Case records of the Massachusetts General Hospital. Case 21-2012. A 27-year-old man with fatigue, weakness, weight loss, and decreased libido.
New Engl J Med. 2012;367(2):157-69 - PMID: 22784119
Case records of the Massachusetts General Hospital. Case 9-2012. A 67-year-old man with a persistently elevated PSA level.
New Engl J Med. 2012;366(12):1143-50 - PMID: 22435374
Case records of the Massachusetts General Hospital. Case 20-2012. A 77-year-old man with leg edema, hematuria, and acute renal failure.
New Engl J Med. 2012;366(26):2503-15 - PMID: 22738101
New Engl J Med. 2012;367(24):2335-46 - PMID: 23234517
Case records of the Massachusetts General Hospital. Case 25-2012. A 15-year-old boy with abdominal pain, hematochezia, and anemia.
New Engl J Med. 2012;367(7):659-67 - PMID: 22894579
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
Myocardial infarction accelerates atherosclerosis
An integrated encyclopedia of DNA elements in the human genome.
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Cell. 2012;149(7):1474-87 - PMID: 22726435
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism.
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.
Molecular biology. Genetic events that shape the cancer epigenome.
Science. 2012;336(6088):1513-4 - PMID: 22723401
Innate Response Activator B Cells Protect Against Microbial Sepsis
Diagnostic Accuracy of Fractional Flow Reserve From Anatomic CT Angiography.
Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.
Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration.
A Tell-Tail Sign of Chromatin: Histone Mutations Drive Pediatric Glioblastoma.
Cancer Cell. 2012;21(3):329-331 - PMID: 22439930
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression.
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Programming human pluripotent stem cells into white and brown adipocytes.
The ins and outs of inflammatory cells in atheromata.
Cell Metab. 2012;15(2):135-6 - PMID: 22326216
A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease.
Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals.
Noninvasive Assessment of Myocardial Inflammation by Cardiovascular Magnetic Resonance in a Rat Model of Experimental Autoimmune Myocarditis.
Circulation. 2012;125(21):2603-12 - PMID: 22550157
Lack of Microsomal Prostaglandin E2 Synthase-1 in Bone Marrow Derived Myeloid Cells Impairs Left Ventricular Function and Increases Mortality after Acute Myocardial Infarction.
Circulation. 2012;125(23):2904-13 - PMID: 22589381
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
PET/MRI of Inflammation in Myocardial Infarction
A Magnetic Gram Stain for Bacterial Detection.
Bioorthogonal Imaging of Aurora Kinase A in Live Cells.
Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.
Modelling biological activities of nanoparticles.
Nano Lett. 2012;12(11):5808-5812 - PMID: 23039907
Tracking Mesenchymal Stem Cells with Iron Oxide Nanoparticle Loaded Poly(lactide-co-glycolide) Microparticles.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Evidence for bistable bacteria-neutrophil interaction and its clinical implications.
Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.
Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing.
Mechanism of Magnetic Relaxation Switching Sensing.
Over a hump for imaging atherosclerosis: nanobodies visualize vascular cell adhesion molecule-1 in inflamed plaque.
Circ Res. 2012;110(7):902-3 - PMID: 22461358
Enlightened stem cells in the heart: more efficient and safer reporter gene imaging.
Circ Res. 2012;111(12):1486-7 - PMID: 23223928
Single Reporter for Targeted Multimodal in Vivo Imaging.
Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell.
Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.
DNA-protein interactions in high definition.
Real-time in vivo imaging of the beating mouse heart at microscopic resolution
Molecular MR Imaging of Liver Fibrosis: A Feasibility Study using Rat and Mouse Models.
Linewidth-Optimized Extraordinary Optical Transmission in Water with Template-Stripped Metallic Nanohole Arrays
Adv Funct Mater. 2012;22(21):4439-4446
Implantable microenvironments to attract hematopoietic stem/cancer cells.
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Reactive polymer enables efficient in vivo bioorthogonal chemistry.
Origins of tumor-associated macrophages and neutrophils.
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.
Hypoxia promotes dissemination of multiple myeloma through acquisition of endothelial to mesenchymal transition-like features.
Molecular Mechanisms of Acid-Base Sensing by the Kidney.
Mechanisms of Anemia in CKD.
Aquaporin 2 Promotes Cell Migration and Epithelial Morphogenesis.
Hypercholesterolemia links hematopoiesis with atherosclerosis.
Magnetic Nanoparticles and microNMR for Diagnostic Applications.
In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution.
A Blueprint for an International Cancer Epigenome Consortium. A Report from the AACR Cancer Epigenome Task Force.
Cancer Res. 2012;72(24):6319-6324 - PMID: 23188507
Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity.
Corin: a key protein of an adaptive renal mechanism to respond to salt variation?
Kidney Int. 2012;82(1):7-8 - PMID: 22699378
Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking.
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.
IgG4-Related disease: recommendations for the nomenclature of this condition and its individual organ system manifestations.
Arthritis Rheum. 2012;64(10):3061-7 - PMID: 22736240
Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure.
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation.
Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.
Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma.
Science to Practice: How Will Myocardial Inflammation Be Imaged with MR Imaging?
Radiology. 2012;264(2):309-11 - PMID: 22821689
Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase.
Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target.
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Consensus statement on the pathology of IgG4-related disease.
Mod Pathol. 2012;25(9):1181-92 - PMID: 22596100
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway.
On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics.
A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum.
Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells
Cells and Iron Oxide Nanoparticles on the Move: Magnetic Resonance Imaging of Monocyte Homing and Myocardial Inflammation in Patients With ST-Elevation Myocardial Infarction.
Cardiovascular Molecular Imaging: The Road Ahead.
Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation.
Nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics.
High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.
Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents
Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance.
Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.
ACS Chem Biol. 2012;7(9):1520-8 - PMID: 22724584
Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy.
New treatment strategies in large-vessel vasculitis.
Curr Opin Rheumatol. 2012;25(1):3-9 - PMID: 23114585
Macrophages in the infarct: fiery friends or friendly fire?
J Mol Cell Cardiol. 2012;53(5):591-2 - PMID: 22975014
Folate receptor: a macrophage "achilles' heel"?
Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient.
Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response.
Heart. 2012;98(18):1384-90 - PMID: 22904145
Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses.
Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity.
Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators.
meso-Arylporpholactones and their Reduction Products.
Regulation of Macrophage and Dendritic Cell Responses by Their Lineage Precursors.
High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo.
ATP secretion in the male reproductive tract: essential role of CFTR.
The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
In vivo imaging of tracheal epithelial cells in mice during airway regeneration.
Crebinostat: A Novel cognitive enhancer that inhibits Histone Deacetylase activity and Modulates Chromatin-mediated Neuroplasticity.
cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit.
Tocilizumab for the treatment of large-vessel vasculitis (giant cell arteritis, takayasu arteritis) and polymyalgia rheumatica.
Arthritis Care Res (Hoboken). 2012;64(11):1720-9 - PMID: 22674883
Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System.
Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function.
Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs).
STARS Is Essential to Maintain Cardiac Development and Function In Vivo via a SRF Pathway.
Ligation of the Jugular Veins Does Not Result in Brain Inflammation or Demyelination in Mice
Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography.
Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent.
Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells.
Identifying biological network structure, predicting network behavior, and classifying network state with High Dimensional Model Representation (HDMR).
New insights into the dynamic regulation of water and acid/base balance by renal epithelial cells.
Basolateral targeting and microtubule dependent transcytosis of the aquaporin-2 water channel.
Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.
Altered V-ATPase expression in renal intercalated cells isolated from B1-subunit deficient mice by fluorescence activated cell sorting.
Multimodal iron oxide nanoparticles for hybrid biomedical imaging.
Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy.
CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
Noise suppressed, multifocus image fusion for enhanced intraoperative navigation.
Characterization of Plasmodium Liver Stage Inhibition by Halofuginone.
Making a Difference: Monocyte Heterogeneity in Cardiovascular Disease.
Imaging of pediatric patients with inflammatory bowel disease.
AJR Am J Roentgenol. 2012;199(4):907-15 - PMID: 22997386
Incidental findings at initial imaging workup of patients with prostate cancer: clinical significance and outcomes.
AJR Am J Roentgenol. 2012;199(6):1305-11 - PMID: 23169722
Newly discovered innate response activator B cells: crucial responders against microbial sepsis.
Expert Rev Clin Immunol. 2012;8(5):405-7 - PMID: 22882214
Instrument for fluorescence sensing of circulating cells with diffuse light in mice in vivo.
Anisotropic light scattering of individual sickle red blood cells.
Improved intravital microscopy via synchronization of respiration and holder stabilization.
Establishment and characterization of a novel chordoma cell line: CH22.
J Orthop Res. 2012;30(10):1666-73 - PMID: 22504929
High-Resolution Optical Mapping of Inflammatory Macrophages Following Endovascular Arterial Injury.
Transforming Growth Factor-β and the Kidney Revisited: Introduction.
Semin Nephrol. 2012;32(3):225-7 - PMID: 22835452
State-of-the-Art PET/CT of the Pancreas: Current Role and Emerging Indications.
Radiographics. 2012;32(4):1133-58 - PMID: 22786999
Tomographic sensing and localization of fluorescently labeled circulating cells in mice in vivo.
Deep Tissue Optical and Optoacoustic Molecular Imaging Technologies for Small Animal Research and Drug Discovery.
Curr Pharm Biotechnol. 2012;13(4):504-22 - PMID: 22216767
Statement of Concern about a Commercial Assay Used to Measure Soluble Hemojuvelin in Humans.
Am J Nephrol. 2012;36(4):332-333 - PMID: 23006450
Dense IgG4 plasma cell infiltrates associated with chronic infectious aortitis: implications for the diagnosis of IgG4-related disease.
Cardiovasc Pathol. 2012;21(6):470-5 - PMID: 22406174
Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles.
Method Enzymol. 2012;508:191-209 - PMID: 22449927
Image-Guided Biopsy of Suspicious Lymph Nodes in Patients with Known Primary Malignancies.
J Vasc Interv Radiol. 2012;23(3):371-6 - PMID: 22265244
Pelvic nodal imaging.
Radiol Clin North Am. 2012;50(6):1111-25 - PMID: 23122041
Optimizing Adjuvant Treatment Decisions for Stage T2 Rectal Cancer Based on Mesorectal Node Size: A Decision Analysis.
Solution structure of subunit a, a (104-363), of the Saccharomyces cerevisiae V-ATPase and the importance of its C-terminus in structure formation.
J Bioenerg Biomembr. 2012;44(3):341-50 - PMID: 22562380
ACR Appropriateness Criteria® Multiple Gestations.
Ultrasound Q. 2012;28(2):149-155 - PMID: 22634795
Direct Tissue Evaluation via Immunofluorescence: in the Diagnosis of Hereditary Transthyretin Cardiac Amyloidosis.
Preoperative evaluation of perinephric fat invasion in patients with renal cell carcinoma: correlation with pathological findings.
Clin Imaging. 2012;37(1):91-6 - PMID: 23206613
AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.
Diagnostic Biopsies of the Native Heart.
Surg Pathol Clin. 2012;5(2):401-16 - PMID: 26838110
Intravascular multispectral optoacoustic tomography of atherosclerosis: prospects and challenges.
Motion compensation using a suctioning stabilizer for intravital microscopy
Advances in Single-cell Tracking of Mesenchymal Stem Cells (MSCs) During Musculoskeletal Regeneration.
Atomic layer deposition (ALD): A versatile technique for plasmonics and nanobiotechnology.
Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells.
In vivo tracking of hematopoietic cells in the retina of chimeric mice with a scanning laser ophthalmoscope