James Stone's Lab

Simulation of CK1-alphaLS

Dr. Stone's laboratory is seeking to understand the biochemical processes resulting in atherosclerosis in order to combat this pervasive disease. Atherosclerosis is characterized by the development of necrotic/lipid cores within the intima of arteries at particular sites in the circulation. These necrotic/lipid cores form in the setting of a pre-existing intimal hyperplasia, characterized by the proliferation of smooth muscle like cells within the intima.

The laboratory is investigating both the mechanisms of signal transduction responsible for the formation of the pre-atherosclerotic intimal hyperplasia, as well as the factors stimulating the formation of intimal necrotic/lipid cores.

Specific projects in the laboratory include elucidation of the biochemical pathways by which low levels of hydrogen peroxide stimulate cell proliferation in the vessel wall, and determination of the vascular extracellular matrix alterations in humans that promote the development of atherosclerosis.

Recent Publications (more...)

Goyal L, Saha SK, Liu LY, Siravegna G, Leshchiner I, Ahronian LG, Lennerz JK, Vu P, Deshpande V, Kambadakone A, Mussolin B, Reyes S, Henderson L, Sun JE, Van Seventer EE, Gurski JM, Baltschukat S, Schacher-Engstler B, Barys L, Stamm C, Furet P, Ryan DP, Stone JR, Iafrate AJ, Getz G, Graus Porta D, Tiedt R, Bardelli A, Juric D, Corcoran RB, Bardeesy N, Zhu AX
Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.
Cancer Discov. 2016;7(3):252-263 - PMID: 28034880 - PMCID: PMC5433349
Li Y, Stone JR
The impact of splenectomy on human coronary artery atherosclerosis and vascular macrophage distribution.
Cardiovasc Pathol. 2016;25(6):453-460 - PMID: 27614166