James Stone's Lab

Simulation of CK1-alphaLS

Dr. Stone's laboratory is seeking to understand the biochemical processes resulting in atherosclerosis in order to combat this pervasive disease. Atherosclerosis is characterized by the development of necrotic/lipid cores within the intima of arteries at particular sites in the circulation. These necrotic/lipid cores form in the setting of a pre-existing intimal hyperplasia, characterized by the proliferation of smooth muscle like cells within the intima.

The laboratory is investigating both the mechanisms of signal transduction responsible for the formation of the pre-atherosclerotic intimal hyperplasia, as well as the factors stimulating the formation of intimal necrotic/lipid cores.

Specific projects in the laboratory include elucidation of the biochemical pathways by which low levels of hydrogen peroxide stimulate cell proliferation in the vessel wall, and determination of the vascular extracellular matrix alterations in humans that promote the development of atherosclerosis.

Recent Publications (more...)

Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
J Exp Med. 2017;214(11):3293-3310 - PMID: 28978634 - PMCID: PMC5679174 - DOI: 10.1084/jem.20170689
Li Y, Stone JR
The impact of splenectomy on human coronary artery atherosclerosis and vascular macrophage distribution.
Cardiovasc Pathol. 2016;25(6):453-460 - PMID: 27614166 - DOI: 10.1016/j.carpath.2016.08.001