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Alsayed Y, Ngo H, Runnels J, Leleu X, Singha UK, Pitsillides CM, Spencer JA, Kimlinger T, Ghobrial JM, Jia X, Lu G, Timm M, Kumar A, Cote D, Veilleux I, Hedin KE, Roodman GD, Witzig TE, Kung AL, Hideshima T, Anderson KC, Lin CP, Ghobrial IM
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.
Blood. 2007;109:2708-17 - PMID: 17119115 - PMCID: PMC1852222 - DOI: 10.1182/blood-2006-07-035857
Leleu X, Jia X, Runnels J, Ngo HT, Moreau AS, Farag M, Spencer JA, Pitsillides CM, Hatjiharissi E, Roccaro A, O'Sullivan G, McMillin DW, Moreno D, Kiziltepe T, Carrasco R, Treon SP, Hideshima T, Anderson KC, Lin CP, Ghobrial IM
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia.
Blood. 2007;110:4417-26 - PMID: 17761832 - PMCID: PMC2234792 - DOI: 10.1182/blood-2007-05-092098
Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
Blood. 2008;111(10):5195-204 - PMID: 18326817 - PMCID: PMC2384142 - DOI: 10.1182/blood-2007-09-111567
Rufer N, Zippelius A, Batard P, Pittet M, Kurth I, Corthesy P, Cerottini J, Leyvraz S, Roosnek E, Nabholz M, Romero P
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
Blood. 2003;102:1779-87 - PMID: 12750165 - DOI: 10.1182/blood-2003-02-0420
Kerre T, De Smet G, De Smedt M, Zippelius A, Pittet M, Langerak A, De Bosscher J, Offner F, Vandekerckhove B, Plum J
Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.
Blood. 2002;99:1620-6 - PMID: 11861276 - DOI: 10.1182/blood.v99.5.1620
Roccaro AM, Sacco A, Thompson B, Leleu X, Azab AK, Azab F, Runnels J, Jia X, Ngo HT, Melhem MR, Lin CP, Ribatti D, Rollins BJ, Witzig TE, Anderson KC, Ghobrial IM
microRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.
Blood. 2009;113(26):6669-80 - PMID: 19401561 - PMCID: PMC2710922 - DOI: 10.1182/blood-2009-01-198408
Azab AK, Azab F, Blotta S, Pitsillides CM, Thompson B, Runnels JM, Roccaro AM, Ngo HT, Melhem MR, Sacco A, Jia X, Anderson KC, Lin CP, Rollins BJ, Ghobrial IM
Rho-A and Rac-1 GTPases play major and differential roles in SDF1-induced cell adhesion and chemotaxis in multiple myeloma.
Blood. 2009;114(3):619-29 - PMID: 19443661 - PMCID: PMC2713475 - DOI: 10.1182/blood-2009-01-199281
Azab A, Runnels J, Pitsillides C, Moreau A, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson A, Alt C, Burwick N, Roccaro A, Ngo H, Farag M, Melhem M, Sacco A, Munshi N, Hideshima T, Rollins B, Anderson K, Kung A, Lin CP, Ghobrial I
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood. 2009;113:4341-51 - PMID: 19139079 - PMCID: PMC2676090 - DOI: 10.1182/blood-2008-10-186668
Kunstfeld R, Hirakawa S, Hong Y-K, Schacht V, Lange-Asschenfeldt B, Velasco P, Lin CP, Fiebiger E, Wu Y, Hicklin D, Bohlen P, Detmar M
VEGF-A overexpression leads to lymphatic vessel enlargement and persistent skin inflammation
Blood. 2004;104:1048-57
Higgins JM, Sloan SR
Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.
Blood. 2008;112(6):2546-53 - PMID: 18535200 - DOI: 10.1182/blood-2008-03-146415
Higgins JM, Sloan SR
Response: Other factors may contribute to differences between sickle cell and non-sickle cell patients.
Blood. 2010;115(21):4315-6 - PMID: 20508172
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, Lopez-Otin C, Grgurevic L, Hong CC, Stirnberg M, Gutschow M, Vukicevic S, Babitt JL, Lin HY
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.
Blood. 2011;118(3):747-56 - PMID: 21622652 - PMCID: PMC3142910 - DOI: 10.1182/blood-2011-04-348698
Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic disease in rats.
Blood. 2011;118(18):4977-84 - PMID: 21730356 - PMCID: PMC3208302 - DOI: 10.1182/blood-2011-03-345066
Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA
Differential niche and Wnt requirements during acute myeloid leukemia progression.
Blood. 2011;118(10):2849-56 - PMID: 21765021 - PMCID: PMC3172801 - DOI: 10.1182/blood-2011-03-345165
Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM
Engineered cell homing.
Blood. 2011;118(25):e184-91 - PMID: 22034631 - PMCID: PMC3242725 - DOI: 10.1182/blood-2010-10-311464
Maiso P, Liu Y, Morgan B, Azab A, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A, Ngo H, Azab F, Quang P, Rodig SJ, Lin CP, Roccaro A, Rommel C, Ghobrial IM
Defining the role of TORC1 and TORC2 in multiple myeloma.
Blood. 2011;118(26):6860-70 - PMID: 22045983 - PMCID: PMC3245208 - DOI: 10.1182/blood-2011-03-342394
Azab AK, Quang P, Azab F, Pitsillides C, Thompson B, Chonghaile T, Patton JT, Maiso P, Monrose V, Sacco A, Ngo HT, Flores LM, Lin CP, Magnani JL, Kung AL, Letai A, Carrasco R, Roccaro AM, Ghobrial IM
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
Blood. 2011;119(6):1468-78 - PMID: 22096244 - PMCID: PMC3286211 - DOI: 10.1182/blood-2011-07-368050
Santo L, Hideshima T, Kung AL, Tseng JC, Tamang D, Yang M, Jarpe M, van Duzer JH, Mazitschek R, Ogier WC, Cirstea D, Rodig S, Eda H, Scullen T, Canavese M, Bradner J, Anderson KC, Jones SS, Raje N
Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.
Blood. 2012;119(11):2579-89 - PMID: 22262760 - PMCID: PMC3337713 - DOI: 10.1182/blood-2011-10-387365
Mosley AJ, Meekings KN, McCarthy C, Shepherd D, Cerundolo V, Mazitschek R, Tanaka Y, Taylor GP, Bangham CR
Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection.
Blood. 2006;108(12):3801-7 - PMID: 16912225 - DOI: 10.1182/blood-2006-03-013235
Azab AK, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, Thompson B, Maiso P, Sun JD, Hart CP, Roccaro AM, Sacco A, Ngo HT, Lin CP, Kung AL, Carrasco RD, Vanderkerken K, Ghobrial IM
Hypoxia promotes dissemination of multiple myeloma through acquisition of endothelial to mesenchymal transition-like features.
Blood. 2012;119(24):5782-94 - PMID: 22394600 - PMCID: PMC3382938 - DOI: 10.1182/blood-2011-09-380410
Cohen KS, Cheng S, Larson MG, Cupples LA, McCabe EL, Wang YA, Ngwa JS, Martin RP, Klein RJ, Hashmi B, Ge Y, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ
Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors.
Blood. 2013;121(8):e50-6 - PMID: 23287867 - PMCID: PMC3578962 - DOI: 10.1182/blood-2012-05-424846
Levy O, Zhao W, Mortensen LJ, Leblanc S, Tsang K, Fu M, Phillips JA, Sagar V, Anandakumaran P, Ngai J, Cui CH, Eimon P, Angel M, Lin CP, Yanik MF, Karp JM
mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation.
Blood. 2013;122(14):e23-e32 - PMID: 23980067 - PMCID: PMC3790516 - DOI: 10.1182/blood-2013-04-495119
Meynard D, Babitt JL, Lin HY
The liver: conductor of systemic iron regulation.
Blood. 2013;123(2):168-76 - PMID: 24200681 - PMCID: PMC3888285 - DOI: 10.1182/blood-2013-06-427757
Babitt JL, Lin HY
BuMPing iron with modified heparins.
Blood. 2014;123(10):1440-1 - PMID: 24627550 - PMCID: PMC3945857 - DOI: 10.1182/blood-2014-01-549519
Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS
CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD.
Blood. 2003;101(10):4033-41 - PMID: 12576324 - DOI: 10.1182/blood-2002-01-0324
Da Silva N, Bharti A, Shelley CS
hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter.
Blood. 2002;100(10):3536-44 - PMID: 12411317 - DOI: 10.1182/blood.V100.10.3536
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Del Toro R, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Blood. 2014;124(19):2937-47 - PMID: 25202142 - PMCID: PMC4224192 - DOI: 10.1182/blood-2014-08-593426
Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression.
Blood. 2015;126(16):1930-9 - PMID: 26320100 - PMCID: PMC4608240 - DOI: 10.1182/blood-2015-06-649087
Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.
Blood. 2016;127(19):2327-36 - PMID: 26755707 - PMCID: PMC4865590 - DOI: 10.1182/blood-2015-11-681494
Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL
Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.
Blood. 2016;129(4):405-414 - PMID: 27864295 - PMCID: PMC5270389 - DOI: 10.1182/blood-2016-06-721571
Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL
Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.
Blood. 2017;130(1):73-83 - PMID: 28438754 - PMCID: PMC5501149 - DOI: 10.1182/blood-2016-12-759423
Wang CY, Babitt JL
Liver iron sensing and body iron homeostasis.
Blood. 2018;133(1):18-29 - PMID: 30401708 - PMCID: PMC6318427 - DOI: 10.1182/blood-2018-06-815894
Wang CY, Xu Y, Traeger L, Dogan DY, Xiao X, Steinbicker AU, Babitt JL
Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
Blood. 2020;135(6):453-456 - PMID: 31800957 - PMCID: PMC7005366 - DOI: 10.1182/blood.2019002620
Park SY, Matte A, Jung Y, Ryu J, Wilson AB, Han EYA, Liu M, Carbone C, Melisi D, Nagasawa T, Locascio JJ, Lin CP, Silberstein LE, De Franceschi L
Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversible by blood transfusion.
Blood. 2020;135(23):2071-2084 - PMID: 31990287 - PMCID: PMC7273832 - DOI: 10.1182/blood.2019002227
Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JC, Fogerty AE, Waheed A, Goodarzi K, Bendapudi P, Bornikova L, Gupta S, Leaf D, Kuter DJ, Rosovsky RP
COVID and Coagulation: Bleeding and Thrombotic Manifestations of SARS-CoV2 Infection.
Blood. 2020;136(4):489-500 - PMID: 32492712 - PMCID: PMC7378457 - DOI: 10.1182/blood.2020006520
Man CH, Mercier FE, Liu N, Dong W, Stephanopoulos G, Jiang L, Jung Y, Lin CP, Leung AYH, Scadden DT
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
Blood. 2022;139(4):502-522 - PMID: 34610101 - PMCID: PMC8796654 - DOI: 10.1182/blood.2021011563
Miller P, Fell G, Foy B, Scherer A, Gibson CJ, Sperling AS, Burugula BB, Nakao T, Uddin MM, Warren H, Bry L, Pozdnyakova O, Frigault MJ, Bick AG, Neuberg D, Higgins JM, Mansour M, Natarajan P, Kim AS, Kitzman J, Ebert BL
Clonal Hematopoiesis of Indeterminate Potential and Risk of Death from COVID-19.
Blood. 2022;140(18):1993-1997 - PMID: 36096050 - PMCID: PMC9474399 - DOI: 10.1182/blood.2022018052
Rhee C, Scadden EW, Wong LP, Schiroli G, Mazzola MC, Chea PL, Kato H, Hoyer FF, Mistry M, Lee BK, Kim J, Nahrendorf M, Mansour M, Sykes DB, Sadreyev R, Scadden DT
Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors.
Blood. 2023;142(7):658-674 - PMID: 37267513 - PMCID: PMC10447620 - DOI: 10.1182/blood.2023020257
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
Cancer Cell. 2002;1:269-77 - PMID: 12086863 - DOI: 10.1016/s1535-6108(02)00046-6
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer Cell. 2006;9(6):485-95 - PMID: 16730237 - DOI: 10.1016/j.ccr.2006.04.022
Wurdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM
miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells.
Cancer Cell. 2008;14(5):382-393 - PMID: 18977327 - PMCID: PMC2597164 - DOI: 10.1016/j.ccr.2008.10.005
Rheinbay E, Louis DN, Bernstein BE, Suvà ML
A Tell-Tail Sign of Chromatin: Histone Mutations Drive Pediatric Glioblastoma.
Cancer Cell. 2012;21(3):329-331 - PMID: 22439930 - DOI: 10.1016/j.ccr.2012.03.001
Abdel-Wahab O, Adli M, Lafave LM, Gao J, Hricik T, Shih AH, Pandey S, Patel JP, Chung YR, Koche R, Perna F, Zhao X, Taylor JE, Park CY, Carroll M, Melnick A, Nimer SD, Jaffe JD, Aifantis I, Bernstein BE, Levine RL
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression.
Cancer Cell. 2012;22(2):180-93 - PMID: 22897849 - PMCID: PMC3422511 - DOI: 10.1016/j.ccr.2012.06.032
Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling.
Cancer Cell. 2013;24(1):45-58 - PMID: 23770013 - PMCID: PMC3746037 - DOI: 10.1016/j.ccr.2013.05.004
Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.
Cancer Cell. 2014;26(5):668-81 - PMID: 25453903 - PMCID: PMC4492343 - DOI: 10.1016/j.ccell.2014.10.004
Pfirschke C, Garris C, Pittet MJ
Common TLR5 Mutations Control Cancer Progression.
Cancer Cell. 2015;27(1):1-3 - PMID: 25584886 - DOI: 10.1016/j.ccell.2014.12.008
Pfirschke C, Siwicki M, Liao HW, Pittet MJ
Tumor Microenvironment: No Effector T Cells without Dendritic Cells.
Cancer Cell. 2017;31(5):614-615 - PMID: 28486102 - DOI: 10.1016/j.ccell.2017.04.007
Kleppe M, Koche R, Zou L, van Galen P, Hill CE, Dong L, De Groote S, Papalexi E, Hanasoge Somasundara AV, Cordner K, Keller M, Farnoud N, Medina J, McGovern E, Reyes J, Roberts J, Witkins M, Rapaport F, Teruya-Feldstein J, Qi J, Rampal R, Bernstein BE, Bradner JE, Levine RL
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.
Cancer Cell. 2017;33(1):29-43.e7 - PMID: 29249691 - PMCID: PMC5760343 - DOI: 10.1016/j.ccell.2017.11.009
Rahme GJ, Gaskell E, Bernstein BE
GABPβ1L Wakes Up TERT.
Cancer Cell. 2018;34(3):358-360 - PMID: 30205042 - DOI: 10.1016/j.ccell.2018.08.011
Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.
Cancer Cell. 2019;36(5):528-544.e10 - PMID: 31631026 - DOI: 10.1016/j.ccell.2019.09.005
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