - PMCID: PMC2677645 - DOI: 10.1021/bc8004446
Shao F, Weissleder R, Hilderbrand SA Monofunctional Carbocyanine Dyes for Bio- and Bioorthogonal Conjugation. Bioconjug Chem. 2008;19(12): :2487-2491 - PMID: 19053316 - PMCID: PMC2656649 - DOI: 10.1021/bc800417b
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garcia-Echeverria C, Weissleder R, Mahmood U, Cantley LC, Wong KK Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Med. 2008;14(12)::1351-1356 - PMID: 19029981 - PMCID: PMC2683415 - DOI: 10.1038/nm.1890
Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proc Natl Acad Sci U S A. 2008;105(49)::19126-19131 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105
Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase. Proc Natl Acad Sci U S A. 2008;105 (47):18584-18589 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105
Kozloff KM, Quinti L, Patntirapong S, Hauschka PV, Tung CH, Weissleder R, Mahmood U Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo. Bone. 2008;44:190-198 - PMID: 19007918 - PMCID: PMC2656637 - DOI: 10.1016/j.bone.2008.10.036
Hingtgen S, Ren X, Terwilliger E, Classon M, Weissleder R, Shah K Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Mol Cancer Ther. 2008;7(11):3575-85 - PMID: 19001440 - PMCID: PMC2748233 - DOI: 10.1158/1535-7163.MCT-08-0640
Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008;118(12):4058-66 - PMID: 19033674 - PMCID: PMC2579705 - DOI: 10.1172/JCI36335
Wurdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells. Cancer Cell. 2008;14(5):382-393 - PMID: 18977327 - PMCID: PMC2597164 - DOI: 10.1016/j.ccr.2008.10.005
Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas. 2008;37(4):440-4 - PMID: 18953259 - PMCID: PMC3806135 - DOI: 10.1097/MPA.0b013e31817c5113
Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK Regression of drug-resistant lung cancer by the combination of rosiglitazone and Carboplatin. Clin Cancer Res. 2008;14(20):6478-86 - PMID: 18927287 - PMCID: PMC2696122 - DOI: 10.1158/1078-0432.CCR-08-1128
Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis. Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881
Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L Simplified syntheses of complex multifunctional nanomaterials. Chem Commun. 2008;39:4792-4 - PMID: 18830495 - PMCID: PMC2692914 - DOI: 10.1039/b809537j
Perez JM, Grimm J, Josephson L, Weissleder R Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia. 2008;10(10):1066-72 - PMID: 18813356 - PMCID: PMC2546593 - DOI: 10.1593/neo.08350
Korosoglou G, Shah S, Vonken EJ, Gilson WD, Schar M, Tang L, Kraitchman DL, Boston RC, Sosnovik DE, Weiss RG, Weissleder R, Stuber M Off-Resonance Angiography: A New Method to Depict Vessels--Phantom and Rabbit Studies. Radiology. 2008;249(2)::501-509 - PMID: 18780823 - PMCID: PMC2657865 - DOI: 10.1148/radiol.2491071706
Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Plough HL, Barrett TA, Weissleder R, Khazaie K Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS ONE. 2008;3:e2916 - PMID: 18698347 - PMCID: PMC2488397 - DOI: 10.1371/journal.pone.0002916
Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schar M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging. J Am Coll Cardiol. 2008;52:483-91 - PMID: 18672170 - PMCID: PMC2628468 - DOI: 10.1016/j.jacc.2008.03.063
Hilderbrand SA, Kelly KA, Niedre M, Weissleder R Near Infrared Fluorescence-Based Bacteriophage Particles for Ratiometric pH Imaging. Bioconjug Chem. 2008;19(8):1635-9 - PMID: 18666791 - PMCID: PMC2705288 - DOI: 10.1021/bc800188p
Sosnovik DE, Nahrendorf M, Weissleder R Targeted imaging of myocardial damage. Nat Clin Pract Card. 2008;5 Suppl 2:S63-70 - PMID: 18641609 - PMCID: PMC2597275 - DOI: 10.1038/ncpcardio1115
Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy. Radiology. 2008;248(3):925-35 - PMID: 18647846 - PMCID: PMC2798096 - DOI: 10.1148/radiol.2482071496
Lin KY, Maricevich M, Bardeesy N, Weissleder R, Mahmood U In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe. Transl Oncol. 2008;1:84-94 - PMID: 18633456 - PMCID: PMC2510813 - DOI: 10.1593/tlo.08118
Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L Slow Self-Activation Enhances The Potency of Viridin Prodrugs. J Med Chem. 2008;51(15):4699-707 - PMID: 18630894 - PMCID: PMC2663427 - DOI: 10.1021/jm800374f
Lee H, Sun E, Ham D, Weissleder R Chip-NMR biosensor for detection and molecular analysis of cells. Nature Med. 2008;14(8):869-74 - PMID: 18607350 - PMCID: PMC2729055 - DOI: 10.1038/nm.1711
Taktak S, Weissleder R, Josephson L Electrode Chemistry Yields a Nanoparticle-Based NMR Sensor for Calcium. Langmuir. 2008;24 (14):7596-7598 - PMID: 18558729 - PMCID: PMC2748273 - DOI: 10.1021/la8006298
McCarthy JR, Weissleder R Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev. 2008;60:1241-1251 - PMID: 18508157 - PMCID: PMC2583936 - DOI: 10.1016/j.addr.2008.03.014
Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R Perturbational profiling of nanomaterial biologic activity. Proc Natl Acad Sci U S A. 2008;105:7387-7392 - PMID: 18492802 - PMCID: PMC2396702 - DOI: 10.1073/pnas.0802878105
Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci. 2008;28:4406-13 - PMID: 18434519 - PMCID: PMC3021321 - DOI: 10.1523/JNEUROSCI.0296-08.2008
Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schar M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON). J Magn Reson Imaging. 2008;27(5):1175-1180 - PMID: 18425827 - PMCID: PMC2740932 - DOI: 10.1002/jmri.21337
Koh I, Hong R, Weissleder R, Josephson L Sensitive NMR Sensors Detect Antibodies to Influenza. Angew Chem Int Ed Engl. 2008;47(22):4119-4121 - PMID: 18428168 - PMCID: PMC2668198 - DOI: 10.1002/anie.200800069
Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma. PLoS Med. 2008;5(4):e85 - PMID: 18416599 - PMCID: PMC2292750 - DOI: 10.1371/journal.pmed.0050085
Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R Detection of early prostate cancer using a hepsin-targeted imaging agent. Cancer Res. 2008;68(7):2286-91 - PMID: 18381435 - PMCID: PMC2709884 - DOI: 10.1158/0008-5472.CAN-07-1349
Weissleder R, Pittet MJ Imaging in the era of molecular oncology. Nature. 2008;452:580-589 - PMID: 18385732 - PMCID: PMC2708079 - DOI: 10.1038/nature06917
Nahrendorf M, Sosnovik DE, Weissleder R MR-optical imaging of cardiovascular molecular targets. Basic Res Cardiol. 2008;103:87-94 - PMID: 18324364 - PMCID: PMC2664635 - DOI: 10.1007/s00395-008-0707-2
Sosnovik DE, Nahrendorf M, Weissleder R Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol. 2008;103(2):122-30 - PMID: 18324368 - PMCID: PMC2597271 - DOI: 10.1007/s00395-008-0710-7
Hong R, Cima MJ, Weissleder R, Josephson L Magnetic microparticle aggregation for viscosity determination by MR. Magn Reson Med. 2008;59:515-520 - PMID: 18306403 - PMCID: PMC2740908 - DOI: 10.1002/mrm.21526
Figueiredo JL, Passerotti CC, Sponholtz T, Nguyen HT, Weissleder R A Novel Method of Imaging Calcium Urolithiasis Using Fluorescence. J Urolology. 2008;179:1610-1614 - PMID: 18295253 - DOI: 10.1016/j.juro.2007.11.100
Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-Enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer. Urology. 2008;71(4):708-12 - PMID: 18295316 - DOI: 10.1016/j.urology.2007.11.096
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne S, Blankesteijn M, Sosnovik D, Jaffer F, Tung CH, Weissleder R Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction. Eur Heart J. 2008;29:445-454 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558
Nahrendorf M*, Sosnovik D*, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury. Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510
Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain. 2008;131(Pt 4):1123-33 - PMID: 18234693 - PMCID: PMC4044727 - DOI: 10.1093/brain/awn004
Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods. 2008;5:171-173 - PMID: 18204457 - PMCID: PMC2699561 - DOI: 10.1038/nmeth.1177
Kircher M, Grimm J, Swirski FK, Libby P, Gerszten R, Allport J, Weissleder R Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation. 2008;117:388-395 - PMID: 18172031 - PMCID: PMC2705289 - DOI: 10.1161/CIRCULATIONAHA.107.719765
Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE Noninvasive imaging of apoptosis in cardiovascular disease. Heart Fail Rev. 2008;13(2)::163-173 - PMID: 18074226 - PMCID: PMC2597223 - DOI: 10.1007/s10741-007-9068-4
Hilderbrand SA, Weissleder R One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes. Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723 - DOI: 10.1016/j.tetlet.2007.04.088
Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408 - DOI: 10.1073/pnas.0704620104
Harisinghani M, Ross R, Guimaraes A, Weissleder R Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging. Neoplasia. 2007;(9)12:1160-1165 - PMID: 18084623 - PMCID: PMC2134912 - DOI: 10.1593/neo.07940
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B. Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy. J Natl Cancer Inst. 2007;(99) 23:1768-1781 - PMID: 18042934 - DOI: 10.1093/jnci/djm229
Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chem Biol. 2007;14:1221-31 - PMID: 18022561 - PMCID: PMC2785040 - DOI: 10.1016/j.chembiol.2007.10.005
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885
Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L Fate of a Bioactive Fluorescent Wortmannin Derivative in Cells. Bioconjug Chem. 2007;19:130-137 - PMID: 17988080 - DOI: 10.1021/bc7002204
Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L Multiparameter Magnetic Relaxation Switch Assays. Anal Chem. 2007;(79) 23:8863-9 - PMID: 17983206 - DOI: 10.1021/ac701976p
Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS ONE. 2007;2(10):e1075 - PMID: 17957257 - PMCID: PMC2034600 - DOI: 10.1371/journal.pone.0001075
Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik D, Aikawa E, Libby P, Swirski F, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2007;117:379-387 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181
Upadhyay R, Sheth RA, Weissleder R, Mahmood U Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice. Radiology. 2007;245(2):523-31 - PMID: 17940307 - DOI: 10.1148/radiol.2452061613
Law B, Weissleder R, Tung CH Protease-Sensitive Fluorescent Nanofibers. Bioconjug Chem. 2007;(18) 6 ::1701-1704 - PMID: 17915958 - PMCID: PMC2528070 - DOI: 10.1021/bc070054z
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res. 2007;67(19):9398-406 - PMID: 17909049 - PMCID: PMC2850558 - DOI: 10.1158/0008-5472.CAN-07-1063
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas. Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999 - DOI: 10.1158/0008-5472.CAN-07-1045
Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. . Circulation. 2007;116(24):2841-50 - PMID: 18040026 - DOI: 10.1161/CIRCULATIONAHA.107.732867
Jaffer FA, Libby P, Weissleder R Molecular imaging of cardiovascular disease. Circulation. 2007;116(9):1052-61 - PMID: 17724271 - DOI: 10.1161/CIRCULATIONAHA.106.647164
Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging. Mol Imaging. 2007;6(4):269-76 - PMID: 17711782
Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment. Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072 - DOI: 10.1002/ijc.22995
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R PepBank - a database of peptides based on sequence text mining and public peptide data sources. BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427 - DOI: 10.1186/1471-2105-8-280
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Med. 2007;13(8):992-997 - PMID: 17676052 - DOI: 10.1038/nm1602
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K. Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo. Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203 - DOI: 10.1158/0008-5472.CAN-07-0077
Kim Y, Choi Y, Weissleder R, Tung CH Membrane permeable esterase-activated fluorescent imaging probe. Bioorg Med Chem Lett. 2007;17(18):5054-7 - PMID: 17664067 - PMCID: PMC1995663 - DOI: 10.1016/j.bmcl.2007.07.026
Kelly KA, Carson J, McCarthy JR, Weissleder R Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging. PLoS ONE. 2007;2:e665 - PMID: 17653285 - PMCID: PMC1919420 - DOI: 10.1371/journal.pone.0000665
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med. 2007;204:1911-1922 - PMID: 17646407 - PMCID: PMC2118664 - DOI: 10.1084/jem.20070285
Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104
Sosnovik DE, Weissleder R Emerging concepts in molecular MRI. Curr Opin Biotech. 2007;18(1):4-10 - PMID: 17126545 - DOI: 10.1016/j.copbio.2006.11.001
Kock N, Kasmieh R, Weissleder R, Shah K Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL. Neoplasia. 2007;9(5):435-42 - PMID: 17534449 - PMCID: PMC1877976 - DOI: 10.1593/neo.07223
Kim YM, Hilderbrand S, Weissleder R, Tung CH Sugar sensing based on induced pH changes. Chem Commun. 2007;(22):2299-2301 - PMID: 17534523 - DOI: 10.1039/b700741h
Sheth RA, Upadhyay R, Weissleder R, Mahmood U Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems. Mol Imaging. 2007;6(3):147-55 - PMID: 17532881
Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection. Radiology. 2007;244(1):232-8 - PMID: 17507718 - DOI: 10.1148/radiol.2441052114
Kozloff KM, Weissleder R, Mahmood U Non-Invasive Optical Detection of Bone Mineral. J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196 - DOI: 10.1359/jbmr.070504
Sosnovik DE, Nahrendorf M, Weissleder R Molecular magnetic resonance imaging in cardiovascular medicine. Circulation. 2007;115(15):2076-86 - PMID: 17438163 - DOI: 10.1161/CIRCULATIONAHA.106.658930
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor. Circulation. 2007;115(17):2292-8 - PMID: 17420353 - DOI: 10.1161/CIRCULATIONAHA.106.660340
Hilderbrand S, Weissleder R. Optimized pH-responsive cyanine fluorochromes for detection of acidic environments. Chem Commun. 2007;(26):2747-9 - PMID: 17594041 - DOI: 10.1039/b703764c
McCarthy J, Kelly KA, Sun EY, Weissleder R. Targeted delivery of multifunctional magnetic nanoparticles. Nanomedicine. 2007;2(2):153-167 - PMID: 17716118 - DOI: 10.2217/17435889.2.2.153
Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L Covalent Reactions of Wortmannin under Physiological Conditions. Chem Biol. 2007;14(3):321-8 - PMID: 17379147 - DOI: 10.1016/j.chembiol.2007.02.007
Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007;100:1218-1225 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo. Circulation. 2007;115:1384-1391 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351
Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT. Am J Physiol-Heart C. 2007;292(6):3172-8 - PMID: 17322414 - PMCID: PMC2680216 - DOI: 10.1152/ajpheart.01307.2006
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R. Tomographic fluorescence imaging of tumor vascular volume in mice. Radiology. 2007;242 (3):751-758 - PMID: 17325064 - DOI: 10.1148/radiol.2423052065
Montet-Abou K, Montet X, Weissleder R, Josephson L Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging. 2007;(6) 1:1-9 - PMID: 17311760
Ho NH, Weissleder R, Tung CH A Self-Immolative Reporter For beta-Galactosidase Sensing. Chembiochem. 2007;8:560-566 - PMID: 17300128 - DOI: 10.1002/cbic.200600386
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T Restoration of p53 function leads to tumour regression in vivo. Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541
McCarthy JR, Weissleder R Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins. ChemMedChem. 2007;2:360-365 - PMID: 17245681 - DOI: 10.1002/cmdc.200600244
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease. Circulation. 2007;115:377-386 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117(1):195-205 - PMID: 17200719 - PMCID: PMC1716211 - DOI: 10.1172/JCI29950
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis. Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214 - DOI: 10.1002/art.22303
Grimm J, Kircher MF, Weissleder R Cell tracking : Principles and applications. Radiologe. 2007;47(1):25-33 - PMID: 17187264 - DOI: 10.1007/s00117-006-1449-5
Nahrendorf M, Weissleder R Advances in cardiovascular medicine through molecular imaging. Radiologe. 2007;47(1):18-24 - PMID: 17187263 - DOI: 10.1007/s00117-006-1450-z
Nahrendorf M, Weissleder R, Ertl G Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?. PLoS ONE. 2006;1:e48 - PMID: 17183677 - PMCID: PMC1762326 - DOI: 10.1371/journal.pone.0000048
Kelly KA, Waterman P, Weissleder R. In vivo imaging of molecularly targeted phage. Neoplasia. 2006;8 (12):1011-1018
Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging. Radiology. 2006;241(3):822-830 - PMID: 17114629 - DOI: 10.1148/radiol.2413050466
Saksena M, Harisinghani M, Hahn P, Kim J, Saokar A, King B, Weissleder R Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers. AJR Am J Roentgenol. 2006;187(6):W582-8 - PMID: 17114509 - DOI: 10.2214/AJR.05.0873
Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity. J Immunol. 2006;177:6991-8 - PMID: 17082614 - DOI: 10.4049/jimmunol.177.10.6991
Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R Molecular imaging of myocardial infarction. J Mol Cell Cardiol. 2006;41:921-933 - PMID: 17067633 - DOI: 10.1016/j.yjmcc.2006.09.008
Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging. Mol Ther. 2006;4(6):779-88 - PMID: 16996314 - PMCID: PMC2819149 - DOI: 10.1016/j.ymthe.2006.08.008
Choi Y, Weissleder R, Tung CH Protease-mediated phototoxicity of a polylysine-chlorin(E6) conjugate. ChemMedChem. 2006;1:698-701 - PMID: 16902920 - DOI: 10.1002/cmdc.200600053
Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization. Gastrointest Endosc. 2006;64(4):589-97 - PMID: 16996355 - DOI: 10.1016/j.gie.2006.02.048
Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis. Circulation. 2006;114:1504-1511 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380
Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L. Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem. 2006;49(20):6087-6093
Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice. Neoplasia. 2006;8(9):772-80 - PMID: 16984734 - PMCID: PMC1584300 - DOI: 10.1593/neo.06331
Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg. 2006;105:445-54 - PMID: 16961141 - DOI: 10.3171/jns.2006.105.3.445
Zacharakis G, Shih H, Ripoll J, Weissleder R, Ntziachristos V Normalized transillumination of fluorescent proteins in small animals. Mol Imaging. 2006;5 (2):153-9 - PMID: 16954030
Jaffer F, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials. Mol Imaging. 2006;(5) 2 :85-92 - PMID: 16954022
Law B, Quinti L, Choi YD, Weissleder R, Tung CH A Mitochondrial Targeted Fusion Peptide Exhibits Remarkable Cytotoxicity. Mol Cancer Ther. 2006;5 (8):1944-1949 - PMID: 16928814 - DOI: 10.1158/1535-7163.MCT-05-0509
Sun EY, Weissleder R, Josephson L. Continuous Analyte Sensing with Magnetic Nanoswitches. Small. 2006;(2) 10:1144-1147 - PMID: 17193579 - DOI: 10.1002/smll.200600204
Sun EY, Josephson L, Weissleder R. Clickable nanoparticles for targeted imaging. Mol Imaging. 2006;(5) 2:122-128 - PMID: 16954026
Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940 - DOI: 10.1073/pnas.0605496103
Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006;25(1):129-41 - PMID: 16860762 - DOI: 10.1016/j.immuni.2006.04.015
Chen JW, Querol Sans M, Bogdanov Jr A, Weissleder R Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology. 2006;240 (2):473-81 - PMID: 16864673 - DOI: 10.1148/radiol.2402050994
Galande A, Hilderbrand S, Weissleder R, Tung CH. Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core. J Med Chem. 2006;49(15):4715-20 - PMID: 16854078 - DOI: 10.1021/jm051001a
Choi YD, Weissleder R, Tung CH. Selective antitumor effect of novel protease-mediated photodynamic agent. Cancer Res. 2006;66 (14):7225-7229 - PMID: 16849570 - DOI: 10.1158/0008-5472.CAN-06-0448
Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem. 2006;17(4):905-911 - PMID: 16848396 - DOI: 10.1021/bc060035+
McCarthy J, Jaffer F, Weissleder R. A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications . Small. 2006;2(8-9):983-987 - PMID: 17193154 - DOI: 10.1002/smll.200600139
Hsiao JK, Law B, Weissleder R, Tung CH In-vivo imaging of tumor associated urokinase-type plasminogen activator activity. J Biomed Opt. 2006;11(3):34013 - PMID: 16822063 - DOI: 10.1117/1.2204029
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P Inflammation in Atherosclerosis. Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo. Circulation. 2006;114:55-62 - PMID: 16801460 - DOI: 10.1161/CIRCULATIONAHA.106.619056
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Pittet M, Swirski F, Reynolds F, Josephson L, Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc. 2006;1(1):73-79 - PMID: 17406214 - DOI: 10.1038/nprot.2006.11
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell. 2006;9(6):485-95 - PMID: 16730237 - DOI: 10.1016/j.ccr.2006.04.022
Weissleder R. Molecular Imaging in Cancer. Science. 2006;312:1168-1171 - PMID: 16728630 - DOI: 10.1126/science.1125949
Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption. Mol Cell Biol. 2006;26(11):4185-200 - PMID: 16705170 - PMCID: PMC1489079 - DOI: 10.1128/MCB.01055-05
Kelly KA, Nahrendorf M, Yu AM, Reynolds F, Weissleder R In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging. Mol Imaging Biol. 2006;8(4):201-7 - PMID: 16791746 - DOI: 10.1007/s11307-006-0043-6
Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. J Biomed Opt. 2006;11(2):21009 - PMID: 16674184 - DOI: 10.1117/1.2186337
Kelly KA, Clemons PA, Yu AM, Weissleder R High throughput identification of phage-derived imaging agents. Mol Imaging. 2006;5(1):24-30 - PMID: 16779967
Trehin R, Figueiredo JL, Pittet M, Weissleder R, Josephson L, Mahmood U. Fluorescent Nanoparticle Uptake for Brain Tumor Visualization. Neoplasia. 2006;8(4):302-311 - PMID: 16756722 - PMCID: PMC1600680 - DOI: 10.1593/neo.05751
Tannous B*, Grimm J*, Perry K, Chen J, Weissleder R, Breakefield X. Metabolic Biotinylation of Cell Surface Receptors for in vivo Imaging. Nat Methods. 2006;3(5):391-396 - PMID: 16628210 - DOI: 10.1038/nmeth875
Kang HW, Torres D, Wald L, Weissleder R, Bogdanov AA Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer. Lab Invest. 2006;86(6):599-609 - PMID: 16607378 - DOI: 10.1038/labinvest.3700421
Law B, Weissleder R, Tung CH Peptide-based Biomaterials for Protease-Enhanced Drug Delivery. Biomacromolecules. 2006;7(4):1261-1265 - PMID: 16602747 - DOI: 10.1021/bm050920f
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678 - DOI: 10.1073/pnas.0601273103
Jaffer F, Libby P, Weissleder R. Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications. J Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517 - DOI: 10.1016/j.jacc.2006.01.029
Choi YD, McCarthy J, Weissleder R, Tung CH Conjugation of a Photosensitizer to an Oligoarginine-based Cell-penetrating Peptide Increases the Efficacy of Photodynamic Therapy. ChemMedChem. 2006;1(4):458-463 - PMID: 16892381 - DOI: 10.1002/cmdc.200500036
Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle Imaging of Integrins on Tumor Cells. Neoplasia. 2006;8(3):214-222 - PMID: 16611415 - PMCID: PMC1578521 - DOI: 10.1593/neo.05769
Montet X, Yuan H, Weissleder R, Josephson L Enzyme-based visualization of receptor-ligand binding in tissues. Lab Invest. 2006;86(5):517-25 - PMID: 16568109 - DOI: 10.1038/labinvest.3700404
Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006;12(5):797-806 - PMID: 16556935 - PMCID: PMC1440893 - DOI: 10.1261/rna.2300406
Galande A, Weissleder R, Tung CH. Fluorescence Probe with a pH-Sensitive Trigger. Bioconjug Chem. 2006;17 (2):255-257 - PMID: 16536452 - DOI: 10.1021/bc050330e
Ho NH, Weissleder R, Tung CH Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate. Bioorg Med Chem. 2006;16:2599-2602 - PMID: 16517162 - DOI: 10.1016/j.bmcl.2006.02.045
Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed G, Jakob P, Rosenzweig A, Bauer W, Weissleder R, Ertl G. Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction. Circulation. 2006;113(9):1196-1202 - PMID: 16505171 - PMCID: PMC4066325 - DOI: 10.1161/CIRCULATIONAHA.105.602094
Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palu G, Irimia D, Toner M, Weissleder R, Poznansky MC Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control. J Immunol. 2006;176(5):2902-14 - PMID: 16493048 - DOI: 10.4049/jimmunol.176.5.2902
Quinti L, Weissleder R, Tung CH A Fluorescent Nanosensor for Apoptotic Cells. Nano Lett. 2006;6 (3):488-490 - PMID: 16522048 - DOI: 10.1021/nl0524694
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol. 2006;7(3):284-92 - PMID: 16444258 - DOI: 10.1038/ni1306
Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater. 2006;5(2):118-22 - PMID: 16444262 - DOI: 10.1038/nmat1571
Yuan H, Luo J, Weissleder R, Cantley L, Josephson L Wortmannin-C20 Conjugates Generate Wortmannin. J Med Chem. 2006;49(2):740-747 - PMID: 16420059 - DOI: 10.1021/jm050699p
Ho NH, Weissleder R, Tung CH Development of water-soluble far-red fluorogenic dyes for enzyme sensing. Tetrahedron. 2006;62:578-585
Banerjee P, Weissleder R, Bogdanov A Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core: A Copolymer for Gene Delivery. Bioconjug Chem. 2006;17(1):125-31 - PMID: 16417260 - DOI: 10.1021/bc050083e
Sun EY, Josephson L, Kelly KA, Weissleder R Development of nanoparticle libraries for biosensing. Bioconjug Chem. 2006;17(1):109-13 - PMID: 16417258 - DOI: 10.1021/bc050290e
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther. 2006;17(1):20-30 - PMID: 16409122 - DOI: 10.1089/hum.2006.17.20
Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006;203(1):141-152 - PMID: 16390934 - PMCID: PMC2118091 - DOI: 10.1084/jem.20050390
Montet X, Rajopadhye M, Weissleder R. An albumin-activated far-red fluorochrome for in vivo imaging. ChemMedChem. 2006;1(1):66-69 - PMID: 16892337 - DOI: 10.1002/cmdc.200500028
Harisinghani MG, Saksena MA, Hahn PF, King B, Kim J, Torabi MT, Weissleder R Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?. AJR Am J Roentgenol. 2006;186(1):144-8 - PMID: 16357394 - DOI: 10.2214/AJR.04.1287
Achilefu S, Contag CH, Savitsky AP, Weissleder R Chemical and Genetic Sensors in Biomedical Research. J Biomed Opt. 2005;10(4):41201 - PMID: 23171967
Zacharakis G, Ripoli G, Weissleder R, Ntziachristos V Fluorescent Protein Tomography Scanner for Small Animal Imaging. 2005;(24) 7:878-885
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar. Cold Spring Harb Symp Quant Biol. 2005;70:241-250 - PMID: 16869760 - DOI: 10.1101/sqb.2005.70.037
Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Hum Gene Ther. 2005;16:1367-76 - PMID: 16390268 - DOI: 10.1089/hum.2005.16.1367
McCarthy JR, Perez JM, Brueckner C, Weissleder R Polymeric Nanoparticle Preparation that Eradicates Tumors. Nano Lett. 2005;5:2552-6 - PMID: 16351214 - DOI: 10.1021/nl0519229
Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V. Volumetric tomography of fluorescent proteins through small animals in vivo. Proc Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905 - DOI: 10.1073/pnas.0504628102
Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe. Mol Imaging. 2005;4 (1):67-74 - PMID: 15912902
Sosnovik D, Weissleder R Magnetic resonance and fluorescence based molecular imaging technologies. Prog Drug Res. 2005;62:83-115 - PMID: 16329255 - DOI: 10.1007/3-7643-7426-8_3
Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R Novel Multiwavelength Microscopic Scanner for Mouse Imaging. Neoplasia. 2005;7(11):977-983 - PMID: 16331883 - PMCID: PMC1502018 - DOI: 10.1593/neo.05376
Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O The progress and promise of molecular imaging probes in oncologic drug development. Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226 - DOI: 10.1158/1078-0432.CCR-05-1302
Querol Sans M*, Chen JW*, Weissleder R, Bogdanov AA Myeloperoxidase Activity Imaging Using (67)Ga Labeled Substrate. Mol Imaging Biol. 2005;7(6):403-10 - PMID: 16292477 - DOI: 10.1007/s11307-005-0020-5
Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation. Urology. 2005;66(5):1066-71 - PMID: 16286125 - DOI: 10.1016/j.urology.2005.05.049
Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R MIPortal: A High Capacity Server for Molecular Imaging Research. Mol Imaging. 2005;4(4):425-31 - PMID: 16285904 - DOI: 10.2310/7290.2005.05136
Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R. Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy. Int J Radiat Oncol Biol Phys. 2005;63(4):1262-9 - PMID: 16253781 - DOI: 10.1016/j.ijrobp.2005.07.952
Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L. Nanoparticles for the Optical Imaging of Tumor E-selectin. Neoplasia. 2005;7(10):904-11 - PMID: 16242073 - DOI: 10.1593/neo.05352
Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol. 2005;23:1418-1423 - PMID: 16244656 - DOI: 10.1038/nbt1159
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr. Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor. Cancer Res. 2005;65(20):9253-60 - PMID: 16230386 - DOI: 10.1158/0008-5472.CAN-03-2619
Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr. Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model. Neoplasia. 2005;7(9):847-53 - PMID: 16229807 - PMCID: PMC1351316 - DOI: 10.1593/neo.05139
Montet-Abou K, Montet X, Weissleder R, Josephson L. Transfection agent induced nanoparticle cell loading. Mol Imaging. 2005;4(3):165-71 - PMID: 16194448 - DOI: 10.1162/15353500200505100
Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V. Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography. J Biomed Opt. 2005;10(4):44019 - PMID: 16178652 - DOI: 10.1117/1.1993427
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R. Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291 - DOI: 10.1073/pnas.0503920102
Hilderbrand SA, Kelly KA, Weissleder R, Tung CH. Monofunctional near-infrared fluorochromes for imaging applications. Bioconjug Chem. 2005;16(5):1275-81 - PMID: 16173808 - DOI: 10.1021/bc0501799
Reynolds F, Weissleder R, Josephson L. Protamine as an efficient membrane-translocating Peptide. Bioconjug Chem. 2005;16(5):1240-5 - PMID: 16173804 - DOI: 10.1021/bc0501451
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R. In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging. Cancer Res. 2005;65(18):8324-30 - PMID: 16166309 - DOI: 10.1158/0008-5472.CAN-05-0027
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D. Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest. 2005;115(9):2454-2461 - PMID: 16110329 - PMCID: PMC1187933 - DOI: 10.1172/JCI25048
Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005;54(3):718-724 - PMID: 16086367 - DOI: 10.1002/mrm.20617
Zhu B, Jaffer F, Nztiachristos V, Weissleder R Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection. J Phys D Appl Phys. 2005;38:2701-2707
Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V. Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology. Cell Oncol. 2005;27(3):183-90 - PMID: 16037639 - PMCID: PMC4615174 - DOI: 10.1155/2005/791936
Zacharakis G, Ripoll J, Weissleder R, Ntziachristos V. Fluorescent protein tomography scanner for small animal imaging. IEEE T Med Imaging. 2005;24(7):878-85 - PMID: 16011317 - DOI: 10.1109/tmi.2004.843254
Law B, Weissleder R, Tung CH. Mechanism-Based Fluorescent Reporter for Protein Kinase A Detection. Chembiochem. 2005;6(8):1361-1367 - PMID: 16010698 - DOI: 10.1002/cbic.200500027
Montet X, Ntziachristos V, Grimm J, Weissleder R. Tomographic Fluorescence Mapping of Tumor Targets. Cancer Res. 2005;65 (14):6330-6336 - PMID: 16024635 - DOI: 10.1158/0008-5472.CAN-05-0382
Wunder A, Schellenberger E, Mahmood U, Bogdanov A Jr, Muller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis. Mol Imaging. 2005;4(1):1-6 - PMID: 15967121 - DOI: 10.1162/15353500200504142
Shah K, Tung CH, Breakefield X, Weissleder R. In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis. Mol Ther. 2005;11 (6):926-931 - PMID: 15922963 - DOI: 10.1016/j.ymthe.2005.01.017
Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R. Optical Imaging of Spontaneous Breast Tumors Using Protease Sensing . Invest Radiol. 2005;(6):321-327 - PMID: 15905717 - DOI: 10.1097/01.rli.0000163797.23172.90
Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U. A novel mouse model for segmental orthotopic colon cancer. Int J Cancer. 2005;117(3):335-9 - PMID: 15900588 - DOI: 10.1002/ijc.21185
Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and Activity of C11-Modified Wortmannin Probes for P13 Kinase. Bioconjug Chem. 2005;(3):669-675 - PMID: 15898736 - DOI: 10.1021/bc049714f
Tsourkas A, Shinde-Patil VR, Kelly KA, Patel P, Wolley A, Allport JR, Weissleder R. In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical Probe. Bioconjug Chem. 2005;(3):576-581 - PMID: 15898724 - DOI: 10.1021/bc050002e
Querol M, Chen JW, Weissleder R, Bogdanov A Jr. DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging. Org Lett. 2005;7(9):1719-22 - PMID: 15844889 - DOI: 10.1021/ol050208v
Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R. Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent Protein. Anal Chem. 2005;77:2862-2867 - PMID: 15859603 - DOI: 10.1021/ac0480747
Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL. Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction. Circulation. 2005;111:1800-1805 - PMID: 15809374 - PMCID: PMC3733536 - DOI: 10.1161/01.CIR.0000160936.91849.9F
Shinde Patil VR, Friedrich EB, Wolley AE, Gerszten RE, Allport JR, Weissleder R. Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma. Neoplasia. 2005;7(3):234-40 - PMID: 15799823 - PMCID: PMC1501134 - DOI: 10.1593/neo.04523
Shah K, Weissleder R Molecular Optical Imaging: Applications Leading to the Development of Present Day Therapeutics. NeuroRx. 2005;2:215-225 - PMID: 15897946 - PMCID: PMC1064987 - DOI: 10.1602/neurorx.2.2.215
Gillies R, Hoffman J, Lam K, Menkens A, Piwnica-Worms D, Sullivan D, Weissleder R. Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents. Mol Imaging. 2005;4:1-6
Galande A, Weissleder R, Tung CH. An Effective Method of On-Resin Disulfide Bond Formation in Peptides. J Comb Chem. 2005;7:174-177 - PMID: 15762743 - DOI: 10.1021/cc049839r
Ntziachristos V, Ripoll J, Wang L, Weissleder R Looking and Listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol. 2005;23:313-320 - PMID: 15765087 - DOI: 10.1038/nbt1074
Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO. Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo. Mol Ther. 2005;11(3):435-43 - PMID: 15727940 - DOI: 10.1016/j.ymthe.2004.10.016
Jaffer F, Weissleder R Molecular Imaging in the Clinical Arena. JAMA. 2005;293(7):855-62 - PMID: 15713776 - DOI: 10.1001/jama.293.7.855
Law B, Hsiao JK, Bugge TH, Weissleder R, Tung CH. Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples. Anal Biochem. 2005;338(1):151-158 - PMID: 15707946 - DOI: 10.1016/j.ab.2004.11.039
Tung CH, Quinti L, Jaffer F, Weissleder R A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets. Mol Pharmacol. 2005;2:92-95 - PMID: 15804182 - DOI: 10.1021/mp0499048
Reynolds F, O'loughlin T, Weissleder R, Josephson L. Method of Determining Nanoparticle Core Weight. Anal Bioanal Chem. 2005;77(3):814-817 - PMID: 15679348 - DOI: 10.1021/ac049307x
Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D. Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis. J Cereb Blood Flow Metab. 2005;25(2):226-33 - PMID: 15678125 - DOI: 10.1038/sj.jcbfm.9600023
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle. Circ Res. 2005;96(3):327-36 - PMID: 15653572 - DOI: 10.1161/01.RES.0000155722.17881.dd
Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L. Transport Of Surface-Modified Nanoparticles Through Cell Monolayers. Chembiochem. 2005;6(2):337-345 - PMID: 15651046 - DOI: 10.1002/cbic.200400174
Chen WT, Mahmood U, Weissleder R, Tung CH Arthritis imaging using a near-infrared fluorescence folate-targeted probe. Arthritis Res Ther. 2005;7:R310-R317 - PMID: 15743478 - PMCID: PMC1065321 - DOI: 10.1186/ar1483
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo. Proc Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311 - DOI: 10.1073/pnas.0408197102
Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol. 2005;57(1):34-41 - PMID: 15622535 - DOI: 10.1002/ana.20306
Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R. Magnetic resonance signal amplification probes. Ernst Schering Res Found Workshop. 2005;49:147-57 - PMID: 15524215 - DOI: 10.1007/3-540-26809-x_8
Tsourkas A, Weissleder R Illuminating the dynamics of intracellular activity with . Mech Chem Biosyst. 2004;1:133-45 - PMID: 16783939
Harisinghani MG, Weissleder R Sensitive, noninvasive detection of lymph node metastases. PLoS Med. 2004;1(3):e66 - PMID: 15630471 - PMCID: PMC539052 - DOI: 10.1371/journal.pmed.0010066
Chen WT, Tung CH, Weissleder R Imaging reactive oxygen species in arthritis. Mol Imaging. 2004;3(3):159-62 - PMID: 15530251 - DOI: 10.1162/15353500200404124
Metelev V, Weissleder R, Bogdanov A Jr Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys. Bioconjug Chem. 2004;15(6):1481-1487 - PMID: 15546218 - DOI: 10.1021/bc049916b
Pham W, Choi Y, Weissleder R, Tung CH Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing. Bioconjug Chem. 2004;15(6):1403-1407 - PMID: 15546208 - DOI: 10.1021/bc049924s
Chen JW, Pham W, Weissleder R, Bogdanov A Jr Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis. Magn Reson Med. 2004;52(5):1021-8 - PMID: 15508166 - DOI: 10.1002/mrm.20270
Graves EE, Weissleder R, Ntziachristos V Fluorescence molecular imaging of small animal tumor models. Curr Mol Med. 2004;4(4):419-30 - PMID: 15354872 - DOI: 10.2174/1566524043360555
Schellenberger EA, Sosnovik D, Weissleder R, Josephson L Magneto/Optical annexin v, a multimodal protein. Bioconjug Chem. 2004;15(5):1062-7 - PMID: 15366960 - DOI: 10.1021/bc049905i
Banerjee P, Reichardt W, Weissleder R, Bogdanov A Jr Novel hyperbranched dendron for gene transfer in vitro and in vivo. Bioconjug Chem. 2004;15(5):960-8 - PMID: 15366948 - DOI: 10.1021/bc0342128
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide. Cancer Res. 2004;64(17):6247-51 - PMID: 15342411 - DOI: 10.1158/0008-5472.CAN-04-0817
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458 - DOI: 10.1002/art.20379
Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A Jr Measurement of tumor interstitial volume fraction: Method and implication for drug delivery. Magn Reson Med. 2004;52(3):485-94 - PMID: 15334566 - DOI: 10.1002/mrm.20182
Pham W, Kircher MF, Weissleder R, Tung CH Enhancing membrane permeability by Fatty acylation of oligoarginine peptides. Chembiochem. 2004;5(8):1148-51 - PMID: 15300843 - DOI: 10.1002/cbic.200400063
Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472 - DOI: 10.1073/pnas.0401137101
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R Imaging inflammation of the pancreatic islets in type 1 diabetes. Proc Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109 - DOI: 10.1073/pnas.0404307101
Law B, Curino A, Bugge TH, Weissleder R, Tung CH Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter. Chem Biol. 2004;11(1):99-106 - PMID: 15112999 - DOI: 10.1016/j.chembiol.2003.12.017
Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neoplasia. 2004;6(2):95-105 - PMID: 15140398 - PMCID: PMC1502090 - DOI: 10.1593/neo.03214
Allport JR, Shinde Patil VR, Weissleder R Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms. Cancer Biol Ther. 2004;3(9):838-44 - PMID: 15254391 - DOI: 10.4161/cbt.3.9.1036
Kelly KA, Reynolds F, Weissleder R, Josephson L Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions. Anal Biochem. 2004;330(2):181-5 - PMID: 15203322 - DOI: 10.1016/j.ab.2004.02.035
Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas. Cancer Res. 2004;64(12):4069-77 - PMID: 15205313 - DOI: 10.1158/0008-5472.CAN-04-1243
Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi. Circulation. 2004;110(2):170-6 - PMID: 15210587 - DOI: 10.1161/01.CIR.0000134484.11052.44
Funovics MA, Weissleder R, Mahmood U Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice. Radiology. 2004;231(3):659-66 - PMID: 15163807 - DOI: 10.1148/radiol.2313030831
Shah K, Jacobs A, Breakefield XO, Weissleder R Molecular imaging of gene therapy for cancer. Gene Ther. 2004;11(15):1175-87 - PMID: 15141158 - DOI: 10.1038/sj.gt.3302278
Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy. Cancer Res. 2004;64(9):3236-42 - PMID: 15126365 - DOI: 10.1158/0008-5472.can-03-3516
Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities. Angew Chem Int Ed Engl. 2004;43(18):2395-2399 - PMID: 15114571 - DOI: 10.1002/anie.200352998
Schellenberger EA, Weissleder R, Josephson L Optimal modification of annexin v with fluorescent dyes. Chembiochem. 2004;5:271-4 - PMID: 14997518 - DOI: 10.1002/cbic.200300741
Schellenberger EA, Reynolds F, Weissleder R, Josephson L Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem. 2004;5:275-9 - PMID: 14997519 - DOI: 10.1002/cbic.200300713
Perez JM, Josephson L, Weissleder R Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. Chembiochem. 2004;5:261-4 - PMID: 14997516 - DOI: 10.1002/cbic.200300730
Kircher MF, Weissleder R, Josephson L A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004;15:242-8 - PMID: 15025519 - DOI: 10.1021/bc034151d
Jaffer FA, Weissleder R Seeing within: molecular imaging of the cardiovascular system. Circ Res. 2004;94(4):433-45 - PMID: 15001542 - DOI: 10.1161/01.RES.0000119321.18573.5A
Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model. Stroke. 2004;35:952-7 - PMID: 14988578 - DOI: 10.1161/01.STR.0000120308.21946.5D
Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch. Cancer Res. 2004;64:1579-1583 - PMID: 14996712 - DOI: 10.1158/0008-5472.can-03-3226
Graves EE, Culver JP, Ripoll J, Weissleder R, Ntziachristos V Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography. J Opt Soc Am A . 2004;21(2):231-41 - PMID: 14763766 - DOI: 10.1364/josaa.21.000231
Grimm J, Perez JM, Josephson L, Weissleder R Novel nanosensors for rapid analysis of telomerase activity. Cancer Res. 2004;64:639-43 - PMID: 14744779 - DOI: 10.1158/0008-5472.can-03-2798
Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas. Cancer Res. 2004;64:273-8 - PMID: 14729634 - DOI: 10.1158/0008-5472.can-03-1123
Zhao M, Weissleder R Intracellular cargo delivery using tat peptide and derivatives. Med Res Rev. 2004;24:1-12 - PMID: 14595670 - DOI: 10.1002/med.10056
Pham W, Weissleder R, Tung CH A practical approach for the preparation of monofunctional azulenyl squaraine dye. Tetrahedron Lett. 2003;44(20):3975-3978 - PMID: 20740053 - PMCID: PMC2926986 - DOI: 10.1016/S0040-4039(03)00819-0
Hogemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003;5(6):495-506 - PMID: 14965443 - PMCID: PMC1502574 - DOI: 10.1016/s1476-5586(03)80034-9
Kircher MF, Josephson L, Weissleder R Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2003;1:89-95 - PMID: 12920849 - DOI: 10.1162/15353500200201124
Allport JR, Weissleder R Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro. Neoplasia. 2003;5:205-17 - PMID: 12869304 - PMCID: PMC1502407 - DOI: 10.1016/S1476-5586(03)80053-2
Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice. Radiology. 2003;226:214-20 - PMID: 12511693 - DOI: 10.1148/radiol.2261012140
Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U Miniaturized multichannel near infrared endoscope for mouse imaging. Mol Imaging. 2003;2:350-7 - PMID: 14717334 - DOI: 10.1162/15353500200303166
Funovics M, Weissleder R, Tung CH Protease sensors for bioimaging. Anal Bioanal Chem. 2003;377:956-63 - PMID: 12955390 - DOI: 10.1007/s00216-003-2199-0
Graves EE, Ripoll J, Weissleder R, Ntziachristos V A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys. 2003;30:901-11 - PMID: 12772999 - DOI: 10.1118/1.1568977
Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749
Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging. 2003;2:18-23 - PMID: 12926234 - DOI: 10.1162/15353500200302154
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003;63:8122-5 - PMID: 14678964
Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003;63:6838-46 - PMID: 14583481
Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjug Chem. 2003;14:1115-21 - PMID: 14624624 - DOI: 10.1021/bc034123v
Lin Y, Weissleder R, Tung CH Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imaging. Mol Imaging. 2003;2:87-92 - PMID: 12964306 - DOI: 10.1162/15353500200303121
Mahmood U, Weissleder R Near-infrared optical imaging of proteases in cancer. Mol Cancer Ther. 2003;2:489-96 - PMID: 12748311
Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI. Mol Imaging. 2003;2:324-32 - PMID: 14717331 - DOI: 10.1162/15353500200303163
Moon, WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate. Bioconjug Chem. 2003;14:539-45 - PMID: 12757377 - DOI: 10.1021/bc0340114
Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc. 2003;125:10192-3 - PMID: 12926940 - DOI: 10.1021/ja036409g
Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 2003;63:1936-42 - PMID: 12702586
Pham W, Lai WF, Weissleder R, Tung CH High efficiency synthesis of a bioconjugatable near-infrared fluorochrome. Bioconjug Chem. 2003;14:1048-51 - PMID: 13129411 - DOI: 10.1021/bc034070h
Rudin M, Weissleder R Molecular imaging in drug discovery and development. Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303 - DOI: 10.1038/nrd1007
Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia. 2003;5:187-92 - PMID: 12869301 - PMCID: PMC1502408 - DOI: 10.1016/S1476-5586(03)80050-7
Shah K, Tang Y, Breakefield X, Weissleder R Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene. 2003;22:6865-72 - PMID: 14534533 - DOI: 10.1038/sj.onc.1206748
Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A Jr Engineering of technetium-99m-binding artificial receptors for imaging gene expression. J Gene Med. 2003;5:1056-66 - PMID: 14661181 - DOI: 10.1002/jgm.448
Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther. 2003;14:1247-54 - PMID: 12952596 - DOI: 10.1089/104303403767740786
Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R Novel Factor XIII Probes for Blood Coagulation Imaging. Chembiochem. 2003;4:897-899 - PMID: 12964167 - DOI: 10.1002/cbic.200300602
Tung CH, Weissleder R Arginine containing peptides as delivery vectors. Adv Drug Deliv Rev. 2003;55:281-94 - PMID: 12564981 - DOI: 10.1016/s0169-409x(02)00183-7
Weissleder R, Ntziachristos V Shedding light onto live molecular targets. Nature Med. 2003;9:123-8 - PMID: 12514725 - DOI: 10.1038/nm0103-123
Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer J. 2003;9:189-204 - PMID: 12952304 - DOI: 10.1097/00130404-200305000-00007
Zhao M, Josephson L, Tang Y, Weissleder R Magnetic sensors for protease assays. Angew Chem Int Ed Engl. 2003;42:1375-8 - PMID: 12671972 - DOI: 10.1002/anie.200390352
Ntziachristos V, Ripoll J, Weissleder R Would near-infrared fluorescence signals propagate through large human organs for clinical studies?. Opt Lett. 2002;27(5):333-5 - PMID: 18007794 - DOI: 10.1364/ol.27.000333
Ripoll J, Nieto-Vesperinas M, Weissleder R, Ntziachristos V Fast analytical approximation for arbitrary geometries in diffuse optical tomography. Opt Lett. 2002;27(7):527-9 - PMID: 18007854 - DOI: 10.1364/ol.27.000527
Ntziachristos V, Ripoll J, Weissleder R Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata. Opt Lett. 2002;27(18):1652 - PMID: 18026531 - DOI: 10.1364/ol.27.001652
Pham W, Weissleder R, Tung CH Intermolecular [8+2] cycloaddition reactions of 2H-3-methoxycarbonylcyclohepta[b]furan-2-one with vinyl ethers: an approach to bicyclo[5.3.0]azulene derivatives. Tetrahedron Lett. 2002;43(1):19-20 - PMID: 20740048 - PMCID: PMC2926969 - DOI: 10.1016/S0040-4039(01)02061-5
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002;1:269-77 - PMID: 12086863 - DOI: 10.1016/s1535-6108(02)00046-6
Bogdanov A Jr, Matuszewski L, Bremer C, Petrovsky A, Weissleder R Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging. 2002;1:16-23 - PMID: 12920857 - DOI: 10.1162/15353500200200001
Bogdanov AA Jr, Lin CP, Simonova M, Matuszewski L, Weissleder R Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment. Neoplasia. 2002;4:228-36 - PMID: 11988842 - PMCID: PMC1531696 - DOI: 10.1038/sj/neo/7900238
Bremer C, Tung CH, Weissleder R Molecular imaging of MMP expression and therapeutic MMP inhibition. Acad Radiol. 2002;9 Suppl 2:S314-5 - PMID: 12188259 - DOI: 10.1016/s1076-6332(03)80214-3
Bremer C, Tung CH, Bogdanov A Jr, Weissleder R Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology. 2002;222:814-8 - PMID: 11867806 - DOI: 10.1148/radiol.2223010812
Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R In vivo imaging of proteolytic activity in atherosclerosis. Circulation. 2002;105:2766-71 - PMID: 12057992 - DOI: 10.1161/01.cir.0000017860.20619.23
Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer. Acad Radiol. 2002;9 Suppl 2:S312-3 - PMID: 12188258 - DOI: 10.1016/s1076-6332(03)80213-1
Hogemann D, Ntziachristos V, Josephson L, Weissleder R High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug Chem. 2002;13:116-21 - PMID: 11792186 - DOI: 10.1021/bc015549h
Ichikawa T, Hogemann D, Saeki Y, Tyminski E, Terada K, Weissleder R, Chiocca EA, Basilion JP MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia. 2002;4:523-30 - PMID: 12407446 - PMCID: PMC1503666 - DOI: 10.1038/sj.neo.7900266
Jaffer FA, Tung CH, Gerszten RE, Weissleder R In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227 - DOI: 10.1161/01.atv.0000033089.56970.2d
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D Arthritis critically dependent on innate immune system players. Immunity. 2002;16:157-68 - PMID: 11869678 - DOI: 10.1016/s1074-7613(02)00275-3
Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002;13:554-60 - PMID: 12009946 - DOI: 10.1021/bc015555d
Kang HW, Weissleder R, Bogdanov A Jr Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitro. Amino Acids. 2002;23:301-8 - PMID: 12373551 - DOI: 10.1007/s00726-001-0142-2
Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A Jr Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002;13:122-7 - PMID: 11792187 - DOI: 10.1021/bc0155521
Kim YR, Savellano MD, Weissleder R, Bogdanov A Jr Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study. Technol Cancer Res T. 2002;1:489-95 - PMID: 12625776 - DOI: 10.1177/153303460200100609
Lin Y, Weissleder R, Tung CH Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation. Bioconjug Chem. 2002;13:605-10 - PMID: 12009952 - DOI: 10.1021/bc0155723
Mahmood U, Tung CH, Tang Y, Weissleder R Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice. Radiology. 2002;224:446-51 - PMID: 12147841 - DOI: 10.1148/radiol.2242011589
Mahmood U, Weissleder R Some tools for molecular imaging. Acad Radiol. 2002;9:629-31 - PMID: 12061735 - DOI: 10.1016/s1076-6332(03)80306-9
Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology. 2002;122:406-14 - PMID: 11832455 - DOI: 10.1053/gast.2002.30990
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia. 2002;4:3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209
Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2. Neoplasia. 2002;4:501-9 - PMID: 12407444 - PMCID: PMC1503664 - DOI: 10.1038/sj.neo.7900265
Moore, A, Sun PZ, Cory D, Hogemann D, Weissleder R, Lipes MA MRI of insulitis in autoimmune diabetes. Magn Reson Med. 2002;47:751-8 - PMID: 11948737 - DOI: 10.1002/mrm.10110
Ntziachristos, V, Bremer C, Graves EE, Ripoll J, Weissleder R In vivo tomographic imaging of near-infrared fluorescent probes. Mol Imaging. 2002;1:82-8 - PMID: 12920848 - DOI: 10.1162/15353500200201121
Ntziachristos, V, Bremer C, Tung C, Weissleder R Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT). Acad Radiol. 2002;9 Suppl 2:S323-5 - PMID: 12188262 - DOI: 10.1016/s1076-6332(03)80217-9
Ntziachristos V, Tung CH, Bremer C, Weissleder R Fluorescence molecular tomography resolves protease activity in vivo. Nature Med. 2002;8:757-60 - PMID: 12091907 - DOI: 10.1038/nm729
Ntziachristos V, Weissleder R Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media. Med Phys. 2002;29:803-9 - PMID: 12033576 - DOI: 10.1118/1.1470209
Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol. 2002;20:816-20 - PMID: 12134166 - DOI: 10.1038/nbt720
Perez JM, O'Loughin T, Simeone F J, Weissleder R, Josephson L DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. J Am Chem Soc. 2002;124:2856-7 - PMID: 11902860 - DOI: 10.1021/ja017773n
Pham W, Weissleder R, Tung CH An azulene dimer as a near-infrared quencher. Angew Chem Int Ed Engl. 2002;41:3659-62, 3519 - PMID: 12370922 - DOI: 10.1002/1521-3773(20021004)41:19<3659::AID-ANIE3659>3.0.CO;2-Q
Schellenberger EA, Bogdanov A Jr, Hogemann D, Tait J, Weissleder R, Josephson L Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging. 2002;1:102-7 - PMID: 12920851 - DOI: 10.1162/15353500200202103
Schellenberger EA, Hogemann D, Josephson L, Weissleder R Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol. 2002;9 Suppl 2:S310-1 - PMID: 12188257 - DOI: 10.1016/s1076-6332(03)80212-x
Schellingerhout D, Accorsi R, Mahmood U, Idoine J, Lanza RC, Weissleder R Coded aperture nuclear scintigraphy: a novel small animal imaging technique. Mol Imaging. 2002;1:344-53 - PMID: 12926230 - DOI: 10.1162/15353500200221362
Tung CH, Mueller S, Weissleder R Novel branching membrane translocational peptide as gene delivery vector. Bioorg Med Chem. 2002;10:3609-14 - PMID: 12213476 - DOI: 10.1016/s0968-0896(02)00248-1
Tung CH, Lin Y, Moon WK, Weissleder R A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging. Chembiochem. 2002;3:784-6 - PMID: 12203978 - DOI: 10.1002/1439-7633(20020802)3:8<784::AID-CBIC784>3.0.CO;2-X
Tung CH, Gerszten RE, Jaffer FA, Weissleder R A novel near-infrared fluorescence sensor for detection of thrombin activation in blood. Chembiochem. 2002;3:207-11 - PMID: 11921399 - DOI: 10.1002/1439-7633(20020301)3:2/3<207::AID-CBIC207>3.0.CO;2-B
Weissleder R Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer. 2002;2:1-8 - PMID: 11902581 - DOI: 10.1038/nrc701
Wunderbaldinger P, Josephson L, Weissleder R Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad Radiol. 2002;9 Suppl 2:S304-6 - PMID: 12188255 - DOI: 10.1016/s1076-6332(03)80210-6
Wunderbaldinger P, Josephson L, Weissleder R Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002;13:264-8 - PMID: 11906263 - DOI: 10.1021/bc015563u
Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002;47:292-7 - PMID: 11810672 - DOI: 10.1002/mrm.10068
Zhao M, Kircher MF, Josephson L, Weissleder R Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002;13:840-4 - PMID: 12121140 - DOI: 10.1021/bc0255236
Bremer C, Ntziachristos V, Weissleder R Optical-based molecular imaging: contrast agents and potential medical applications. Eur J Radiol. 2002;13:231-43 - PMID: 12598985 - DOI: 10.1007/s00330-002-1610-0
Ntziachristos V, Bremer C, Weissleder R Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur J Radiol. 2002;13:195-208 - PMID: 12541130 - DOI: 10.1007/s00330-002-1524-x
Josephson L, Perez JM, Weissleder R Magnetic Nanosensors for the Detection of Oligonucleotide Sequences. Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H
Ntziachristos V, Weissleder R Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett. 2001;26(12):893-5 - PMID: 18040483 - DOI: 10.1364/ol.26.000893
Allport JR, Weissleder R In vivo imaging of gene and cell therapies. Exp Hematol. 2001;29:1237-46 - PMID: 11698119 - DOI: 10.1016/s0301-472x(01)00739-1
Bogdanov A Jr, Tung CH, Bredow S, Weissleder R DNA binding chelates for nonviral gene delivery imaging. Gene Ther. 2001;8:515-22 - PMID: 11319618 - DOI: 10.1038/sj.gt.3301410
Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Radiology. 2001;221:523-9 - PMID: 11687699 - DOI: 10.1148/radiol.2212010368
Bremer C, Tung CH, Weissleder R In vivo molecular target assessment of matrix metalloproteinase inhibition. Nature Med. 2001;7:743-8 - PMID: 11385514 - DOI: 10.1038/89126
Bremer C, Bogdanov AA, Weissleder R [Imaging of angiogenesis]. Radiologe. 2001;41:138-45 - PMID: 11253099 - DOI: 10.1007/s001170050956
Bremer C, Ntziachristos V, Mahmood U, Tung CH, Weissleder R [Progress in optical imaging]. Radiologe. 2001;41:131-7 - PMID: 11253098 - DOI: 10.1007/s001170050955
Bremer C, Weissleder R In vivo imaging of gene expression. Acad Radiol. 2001;8:15-23 - PMID: 11201452 - DOI: 10.1016/s1076-6332(03)80739-0
Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD Jr, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods. 2001;256:89-105 - PMID: 11516758 - DOI: 10.1016/s0022-1759(01)00433-1
Harisinghani MG, Jhaveri KS, Weissleder R, Schima W, Saini S, Hahn PF, Mueller PR MRI contrast agents for evaluating focal hepatic lesions. Clin Radiol. 2001;56:714-25 - PMID: 11585393 - DOI: 10.1053/crad.2001.0764
Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations. J Comput Assist Tomogr. 2001;25:770-6 - PMID: 11584239 - DOI: 10.1097/00004728-200109000-00017
Hogemann D, Basilion JP, Weissleder R [Molecular imaging in magnetic resonance tomography and nuclear medicine]. Radiologe. 2001;41:116-20 - PMID: 11253096 - DOI: 10.1007/s001170050953
Moore A, Bonner-Weir S, Weissleder R Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Diabetes. 2001;50:2231-6 - PMID: 11574403 - DOI: 10.2337/diabetes.50.10.2231
Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R Human transferrin receptor gene as a marker gene for MR imaging. Radiology. 2001;221:244-50 - PMID: 11568347 - DOI: 10.1148/radiol.2211001784
O'Neill MJ, Weissleder R, Gervais DA, Hahn PF, Mueller PR Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of malignant ascites. AJR Am J Roentgenol. 2001;177:615-8 - PMID: 11517056 - DOI: 10.2214/ajr.177.3.1770615
Spear MA, Breakefield XO, Beltzer J, Schuback D, Weissleder R, Pardo FS, Ladner R Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells. Cancer Gene Ther. 2001;8:506-11 - PMID: 11498772 - DOI: 10.1038/sj.cgt.7700334
Wagenaar DJ, Weissleder R, Hengerer A Glossary of molecular imaging terminology. Acad Radiol. 2001;8:409-20 - PMID: 11345272 - DOI: 10.1016/S1076-6332(03)80549-4
Weissleder R, Mahmood U Molecular imaging. Radiology. 2001;219:316-33 - PMID: 11323453 - DOI: 10.1148/radiology.219.2.r01ma19316
Weissleder R, Bogdanov A Jr, Tung CH, Weinmann HJ Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging. Bioconjug Chem. 2001;12:213-9 - PMID: 11312682 - DOI: 10.1021/bc000091p
Weissleder R A clearer vision for in vivo imaging. Nat Biotechnol. 2001;19:316-7 - PMID: 11283581 - DOI: 10.1038/86684
Weissleder R [Experimental radiology in the USA]. Radiologe. 2001;41:115 - PMID: 11253095 - DOI: 10.1007/s001170050952
Wunderbaldinger P, Weissleder R [Experimental and clinical approaches to lymph node imaging]. Radiologe. 2001;41:121-30 - PMID: 11253097 - DOI: 10.1007/s001170050954
Contag C, Fraser S, Weissleder, R Strategies in in vivo molecular imaging. Neoreviews. 2000;1:225-232
Contag C, Weissleder R, Bachmann M, Fraser S Appllications of In Vivo Molecular Imaging in Biology and Medicine. Neoreviews. 2000;1:233-240
Bhorade R, Weissleder R, Nakakoshi T, Moore A, Tung CH Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide. Bioconjug Chem. 2000;11:301-5 - PMID: 10821645 - DOI: 10.1021/bc990168d
Bogdanov AA Jr, Simonova M, Weissleder R Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking. Q J Nucl Med Mol IM. 2000;44:224-35 - PMID: 11105587
Bredow S, Lewin M, Hofmann B, Marecos E, Weissleder R Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin. Eur J Cancer. 2000;36:675-81 - PMID: 10738134 - DOI: 10.1016/s0959-8049(99)00335-4
Hogemann D, Josephson L, Weissleder R, Basilion JP Improvement of MRI probes to allow efficient detection of gene expression. Bioconjug Chem. 2000;11:941-6 - PMID: 11087345 - DOI: 10.1021/bc000079x
Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol. 2000;18:410-4 - PMID: 10748521 - DOI: 10.1038/74464
Moore A, Marecos E, Bogdanov A Jr, Weissleder R Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model. Radiology. 2000;214:568-74 - PMID: 10671613 - DOI: 10.1148/radiology.214.2.r00fe19568
Schellingerhout D, Rainov NG, Breakefield XO, Weissleder R Quantitation of HSV mass distribution in a rodent brain tumor model. Gene Ther. 2000;7:1648-55 - PMID: 11083473 - DOI: 10.1038/sj.gt.3301272
Simonova M, Wall A, Weissleder R, Bogdanov A Jr Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. Cancer Res. 2000;60:6656-62 - PMID: 11118049
Tung CH, Mahmood U, Bredow S, Weissleder R In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res. 2000;60:4953-8 - PMID: 10987312
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP In vivo magnetic resonance imaging of transgene expression. Nature Med. 2000;6:351-5 - PMID: 10700241 - DOI: 10.1038/73219
Wunderbaldinger P, Bogdanov A, Weissleder R New approaches for imaging in gene therapy. Eur J Radiol. 2000;34:156-65 - PMID: 10927158 - DOI: 10.1016/s0720-048x(00)00196-0
Bogdanov A Jr, Marecos E, Cheng HC, Chandrasekaran L, Krutzsch HC, Roberts DD, Weissleder R Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study. Neoplasia. 1999;1:438-45 - PMID: 10933059 - PMCID: PMC1508110 - DOI: 10.1038/sj.neo.7900044
Bogdanov AA, Lewin M, Weissleder R Approaches and agents for imaging the vascular system. Adv Drug Deliv Rev. 1999;37:279-293 - PMID: 10837740 - DOI: 10.1016/s0169-409x(98)00098-2
Enochs WS, Harsh G, Hochberg F, Weissleder R Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent. J Magn Reson Imaging. 1999;9:228-32 - PMID: 10077018 - DOI: 10.1002/(sici)1522-2586(199902)9:2<228::aid-jmri12>3.0.co;2-k
Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation. AJR Am J Roentgenol. 1999;172:1347-51 - PMID: 10227514 - DOI: 10.2214/ajr.172.5.10227514
Hofmann, B, Bogdanov A Jr, Marecos E, Ebert W, Semmler W, Weissleder R Mechanism of gadophrin-2 accumulation in tumor necrosis. J Magn Reson Imaging. 1999;9:336-41 - PMID: 10077034 - DOI: 10.1002/(sici)1522-2586(199902)9:2<336::aid-jmri28>3.0.co;2-3
Josephson L, Tung CH, Moore A, Weissleder R High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem. 1999;10:186-91 - PMID: 10077466 - DOI: 10.1021/bc980125h
Lewin M, Bredow S, Sergeyev N, Marecos E, Bogdanov A Jr, Weissleder R In vivo assessment of vascular endothelial growth factor-induced angiogenesis. Int J Cancer. 1999;83:798-802 - PMID: 10597197 - DOI: 10.1002/(sici)1097-0215(19991210)83:6<798::aid-ijc16>3.0.co;2-w
Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R Near-infrared optical imaging of protease activity for tumor detection. Radiology. 1999;213:866-70 - PMID: 10580968 - DOI: 10.1148/radiology.213.3.r99dc14866
Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses. J Magn Reson Imaging. 1999;10:80-3 - PMID: 10398981 - DOI: 10.1002/(sici)1522-2586(199907)10:1<80::aid-jmri11>3.0.co;2-s
Simonova M, Weissleder R, Sergeyev N, Vilissova N, Bogdanov A Jr Targeting of green fluorescent protein expression to the cell surface. Biochem Bioph Res Co. 1999;262:638-42 - PMID: 10471377 - DOI: 10.1006/bbrc.1999.1251
Tung CH, Bredow S, Mahmood U, Weissleder R Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. Bioconjug Chem. 1999;10:892-6 - PMID: 10502358 - DOI: 10.1021/bc990052h
Weissleder R Molecular imaging: exploring the next frontier. Radiology. 1999;212:609-14 - PMID: 10478223 - DOI: 10.1148/radiology.212.3.r99se18609
Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol. 1999;17:375-8 - PMID: 10207887 - DOI: 10.1038/7933
Zaharchuk G, Mandeville JB, Bogdanov AA Jr, Weissleder R, Rosen BR, Marota JJ Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension. Stroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929 - DOI: 10.1161/01.str.30.10.2197
Moore A, Weissleder R, Bogdanov A Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages. J Magn Reson Imaging. 1998;7(6):1140-5 - PMID: 9400860 - DOI: 10.1002/jmri.1880070629
Bogdanov A, Weissleder R The development of in vivo imaging systems to study gene expression. Trends Biotechnol. 1998;16(1):5-10 - PMID: 9470227 - DOI: 10.1016/S0167-7799(97)01150-5
Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med. 1998;39(4):615-24 - PMID: 9543424 - DOI: 10.1002/mrm.1910390415
Bogdanov A, Simonova M, Weissleder R Design of metal-binding green fluorescent protein variants. Biochim Biophys Acta. 1998;1397(1):56-64 - PMID: 9545533 - DOI: 10.1016/s0167-4781(97)00221-2
Marecos E, Weissleder R, Bogdanov A Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model. Bioconjug Chem. 1998;9(2):184-91 - PMID: 9548533 - DOI: 10.1021/bc970146w
Harisinghani MG, Saini S, Hahn PF, Weissleder R, Mueller PR MR imaging of lymph nodes in patients with primary abdominal and pelvic malignancies using ultrasmall superparamagnetic iron oxide (Combidex). Acad Radiol. 1998;5 Suppl 1:S167-9, discussion S183-4 - PMID: 9561072 - DOI: 10.1016/s1076-6332(98)80095-0
Spear MA, Herrlinger U, Rainov N, Pechan P, Weissleder R, Breakefield XO Targeting gene therapy vectors to CNS malignancies. J Neurovirol. 1998;4(2):133-47 - PMID: 9584951 - DOI: 10.3109/13550289809114514
Moore A, Basilion JP, Chiocca EA, Weissleder R Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta. 1998;1402(3):239-49 - PMID: 9606982 - DOI: 10.1016/s0167-4889(98)00002-0
Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies. Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01
Reimer P, Bader A, Weissleder R Preclinical assessment of hepatocyte-targeted MR contrast agents in stable human liver cell cultures. J Magn Reson Imaging. 1998;8(3):687-9 - PMID: 9626887 - DOI: 10.1002/jmri.1880080326
de Marco G, Bogdanov A, Marecos E, Moore A, Simonova M, Weissleder R MR imaging of gene delivery to the central nervous system with an artificial vector. Radiology. 1998;208(1):65-71 - PMID: 9646794 - DOI: 10.1148/radiology.208.1.9646794
Callahan RJ, Bogdanov A, Fischman AJ, Brady TJ, Weissleder R Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging. AJR Am J Roentgenol. 1998;171(1):137-43 - PMID: 9648777 - DOI: 10.2214/ajr.171.1.9648777
Schellingerhout D, Bogdanov A, Marecos E, Spear M, Breakefield X, Weissleder R Mapping the in vivo distribution of herpes simplex virions. Hum Gene Ther. 1998;9(11):1543-9 - PMID: 9694153 - DOI: 10.1089/hum.1998.9.11-1543
Boiselle PM, Patz EF, Vining DJ, Weissleder R, Shepard JA, McLoud TC Imaging of mediastinal lymph nodes: CT, MR, and FDG PET. Radiographics. 1998;18(5):1061-9 - PMID: 9747607 - DOI: 10.1148/radiographics.18.5.9747607
Zaharchuk G, Bogdanov AA, Marota JJ, Shimizu-Sasamata M, Weisskoff RM, Kwong KK, Jenkins BG, Weissleder R, Rosen BR Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction. Magn Reson Med. 1998;40(5):666-78 - PMID: 9797148 - DOI: 10.1002/mrm.1910400504
Moore A, Marecos E, Simonova M, Weissleder R, Bogdanov A Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis. Microvasc Res. 1998;56(3):145-53 - PMID: 9828152 - DOI: 10.1006/mvre.1998.2102
Frank H, Loewe R, Loewe C, Oberhuber G, Schwaighofer B, Huber K, Weissleder R Efficacy of thrombolytic therapy in pulmonary embolism determined by MION-enhanced MRA: an experimental study in rabbits. Invest Radiol. 1998;33(12):853-7 - PMID: 9851818 - DOI: 10.1097/00004424-199812000-00002
Weissleder R, Cheng HC, Marecos E, Kwong K, Bogdanov A Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions. Eur J Cancer. 1998;34(9):1448-54 - PMID: 9849430 - DOI: 10.1016/s0959-8049(98)00195-6
Stiskal M, Schwickert HC, Demsar F, Roberts TP, Szolar D, Weissleder R, Brasch RC Contrast enhancement in experimental radiation-induced liver injury: comparison of hepatocellular and reticuloendothelial particulate contrast agents. J Magn Reson Imaging. 1997;6(2):286-90 - PMID: 9132091 - DOI: 10.1002/jmri.1880060205
Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface. Exp Neurol. 1997;143(1):61-9 - PMID: 9000446 - DOI: 10.1006/exnr.1996.6350
Weissleder R, Cheng HC, Bogdanova A, Bogdanov A Magnetically labeled cells can be detected by MR imaging. J Magn Reson Imaging. 1997;7(1):258-63 - PMID: 9039625 - DOI: 10.1002/jmri.1880070140
Bogdanov A, Wright SC, Marecos EM, Bogdanova A, Martin C, Petherick P, Weissleder R A long-circulating co-polymer in "passive targeting" to solid tumors. J Drug Target. 1997;4(5):321-30 - PMID: 9169989 - DOI: 10.3109/10611869708995848
Reimer P, Bader A, Weissleder R Application of a stable cell culture assay for the functional assessment of novel MR contrast agents. Eur Radiol. 1997;7(4):527-31 - PMID: 9204333 - DOI: 10.1007/s003300050197
Harisinghani MG, Saini S, Weissleder R, Halpern EF, Schima W, Rubin DL, Stillman AE, Sica GT, Small WC, Hahn PF Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227. Radiology. 1997;202(3):687-91 - PMID: 9051017 - DOI: 10.1148/radiology.202.3.9051017
Mandeville JB, Moore J, Chesler DA, Garrido L, Weissleder R, Weisskoff RM Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast. Magn Reson Med. 1997;37(6):885-90 - PMID: 9178240 - DOI: 10.1002/mrm.1910370613
Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R Paramagnetic metal scavenging by melanin: MR imaging. Radiology. 1997;204(2):417-23 - PMID: 9240529 - DOI: 10.1148/radiology.204.2.9240529
Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A MR imaging and scintigraphy of gene expression through melanin induction. Radiology. 1997;204(2):425-9 - PMID: 9240530 - DOI: 10.1148/radiology.204.2.9240530
Cheng HC, Khan MA, Bogdanov A, Kwong K, Weissleder R Relative blood volume measurements by magnetic resonance imaging facilitate detection of testicular torsion. Invest Radiol. 1997;32(12):763-9 - PMID: 9406017 - DOI: 10.1097/00004424-199712000-00007
Bogdanov A, Petherick P, Marecos E, Weissleder R In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation. Nucl Med Biol. 1997;24(8):739-42 - PMID: 9428599 - DOI: 10.1016/s0969-8051(97)00117-0
Bader A, Reimer P, Knop E, Boker K, Christians U, Weissleder R, Sewing KF An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magn Reson Imaging. 1996;13(7):991-1002 - PMID: 8583878 - DOI: 10.1016/0730-725x(95)00053-j
Bogdanov AA, Martin C, Bogdanova AV, Brady TJ, Weissleder R An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties. Bioconjug Chem. 1996;7(1):144-9 - PMID: 8742003 - DOI: 10.1021/bc950089b
Papisov M, Weissleder R Drug delivery to lymphatic tissue. Crit Rev Ther Drug Carrier Syst. 1996;13(1-2):57-84 - PMID: 8853959
Harika L, Weissleder R, Poss K, Papisov MI Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies. Radiology. 1996;198(2):365-70 - PMID: 8596833 - DOI: 10.1148/radiology.198.2.8596833
Gupta H, Weissleder R Targeted contrast agents in MR imaging. Magn Reson Imaging. 1996;4(1):171-84 - PMID: 8673713
Petersein J, Saini S, Weissleder R Liver. II: Iron oxide-based reticuloendothelial contrast agents for MR imaging. Clinical review. Magn Reson Imaging. 1996;4(1):53-60 - PMID: 8673716
Reimer P, Weissleder R [Development and experimental use of receptor-specific MR contrast media]. Radiologe. 1996;36(2):153-63 - PMID: 8867433 - DOI: 10.1007/s001170050053
Remsen LG, McCormick CI, Roman-Goldstein S, Nilaver G, Weissleder R, Bogdanov A, HellstrÃ¶m I, Kroll RA, Neuwelt EA MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis. AJNR Am J Neuroradiol. 1996;17(3):411-8 - PMID: 8881233 - PMCID: PMC8337991
Shen TT, Bogdanov A, Bogdanova A, Poss K, Brady TJ, Weissleder R Magnetically labeled secretin retains receptor affinity to pancreas acinar cells. Bioconjug Chem. 1996;7(3):311-6 - PMID: 8816953 - DOI: 10.1021/bc960003u
Mohr U, Weissleder R [Lymph node diagnosis with imaging methods. An overview with special reference to recent developments in the area of MR contrast media]. Z Lymphol. 1996;20(1):15-20 - PMID: 8768044
Weissleder R Can gadolinium be safely given in renal failure?. AJR Am J Roentgenol. 1996;167(1):278-9 - PMID: 8659405 - DOI: 10.2214/ajr.167.1.8659405
Bogdanov A, Weissleder R, Brady T Long-circulating blood pool imaging agents. Adv Drug Deliv Rev. 1995;15:335-348
Weissleder R, Bogdanov A, Neuwelt EA, Papisov M Long-circulating iron oxides for MR imaging. Adv Drug Deliv Rev. 1995;16:321-334
Harika L, Weissleder R, Poss K, Zimmer C, Papisov MI, Brady TJ MR lymphography with a lymphotropic T1-type MR contrast agent: Gd-DTPA-PGM. Magn Reson Med. 1995;33(1):88-92 - PMID: 7891541 - DOI: 10.1002/mrm.1910330113
Frank H, Weissleder R, Papisov M [Presentation and quantification of acute myocardial infarct using antibody-bound MR contrast medium]. Z Kardiol. 1995;84(4):311-5 - PMID: 7785304
Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging. Antimicrob Agents Chemother. 1995;39(4):839-45 - PMID: 7785981 - PMCID: PMC162639 - DOI: 10.1128/aac.39.4.839
Petropoulos AE, Schaffer BK, Cheney ML, Enochs S, Zimmer C, Weissleder R MR imaging of neuronal transport in the guinea pig facial nerve: initial findings. Acta Otolaryngol. 1995;115(4):512-6 - PMID: 7572127 - DOI: 10.3109/00016489509139358
Gupta H, Weissleder R, Bogdanov AA, Brady TJ Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy. Radiology. 1995;196(1):239-44 - PMID: 7784574 - DOI: 10.1148/radiology.196.1.7784574
Zimmer C, Weissleder R, O'Connor D, LaPointe L, Brady TJ, Enochs WS Cerebral iron oxide distribution: in vivo mapping with MR imaging. Radiology. 1995;196(2):521-7 - PMID: 7617871 - DOI: 10.1148/radiology.196.2.7617871
Schulze E, Ferrucci JT, Poss K, Lapointe L, Bogdanova A, Weissleder R Cellular uptake and trafficking of a prototypical magnetic iron oxide label in vitro. Invest Radiol. 1995;30(10):604-10 - PMID: 8557500 - DOI: 10.1097/00004424-199510000-00006
Zimmer C, Weissleder R, Poss K, Bogdanova A, Wright SC, Enochs WS MR imaging of phagocytosis in experimental gliomas. Radiology. 1995;197(2):533-8 - PMID: 7480707 - DOI: 10.1148/radiology.197.2.7480707
Gupta H, Wilkinson RA, Bogdanov AA, Callahan RJ, Weissleder R Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer. Radiology. 1995;197(3):665-9 - PMID: 7480736 - DOI: 10.1148/radiology.197.3.7480736
Muldoon LL, Nilaver G, Kroll RA, Pagel MA, Breakefield XO, Chiocca EA, Davidson BL, Weissleder R, Neuwelt EA Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol. 1995;147(6):1840-51 - PMID: 7495307 - PMCID: PMC1869962
Rainov NG, Zimmer C, Chase M, Kramm CM, Chiocca EA, Weissleder R, Breakefield XO Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Hum Gene Ther. 1995;6(12):1543-52 - PMID: 8664379 - DOI: 10.1089/hum.1995.6.12-1543
Frank H, Weissleder R, Brady TJ Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals. AJR Am J Roentgenol. 1994;162(1):209-13 - PMID: 8273667 - DOI: 10.2214/ajr.162.1.8273667
Neuwelt EA, Weissleder R, Nilaver G, Kroll RA, Roman-Goldstein S, Szumowski J, Pagel MA, Jones RS, Remsen LG, McCormick CI Delivery of virus-sized iron oxide particles to rodent CNS neurons. Neurosurgery. 1994;34(4):777-84 - PMID: 8008188 - DOI: 10.1227/00006123-199404000-00048
Weissleder R, Heautot JF, Schaffer BK, Nossiff N, Papisov MI, Bogdanov A, Brady TJ MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology. 1994;191(1):225-30 - PMID: 8134576 - DOI: 10.1148/radiology.191.1.8134576
Enochs WS, Weissleder R MR imaging of the peripheral nervous system. J Magn Reson Imaging. 1994;4(3):251-7 - PMID: 7520307 - DOI: 10.1002/jmri.1880040306
Reimer P, Saini S, Kwong KK, Cohen MS, Weissleder R, Brady TJ Dynamic gadolinium-enhanced echo-planar MR imaging of the liver: effect of pulse sequence and dose on enhancement. J Magn Reson Imaging. 1994;4(3):331-5 - PMID: 8061430 - DOI: 10.1002/jmri.1880040318
Frank H, Weissleder R, Bogdanov AA, Brady TJ Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits. AJR Am J Roentgenol. 1994;162(5):1041-6 - PMID: 8165978 - DOI: 10.2214/ajr.162.5.8165978
Lu DS, Saini S, Hahn PF, Goldberg M, Lee MJ, Weissleder R, Gerard B, Halpern E, Cats A T2-weighted MR imaging of the upper part of the abdomen: should fat suppression be used routinely?. AJR Am J Roentgenol. 1994;162(5):1095-100 - PMID: 8165989 - DOI: 10.2214/ajr.162.5.8165989
Bogdanov AA, Martin C, Weissleder R, Brady TJ Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes. Biochim Biophys Acta. 1994;1193(1):212-8 - PMID: 7518693 - DOI: 10.1016/0005-2736(94)90350-6
van Everdingen KJ, Enochs WS, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R Determinants of in vivo MR imaging of slow axonal transport. Radiology. 1994;193(2):485-91 - PMID: 7526413 - DOI: 10.1148/radiology.193.2.7526413
Bogdanov AA, Callahan RJ, Wilkinson RA, Martin C, Cameron JA, Fischman AJ, Brady TJ, Weissleder R Synthetic copolymer kit for radionuclide blood-pool imaging. J Nucl Med. 1994;35(11):1880-6 - PMID: 7965173
Reimer P, Weissleder R, Shen T, Knoefel WT, Brady TJ Pancreatic receptors: initial feasibility studies with a targeted contrast agent for MR imaging. Radiology. 1994;193(2):527-31 - PMID: 7972773 - DOI: 10.1148/radiology.193.2.7972773
Weissleder R Liver MR imaging with iron oxides: toward consensus and clinical practice. Radiology. 1994;193(3):593-5 - PMID: 7972790 - DOI: 10.1148/radiology.193.3.7972790
Weissleder R, Reimer P Iron oxide based magnetopharmaceuticals for MR imaging. Eur J Radiol. 1993;3:198-212
Schaffer BK, Linker C, Papisov M, Tsai E, Nossiff N, Shibata T, Bogdanov A, Brady TJ, Weissleder R MION-ASF: biokinetics of an MR receptor agent. Magn Reson Imaging. 1993;11(3):411-7 - PMID: 7685055 - DOI: 10.1016/0730-725x(93)90074-n
Weissleder R, Wang YM, Papisov M, Bogdanov A, Schaffer B, Brady TJ, Wittenberg J Polymeric contrast agents for MR imaging of adrenal glands. J Magn Reson Imaging. 1993;3(1):93-7 - PMID: 8428107 - DOI: 10.1002/jmri.1880030116
Shen T, Weissleder R, Papisov M, Bogdanov A, Brady TJ Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med. 1993;29(5):599-604 - PMID: 8505895 - DOI: 10.1002/mrm.1910290504
Bogdanov AA, Weissleder R, Frank HW, Bogdanova AV, Nossif N, Schaffer BK, Tsai E, Papisov MI, Brady TJ A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. Radiology. 1993;187(3):701-6 - PMID: 8497616 - DOI: 10.1148/radiology.187.3.8497616
Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R MR imaging of slow axonal transport in vivo. Exp Neurol. 1993;123(2):235-42 - PMID: 8405287 - DOI: 10.1006/exnr.1993.1156
Weissleder R, Bogdanov A, Frank H, Nossiff N, Bogdanova A, Schaffer BK, Brady T, Wittenberg J AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy. Invest Radiol. 1993;28(12):1083-9 - PMID: 8307710 - DOI: 10.1097/00004424-199312000-00001
Weissleder R, Papisov M Pharmaceutical iron oxides for MR imaging. J Magn Reson Imaging. 1992;4:1-6
Josephson L, Groman E, Weissleder R Contrast agents for magnetic resonance imaging of the liver. Targeted Diagn Ther. 1992;4:163-87 - PMID: 1797156
Weissleder R, Lee AS, Khaw BA, Shen T, Brady TJ Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging. Radiology. 1992;182(2):381-5 - PMID: 1732953 - DOI: 10.1148/radiology.182.2.1732953
Reimer P, Weissleder R, Wittenberg J, Brady TJ Receptor-directed contrast agents for MR imaging: preclinical evaluation with affinity assays. Radiology. 1992;182(2):565-9 - PMID: 1732982 - DOI: 10.1148/radiology.182.2.1732982
Reimer P, Kwong KK, Weisskoff R, Cohen MS, Brady TJ, Weissleder R Dynamic signal intensity changes in liver with superparamagnetic MR contrast agents. J Magn Reson Imaging. 1992;2(2):177-81 - PMID: 1562768 - DOI: 10.1002/jmri.1880020210
Weissleder R, Bogdanov A, Papisov M Drug targeting in magnetic resonance imaging. Magn Reson Q. 1992;8(1):55-63 - PMID: 1567758
Reimer P, Weissleder R, Nickeleit V, Brady TJ Animal models for magnetic resonance imaging research of the liver. Invest Radiol. 1992;27(5):390-3 - PMID: 1582824 - DOI: 10.1097/00004424-199205000-00014
Lee AS, Weissleder R, Brady TJ, Wittenberg J Lymph nodes: microstructural anatomy at MR imaging. Radiology. 1991;178(2):519-22 - PMID: 1987619 - DOI: 10.1148/radiology.178.2.1987619
Reimer P, Weissleder R, Lee AS, Buettner S, Wittenberg J, Brady TJ Asialoglycoprotein receptor function in benign liver disease: evaluation with MR imaging. Radiology. 1991;178(3):769-74 - PMID: 1994416 - DOI: 10.1148/radiology.178.3.1994416
Seneterre E, Weissleder R, Jaramillo D, Reimer P, Lee AS, Brady TJ, Wittenberg J Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging. Radiology. 1991;179(2):529-33 - PMID: 2014305 - DOI: 10.1148/radiology.179.2.2014305
Reimer P, Weissleder R, Brady TJ, Yeager AE, Baldwin BH, Tennant BC, Wittenberg J Experimental hepatocellular carcinoma: MR receptor imaging. Radiology. 1991;180(3):641-5 - PMID: 1871273 - DOI: 10.1148/radiology.180.3.1871273
Chew FS, Weissleder R Mediastinal thymolipoma. AJR Am J Roentgenol. 1991;157(3):468 - PMID: 1872228 - DOI: 10.2214/ajr.157.3.1872228
Weissleder R, Lee AS, Fischman AJ, Reimer P, Shen T, Wilkinson R, Callahan RJ, Brady TJ Polyclonal human immunoglobulin G labeled with polymeric iron oxide: antibody MR imaging. Radiology. 1991;181(1):245-9 - PMID: 1887040 - DOI: 10.1148/radiology.181.1.1887040
Chew FS, Weissleder R Radiation-induced osteochondroma. AJR Am J Roentgenol. 1991;157(4):792 - PMID: 1892038 - DOI: 10.2214/ajr.157.4.1892038
Weissleder R Target-specific superparamagnetic MR contrast agents. Magn Reson Med. 1991;22(2):209-12; discussion 213-5 - PMID: 1812348 - DOI: 10.1002/mrm.1910220209
Hahn PF, Stark DD, Saini S, Rummeny E, Elizondo G, Weissleder R, Wittenberg J, Ferrucci JT The differential diagnosis of ringed hepatic lesions in MR imaging. AJR Am J Roentgenol. 1990;154(2):287-90 - PMID: 2153330 - DOI: 10.2214/ajr.154.2.2153330
Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferrucci JT Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology. 1990;174(2):361-6 - PMID: 2296646 - DOI: 10.1148/radiology.174.2.2296646
Elizondo G, Weissleder R, Stark DD, Guerra J, Garza J, Fretz CJ, Todd LE, Ferrucci JT Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide. Radiology. 1990;174(3 Pt 1):797-801 - PMID: 2305063 - DOI: 10.1148/radiology.174.3.2305063
Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology. 1990;175(2):489-93 - PMID: 2326474 - DOI: 10.1148/radiology.175.2.2326474
Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990;175(2):494-8 - PMID: 2326475 - DOI: 10.1148/radiology.175.2.2326475
Hahn PF, Stark DD, Lewis JM, Saini S, Elizondo G, Weissleder R, Fretz CJ, Ferrucci JT First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging. Radiology. 1990;175(3):695-700 - PMID: 2343116 - DOI: 10.1148/radiology.175.3.2343116
Fretz CJ, Stark DD, Metz CE, Elizondo G, Weissleder R, Shen JH, Wittenberg J, Simeone J, Ferrucci JT Detection of hepatic metastases: comparison of contrast-enhanced CT, unenhanced MR imaging, and iron oxide-enhanced MR imaging. AJR Am J Roentgenol. 1990;155(4):763-70 - PMID: 2119106 - DOI: 10.2214/ajr.155.4.2119106
Weissleder R, Reimer P, Lee AS, Wittenberg J, Brady TJ MR receptor imaging: ultrasmall iron oxide particles targeted to asialoglycoprotein receptors. AJR Am J Roentgenol. 1990;155(6):1161-7 - PMID: 2122660 - DOI: 10.2214/ajr.155.6.2122660
Reimer P, Weissleder R, Lee AS, Wittenberg J, Brady TJ Receptor imaging: application to MR imaging of liver cancer. Radiology. 1990;177(3):729-34 - PMID: 2243978 - DOI: 10.1148/radiology.177.3.2243978
Riojas GE, Weissleder R, Gonzalez HG, Miguel MC, Riojas AE, Morantes JG, Perez LET Physical principles of magnetic resonance imaging. Rev Mex Radiol. 1989;43:3-12
Weissleder R, Stark DD, Elizondo G, Hahn PF, Compton C, Saini S, Wittenberg J, Ferrucci JT MRI of hepatic lymphoma. Magn Reson Imaging. 1989;6(6):675-81 - PMID: 3062298 - DOI: 10.1016/0730-725x(88)90092-6
Rummeny E, Weissleder R, Stark DD, Saini S, Compton CC, Bennett W, Hahn PF, Wittenberg J, Malt RA, Ferrucci JT Primary liver tumors: diagnosis by MR imaging. AJR Am J Roentgenol. 1989;152(1):63-72 - PMID: 2535770 - DOI: 10.2214/ajr.152.1.63
Weissleder R, Stark DD, Engelstad BL, Bacon BR, Compton CC, White DL, Jacobs P, Lewis J Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol. 1989;152(1):167-73 - PMID: 2783272 - DOI: 10.2214/ajr.152.1.167
Weissleder R, Elizondo G, Stark DD, Hahn PF, Marfil J, Gonzalez JF, Saini S, Todd LE, Ferrucci JT The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron oxide. AJR Am J Roentgenol. 1989;152(1):175-80 - PMID: 2783273 - DOI: 10.2214/ajr.152.1.175
Chen MC, Tsang YM, Stark DD, Weissleder R, Saini S, Brandhorst J, White DL, Engelstad BL, Ferrucci JT Hepatic metastases: rat models for imaging research. Magn Reson Imaging. 1989;7(1):1-8 - PMID: 2918813 - DOI: 10.1016/0730-725x(89)90318-4
Weissleder R, Stark DD Magnetic resonance imaging of liver tumors. Semin Ultrasound CT MR. 1989;10(1):63-77 - PMID: 2560665
Weissleder H, Weissleder R Interstitial lymphangiography: initial clinical experience with a dimeric nonionic contrast agent. Radiology. 1989;170(2):371-4 - PMID: 2911660 - DOI: 10.1148/radiology.170.2.2911660
Rummeny E, Saini S, Wittenberg J, Compton C, Hahn PF, Mueller PR, Simeone JF, Stark DD, Weissleder R, Dousset MG MR imaging of liver neoplasms. AJR Am J Roentgenol. 1989;152(3):493-9 - PMID: 2536996 - DOI: 10.2214/ajr.152.3.493
Weissleder R, Stark DD Magnetic resonance imaging of the liver. Magn Reson Q. 1989;5(2):97-121 - PMID: 2701280
Rummeny E, Weissleder R, Sironi S, Stark DD, Comptom CC, Hahn PF, Saini S, Wittenberg J, Ferrucci JT Central scars in primary liver tumors: MR features, specificity, and pathologic correlation. Radiology. 1989;171(2):323-6 - PMID: 2539605 - DOI: 10.1148/radiology.171.2.2539605
Dousset M, Weissleder R, Hendrick RE, Stark DD, Fretz CJ, Elizondo G, Hahn PF, Saini S, Ferrucci JT Short TI inversion-recovery imaging of the liver: pulse-sequence optimization and comparison with spin-echo imaging. Radiology. 1989;171(2):327-33 - PMID: 2704797 - DOI: 10.1148/radiology.171.2.2704797
Weissleder R, Elizondo G, Josephson L, Compton CC, Fretz CJ, Stark DD, Ferrucci JT Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology. 1989;171(3):835-9 - PMID: 2717761 - DOI: 10.1148/radiology.171.3.2717761
Weissleder R, Thrall JH The lymphatic system: diagnostic imaging studies. Radiology. 1989;172(2):315-7 - PMID: 2748809 - DOI: 10.1148/radiology.172.2.2748809
Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer. Radiology. 1989;172(2):393-7 - PMID: 2748820 - DOI: 10.1148/radiology.172.2.2748820
Rummeny E, Saini S, Stark DD, Weissleder R, Compton CC, Ferrucci JT Detection of hepatic metastases with MR imaging: spin-echo vs phase-contrast pulse sequences at 0.6 T. AJR Am J Roentgenol. 1989;153(6):1207-11 - PMID: 2683677 - DOI: 10.2214/ajr.153.6.1207
Weissleder R, Galarza DA, Garza MA Lupus nephritis: classification, clinical features, and treatment. 1988;39(3):263-76 - PMID: 3324251
Weissleder R, Saini S, Stark DD, Elizondo G, Compton C, Wittenberg J, Ferrucci JT Pyogenic liver abscess: contrast-enhanced MR imaging in rats. 1988;150(1):115-20 - PMID: 3257107 - DOI: 10.2214/ajr.150.1.115
Weissleder R, Stark DD, Rummeny EJ, Compton CC, Ferrucci JT Splenic lymphoma: ferrite-enhanced MR imaging in rats. Radiology. 1988;166(2):423-30 - PMID: 3336717 - DOI: 10.1148/radiology.166.2.3336717
Weissleder R, Saini S, Stark DD, Wittenberg J, Ferrucci JT Dual-contrast MR imaging of liver cancer in rats. AJR Am J Roentgenol. 1988;150(3):561-6 - PMID: 3257610 - DOI: 10.2214/ajr.150.3.561
Hahn PF, Weissleder R, Stark DD, Saini S, Elizondo G, Ferrucci JT MR imaging of focal splenic tumors. AJR Am J Roentgenol. 1988;150(4):823-7 - PMID: 3279735 - DOI: 10.2214/ajr.150.4.823
Tsang YM, Stark DD, Chen MC, Weissleder R, Wittenberg J, Ferrucci JT Hepatic micrometastases in the rat: ferrite-enhanced MR imaging. Radiology. 1988;167(1):21-4 - PMID: 3347724 - DOI: 10.1148/radiology.167.1.3347724
Weissleder R, Stark DD, Compton CC, Simeone JF, Ferrucci JT Cholecystitis: diagnosis by MR imaging. Magn Reson Imaging. 1988;6(3):345-8 - PMID: 3398743 - DOI: 10.1016/0730-725x(88)90412-2
Weissleder H, Weissleder R Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients. Radiology. 1988;167(3):729-35 - PMID: 3363131 - DOI: 10.1148/radiology.167.3.3363131
Wittenberg J, Stark DD, Forman BH, Hahn PF, Saini S, Weissleder R, Rummeny E, Ferrucci JT Differentiation of hepatic metastases from hepatic hemangiomas and cysts by using MR imaging. AJR Am J Roentgenol. 1988;151(1):79-84 - PMID: 3259825 - DOI: 10.2214/ajr.151.1.79
Rummeny E, Weissleder R, Stark DD, Elizondo G, Ferrucci JT [Magnetic resonance tomography of focal liver and spleen lesions. Experiences using ferrite, a new RES-specific MR contrast medium]. Radiologe. 1988;28(8):380-6 - PMID: 3174975
Stark DD, Weissleder R, Elizondo G, Hahn PF, Saini S, Todd LE, Wittenberg J, Ferrucci JT Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology. 1988;168(2):297-301 - PMID: 3393649 - DOI: 10.1148/radiology.168.2.3393649
Weissleder R, Hahn PF, Stark DD, Elizondo G, Saini S, Todd LE, Wittenberg J, Ferrucci JT Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging. Radiology. 1988;169(2):399-403 - PMID: 3174987 - DOI: 10.1148/radiology.169.2.3174987
Weissleder R, Galarza D, Garza MA Lupus nephritis: Classification, clinical features and treatment. Rev Invest Clin. 1987;39:263-276
Weissleder R, Marfil A, Martinez HR, Rangel-Guerra RA Limb girdle type muscular dystrophy associated with a Wolff-Parkinson-White syndrome. J Neurol Neurosurg Psych. 1987;50(4):500-1 - PMID: 3585373 - PMCID: PMC1031899 - DOI: 10.1136/jnnp.50.4.500
Weissleder R, Elizondo G, Stark DD Sonographic diagnosis of subclavian and internal jugular vein thrombosis. J Ultrasound Med. 1987;6(10):577-87 - PMID: 3316690 - DOI: 10.7863/jum.1987.6.10.577
Weissleder R, Hahn PF, Stark DD, Rummeny E, Saini S, Wittenberg J, Ferrucci JT MR imaging of splenic metastases: ferrite-enhanced detection in rats. AJR Am J Roentgenol. 1987;149(4):723-6 - PMID: 3498320 - DOI: 10.2214/ajr.149.4.723
Elizondo G, Weissleder R, Stark DD, Todd LE, Compton C, Wittenberg J, Ferrucci JT Amebic liver abscess: diagnosis and treatment evaluation with MR imaging. Radiology. 1987;165(3):795-800 - PMID: 2891154 - DOI: 10.1148/radiology.165.3.2891154
Weissleder R, Stark DD, Compton CC, Wittenberg J, Ferrucci JT Ferrite-enhanced MR imaging of hepatic lymphoma: an experimental study in rats. 1987;149(6):1161-5 - PMID: 3318339 - DOI: 10.2214/ajr.149.6.1161
Weissleder R, Bauer M After loading therapy with Cs-137 for cervical cancer: Evaluation of the first 117 patients treated. 1986;32:147-153
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Bronson R, Chen J, Weissleder R, Housman D, Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesis. Proc Natl Acad Sci U S A. 0;:ePub
Perez JM, Simeone FJ, Tsourkas A, Josephson L, Weissleder R Peroxidase substrate nanosensors for MR imaging. Nano Lett. 0;4:119-122