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Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187
Ng TSC, Garlin MA, Weissleder R, Miller MA Understanding the EPR effect through image-guided systems pharmacology Theranostics. 2019;:ePub
Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy Theranostics. 2019;9(26):8426-8436 - PMID: 31879528 - PMCID: PMC6924259 - DOI: 10.7150/thno.35434
Rodell CB, Koch PD, Weissleder R Screening for new macrophage therapeutics. Theranostics. 2019;9(25):7714-7729 - PMID: 31695796 - PMCID: PMC6831478 - DOI: 10.7150/thno.34421
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Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L Large and small extracellular vesicles released by glioma cells in vitro and in vivo. J Extracell Vesicles. 2019;9(1):1689784 - PMID: 31839905 - PMCID: PMC6896449 - DOI: 10.1080/20013078.2019.1689784
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Yassin M, Aqaqe N, Yassin AA, van Galen P, Kugler E, Bernstein BE, Koren-Michowitz M, Canaani J, Nagler A, Lechman ER, Dick JE, Wienholds E, Izraeli S, Milyavsky M A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity. Leukemia. 2019;33(8):2061-2077 - PMID: 30705411 - DOI: 10.1038/s41375-019-0386-z
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Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019;21(5):606-615 - PMID: 30561734 - PMCID: PMC6502493 - DOI: 10.1093/neuonc/noy187
Morini E, Gao D, Montgomery CM, Salani M, Mazzasette C, Krussig TA, Swain B, Dietrich P, Narasimhan J, Gabbeta V, Dakka A, Hedrick J, Zhao X, Weetall M, Naryshkin NA, Wojtkiewicz GG, Ko CP, Talkowski ME, Dragatsis I, Slaugenhaupt SA ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia. Am J Hum Genet. 2019;104(4):638-650 - PMID: 30905397 - PMCID: PMC6451698 - DOI: 10.1016/j.ajhg.2019.02.009
Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS Iron, Hepcidin, and Death in Human AKI. J Am Soc Nephrol. 2019;30(3):493-504 - PMID: 30737269 - PMCID: PMC6405140 - DOI: 10.1681/ASN.2018100979
Chaudhury A, Miller GD, Eichner D, Higgins JM Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss. eLife. 2019;8:ePub - PMID: 31845889 - PMCID: PMC6917488 - DOI: 10.7554/eLife.48590
Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice. PLoS Genet. 2019;15(5):e1008084 - PMID: 31059511 - PMCID: PMC6502318 - DOI: 10.1371/journal.pgen.1008084
Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - PMCID: PMC6528836 - DOI: 10.1016/j.celrep.2019.03.003
Shikatani EA, Besla R, Ensan S, Upadhye A, Khyzha N, Li A, Emoto T, Chiu F, Degousee N, Moreau JM, Perry HM, Thayaparan D, Cheng HS, Pacheco S, Smyth D, Noyan H, Zavitz CCJ, Bauer CMT, Hilgendorf I, Libby P, Swirski FK, Gommerman JL, Fish JE, Stampfli MR, Cybulsky MI, Rubin BB, Paige CJ, Bender TP, McNamara CA, Husain M, Robbins CS c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. Cell Rep. 2019;27(8):2304-2312.e6 - PMID: 31116977 - DOI: 10.1016/j.celrep.2019.04.090
Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity. Cell Rep. 2019;27(13):3972-3987.e6 - PMID: 31242427 - PMCID: PMC6604862 - DOI: 10.1016/j.celrep.2019.05.089
Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - PMCID: PMC6571021 - DOI: 10.1038/s41596-018-0105-7
Li A, Wu Y, Pulli B, Wojtkiewicz GR, Iwamoto Y, Wang C, Li JH, Ali M, Feng X, Yao Z, Chen JW Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation. Radiology. 2019;293(1):158-165 - PMID: 31478802 - PMCID: PMC6776885 - DOI: 10.1148/radiol.2019182492
Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiother Oncol. 2019;142:154-161 - PMID: 31563411 - DOI: 10.1016/j.radonc.2019.09.008
Mindur JE, Swirski FK Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019;39(7):1275-1287 - PMID: 31092009 - PMCID: PMC6613384 - DOI: 10.1161/ATVBAHA.119.311994
Lan YY, Heather JM, Eisenhaure T, Garris CS, Lieb D, Raychowdhury R, Hacohen N Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation. Aging Cell. 2019;18(2):e12901 - PMID: 30706626 - PMCID: PMC6413746 - DOI: 10.1111/acel.12901
Battistone MA, Spallanzani RG, Mendelsohn AC, Capen D, Nair AV, Brown D, Breton S Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity. J Cell Sci. 2019;133(5):ePub - PMID: 31636115 - PMCID: PMC7003979 - DOI: 10.1242/jcs.233239
Cohen RM, Franco RS, Smith EP, Higgins JM When the A1c and the blood glucose don't match: how much is determined by race, by genetics, by differences in mean red blood cell age? J Clin Endocrinol Metab. 2019;104(3):707-710 - PMID: 30445523 - DOI: 10.1210/jc.2018-02409
Parikh AS, Puram SV, Faquin WC, Richmon JD, Emerick KS, Deschler DG, Varvares MA, Tirosh I, Bernstein BE, Lin DT Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis. Oral Oncol. 2019;99:104458 - PMID: 31704557 - PMCID: PMC7382966 - DOI: 10.1016/j.oraloncology.2019.104458
Sanford NN, Hwang WL, Pike LRG, Lam AC, Royce TJ, Mahal BA Trimodality therapy for HPV-positive oropharyngeal cancer: A population-based study: Trimodality therapy for HPV+ OPC. Oral Oncol. 2019;98:28-34 - PMID: 31536843 - PMCID: PMC7358785 - DOI: 10.1016/j.oraloncology.2019.09.009
Foy BH, Li A, McClung J, Ranganath R, Higgins JM Data-driven physiologic thresholds for iron deficiency associated with hematologic decline. Am J Hematol. 2019;95(3):302-309 - PMID: 31849101 - DOI: 10.1002/ajh.25706
Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre A, Nahrendorf M, Weissleder R A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019;30(3):733-740 - PMID: 30615425 - PMCID: PMC6483069 - DOI: 10.1021/acs.bioconjchem.8b00882
Stokes KL, Cortez-Retamozo V, Acosta J, Lauderback B, Robles-Oteiza C, Cicchini M, Pittet MJ, Feldser DM Natural killer cells limit the clearance of senescent lung adenocarcinoma cells. Oncogenesis. 2019;8(4):24 - PMID: 30936429 - PMCID: PMC6443683 - DOI: 10.1038/s41389-019-0133-3
Krasner CN, Castro C, Penson RT, Roche M, Matulonis UA, Morgan MA, Drescher C, Armstrong DK, Wolfe JK, Lee H, Supko JG, Seiden M, Birrer MJ, Dizon DS Final report on serial phase II trials of all-intraperitoneal chemotherapy with or without bevacizumab for women with newly diagnosed, optimally cytoreduced carcinoma of Müllerian origin. Gynecol Oncol. 2019;153(2):223-229 - PMID: 30765148 - DOI: 10.1016/j.ygyno.2019.02.004
Rangarajan N, Gordy CL, Askew L, Bevill SM, Elston TC, Errede B, Hurst JH, Kelley JB, Sheetz JB, Suzuki SK, Valentin NH, Young E, Dohlman HG Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway. J Biol Chem. 2019;294(40):14717-14731 - PMID: 31399514 - PMCID: PMC6779436 - DOI: 10.1074/jbc.RA119.010063
Tan X, Patil R, Bartosik P, Runnels JM, Lin CP, Niedre M In Vivo Flow Cytometry of Extremely Rare Circulating Cells. Sci Rep. 2019;9(1):3366 - PMID: 30833671 - PMCID: PMC6399281 - DOI: 10.1038/s41598-019-40143-2
Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Sci Rep. 2019;9(1):17387 - PMID: 31758005 - PMCID: PMC6874653 - DOI: 10.1038/s41598-019-53554-y
Larkin M, Nathan DM, Bebu I, Krause-Steinrauf H, Herman WH, Higgins JM, Tiktin M, Cohen RM, Lund C, Bergenstal RM, Johnson M, Arends V, Research Group G Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring. Diabetes Technol Ther. 2019;21(12):682-690 - PMID: 31393176 - PMCID: PMC7207016 - DOI: 10.1089/dia.2019.0202
Battistone MA, Merkulova M, Park YJ, Peralta MA, Gombar F, Brown D, Breton S Unraveling purinergic regulation in the epididymis: Activation of V-ATPase-dependent acidification by luminal ATP and adenosine. J Physiol. 2019;597(7):1957-1973 - PMID: 30746715 - PMCID: PMC6441927 - DOI: 10.1113/JP277565
Koch PD, Ahmed MS, Kohler RH, Li R, Weissleder R Imaging of Tie2 with a fluorescently labeled small molecule affinity ligand. ACS Chem Biol. 2019;15(1):151-157 - PMID: 31809013 - PMCID: PMC7808335 - DOI: 10.1021/acschembio.9b00724
Fagbami L, Deik AA, Herman JD, Singh K, Santos SA, Bopp S, Lukens AK, Clish CB, Wirth DF, Mazitschek R The adaptive proline response in P. falciparum is independent of PfeIK1 and eIF2α signaling. ACS Infect Dis. 2019;5(4):515-520 - PMID: 30773881 - PMCID: PMC6747701 - DOI: 10.1021/acsinfecdis.8b00363
Bassir SH, Garakani S, Wilk K, Aldawood ZA, Hou J, Yeh SA, Sfeir C, Lin CP, Intini G Prx1 Expressing Cells Are Required for Periodontal Regeneration of the Mouse Incisor. Front Physiol. 2019;10:591 - PMID: 31231227 - PMCID: PMC6558369 - DOI: 10.3389/fphys.2019.00591
Babitt JL, Sitara D Crosstalk between fibroblast growth factor 23, iron, erythropoietin, and inflammation in kidney disease. Curr Opin Nephrol Hypertens. 2019;28(4):304-310 - PMID: 31145704 - PMCID: PMC6693648 - DOI: 10.1097/MNH.0000000000000514
Nair AV, Yanhong W, Paunescu TG, Bouley R, Brown D Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice. PLoS ONE. 2019;14(8):e0219940 - PMID: 31386675 - PMCID: PMC6684071 - DOI: 10.1371/journal.pone.0219940
Chin LY, Carroll C, Raigani S, Detelich DM, Tessier SN, Wojtkiewicz GR, Schmidt SP, Weissleder R, Yeh H, Uygun K, Parekkadan B Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs. PLoS ONE. 2019;14(12):e0225222 - PMID: 31790444 - PMCID: PMC6886851 - DOI: 10.1371/journal.pone.0225222
Li R, Attari A, Prytyskach M, Garlin MA, Weissleder R, Miller MA Single‐Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics Cytometry A. 2019;97(5):528-539 - PMID: 31423731 - PMCID: PMC7028488 - DOI: 10.1002/cyto.a.23872
Marshansky V, Hosokawa H, Merkulova M, Bakulina A, Dip PV, Thaker YR, Bjargava A, Tonra JR, Ausiello DA, Grüber G Structural model of a2-subunit N-terminus and its binding interface for Arf-GEF CTH2: Implication for regulation of V-ATPase, CTH2 function and rational drug design. Curr Top Membr. 2019;83:77-106 - PMID: 31196611 - DOI: 10.1016/bs.ctm.2019.01.008
Marquard AN, Carlson JCT, Weissleder R Glass Chemistry to Analyze Human Cells under Adverse Conditions ACS Omega. 2019;4:11515−11521 - PMID: 31460257 - PMCID: PMC6682085 - DOI: 10.1021/acsomega.9b01036
Zhao WN, Hylton NK, Wang J, Chindavong PS, Alural B, Kurtser I, Subramanian A, Mazitschek R, Perlis RH, Haggarty SJ Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA). Mol Cell Neurosci. 2019;99:103386 - PMID: 31202891 - PMCID: PMC7001743 - DOI: 10.1016/j.mcn.2019.06.006
Ahrens CC, Chiswick EL, Ravindra KC, Miller MA, Ramseier J, Isaacson KB, Lauffenburger DA, Griffith LG Development and Application of the Metalloprotease Activity Multi-plexed Bead-based Immunoassay (MAMBI). Biochemistry. 2019;58(38):3938-3942 - PMID: 31474112 - DOI: 10.1021/acs.biochem.9b00584
Patil R, Tan X, Bartosik P, Detappe A, Runnels JM, Ghobrial I, Lin CP, Niedre M Fluorescence monitoring of rare circulating tumor cell and cluster dissemination in a multiple myeloma xenograft model in vivo. J Biomed Opt. 2019;24(8):1-11 - PMID: 31456386 - PMCID: PMC6983486 - DOI: 10.1117/1.JBO.24.8.085004
Sullivan R, Légaré C, Lamontagne-Proulx J, Breton S, Soulet D Revisiting structure/functions of the human epididymis. Andrology. 2019;7(5):748-757 - PMID: 31033221 - DOI: 10.1111/andr.12633
Breton S, Nair AV, Battistone MA Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa. Andrology. 2019;7(5):631-643 - PMID: 31044554 - PMCID: PMC6688936 - DOI: 10.1111/andr.12632
Chulroek T, Kordbacheh H, Wangcharoenrung D, Cattapan K, Heidari P, Harisinghani MG Comparative accuracy of qualitative and quantitative 18F-FDG PET/CT analysis in detection of lymph node metastasis from anal cancer. Abdom Radiol (NY). 2019;44(3):828-835 - PMID: 30694369 - DOI: 10.1007/s00261-019-01907-6
Kordbacheh H, Baliyan V, Parakh A, Wojtkiewicz GR, Hedgire S, Harisinghani MG Pictorial review on abdominal applications of ferumoxytol in MR imaging. Abdom Radiol (NY). 2019;44(10):3273-3284 - PMID: 31378828 - DOI: 10.1007/s00261-019-02163-4
Valdez JM, Datta YH, Higgins JM, Wood DK A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood. APL Bioeng. 2019;3(4):046102 - PMID: 31803859 - PMCID: PMC6881198 - DOI: 10.1063/1.5118212
Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects. Cell Stress. 2019;3(11):348-360 - PMID: 31799501 - PMCID: PMC6859426 - DOI: 10.15698/cst2019.11.204
Hansen S, Wood DK, Higgins JM 5-(Hydroxymethyl)furfural restores low-oxygen rheology of sickle trait blood in vitro. Br J Haematol. 2019;188(6):985-993 - PMID: 31889311 - PMCID: PMC7150585 - DOI: 10.1111/bjh.16251
Bevill SM, Olivares-Quintero JF, Sciaky N, Golitz BT, Singh D, Beltran AS, Rashid NU, Stuhlmiller TJ, Hale A, Moorman NJ, Santos CM, Angus SP, Zawistowski JS, Johnson GL GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer. Mol Cancer Res. 2019;17(7):1503-1518 - PMID: 31000582 - PMCID: PMC6610760 - DOI: 10.1158/1541-7786.MCR-18-1121
Kim J, Lee SK, Schellingerhout D, Nahrendorf M, Kim K, Kim J, Kim DE Spectroscopic Assessment of Gold Nanoparticle Biodistribution Using Surface Plasmon Resonance Phenomena. ACS Biomater Sci Eng. 2019;5(12):6389-6394 - PMID: 33417791 - DOI: 10.1021/acsbiomaterials.9b01079
Banik G, Betts CB, Liudahl SM, Sivagnanam S, Kawashima R, Cotechini T, Larson W, Goecks J, Pai SI, Clayburgh DR, Tsujikawa T, Coussens LM High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers. Methods Enzymol. 2019;635:1-20 - PMID: 32122539 - PMCID: PMC7390987 - DOI: 10.1016/bs.mie.2019.05.039
Pai SI, Marincola FM Peripheral Circulating CD45RA-FOXP3hi T Regulatory (TReg) II Cells Provide a Window into the Activity of Intratumoral TReg Cells. Trends Cancer. 2019;6(1):3-6 - PMID: 31952778 - PMCID: PMC7390988 - DOI: 10.1016/j.trecan.2019.11.003
Pai SI, Cohen EEW, Lin D, Fountzilas G, Kim ES, Mehlhorn H, Baste N, Clayburgh D, Lipworth L, Resteghini C, Shara N, Fujii T, Zhang J, Stokes M, Wang H, Twumasi-Ankrah P, Wildsmith S, Khaliq A, Melillo G, Shire N SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. J Transl Med. 2019;17(1):429 - PMID: 31878938 - PMCID: PMC6933901 - DOI: 10.1186/s12967-019-02182-1
Ishida E, Lee J, Campbell JS, Chakravarty PD, Katori Y, Ogawa T, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model. Cancer Immunol Immunother. 2019;68(8):1273-1286 - PMID: 31243491 - PMCID: PMC6684362 - DOI: 10.1007/s00262-019-02357-1
Wolkow N, Jakobiec FA, Afrogheh AH, Eagle RC, Pai SI, Faquin WC Programmed Cell Death 1 Ligand 1 and Programmed Cell Death 1 Ligand 2 Are Expressed in Conjunctival Invasive Squamous Cell Carcinoma: Therapeutic Implications. Am J Ophthalmol. 2019;200:226-241 - PMID: 30633894 - PMCID: PMC7456462 - DOI: 10.1016/j.ajo.2018.12.020
Lamba N, Hwang WL, Kim DW, Niemierko A, Marciscano AE, Mehan WA, Benayoun MD, Curry WT, Barker FG, Martuza RL, Dunn IF, Claus E, Bi WL, Aizer AA, Alexander BM, Oh KS, Loeffler JS, Shih HA Atypical Histopathological Features and the Risk of Treatment Failure in Nonmalignant Meningiomas: A Multi-Institutional Analysis. World Neurosurg. 2019;133:e804-e812 - PMID: 31605839 - DOI: 10.1016/j.wneu.2019.10.002
Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA Risk stratification by somatic mutation burden in Ewing sarcoma. Cancer. 2019;125(8):1357-1364 - PMID: 30602061 - DOI: 10.1002/cncr.31919