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Klein HU, McCabe C, Gjoneska E, Sullivan SE, Kaskow BJ, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, Bennett DA, De Jager PL
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.
Nat Neurosci. 2018;22(1):37-46 - PMID: 30559478 - PMCID: PMC6516529 - DOI: 10.1038/s41593-018-0291-1
Cruz Hernández JC, Bracko O, Kersbergen CJ, Muse V, Haft-Javaherian M, Berg M, Park L, Vinarcsik LK, Ivasyk I, Rivera DA, Kang Y, Cortes-Canteli M, Peyrounette M, Doyeux V, Smith A, Zhou J, Otte G, Beverly JD, Davenport E, Davit Y, Lin CP, Strickland S, Iadecola C, Lorthois S, Nishimura N, Schaffer CB
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models.
Nat Neurosci. 2019;22(3):413-420 - PMID: 30742116 - PMCID: PMC6508667 - DOI: 10.1038/s41593-018-0329-4
Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.
Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2
Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A
IKKb regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways.
Nat Commun. 2011;2:318 - PMID: 21587235 - PMCID: PMC3113230 - DOI: 10.1038/ncomms1317
Shi P, Scott MA, Ghosh B, Wan D, Wissner-Gross Z, Mazitschek R, Haggarty SJ, Yanik MF
Synapse microarray identification of small molecules that enhance synaptogenesis.
Nat Commun. 2011;2:510 - PMID: 22027590 - PMCID: PMC3544154 - DOI: 10.1038/ncomms1518
Lee S, Vinegoni C, Feruglio PF, Fexon L, Gorbatov R, Pivovarov M, Sbarbati A, Nahrendorf M, Weissleder R
Real-time in vivo imaging of the beating mouse heart at microscopic resolution
Nat Commun. 2012;3:1054 - PMID: 22968700 - PMCID: PMC3622400 - DOI: 10.1038/ncomms2060
Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Nat Commun. 2013;4:1504 - PMID: 23422672 - PMCID: PMC3579506 - DOI: 10.1038/ncomms2506
Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H*, Weissleder R*
Magnetic barcode assay for genetic detection of pathogens
Nat Commun. 2013;4:1752 - PMID: 23612293 - PMCID: PMC3635151 - DOI: 10.1038/ncomms2745
Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW
Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.
Nat Commun. 2013;4:2189 - PMID: 23877263 - PMCID: PMC3740589 - DOI: 10.1038/ncomms3189
Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.
Nat Commun. 2013;4:2532 - PMID: 24113571 - PMCID: PMC3826633 - DOI: 10.1038/ncomms3532
Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Fisher EA, Fayad ZA, Mulder WJ
A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.
Nat Commun. 2014;5:3065 - PMID: 24445279 - PMCID: PMC4001802 - DOI: 10.1038/ncomms4065
Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R
In vivo imaging of specific drug-target binding at subcellular resolution.
Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946
Lee SK, Mortensen LJ, Lin CP, Tung CH
An authentic imaging probe to track cell fate from beginning to end.
Nat Commun. 2014;5:5216 - PMID: 25323442 - PMCID: PMC4852472 - DOI: 10.1038/ncomms6216
Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Nat Commun. 2014;5:5662 - PMID: 25489927 - PMCID: PMC4261930 - DOI: 10.1038/ncomms6662
Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H*, Weissleder R*
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Nat Commun. 2015;6:6999 - PMID: 25959588 - PMCID: PMC4430127 - DOI: 10.1038/ncomms7999
Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Nat Commun. 2015;6:7029 - PMID: 25967391 - PMCID: PMC4435621 - DOI: 10.1038/ncomms8029
Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Nat Commun. 2015;6:8692 - PMID: 26503691 - PMCID: PMC4711745 - DOI: 10.1038/ncomms9692
Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M
Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.
Nat Commun. 2015;6:8803 - PMID: 26541940 - PMCID: PMC4638135 - DOI: 10.1038/ncomms9803
Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666
Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R
Real-time high dynamic range laser scanning microscopy.
Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995 - DOI: 10.1038/ncomms11077
Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Nat Commun. 2016;7:12313 - PMID: 27460411 - PMCID: PMC4974469 - DOI: 10.1038/ncomms12313
Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064
Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW
ADAM8 as a drug target in pancreatic cancer.
Nat Commun. 2015;6:6175 - PMID: 25629724 - PMCID: PMC5014123 - DOI: 10.1038/ncomms7175
Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
Nat Commun. 2017;8:15142 - PMID: 28485378 - PMCID: PMC5436068 - DOI: 10.1038/ncomms15142
Chen X, Park HR, Pelton M, Piao X, Lindquist NC, Im H, Kim YJ, Ahn JS, Ahn KJ, Park N, Kim DS, Oh SH
Atomic layer lithography of wafer-scale nanogap arrays for extreme confinement of electromagnetic waves.
Nat Commun. 2013;4:2361 - PMID: 23999053 - DOI: 10.1038/ncomms3361
Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R
Nano-palladium is a cellular catalyst for in vivo chemistry
Nat Commun. 2017;8:15906 - PMID: 28699627 - PMCID: PMC5510178 - DOI: 10.1038/ncomms15906
Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL
PD-L1 is an activation-independent marker of brown adipocytes.
Nat Commun. 2017;8(1):647 - PMID: 28935898 - PMCID: PMC5608754 - DOI: 10.1038/s41467-017-00799-8
Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC
Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts.
Nat Commun. 2017;8(1):765 - PMID: 29018244 - PMCID: PMC5635127 - DOI: 10.1038/s41467-017-00779-y
Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA
The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.
Nat Commun. 2018;9(1):2377 - PMID: 29915352 - PMCID: PMC6006146 - DOI: 10.1038/s41467-018-04716-5
Karaayvaz M, Cristea S, Gillespie SM, Patel AP, Mylvaganam R, Luo CC, Specht MC, Bernstein BE, Michor F, Ellisen LW
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq.
Nat Commun. 2018;9(1):3588 - PMID: 30181541 - PMCID: PMC6123496 - DOI: 10.1038/s41467-018-06052-0
Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R
Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens
Nat Commun. 2018;9(1):4550 - PMID: 30382095 - PMCID: PMC6208406 - DOI: 10.1038/s41467-018-07002-6
Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G
Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
Nat Commun. 2019;10(1):1486 - PMID: 30940805 - PMCID: PMC6445096 - DOI: 10.1038/s41467-019-09415-3
Pastore A, Gaiti F, Lu SX, Brand RM, Kulm S, Chaligne R, Gu H, Huang KY, Stamenova EK, Béguelin W, Jiang Y, Schulman RC, Kim KT, Alonso A, Allan JN, Furman RR, Gnirke A, Wu CJ, Melnick AM, Meissner A, Bernstein BE, Abdel-Wahab O, Landau DA
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL.
Nat Commun. 2019;10(1):1874 - PMID: 31015400 - PMCID: PMC6478836 - DOI: 10.1038/s41467-019-09645-5
Liu CL, Zhang X, Liu J, Wang Y, Sukhova GK, Wojtkiewicz GR, Liu T, Tang R, Achilefu S, Nahrendorf M, Libby P, Guo J, Zhang JY, Shi GP
Na+ - H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis.
Nat Commun. 2019;10(1):3978 - PMID: 31484936 - PMCID: PMC6726618 - DOI: 10.1038/s41467-019-11983-3
Tarjan DR, Flavahan WA, Bernstein BE
Epigenome editing strategies for the functional annotation of CTCF insulators.
Nat Commun. 2019;10(1):4258 - PMID: 31534142 - PMCID: PMC6751197 - DOI: 10.1038/s41467-019-12166-w
Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.
Nat Commun. 2020;11(1):1406 - PMID: 32179749 - PMCID: PMC7076002 - DOI: 10.1038/s41467-020-15221-z
Boivin G, Faget J, Ancey PB, Gkasti A, Mussard J, Engblom C, Pfirschke C, Contat C, Pascual J, Vazquez J, Bendriss-Vermare N, Caux C, Vozenin MC, Pittet MJ, Gunzer M, Meylan E
Durable and controlled depletion of neutrophils in mice.
Nat Commun. 2020;11(1):2762 - PMID: 32488020 - PMCID: PMC7265525 - DOI: 10.1038/s41467-020-16596-9
Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
Nat Commun. 2020;11:3521 - PMID: 32665556 - PMCID: PMC7360550 - DOI: 10.1038/s41467-020-17147-y
Javed N, Farjoun Y, Fennell TJ, Epstein CB, Bernstein BE, Shoresh N
Detecting sample swaps in diverse NGS data types using linkage disequilibrium.
Nat Commun. 2020;11(1):3697 - PMID: 32728101 - PMCID: PMC7391710 - DOI: 10.1038/s41467-020-17453-5
Oki T, Mercier F, Kato H, Jung Y, McDonald TO, Spencer JA, Mazzola MC, van Gastel N, Lin CP, Michor F, Kitamura T, Scadden DT
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.
Nat Commun. 2021;12(1):245 - PMID: 33431855 - PMCID: PMC7801403 - DOI: 10.1038/s41467-020-20491-8
Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G
p53 dynamics vary between tissues and are linked with radiation sensitivity
Nat Commun. 2021;12(1):898 - PMID: 33563973 - PMCID: PMC7873198 - DOI: 10.1038/s41467-021-21145-z
Bénard A, Jacobsen A, Brunner M, Krautz C, Klösch B, Swierzy I, Naschberger E, Podolska MJ, Kouhestani D, David P, Birkholz T, Castellanos I, Trufa D, Sirbu H, Vetter M, Kremer AE, Hildner K, Hecker A, Edinger F, Tenbusch M, Mühl-Zürbes P, Steinkasserer A, Richter E, Streeck H, Berger MM, Brenner T, Weigand MA, Swirski FK, Schett G, Grützmann R, Weber GF
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Nat Commun. 2021;12(1):1112 - PMID: 33602937 - PMCID: PMC7893044 - DOI: 10.1038/s41467-021-21310-4
Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Nat Commun. 2021;12(1):6271 - PMID: 34725346 - PMCID: PMC8560803 - DOI: 10.1038/s41467-021-26571-7
Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP
Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.
Nat Commun. 2022;13(1):393 - PMID: 35046411 - PMCID: PMC8770570 - DOI: 10.1038/s41467-022-27973-x
Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2
Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Nat Commun. 2022;13(1):4976 - PMID: 36008486 - PMCID: PMC9403976 - DOI: 10.1038/s41467-022-32630-4
Chapman S, Dobrovolskaia M, Farahani K, Goodwin A, Joshi A, Lee H, Meade T, Pomper M, Ptak K, Rao J, Singh R, Sridhar S, Stern S, Wang A, Weaver JB, Woloschak G, Yang L
Nanoparticles for cancer imaging: The good, the bad, and the promise.
Nano Today. 2013;8(5):454-460 - PMID: 25419228 - PMCID: PMC4240321 - DOI: 10.1016/j.nantod.2013.06.001
Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
Gastroenterology. 2002;122:406-14 - PMID: 11832455 - DOI: 10.1053/gast.2002.30990
Mahmood U, Wallace MB
Molecular imaging in gastrointestinal disease.
Gastroenterology. 2007;132(1):11-4 - PMID: 17241854 - DOI: 10.1053/j.gastro.2006.12.013
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