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Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
N Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749
Merkel PA, McCarty D, Sharma A, Stone JR
Case records of the Massachusetts General Hospital. Case 31-2008. A 39-year-old man with chest pain, arthralgias, and a mediastinal mass.
N Engl J Med. 2008;359:1603-14 - PMID: 18843125 - DOI: 10.1056/NEJMcpc0805310
Brass SD, Durand ML, Stone JH, Chen JW, Stone JR
Case records of the Massachusetts General Hospital. Case 36-2008. A 59-year-old man with chronic daily headache.
N Engl J Med. 2008;359(21):2267-78 - PMID: 19020329 - DOI: 10.1056/NEJMcpc0805313
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541
Weissleder R, Pittet MJ
Imaging in the era of molecular oncology
Nature. 2008;452:580-589 - PMID: 18385732 - PMCID: PMC2708079 - DOI: 10.1038/nature06917
Mikkelsen T, Ku M, Jaffe D, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim T, Koche R, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander E, Bernstein B
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
Nature. 2007;448(7153):553-60 - PMID: 17603471 - PMCID: PMC2921165 - DOI: 10.1038/nature06008
Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luster AD, Scadden DT, Lin CP
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.
Nature. 2005;435:969-73 - PMID: 15959517 - PMCID: PMC2570168 - DOI: 10.1038/nature03703
Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149
Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES
Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140
Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES
Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Nature. 2008;454(7205):766-70 - PMID: 18600261 - PMCID: PMC2896277 - DOI: 10.1038/nature07107
Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A
Dissecting direct reprogramming through integrative genomic analysis.
Nature. 2008;454(7200):49-55 - PMID: 18509334 - PMCID: PMC2754827 - DOI: 10.1038/nature07056
Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, Newman J, Bronson R, Crowley D, Stone J, Jaenisch R, Sharp P, Jacks T
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.
Cell. 2008;132(5):875-86 - PMID: 18329372 - PMCID: PMC2323338 - DOI: 10.1016/j.cell.2008.02.019
Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S
Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia
Cell. 2008;135:1108-17 - PMID: 19070580 - PMCID: PMC2646085 - DOI: 10.1016/j.cell.2008.10.020
Bernstein B, Meissner A, Lander E
The mammalian epigenome.
Cell. 2007;128(4):669-81 - PMID: 17320505 - DOI: 10.1016/j.cell.2007.01.033
Bernstein B, Mikkelsen T, Xie X, Kamal M, Huebert D, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber S, Lander E
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Cell. 2006;125(2):315-26 - PMID: 16630819 - DOI: 10.1016/j.cell.2006.02.041
Bernstein B, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey D, Huebert D, McMahon S, Karlsson E, Kulbokas E, Gingeras T, Schreiber S, Lander E
Genomic maps and comparative analysis of histone modifications in human and mouse.
Cell. 2005;120(2):169-81 - PMID: 15680324 - DOI: 10.1016/j.cell.2005.01.001
Schreiber S, Bernstein B
Signaling network model of chromatin.
Cell. 2002;111(6):771-8 - PMID: 12526804 - DOI: 10.1016/s0092-8674(02)01196-0
Weissleder R
Scaling down imaging: molecular mapping of cancer in mice
Nat Rev Cancer. 2002;2:1-8 - PMID: 11902581 - DOI: 10.1038/nrc701
Weissleder R.
Molecular Imaging in Cancer
Science. 2006;312:1168-1171 - PMID: 16728630 - DOI: 10.1126/science.1125949
Shaw S, Wang J
Knotting of a DNA chain during ring closure.
Science. 1993;260(5107):533-6 - PMID: 8475384 - DOI: 10.1126/science.8475384
Huang D, Swanson E, Lin C, Schuman J, Stinson W, Chang W, Hee M, Flotte T, Gregory K, Puliafito C
Optical coherence tomography.
Science. 1991;254:1178-81 - PMID: 1957169 - PMCID: PMC4638169 - DOI: 10.1126/science.1957169
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D
The structure of haplotype blocks in the human genome.
Science. 2002;296(5576):2225-9 - PMID: 12029063 - DOI: 10.1126/science.1069424
Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R
Magnetic relaxation switches capable of sensing molecular interactions
Nat Biotechnol. 2002;20:816-20 - PMID: 12134166 - DOI: 10.1038/nbt720
Weissleder R
A clearer vision for in vivo imaging
Nat Biotechnol. 2001;19:316-7 - PMID: 11283581 - DOI: 10.1038/86684
Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Nat Biotechnol. 2000;18:410-4 - PMID: 10748521 - DOI: 10.1038/74464
Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Nat Biotechnol. 1999;17:375-8 - PMID: 10207887 - DOI: 10.1038/7933
Ntziachristos V, Ripoll J, Wang L, Weissleder R
Looking and Listening to light: the evolution of whole-body photonic imaging
Nat Biotechnol. 2005;23:313-320 - PMID: 15765087 - DOI: 10.1038/nbt1074
Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L.
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Nat Biotechnol. 2005;23:1418-1423 - PMID: 16244656 - DOI: 10.1038/nbt1159
Peterson R, Shaw S, Peterson T, Milan D, Zhong T, Schreiber S, MacRae C, Fishman M
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.
Nat Biotechnol. 2004;22(5):595-9 - PMID: 15097998 - DOI: 10.1038/nbt963
Tannous B*, Grimm J*, Perry K, Chen J, Weissleder R, Breakefield X.
Metabolic Biotinylation of Cell Surface Receptors for in vivo Imaging
Nat Methods. 2006;3(5):391-396 - PMID: 16628210 - DOI: 10.1038/nmeth875
Vinegoni C, Pitsouli C, Razansky D, Perrimon N, Ntziachristos V
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography.
Nat Methods. 2007;5(1):45-7 - PMID: 18066071 - DOI: 10.1038/nmeth1149
Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA
A secreted luciferase for ex vivo monitoring of in vivo processes.
Nat Methods. 2008;5:171-173 - PMID: 18204457 - PMCID: PMC2699561 - DOI: 10.1038/nmeth.1177
Corsten MF, Shah K
Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare.
Lancet Oncol. 2008;9(4):376-84 - PMID: 18374291 - DOI: 10.1016/S1470-2045(08)70099-8
Harisinghani M
Nanoparticle-enhanced MRI: are we there yet?
Lancet Oncol. 2008;9(9):814-815 - PMID: 18760237 - DOI: 10.1016/S1470-2045(08)70215-8
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D
Arthritis critically dependent on innate immune system players
Immunity. 2002;16:157-68 - PMID: 11869678 - DOI: 10.1016/s1074-7613(02)00275-3
Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U.
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
Immunity. 2006;25(1):129-41 - PMID: 16860762 - DOI: 10.1016/j.immuni.2006.04.015
Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Nat Genet. 2005;37(7):739-44 - PMID: 15924139 - PMCID: PMC1360984 - DOI: 10.1038/ng1592
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.
Nat Genet. 2006;38(5):531-9 - PMID: 16604073 - DOI: 10.1038/ng1777
Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D
Human genome sequence variation and the influence of gene history, mutation and recombination.
Nat Genet. 2002;32(1):135-42 - PMID: 12161752 - DOI: 10.1038/ng947
Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.
Nat Mater. 2006;5(2):118-22 - PMID: 16444262 - DOI: 10.1038/nmat1571
Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
Gastroenterology. 2002;122:406-14 - PMID: 11832455 - DOI: 10.1053/gast.2002.30990
Mahmood U, Wallace MB
Molecular imaging in gastrointestinal disease.
Gastroenterology. 2007;132(1):11-4 - PMID: 17241854 - DOI: 10.1053/j.gastro.2006.12.013
Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, Khazaie K
Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.
Gastroenterology. 2008;134(4):1028-37 - PMID: 18395084 - DOI: 10.1053/j.gastro.2008.01.070
Rudin M, Weissleder R
Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303 - DOI: 10.1038/nrd1007
Im H, Huang XJ, Gu B, Choi YK
A dielectric-modulated field-effect transistor for biosensing.
Nat Nanotechnol. 2007;2(7):430-4 - PMID: 18654328 - DOI: 10.1038/nnano.2007.180
Jaffer F, Weissleder R
Molecular Imaging in the Clinical Arena
JAMA. 2005;293(7):855-62 - PMID: 15713776 - DOI: 10.1001/jama.293.7.855
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne S, Blankesteijn M, Sosnovik D, Jaffer F, Tung CH, Weissleder R
Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558
Weissleder R, Ntziachristos V
Shedding light onto live molecular targets
Nature Med. 2003;9:123-8 - PMID: 12514725 - DOI: 10.1038/nm0103-123
Ntziachristos V, Tung CH, Bremer C, Weissleder R
Fluorescence molecular tomography resolves protease activity in vivo
Nature Med. 2002;8:757-60 - PMID: 12091907 - DOI: 10.1038/nm729
Bremer C, Tung CH, Weissleder R
In vivo molecular target assessment of matrix metalloproteinase inhibition
Nature Med. 2001;7:743-8 - PMID: 11385514 - DOI: 10.1038/89126
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