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Case records of the Massachusetts General Hospital. Case 5-2011. A 65-year-old man with hematuria after treatment for prostate cancer.
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Case records of the Massachusetts General Hospital. Case 9-2012. A 67-year-old man with a persistently elevated PSA level.
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Case records of the Massachusetts General Hospital. Case 20-2012. A 77-year-old man with leg edema, hematuria, and acute renal failure.
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Case records of the Massachusetts General Hospital. Case 21-2012. A 27-year-old man with fatigue, weakness, weight loss, and decreased libido.
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Case records of the Massachusetts General Hospital. Case 25-2012. A 15-year-old boy with abdominal pain, hematochezia, and anemia.
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Case records of the Massachusetts General Hospital. Case 3-2013. A 72-year-old woman with abdominal pain and distention after peritoneal dialysis.
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Case records of the Massachusetts General Hospital. Case 25-2013. A 71-year-old man with hematuria and a mass in the bladder.
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Case 5-2019: A 48-Year-Old Woman with Delusional Thinking and Paresthesia of the Right Hand.
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Blood. 2003;101(10):4033-41 - PMID: 12576324 - DOI: 10.1182/blood-2002-01-0324
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Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo.
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Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R.
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50 - PMID: 18040026 - DOI: 10.1161/CIRCULATIONAHA.107.732867
Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik D, Aikawa E, Libby P, Swirski F, Weissleder R.
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
Circulation. 2007;117:379-387 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181
Kircher M, Grimm J, Swirski FK, Libby P, Gerszten R, Allport J, Weissleder R
Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions.
Circulation. 2008;117:388-395 - PMID: 18172031 - PMCID: PMC2705289 - DOI: 10.1161/CIRCULATIONAHA.107.719765
Nahrendorf M*, Sosnovik D*, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R
Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury.
Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510
Libby P, Nahrendorf M, Pittet MJ, Swirski FK
Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal.
Circulation. 2008;117(25):3168-70 - PMID: 18574058 - DOI: 10.1161/CIRCULATIONAHA.108.783068
Aikawa E, Whittaker P, Farber M, Mendelson K, Padera R, Aikawa M, Schoen F
Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.
Circulation. 2006;113:1344-52 - PMID: 16534030 - DOI: 10.1161/CIRCULATIONAHA.105.591768
Aikawa M, Sugiyama S, Hill C, Voglic S, Rabkin E, Fukumoto Y, Schoen F, Witztum J, Libby P
Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma.
Circulation. 2002;106:1390-6 - PMID: 12221058 - DOI: 10.1161/01.cir.0000028465.52694.9b
Deguchi J, Aikawa E, Libby P, Vachon J, Inada M, Krane S, Whittaker P, Aikawa M
Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques.
Circulation. 2005;112:2708-15 - PMID: 16230484 - DOI: 10.1161/CIRCULATIONAHA.105.562041
Lindsey M, Gannon J, Aikawa M, Schoen F, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell P, Lee R
Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.
Circulation. 2002;105:753-8 - PMID: 11839633 - DOI: 10.1161/hc0602.103674
Larose E, Yeghiazarians Y, Libby P, Yucel E, Aikawa M, Kacher D, Aikawa E, Kinlay S, Schoen F, Selwyn A, Ganz P
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Circulation. 2005;112:2324-31 - PMID: 16203910 - DOI: 10.1161/CIRCULATIONAHA.105.538942
Heller E, Liu E, Tager A, Sinha S, Roberts J, Koehn S, Libby P, Aikawa E, Chen J, Huang P, Freeman M, Moore K, Luster A, Gerszten R
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation. 2005;112:578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616
Sutherland F, Perry T, Yu Y, Sherwood M, Rabkin E, Masuda Y, Garcia G, McLellan D, Engelmayr G, Sacks M, Schoen F, Mayer J
From stem cells to viable autologous semilunar heart valve.
Circulation. 2005;111:2783-91 - PMID: 15927990 - DOI: 10.1161/CIRCULATIONAHA.104.498378
Fukumoto Y, Deguchi J, Libby P, Rabkin-Aikawa E, Sakata Y, Chin M, Hill C, Lawler P, Varo N, Schoen F, Krane S, Aikawa M
Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques.
Circulation. 2004;110:1953-9 - PMID: 15451791 - DOI: 10.1161/01.CIR.0000143174.41810.10
Waller C, Hiller K, Kahler E, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer W
Serial magnetic resonance imaging of microvascular remodeling in the infarcted rat heart.
Circulation. 2001;103(11):1564-9 - PMID: 11257086 - DOI: 10.1161/01.cir.103.11.1564
Rabkin E, Aikawa M, Stone J, Fukumoto Y, Libby P, Schoen F
Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves.
Circulation. 2001;104:2525-32 - PMID: 11714645 - DOI: 10.1161/hc4601.099489
Aikawa M, Rabkin E, Sugiyama S, Voglic S, Fukumoto Y, Furukawa Y, Shiomi M, Schoen F, Libby P
An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
Circulation. 2001;103:276-83 - PMID: 11208689 - DOI: 10.1161/01.cir.103.2.276
Fukumoto Y, Libby P, Rabkin E, Hill C, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M
Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits.
Circulation. 2001;103:993-9 - PMID: 11181475 - DOI: 10.1161/01.cir.103.7.993
Aikawa M, Voglic S, Sugiyama S, Rabkin E, Taubman M, Fallon J, Libby P
Dietary lipid lowering reduces tissue factor expression in rabbit atheroma.
Circulation. 1999;100:1215-22 - PMID: 10484543 - DOI: 10.1161/01.cir.100.11.1215
Aikawa M, Rabkin E, Okada Y, Voglic S, Clinton S, Brinckerhoff C, Sukhova G, Libby P
Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.
Circulation. 1998;97:2433-44 - PMID: 9641696 - DOI: 10.1161/01.cir.97.24.2433
Nakagawa T, Sukhova G, Rabkin E, Winters G, Schoen F, Libby P
Acute rejection accelerates graft coronary disease in transplanted rabbit hearts.
Circulation. 1995;92:987-93 - PMID: 7641383 - DOI: 10.1161/01.cir.92.4.987
Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R
Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis.
Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881
Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R
Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease.
Circulation. 2009;119(13):1785-94 - PMID: 19307473 - PMCID: PMC2717745 - DOI: 10.1161/CIRCULATIONAHA.108.827972
Christen T*, Nahrendorf M*, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P
Molecular Imaging of Innate Immune Cell Function in Transplant Rejection.
Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A
Active Adaptation of the Tethered Mitral Valve. Insights Into a Compensatory Mechanism for Functional Mitral Regurgitation.
Circulation. 2009;120(4):334-42 - PMID: 19597052 - PMCID: PMC2752046 - DOI: 10.1161/CIRCULATIONAHA.108.846782
Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK
Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques.
Circulation. 2009;120(7):592-9 - PMID: 19652086 - PMCID: PMC2736635 - DOI: 10.1161/CIRCULATIONAHA.108.813998
Cheng S*, Cohen KS*, Shaw SY*, Larson MG, Hwang SJ, McCabe EL, Martin RP, Klein RJ, Hashmi B, Hoffmann U, Fox CS, Vasan RS, O'Donnell CJ, Wang TJ
Association of Colony-Forming Units With Coronary Artery and Abdominal Aortic Calcification.
Circulation. 2010;122(12):1176-1182 - PMID: 20823386 - PMCID: PMC3050056 - DOI: 10.1161/CIRCULATIONAHA.109.931279
Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M
High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis.
Circulation. 2010;122(17):1707-15 - PMID: 20937980 - PMCID: PMC3003265 - DOI: 10.1161/CIRCULATIONAHA.109.891804
Sakhuja R, Suh WM, Jaffer FA, Jang IK
Residual Thrombogenic Substrate After Rupture of a Lipid-Rich Plaque: Possible Mechanism of Acute Stent Thrombosis?
Circulation. 2010;122(22):2349-2350 - PMID: 21147731 - DOI: 10.1161/CIRCULATIONAHA.110.970079
Buxton DB, Antman M, Danthi N, Dilsizian V, Fayad ZA, Garcia MJ, Jaff MR, Klimas M, Libby P, Nahrendorf M, Sinusas AJ, Wickline SA, Wu JC, Bonow RO, Weissleder R
Report of the national heart, lung, and blood institute working group on the translation of cardiovascular molecular imaging.
Circulation. 2011;123(19):2157-63 - PMID: 21576680 - PMCID: PMC3119488 - DOI: 10.1161/CIRCULATIONAHA.110.000943
Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK
Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes that Infiltrate Atherosclerotic Lesions.
Circulation. 2011;125(2):364-74 - PMID: 22144566 - PMCID: PMC3263762 - DOI: 10.1161/CIRCULATIONAHA.111.061986
Moon H, Park HE, Kang J, Lee H, Cheong C, Lim YT, Ihm SH, Seung KB, Jaffer FA, Narula J, Chang K, Hong KS
Noninvasive Assessment of Myocardial Inflammation by Cardiovascular Magnetic Resonance in a Rat Model of Experimental Autoimmune Myocarditis.
Circulation. 2012;125(21):2603-12 - PMID: 22550157 - DOI: 10.1161/CIRCULATIONAHA.111.075283
Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB
Lack of Microsomal Prostaglandin E2 Synthase-1 in Bone Marrow Derived Myeloid Cells Impairs Left Ventricular Function and Increases Mortality after Acute Myocardial Infarction.
Circulation. 2012;125(23):2904-13 - PMID: 22589381 - DOI: 10.1161/CIRCULATIONAHA.112.099754
Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M
Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice.
Circulation. 2013;127(20):2038-2046 - PMID: 23616627 - PMCID: PMC3661714 - DOI: 10.1161/CIRCULATIONAHA.112.000116
Kroll MW, Lakkireddy DR, Stone JR, Luceri RM
TASER Electronic Control Devices and Cardiac Arrests: Coincidental or Causal?
Circulation. 2014;129(1):93-100 - PMID: 24396012 - DOI: 10.1161/CIRCULATIONAHA.113.004401
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK
Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity.
Circulation. 2014;129(16):1677-87 - PMID: 24488984 - PMCID: PMC3997655 - DOI: 10.1161/CIRCULATIONAHA.113.006381
Hara T, Truelove J, Tawakol A, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA
FDG-PET/CT Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus.
Circulation. 2014;130(13):1044-52 - PMID: 25070665 - PMCID: PMC4174982 - DOI: 10.1161/CIRCULATIONAHA.114.008902
Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA
Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus"
Circulation. 2015;131(24):e531-2 - PMID: 26078375 - DOI: 10.1161/CIRCULATIONAHA.115.014802
Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M
Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.
Circulation. 2015;132(20):1880-90 - PMID: 26358260 - PMCID: PMC4651795 - DOI: 10.1161/CIRCULATIONAHA.115.016160
RamÍrez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C
Caveolin-1 Regulates Atherogenesis by Attenuating LDL Transcytosis and Vascular Inflammation Independent of Endothelial Nitric Oxide Synthase Activation.
Circulation. 2019;140(3):225-239 - PMID: 31154825 - PMCID: PMC6778687 - DOI: 10.1161/CIRCULATIONAHA.118.038571
Wang Y, Sano S, Oshima K, Sano M, Watanabe Y, Katanasaka Y, Yura Y, Jung C, Anzai A, Swirski FK, Gokce N, Walsh K
Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload-Induced Cardiac Dysfunction.
Circulation. 2019;140(6):487-499 - PMID: 31170826 - PMCID: PMC6684855 - DOI: 10.1161/CIRCULATIONAHA.118.038820
Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M
Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes.
Circulation. 2020;142(3):244-258 - PMID: 32316750 - PMCID: PMC7375017 - DOI: 10.1161/CIRCULATIONAHA.120.046038
Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi JJ, Nahrendorf M, Ellinor PT, Milan DJ
Ibrutinib-Mediated Atrial Fibrillation Due to Inhibition of CSK.
Circulation. 2020;142(25):2443-2455 - PMID: 33092403 - PMCID: PMC9661397 - DOI: 10.1161/CIRCULATIONAHA.120.049210
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D
Arthritis critically dependent on innate immune system players
Immunity. 2002;16:157-68 - PMID: 11869678 - DOI: 10.1016/s1074-7613(02)00275-3
Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U.
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
Immunity. 2006;25(1):129-41 - PMID: 16860762 - DOI: 10.1016/j.immuni.2006.04.015
Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ
Angiotensin II Drives the Production of Tumor-Promoting Macrophages
Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015
Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865 - DOI: 10.1016/j.immuni.2015.11.024
Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
Immunity. 2018;49(5):819-828.e6 - PMID: 30413362 - PMCID: PMC6251711 - DOI: 10.1016/j.immuni.2018.09.008
Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024
Zilionis R*, Engblom C*, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ**, Klein AM**
Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.
Immunity. 2019;50(5):1317-1334.e10 - PMID: 30979687 - PMCID: PMC6620049 - DOI: 10.1016/j.immuni.2019.03.009
Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010
Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T
Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes.
Immunity. 2021;54(10):2338-2353.e6 - PMID: 34534439 - PMCID: PMC8604155 - DOI: 10.1016/j.immuni.2021.08.026
Liu JF, Herold C, Gray KP, Penson RT, Horowitz N, Konstantinopoulos PA, Castro CM, Hill SJ, Curtis J, Luo W, Matulonis UA, Cannistra SA, Dizon DS
Assessment of Combined Nivolumab and Bevacizumab in Relapsed Ovarian Cancer: A Phase 2 Clinical Trial.
JAMA Oncol. 2019;5(12):1731-1738 - PMID: 31600397 - PMCID: PMC6802049 - DOI: 10.1001/jamaoncol.2019.3343
Hwang WL, Niemierko A, Efstathiou JA
Comparing Adjuvant vs Early-Salvage Radiotherapy After Radical Prostatectomy-Reply.
JAMA Oncol. 2018;4(11):1620-1621 - PMID: 30422248 - DOI: 10.1001/jamaoncol.2018.3552
Hwang WL, Tendulkar RD, Niemierko A, Agrawal S, Stephans KL, Spratt DE, Hearn JW, Koontz BF, Lee WR, Michalski JM, Pisansky TM, Liauw SL, Abramowitz MC, Pollack A, Moghanaki D, Anscher MS, Den RB, Zietman AL, Stephenson AJ, Efstathiou JA
Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer With Adverse Pathological Features.
JAMA Oncol. 2018;4(5):e175230 - PMID: 29372236 - PMCID: PMC5885162 - DOI: 10.1001/jamaoncol.2017.5230
Hwang WL, Niemierko A, Hwang KL, Hubbeling H, Schapira E, Gainor JF, Keane FK
Clinical Outcomes in Patients With Metastatic Lung Cancer Treated With PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy.
JAMA Oncol. 2018;4(2):253-255 - PMID: 28973343 - PMCID: PMC5838581 - DOI: 10.1001/jamaoncol.2017.3808
Lee CY, Degani I, Cheong J, Weissleder R, Lee JH, Cheon J, Lee H
Development of Integrated Systems for On-Site Infection Detection.
Acc Chem Res. 2021;54(21):3991-4000 - PMID: 34677927 - PMCID: PMC9099220 - DOI: 10.1021/acs.accounts.1c00498
Villalba JA, Hilburn CF, Garlin MA, Elliott GA, Li Y, Kunitoki K, Poli S, Alba GA, Madrigal E, Taso M, Price MC, Aviles AJ, Araujo-Medina M, Bonanno L, Boyraz B, Champion SN, Harris CK, Helland TL, Hutchison B, Jobbagy S, Marshall MS, Shepherd DJ, Barth JL, Hung YP, Ly A, Hariri LP, Turbett SE, Pierce VM, Branda JA, Rosenberg ES, Mendez-Pena J, Chebib I, Rosales IA, Smith RN, Miller MA, Rosas IO, Hardin CC, Baden LR, Medoff BD, Colvin RB, Little BP, Stone JR, Mino-Kenudson M, Shih AR
Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and ARDS.
Am J Respir Crit Care Med. 2022;206(7):857-873 - PMID: 35671465 - DOI: 10.1164/rccm.202109-2150OC
Devaraj NK, Weissleder R
Biomedical Applications of Tetrazine Cycloadditions.
Accounts Chem Res. 2011;44(9):816-27 - PMID: 21627112 - PMCID: PMC3166440 - DOI: 10.1021/ar200037t
Tassa C, Shaw SY, Weissleder R
Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy.
Accounts Chem Res. 2011;44(10):842-52 - PMID: 21661727 - PMCID: PMC3182289 - DOI: 10.1021/ar200084x
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Nat Cell Biol. 2006;8(2):124-36 - PMID: 16415858 - DOI: 10.1038/ncb1348
Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA
Programming human pluripotent stem cells into white and brown adipocytes.
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Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
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Nahrendorf M, Hu K, Hiller K, Galuppo P, Fraccarollo D, Schweizer G, Haase A, Ertl G, Bauer W, Bauersachs J
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Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schar M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M
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J Am Coll Cardiol. 2008;52:483-91 - PMID: 18672170 - PMCID: PMC2628468 - DOI: 10.1016/j.jacc.2008.03.063
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Assessing niacin as an atherosclerosis therapeutic agent valuable insights provided by high-resolution vascular magnetic resonance imaging.
J Am Coll Cardiol. 2009;54(19):1795-6 - PMID: 19874993 - DOI: 10.1016/j.jacc.2009.07.026
Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089
Jaffer FA, Calfon MA, Rosenthal A, Mallas G, Razansky RN, Mauskapf A, Weissleder R, Libby P, Ntziachristos V
Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury.
J Am Coll Cardiol. 2011;57(25):2516-26 - PMID: 21679853 - PMCID: PMC3123768 - DOI: 10.1016/j.jacc.2011.02.036
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PET/MRI of Inflammation in Myocardial Infarction
J Am Coll Cardiol. 2012;59:153-163 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066
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J Am Coll Cardiol. 2013;62(20):1902-4 - PMID: 23973700 - DOI: 10.1016/j.jacc.2013.07.058
Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M
In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.
J Am Coll Cardiol. 2013;63(15):1556-66 - PMID: 24361318 - PMCID: PMC3992176 - DOI: 10.1016/j.jacc.2013.11.023
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Imaging Systemic Inflammatory Networks in Ischemic Heart Disease.
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Libby P, Nahrendorf M, Swirski FK
Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum"
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Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study.
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Unraveling Vascular Inflammation: From Immunology to Imaging.
J Am Coll Cardiol. 2017;70(11):1403-1412 - PMID: 28882238 - PMCID: PMC5658004 - DOI: 10.1016/j.jacc.2017.07.750
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Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3).
J Am Coll Cardiol. 2018;72(18):2198-2212 - PMID: 30360828 - PMCID: PMC6258199 - DOI: 10.1016/j.jacc.2018.08.2150
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IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection.
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Libby P, Nahrendorf M, Swirski FK
Reply: The Networks Between the Sympathetic Nervous System and Immune System in Atherosclerosis.
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Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.
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Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease.
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Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction.
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Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.
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Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
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Magnetic barcode assay for genetic detection of pathogens
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Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.
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A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.
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Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R
In vivo imaging of specific drug-target binding at subcellular resolution.
Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946
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An authentic imaging probe to track cell fate from beginning to end.
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Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Nat Commun. 2014;5:5662 - PMID: 25489927 - PMCID: PMC4261930 - DOI: 10.1038/ncomms6662
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Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Nat Commun. 2015;6:6999 - PMID: 25959588 - PMCID: PMC4430127 - DOI: 10.1038/ncomms7999
Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Nat Commun. 2015;6:7029 - PMID: 25967391 - PMCID: PMC4435621 - DOI: 10.1038/ncomms8029
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Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Nat Commun. 2015;6:8692 - PMID: 26503691 - PMCID: PMC4711745 - DOI: 10.1038/ncomms9692
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Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.
Nat Commun. 2015;6:8803 - PMID: 26541940 - PMCID: PMC4638135 - DOI: 10.1038/ncomms9803
Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666
Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R
Real-time high dynamic range laser scanning microscopy.
Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995 - DOI: 10.1038/ncomms11077
Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
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Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
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Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293
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ADAM8 as a drug target in pancreatic cancer.
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Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
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Chen X, Park HR, Pelton M, Piao X, Lindquist NC, Im H, Kim YJ, Ahn JS, Ahn KJ, Park N, Kim DS, Oh SH
Atomic layer lithography of wafer-scale nanogap arrays for extreme confinement of electromagnetic waves.
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Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R
Nano-palladium is a cellular catalyst for in vivo chemistry
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Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL
PD-L1 is an activation-independent marker of brown adipocytes.
Nat Commun. 2017;8(1):647 - PMID: 28935898 - PMCID: PMC5608754 - DOI: 10.1038/s41467-017-00799-8
Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC
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Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA
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Karaayvaz M, Cristea S, Gillespie SM, Patel AP, Mylvaganam R, Luo CC, Specht MC, Bernstein BE, Michor F, Ellisen LW
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Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R
Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens
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Oki T, Mercier F, Kato H, Jung Y, McDonald TO, Spencer JA, Mazzola MC, van Gastel N, Lin CP, Michor F, Kitamura T, Scadden DT
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Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G
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Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP
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Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R
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Gastroenterology. 2002;122:406-14 - PMID: 11832455 - DOI: 10.1053/gast.2002.30990
Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, Khazaie K
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Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes.
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Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN
Gastroenterology. 2020;160(4):1345-1358.e11 - PMID: 33301777 - PMCID: PMC7956058 - DOI: 10.1053/j.gastro.2020.11.046
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Dissolvable Polyacrylamide Beads for High-Throughput Droplet DNA Barcoding.
Adv Sci. 2020;7(8):1903463 - PMID: 32328429 - PMCID: PMC7175265 - DOI: 10.1002/advs.201903463
Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R
Integrated Analytical System for Clinical Single-Cell Analysis
Adv Sci (Weinh). 2022;9(20):e2200415 - PMID: 35508767 - PMCID: PMC9284190 - DOI: 10.1002/advs.202200415
Kim H, Sa JK, Kim J, Cho HJ, Oh HJ, Choi DH, Kang SH, Jeong DE, Nam DH, Lee H, Lee HW, Chung S
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Ko J, Lucas K, Kohler RH, Halabi EA, Wilkovitsch M, Carlson JCT, Weissleder R
In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy
Adv Sci (Weinh). 2022;9(24):e2200064 - PMID: 35750648 - PMCID: PMC9405492 - DOI: 10.1002/advs.202200064
Haun JB*, Castro CM*, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R.
Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples
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Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA
Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques
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Ferraro F, Lymperi S, Méndez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT
Diabetes impairs hematopoietic stem cell mobilization by altering niche function.
Sci Transl Med. 2011;3(104):104ra101 - PMID: 21998408 - PMCID: PMC3754876 - DOI: 10.1126/scitranslmed.3002191
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A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease.
Sci Transl Med. 2012;4(123):123ra26 - PMID: 22378926 - PMCID: PMC3633235 - DOI: 10.1126/scitranslmed.3002738
Issadore D, Chung J*, Shao H*, Liong M, Ghazani AA, Castro CM, Weissleder R*, Lee H*
Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747
Ullal AV*, Peterson V*, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361
Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318
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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
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Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
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Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Sci Transl Med. 2016;8:342 - PMID: 27280687 - PMCID: PMC5125383 - DOI: 10.1126/scitranslmed.aaf1435
Weissleder R, Schwaiger MC, Gambhir SS, Hricak H
Imaging approaches to optimize molecular therapies
Sci Transl Med. 2016;8(355):355ps16 - PMID: 27605550 - DOI: 10.1126/scitranslmed.aaf3936
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Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring
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Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ
In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604
Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226
Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R
Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
Sci Transl Med. 2017;9(392):eaal0225 - PMID: 28566423 - PMCID: PMC6681815 - DOI: 10.1126/scitranslmed.aal0225
Miller MA
Nanotransfection brings progress that’s more than skin-deep
Sci Transl Med. 2017;9(405):eaao4216
Miller MA
Counting on carbon quantum dots to clear infection
Sci Transl Med. 2017;9(399):eaao0969
Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682
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Gold photothermal therapy: A positive for negative margins
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Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.
Sci Transl Med. 2019;11(506):ePub - PMID: 31434756 - PMCID: PMC7328283 - DOI: 10.1126/scitranslmed.aaw7736
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Interrogating CD8+ T cell reactivity on a genome-wide scale
Sci Transl Med. 2019;11(506):eaaz0302 - DOI: 10.1126/scitranslmed.aaz0302
Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R
CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis
Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746
Panizzi P, Krohn-Grimberghe M, Keliher E, Ye YX, Grune J, Frodermann V, Sun Y, Muse CG, Bushey K, Iwamoto Y, van Leent MMT, Meerwaldt A, Toner YC, Munitz J, Maier A, Soultanidis G, Calcagno C, Pérez-Medina C, Carlucci G, Riddell KP, Barney S, Horne G, Anderson B, Maddur-Appajaiah A, Verhamme IM, Bock PE, Wojtkiewicz GR, Courties G, Swirski FK, Church WR, Walz PH, Tillson DM, Mulder WJM, Nahrendorf M
Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis.
Sci Transl Med. 2020;12(568):ePub - PMID: 33148623 - PMCID: PMC7818516 - DOI: 10.1126/scitranslmed.aay2104
van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R
Prosaposin mediates inflammation in atherosclerosis.
Sci Transl Med. 2021;13(584):eabe1433 - PMID: 33692130 - PMCID: PMC8209679 - DOI: 10.1126/scitranslmed.abe1433
Garris CS, Wong JL, Ravetch JV, Knorr DA
Dendritic cell targeting with Fc-enhanced CD40 antibody agonists induces durable antitumor immunity in humanized mouse models of bladder cancer.
Sci Transl Med. 2021;13(594):ePub - PMID: 34011627 - PMCID: PMC8325152 - DOI: 10.1126/scitranslmed.abd1346
Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H
A rapid assay provides on-site quantification
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Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover
Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J
IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.
Cell Metab. 2015;21(4):609-21 - PMID: 25863250 - PMCID: PMC4663978 - DOI: 10.1016/j.cmet.2015.03.006
Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Cell Metab. 2019;30(4):824-832.e3 - PMID: 31402314 - PMCID: PMC6903907 - DOI: 10.1016/j.cmet.2019.07.006
Insin N, Tracy JB, Lee H, Zimmer JP, Westervelt RM, Bawendi MG
Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres.
ACS Nano. 2008;2(2):197-202 - PMID: 19206619 - DOI: 10.1021/nn700344x
Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A
Quantitative Nanostructure-Activity Relationship Modeling.
ACS Nano. 2010;4(10):5703-12 - PMID: 20857979 - PMCID: PMC2997621 - DOI: 10.1021/nn1013484
Haun J, Devaraj NK, Marinelli B, Lee H, Weissleder R
Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry.
ACS Nano. 2011;5(4):3204-13 - PMID: 21351804 - PMCID: PMC3088084 - DOI: 10.1021/nn200333m
Chung H, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R
Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles.
ACS Nano. 2011;5(11):8834-41 - PMID: 21967150 - PMCID: PMC3222727 - DOI: 10.1021/nn2029692
Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R
Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells.
ACS Nano. 2011;5(11):9216-24 - PMID: 21962084 - PMCID: PMC3297118 - DOI: 10.1021/nn203450p
Peterson VM, Castro CM, Lee H, Weissleder R
Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing.
ACS Nano. 2012;6(4):3506-13 - PMID: 22424443 - PMCID: PMC3337350 - DOI: 10.1021/nn300536y
Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H
Mechanism of Magnetic Relaxation Switching Sensing.
ACS Nano. 2012;6(8):6821-8 - PMID: 22762250 - PMCID: PMC3429660 - DOI: 10.1021/nn301615b
Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H
Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles.
ACS Nano. 2013;7(12):11227-33 - PMID: 24295203 - PMCID: PMC3898036 - DOI: 10.1021/nn405016y
Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire C, Chen JW, Tannous BA, Breakefield XO
Dynamic Biodistribution of Extracellular Vesicles In Vivo Using a Multimodal Imaging Reporter.
ACS Nano. 2014;8(1):483-94 - PMID: 24383518 - PMCID: PMC3934350 - DOI: 10.1021/nn404945r
Lee K, Shao H, Weissleder R, Lee H
Acoustic Purification of Extracellular Microvesicles.
ACS Nano. 2015;9(3):2321-7 - PMID: 25672598 - PMCID: PMC4373978 - DOI: 10.1021/nn506538f
Nair AV, Keliher EJ, Core AB, Brown D, Weissleder R
Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo.
ACS Nano. 2015;9(4):3641-53 - PMID: 25790730 - PMCID: PMC4414893 - DOI: 10.1021/acsnano.5b00428
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H
Integrated Magneto-Electrochemical Sensor for Exosome Analysis.
ACS Nano. 2016;10(2):1802-1809 - PMID: 26808216 - PMCID: PMC4802494 - DOI: 10.1021/acsnano.5b07584
Seo KJ, Qiang Y, Bilgin I, Kar S, Vinegoni C, Weissleder R, Fang H
Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh.
ACS Nano. 2017;11(4):4365-4372 - PMID: 28391679 - DOI: 10.1021/acsnano.7b01995
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Facile assembly of micro- and nanoarrays for sensing with natural cell membranes.
ACS Nano. 2011;5(9):7555-64 - PMID: 21842844 - PMCID: PMC3183111 - DOI: 10.1021/nn202554t
Im H, Lee SH, Wittenberg NJ, Johnson TW, Lindquist NC, Nagpal P, Norris DJ, Oh SH
Template-stripped smooth Ag nanohole arrays with silica shells for surface plasmon resonance biosensing.
ACS Nano. 2011;5(8):6244-53 - PMID: 21770414 - PMCID: PMC3160512 - DOI: 10.1021/nn202013v
Im H, Lindquist NC, Lesuffleur A, Oh SH
Atomic layer deposition of dielectric overlayers for enhancing the optical properties and chemical stability of plasmonic nanoholes.
ACS Nano. 2010;4(2):947-54 - PMID: 20131870 - DOI: 10.1021/nn901842r
Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318
Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR
Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection.
ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083
Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - PMCID: PMC6296367 - DOI: 10.1021/acsnano.7b06074
Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R
Multiplexed Profiling of Single Extracellular Vesicles.
ACS Nano. 2018;12(1):494-503 - PMID: 29286635 - PMCID: PMC5898240 - DOI: 10.1021/acsnano.7b07060
Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H
Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis.
ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - PMCID: PMC6019292 - DOI: 10.1021/acsnano.7b08965
Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel J, Castro CM, Weissleder R, Lee H
Computational Optics Enables Breast Cancer Profiling in Point-Of-Care Settings.
ACS Nano. 2018;12(9):9081-9090 - PMID: 30113824 - PMCID: PMC6519708 - DOI: 10.1021/acsnano.8b03029
Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet M, Nahrendorf M, Weissleder R, Miller MA
Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.
ACS Nano. 2018;12(12):12015-12029 - PMID: 30508377 - PMCID: PMC6482841 - DOI: 10.1021/acsnano.8b04338
Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R
Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.
ACS Nano. 2018;12(12):12814-12826 - PMID: 30550257 - PMCID: PMC6307086 - DOI: 10.1021/acsnano.8b07954
Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA
Radiation-Induced Targeted Nanoparticle- Based Gene Delivery for Brain Tumor Therapy
ACS Nano. 2019;13(4):4028-4040 - PMID: 30916923 - PMCID: PMC7104714 - DOI: 10.1021/acsnano.8b08177
Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H
Compact and Filter-Free Luminescence Biosensor for Mobile In-Vitro Diagnoses.
ACS Nano. 2019;13(10):11698-11706 - PMID: 31461265 - PMCID: PMC7307311 - DOI: 10.1021/acsnano.9b05634
Chin LK*, Son T*, Hong JS, Liu AQ, Skog J, Castro CM, Weissleder R, Lee H*, Im H*
Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research.
ACS Nano. 2020;14(11):14528-14548 - PMID: 33119256 - PMCID: PMC8423498 - DOI: 10.1021/acsnano.0c07581
Ko J*, Wang Y*, Sheng K, Weitz DA, Weissleder R
Sequencing-Based Protein Analysis of Single Extracellular Vesicles
ACS Nano. 2021;15(3):5631-5638 - PMID: 33687214 - PMCID: PMC8742254 - DOI: 10.1021/acsnano.1c00782
Tian T, Liang R, Erel-Akbaba G, Saad L, Obeid PJ, Gao J, Chiocca EA, Weissleder R, Tannous BA
Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles.
ACS Nano. 2022;16(2):1940-1953 - PMID: 35099172 - PMCID: PMC9020451 - DOI: 10.1021/acsnano.1c05505
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R.
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Circ Res. 2005;96(3):327-36 - PMID: 15653572 - DOI: 10.1161/01.RES.0000155722.17881.dd
Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R.
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
Circ Res. 2007;100:1218-1225 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31
Paruchuri S, Yang J, Aikawa E, Melero-Martin J, Khan Z, Loukogeorgakis S, Schoen F, Bischoff J
Human Pulmonary Valve Progenitor Cells Exhibit Endothelial/Mesenchymal Plasticity in Response to Vascular Endothelial Growth Factor-A and Transforming Growth Factor-{beta}2.
Circ Res. 2006;99(8):861-9 - PMID: 16973908 - PMCID: PMC2810464 - DOI: 10.1161/01.RES.0000245188.41002.2c
Aikawa M, Rabkin E, Voglic S, Shing H, Nagai R, Schoen F, Libby P
Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma.
Circ Res. 1998;83:1015-26 - PMID: 9815149 - DOI: 10.1161/01.res.83.10.1015
Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M
Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction.
Circ Res. 2010;107(11):1364-73 - PMID: 20930148 - PMCID: PMC2992104 - DOI: 10.1161/CIRCRESAHA.110.227454
Leuschner F, Nahrendorf M
Molecular imaging of coronary atherosclerosis and myocardial infarction: considerations for the bench and perspectives for the clinic.
Circ Res. 2011;108(5):593-606 - PMID: 21372291 - PMCID: PMC3397211 - DOI: 10.1161/CIRCRESAHA.110.232678
Nahrendorf M, McCarthy JR, Libby P
Over a hump for imaging atherosclerosis: nanobodies visualize vascular cell adhesion molecule-1 in inflamed plaque.
Circ Res. 2012;110(7):902-3 - PMID: 22461358 - DOI: 10.1161/CIRCRESAHA.112.267260
Courties G, Nahrendorf M
Enlightened stem cells in the heart: more efficient and safer reporter gene imaging.
Circ Res. 2012;111(12):1486-7 - PMID: 23223928 - DOI: 10.1161/CIRCRESAHA.112.280982
Majmudar MD, Yoo J, Keliher E, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson D, Swirski FK, Weissleder R, Nahrendorf M
Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques.
Circ Res. 2013;112(5):755-61 - PMID: 23300273 - PMCID: PMC3586287 - DOI: 10.1161/CIRCRESAHA.111.300576
Jung K, Kim P, Leuschner F, Gorbatov R, Kim JK, Ueno T, Nahrendorf M, Yun SH
Endoscopic Time-Lapse Imaging of Immune Cells in Infarcted Mouse Hearts.
Circ Res. 2013;112(6):891-899 - PMID: 23392842 - PMCID: PMC3834270 - DOI: 10.1161/CIRCRESAHA.111.300484
Hilgendorf I, Gerhardt L, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherrer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK
Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium.
Circ Res. 2014;114(10):1611-22 - PMID: 24625784 - PMCID: PMC4017349 - DOI: 10.1161/CIRCRESAHA.114.303204
Heidt T, Courties G, Dutta P, Sager H, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M
Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction.
Circ Res. 2014;115(2):284-95 - PMID: 24786973 - PMCID: PMC4082439 - DOI: 10.1161/CIRCRESAHA.115.303567
Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M
Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Circ Res. 2015;116(3):407-17 - PMID: 25362208 - PMCID: PMC4312511 - DOI: 10.1161/CIRCRESAHA.116.305207
Konishi M, Erdem SS, Weissleder R, Lichtman AH, McCarthy J, Libby P
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Circ Res. 2015;117(6):502-12 - PMID: 26199323 - PMCID: PMC4553143 - DOI: 10.1161/CIRCRESAHA.115.306364
Ye YX, Calcagno C, Binderup T, Courties G, Keliher E, Wojtkiewicz GR, Iwamoto Y, Tang J, Perez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjær A, Mulder W, Nahrendorf M
Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.
Circ Res. 2015;117(10):835-45 - PMID: 26394773 - PMCID: PMC4619168 - DOI: 10.1161/CIRCRESAHA.115.307024
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circ Res. 2016;119(7):853-64 - PMID: 27444755 - PMCID: PMC5378496 - DOI: 10.1161/CIRCRESAHA.116.309001
Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P
Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion.
Circ Res. 2017;121(1):31-42 - PMID: 28428204 - PMCID: PMC5488735 - DOI: 10.1161/CIRCRESAHA.117.310694
Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasche P, Silvestre JS, Boulanger CM
Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction.
Circ Res. 2018;123(1):100-106 - PMID: 29592957 - PMCID: PMC6023578 - DOI: 10.1161/CIRCRESAHA.117.311326
Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz GR, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson FE, Jung Y, Désogère P, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M
Imaging the Vascular Bone Marrow Niche During Inflammatory Stress.
Circ Res. 2018;123(4):415-427 - PMID: 29980569 - PMCID: PMC6202141 - DOI: 10.1161/CIRCRESAHA.118.313302
Hulsmans M, Aguirre AD, Bonner M, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M
Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse
Circ Res. 2018;123(11):1208-1219 - PMID: 30571465 - PMCID: PMC6309285 - DOI: 10.1161/CIRCRESAHA.118.313429
Courties G, Frodermann V, Honold L, Zheng Y, Herisson FE, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden D, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M
Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.
Circ Res. 2019;124(9):1372-1385 - PMID: 30782088 - PMCID: PMC6483874 - DOI: 10.1161/CIRCRESAHA.118.314518
Taboada E, Solanas R, Rodriguez E, Weissleder R, Roig A
Supercritical-Fluid-Assisted One-Pot Synthesis of Biocompatible Core (γ-Fe2O3)/Shell(SiO2) Nanoparticles as High Relaxivity T2-Contrast Agents for Magnetic Resonance Imaging
Adv Funct Mater. 2009;19 :2319-2324
Lee S, Johnson TW, Lindquist NC, Im H, Norris DJ, Oh SH
Linewidth-Optimized Extraordinary Optical Transmission in Water with Template-Stripped Metallic Nanohole Arrays
Adv Funct Mater. 2012;22(21):4439-4446
Park SG, Xiao X, Min J, Mun CW, Jung HS, Giannini V, Weissleder R, Maier SA, Im H, Kim DH
Self‐Assembly of Nanoparticle‐Spiked Pillar Arrays for Plasmonic Biosensing
Adv Funct Mater. 2019;29(43):1904257 - DOI: 10.1002/adfm.201904257
Li R, Ng TSC, Garlin MA, Weissleder R*, Miller MA*
Understanding the In Vivo Fate of Advanced Materials by Imaging
Adv Funct Mater. 2020;:1910369 - DOI: 10.1002/adfm.201910369
Wang Z, Shin J, Park JH, Lee H, Kim DH, Liu H
Engineering Materials for Electrochemical Sweat Sensing
Adv Funct Mater. 2021;:ePub - DOI: 10.1002/adfm.202008130
Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U
Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.
Arthritis Rheumatol. 2009;60:2314-2324 - PMID: 19644878 - PMCID: PMC3080016 - DOI: 10.1002/art.24704
Stone JH, Khosroshahi A, Hilgenberg A, Spooner A, Isselbacher EM, Stone JR
IgG4-related systemic disease and lymphoplasmacytic aortitis.
Arthritis Rheumatol. 2009;60(10):3139-3145 - PMID: 19790067 - DOI: 10.1002/art.24798
Wang H, Smith RN, Spooner AE, Isselbacher EM, Cambria RP, Macgillivray TE, Stone JH, Stone JR
Giant cell aortitis of the ascending aorta without signs or symptoms of systemic vasculitis is associated with elevated risk of distal aortic events.
Arthritis Rheumatol. 2012;64(1):317-9 - PMID: 21953530 - DOI: 10.1002/art.33343
Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, Cheuk W, Cornell L, Castillo CF, Ferry JA, Forcione D, Klöppel G, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Masaki Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani D, Sato Y, Smyrk T, Stone JR, Takahira M, Umehara H, Webster G, Yamamoto M, Yi E, Yoshino T, Zamboni G, Zen Y, Chari S
IgG4-Related disease: recommendations for the nomenclature of this condition and its individual organ system manifestations.
Arthritis Rheumatol. 2012;64(10):3061-7 - PMID: 22736240 - PMCID: PMC5963880 - DOI: 10.1002/art.34593
Patel NJ, Tozzo V, Higgins JM, Stone JH
The effects of daily prednisone and tocilizumab on hemoglobin A1c during the treatment of giant cell arteritis.
Arthritis Rheumatol. 2022;:ePub - PMID: 36383175 - DOI: 10.1002/art.42405
Zhao M, Josephson L, Tang Y, Weissleder R
Magnetic sensors for protease assays
Angew Chem Int Ed Engl. 2003;42:1375-8 - PMID: 12671972 - DOI: 10.1002/anie.200390352
Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L
Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities
Angew Chem Int Ed Engl. 2004;43(18):2395-2399 - PMID: 15114571 - DOI: 10.1002/anie.200352998
Koh I, Hong R, Weissleder R, Josephson L
Sensitive NMR Sensors Detect Antibodies to Influenza.
Angew Chem Int Ed Engl. 2008;47(22):4119-4121 - PMID: 18428168 - PMCID: PMC2668198 - DOI: 10.1002/anie.200800069
Lee H*, Yoon TJ*, Weissleder R
Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.
Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791
Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R
Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition.
Angew Chem Int Ed Engl. 2009;48(38):7013-6 - PMID: 19697389 - PMCID: PMC2790075 - DOI: 10.1002/anie.200903233
Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R
Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.
Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120
Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R
Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method.
Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579
Yoon TJ*, Lee H*, Shao H, Weissleder R
Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101
Budin G, Yang KS, Reiner T, Weissleder R
Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification.
Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273
Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R
Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.
Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670
Karver MR, Weissleder R, Hilderbrand SA
Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging.
Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389
Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H
Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors.
Angew Chem Int Ed Engl. 2004;43(2):224-8 - PMID: 14695616 - DOI: 10.1002/anie.200352582
Huwe A, Mazitschek R, Giannis A
Small molecules as inhibitors of cyclin-dependent kinases.
Angew Chem Int Ed Engl. 2003;42(19):2122-38 - PMID: 12761741 - DOI: 10.1002/anie.200200540
Stieber F, Mazitschek R, Soric N, Giannis A, Waldmann H
Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.
Angew Chem Int Ed Engl. 2002;41(24):4757-61 - PMID: 12481350 - DOI: 10.1002/anie.200290040
Hendricks JA, Keliher EJ, Wan D, Hilderbrand SA, Weissleder R, Mazitschek R
Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.
Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957
Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R
Bioorthogonal Imaging of Aurora Kinase A in Live Cells.
Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994
Carlson JC, Meimetis LG, Hilderbrand SA, Weissleder R
BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes.
Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100
Yang* KS, Budin* G, Tassa C, Kister O, Weissleder R
Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells
Angew Chem Int Ed Engl. 2013;52(40):10593-7 - PMID: 23960025 - PMCID: PMC3856564 - DOI: 10.1002/anie.201304096
Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R
Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging.
Angew Chem Int Ed Engl. 2014;53(29):7531-4 - PMID: 24915832 - PMCID: PMC4122131 - DOI: 10.1002/anie.201403890
Choudhary A, Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law B, Mazitschek R
A singular system with precise dosing and spatiotemporal control of CRISPR-Cas9.
Angew Chem Int Ed Engl. 2019;58(19):6285-6289 - PMID: 30834641 - PMCID: PMC7067309 - DOI: 10.1002/anie.201900788
Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R
Ultra-fast cycling for multiplexed cellular fluorescence imaging.
Angew Chem Int Ed Engl. 2020;59(17):6839-6846 - PMID: 32004403 - DOI: 10.1002/anie.201915153
Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB
Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis.
Mol Cell. 2009;36(4):682-95 - PMID: 19941827 - PMCID: PMC2800995 - DOI: 10.1016/j.molcel.2009.11.002
Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I
A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals.
Mol Cell. 2012;47(5):810-22 - PMID: 22940246 - PMCID: PMC3873101 - DOI: 10.1016/j.molcel.2012.07.030
van Galen P, Viny AD, Ram O, Ryan RJ, Cotton MJ, Donohue L, Sievers C, Drier Y, Liau BB, Gillespie SM, Carroll KM, Cross MB, Levine RL, Bernstein BE
A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.
Mol Cell. 2015;61(1):170-80 - PMID: 26687680 - PMCID: PMC4707994 - DOI: 10.1016/j.molcel.2015.11.003
Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.
PLoS Med. 2008;5(4):e85 - PMID: 18416599 - PMCID: PMC2292750 - DOI: 10.1371/journal.pmed.0050085
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B.
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy
J Natl Cancer I. 2007;(99) 23:1768-1781 - PMID: 18042934 - DOI: 10.1093/jnci/djm229
Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H
The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.
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Xiao X, Dev S, Canali S, Bayer A, Xu Y, Agarwal A, Wang CY, Babitt JL
Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice.
Hepatology. 2020;72(2):642-655 - PMID: 31778583 - PMCID: PMC7253321 - DOI: 10.1002/hep.31048
Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H
Magnetic Nanoparticles and microNMR for Diagnostic Applications.
Theranostics. 2012;2(1):55-65 - PMID: 22272219 - PMCID: PMC3263516 - DOI: 10.7150/thno.3465
Shan G, Weissleder R, Hilderbrand SA
Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal Therapy.
Theranostics. 2013;3(4):267-74 - PMID: 23606913 - PMCID: PMC3630527 - DOI: 10.7150/thno.5226
Wildgruber M, Swirski FK, Zernecke A
Molecular Imaging of Inflammation in Atherosclerosis.
Theranostics. 2013;3(11):865-884 - PMID: 24312156 - PMCID: PMC3841337 - DOI: 10.7150/thno.5771
Yoon YI, Kwon YS, Cho HS, Heo SH, Park KS, Park SG, Lee SH, Hwang SI, Kim YI, Jae HJ, Ahn GJ, Cho YS, Lee H*, Lee HJ*, Yoon TJ*
Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System
Theranostics. 2014;4(11):1133-1144
Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R
On chip analysis of CNS lymphoma in cerebrospinal fluid.
Theranostics. 2015;5(8):796-804 - PMID: 26000053 - PMCID: PMC4440438 - DOI: 10.7150/thno.11220
Kim JY, Ryu JH, Schellingerhout D, Sun IC, Lee SK, Jeon S, Kim J, Kwon IC, Nahrendorf M, Ahn CH, Kim K, Kim DE
Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles.
Theranostics. 2015;5(10):1098-114 - PMID: 26199648 - PMCID: PMC4508499 - DOI: 10.7150/thno.11679
Stein-Merlob AF, Kessinger CW, Erdem SS, Zelada H, Hilderbrand SA, Lin CP, Tearney GJ, Jaff MR, Reed GL, Henke PK, McCarthy JR, Jaffer FA
Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study.
Theranostics. 2015;5(12):1317-27 - PMID: 26516370 - PMCID: PMC4615735 - DOI: 10.7150/thno.12494
Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM
Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications
Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059 - DOI: 10.7150/thno.15534
Mikula H, Stapleton S, Kohler RH, Vinegoni C, Weissleder R
Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.
Theranostics. 2017;7(5):1257-1265 - PMID: 28435463 - PMCID: PMC5399591 - DOI: 10.7150/thno.18238
Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Theranostics. 2018;8(21):5842-5854 - PMID: 30613266 - PMCID: PMC6299430 - DOI: 10.7150/thno.26888
Ammari M, Presumey J, Ponsolles C, Roussignol G, Roubert C, Escriou V, Toupet K, Mausset-Bonnefont AL, Cren M, Robin M, Georgel P, Nehmar R, Taams L, Grün J, Grützkau A, Häupl T, Pers YM, Jorgensen C, Duroux-Richard I, Courties G, Apparailly F
Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis.
Theranostics. 2018;8(21):5972-5985 - PMID: 30613275 - PMCID: PMC6299444 - DOI: 10.7150/thno.29313
Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J
Bioassay for monitoring the anti-aging effect of cord blood treatment.
Theranostics. 2019;9(1):1-10 - PMID: 30662549 - PMCID: PMC6332798 - DOI: 10.7150/thno.30422
Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM
Point-of-care cervical cancer screening using deep learning-based microholography
Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187
Ng TSC, Garlin MA, Weissleder R, Miller MA
Understanding the EPR effect through image-guided systems pharmacology
Theranostics. 2019;:ePub
Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R
Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy
Theranostics. 2019;9(26):8426-8436 - PMID: 31879528 - PMCID: PMC6924259 - DOI: 10.7150/thno.35434
Wang C, Pulli B, Jalali Motlagh N, Li A, Wojtkiewicz GR, Schmidt SP, Wu Y, Zeller MWG, Chen JW
A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales.
Theranostics. 2019;9(25):7525-7536 - PMID: 31695784 - PMCID: PMC6831463 - DOI: 10.7150/thno.36264
Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H
Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma.
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Mattoo H, Mahajan VS, Maehara T, Deshpande V, Della-Torre E, Wallace ZS, Kulikova M, Drijvers JM, Daccache J, Carruthers MN, Castellino F, Stone JR, Stone JH, Pillai S
Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease.
J Allergy Clin Immunol. 2016;138(3):825-38 - PMID: 26971690 - PMCID: PMC5014627 - DOI: 10.1016/j.jaci.2015.12.1330
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Staged development of long lived TCRαβ Th17 resident memory T cell population to Candida albicans after skin infection.
J Allergy Clin Immunol. 2017;142(2):647-662 - PMID: 29128674 - PMCID: PMC5943196 - DOI: 10.1016/j.jaci.2017.09.042
Sun Z, Kim JH, Kim SH, Kim HR, Zhang K, Pan Y, Ko MK, Kim BM, Chu H, Lee HR, Kim HL, Kim JH, Fu X, Hyun YM, Yun KN, Kim JY, Lee DW, Song SY, Lin CP, Clark RA, Lee KH, Kupper TS, Park CO
Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis.
J Allergy Clin Immunol. 2021;147(5):1764-1777 - PMID: 33516870 - PMCID: PMC9272812 - DOI: 10.1016/j.jaci.2020.11.049
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Nat Biomed Eng. 2018;2:578-588 - PMID: 31015631 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8
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Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning
Nat Biomed Eng. 2018;2(9):666-674 - PMID: 30555750 - PMCID: PMC6291220 - DOI: 10.1038/s41551-018-0265-3
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Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.
Nat Biomed Eng. 2018;2(5):279-292 - PMID: 30936448 - PMCID: PMC6447057 - DOI: 10.1038/s41551-018-0221-2
Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche.
Nat Biomed Eng. 2020;4(11):1076-1089 - PMID: 33020600 - PMCID: PMC7655681 - DOI: 10.1038/s41551-020-00623-7
Cheong J, Yu H, Lee CY, Lee JU, Choi HJ, Lee JH, Lee H, Cheon J
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device.
Nat Biomed Eng. 2020;4(12):1159-1167 - PMID: 33273713 - PMCID: PMC8202505 - DOI: 10.1038/s41551-020-00654-0
Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma
Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7
Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ
Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
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Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R
Imaging inflammation of the pancreatic islets in type 1 diabetes.
Proc Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109 - DOI: 10.1073/pnas.0404307101
Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Proc Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472 - DOI: 10.1073/pnas.0401137101
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
Proc Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311 - DOI: 10.1073/pnas.0408197102
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
Proc Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291 - DOI: 10.1073/pnas.0503920102
Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.
Volumetric tomography of fluorescent proteins through small animals in vivo
Proc Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905 - DOI: 10.1073/pnas.0504628102
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Proc Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678 - DOI: 10.1073/pnas.0601273103
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A.
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
Proc Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940 - DOI: 10.1073/pnas.0605496103
Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP
The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.
Proc Natl Acad Sci U S A. 2005;102(38):13616-21 - PMID: 16174750 - PMCID: PMC1224669 - DOI: 10.1073/pnas.0506769102
Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
Proc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104
Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K
Mast cells are an essential hematopoietic component for polyp development.
Proc Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408 - DOI: 10.1073/pnas.0704620104
Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R
Perturbational profiling of nanomaterial biologic activity.
Proc Natl Acad Sci U S A. 2008;105:7387-7392 - PMID: 18492802 - PMCID: PMC2396702 - DOI: 10.1073/pnas.0802878105
Gold L, Brown D, He Y, Shtatland T, Singer B, Wu Y
From oligonucleotide shapes to genomic SELEX: novel biological regulatory loops.
Proc Natl Acad Sci U S A. 1997;94:59-64 - PMID: 8990161 - PMCID: PMC19236 - DOI: 10.1073/pnas.94.1.59
Hahn C, Ross K, Warrington I, Mazitschek R, Kanegai C, Wright R, Kung A, Golub T, Stegmaier K
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.
Proc Natl Acad Sci U S A. 2008;105(28):9751-6 - PMID: 18607002 - PMCID: PMC2474517 - DOI: 10.1073/pnas.0710413105
Shaw S, Wang J
Chirality of DNA trefoils: implications in intramolecular synapsis of distant DNA segments.
Proc Natl Acad Sci U S A. 1997;94(5):1692-7 - PMID: 9050840 - PMCID: PMC19978 - DOI: 10.1073/pnas.94.5.1692
Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R
Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
Proc Natl Acad Sci U S A. 2008;105 (47):18584-18589 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105
Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
Proc Natl Acad Sci U S A. 2008;105(49)::19126-19131 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105
Okazaki M, Ferrandon S, Vilardaga J, Bouxsein M, Potts J, Gardella T
Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.
Proc Natl Acad Sci U S A. 2008;105(43):16525-30 - PMID: 18946036 - PMCID: PMC2571912 - DOI: 10.1073/pnas.0808750105
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Bronson R, Chen J, Weissleder R, Housman D, Charest A.
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesis
Proc Natl Acad Sci U S A. 0;:ePub
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Proc Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331 - DOI: 10.1073/pnas.0813314106
Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.
Proc Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771 - DOI: 10.1073/pnas.0806647106
Butcher R, Ragains J, Li W, Ruvkun G, Clardy J, Mak H
Biosynthesis of the Caenorhabditis elegans dauer pheromone.
Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106
Kroh H, Panizzi P, Bock P
Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin.
Proc Natl Acad Sci U S A. 2009;106(19):7786-91 - PMID: 19416890 - PMCID: PMC2683071 - DOI: 10.1073/pnas.0811750106
Lee H*, Yoon TJ*, Figueiredo JL, Swirski FK, Weissleder R
Rapid detection and profiling of cancer cells in fine-needle aspirates.
Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106
Yoo B, Gredler R, Vozhilla N, Su Z, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher P, Sarkar D
Identification of genes conferring resistance to 5-fluorouracil.
Proc Natl Acad Sci U S A. 2009;106(31):12938-43 - PMID: 19622726 - PMCID: PMC2722317 - DOI: 10.1073/pnas.0901451106
Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA
Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.
Proc Natl Acad Sci U S A. 2009;106(35):14932-6 - PMID: 19706423 - PMCID: PMC2736449 - DOI: 10.1073/pnas.0902408106
Evans C, Potma E, Puoris'haag M, C
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy.
Proc Natl Acad Sci U S A. 2005;102:16807-12 - PMID: 16263923 - PMCID: PMC1283840 - DOI: 10.1073/pnas.0508282102
Higgins JM, Eddington DT, Bhatia SN, Mahadevan L
Sickle cell vasoocclusion and rescue in a microfluidic device.
Proc Natl Acad Sci U S A. 2007;104(51):20496-500 - PMID: 18077341 - PMCID: PMC2154459 - DOI: 10.1073/pnas.0707122105
Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proc Natl Acad Sci U S A. 2010;107(4):1565-70 - PMID: 20080688 - PMCID: PMC2824379 - DOI: 10.1073/pnas.0908682107
Tsigkou O, Pomerantseva I, Spencer JA, Redondo PA, Hart AR, O'Doherty E, Lin Y, Friedrich CC, Daheron L, Lin CP, Sundback CA, Vacanti JP, Neville C
Regenerative Medicine Special Feature: Engineered vascularized bone grafts.
Proc Natl Acad Sci U S A. 2010;107(8):3311-6 - PMID: 20133604 - PMCID: PMC2840421 - DOI: 10.1073/pnas.0905445107
Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922 - DOI: 10.1073/pnas.0911929107
Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R
Hybrid PET-optical imaging using targeted probes
Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, Deangelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Proc Natl Acad Sci U S A. 2010;107(28):12617-22 - PMID: 20616024 - PMCID: PMC2906581 - DOI: 10.1073/pnas.1006774107
Higgins JM, Mahadevan L
Physiological and pathological population dynamics of circulating human red blood cells.
Proc Natl Acad Sci U S A. 2010;107(47):20587-92 - PMID: 21059904 - PMCID: PMC2996693 - DOI: 10.1073/pnas.1012747107
Gao X, Eladari D, Leviel F, Tew BY, Miro-Julia
Deletion of hensin/DMBT1 blocks conversion of {beta}- to {alpha}-intercalated cells and induces distal renal tubular acidosis.
Proc Natl Acad Sci U S A. 2010;107(50):21872-7 - PMID: 21098262 - PMCID: PMC3003085 - DOI: 10.1073/pnas.1010364107
Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL
Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.
Proc Natl Acad Sci U S A. 2010;108(2):492-7 - PMID: 21183721 - PMCID: PMC3021060 - DOI: 10.1073/pnas.1016789108
Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR
Measuring single-cell density.
Proc Natl Acad Sci U S A. 2011;108(27):10992-10996 - PMID: 21690360 - PMCID: PMC3131325 - DOI: 10.1073/pnas.1104651108
Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
Proc Natl Acad Sci U S A. 2011;108(36):14908-13 - PMID: 21737748 - PMCID: PMC3169118 - DOI: 10.1073/pnas.1109023108
Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E
Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.
Proc Natl Acad Sci U S A. 2011;108(36):14902-7 - PMID: 21746931 - PMCID: PMC3169132 - DOI: 10.1073/pnas.1108892108
Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R
Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog.
Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108
Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ
Origins of tumor-associated macrophages and neutrophils.
Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109
Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R
Reactive polymer enables efficient in vivo bioorthogonal chemistry.
Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109
Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B
Implantable microenvironments to attract hematopoietic stem/cancer cells.
Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109
Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110
Liu Y, Shoji-Kawata S, Sumpter RM, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Proc Natl Acad Sci U S A. 2013;110(51):20364-71 - PMID: 24277826 - PMCID: PMC3870705 - DOI: 10.1073/pnas.1319661110
Peterson VM*, Castro CM*, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R
Ascites analysis by a microfluidic chip allows tumor-cell profiling
Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110
Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos JA, Weng Z, White KP, Hardison RC
Defining functional DNA elements in the human genome.
Proc Natl Acad Sci U S A. 2014;111(17):6131-6138 - PMID: 24753594 - PMCID: PMC4035993 - DOI: 10.1073/pnas.1318948111
Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.
Proc Natl Acad Sci U S A. 2014;111(18):6696-701 - PMID: 24753589 - PMCID: PMC4020091 - DOI: 10.1073/pnas.1405634111
Stangenberg L, Burzyn D, Binstadt BA, Weissleder R, Mahmood U, Benoist C, Mathis D
Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
Proc Natl Acad Sci U S A. 2014;111(31):11419-24 - PMID: 25049388 - PMCID: PMC4128122 - DOI: 10.1073/pnas.1410854111
Aguirre AD, Vinegoni C, Sebas M, Weissleder R
Intravital imaging of cardiac function at the single-cell level.
Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111
Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos J, Weng Z, White KP, Hardison RC
Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease.
Proc Natl Acad Sci U S A. 2014;111(33):E3366 - PMID: 25275169 - PMCID: PMC4143047 - DOI: 10.1073/pnas.1410434111
Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
Proc Natl Acad Sci U S A. 2014;111(46):E4946-53 - PMID: 25369933 - PMCID: PMC4246292 - DOI: 10.1073/pnas.1407079111
Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C
Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Proc Natl Acad Sci U S A. 2015;112(5):1511-6 - PMID: 25605891 - PMCID: PMC4321317 - DOI: 10.1073/pnas.1423769112
Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C Mathis D, Weissleder R
Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
Proc Natl Acad Sci U S A. 2015;112(7):2139-44 - PMID: 25650428 - PMCID: PMC4343112 - DOI: 10.1073/pnas.1424993112
Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H*
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112
Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL
Noninvasive imaging of immune responses.
Proc Natl Acad Sci U S A. 2015;112(19):6146-51 - PMID: 25902531 - PMCID: PMC4434737 - DOI: 10.1073/pnas.1502609112
Di Caprio G, Stokes C, Higgins JM, Schonbrun E
Single-cell measurement of red blood cell oxygen affinity.
Proc Natl Acad Sci U S A. 2015;112(32):9984-9 - PMID: 26216973 - PMCID: PMC4538663 - DOI: 10.1073/pnas.1509252112
Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK
AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer.
Proc Natl Acad Sci U S A. 2015;112(32):E4418-27 - PMID: 26216943 - PMCID: PMC4538667 - DOI: 10.1073/pnas.1510604112
Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Proc Natl Acad Sci U S A. 2016;113(7):1871-6 - PMID: 26831087 - PMCID: PMC4763742 - DOI: 10.1073/pnas.1511380113
Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT
Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.
Proc Natl Acad Sci U S A. 2016;113(34):9527-32 - PMID: 27512047 - PMCID: PMC5003247 - DOI: 10.1073/pnas.1610435113
Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, Richardson PG, Carrasco RD, Wiest O, Schreiber SL, Anderson KC, Bradner JE
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Proc Natl Acad Sci U S A. 2016;113(46):13162-13167 - PMID: 27799547 - PMCID: PMC5135369 - DOI: 10.1073/pnas.1608067113
Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Proc Natl Acad Sci U S A. 2016;113(46):13227-13232 - PMID: 27799546 - PMCID: PMC5135308 - DOI: 10.1073/pnas.1609397113
Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ
Immune cell screening of a nanoparticle library improves atherosclerosis therapy.
Proc Natl Acad Sci U S A. 2016;113(44):E6731-E6740 - PMID: 27791119 - PMCID: PMC5098679 - DOI: 10.1073/pnas.1609629113
Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES
Systematic dissection of genomic features determining transcription factor binding and enhancer function.
Proc Natl Acad Sci U S A. 2017;114(7):E1291-E1300 - PMID: 28137873 - PMCID: PMC5321001 - DOI: 10.1073/pnas.1621150114
Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Proc Natl Acad Sci U S A. 2013;110(22):E2074-83 - PMID: 23674691 - PMCID: PMC3670354 - DOI: 10.1073/pnas.1222387110
Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Proc Natl Acad Sci U S A. 2013;110(24):9776-81 - PMID: 23720309 - PMCID: PMC3683718 - DOI: 10.1073/pnas.1307478110
Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C
Imaging the emergence and natural progression of spontaneous autoimmune diabetes.
Proc Natl Acad Sci U S A. 2017;114(37):E7776-E7785 - PMID: 28839093 - PMCID: PMC5604023 - DOI: 10.1073/pnas.1707381114
He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M
Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.
Proc Natl Acad Sci U S A. 2017;114(45):E9559-E9568 - PMID: 29078380 - PMCID: PMC5692581 - DOI: 10.1073/pnas.1712670114
Chaudhury A, Noiret L, Higgins JM
White blood cell population dynamics for risk stratification of acute coronary syndrome.
Proc Natl Acad Sci U S A. 2017;114(46):12344-12349 - PMID: 29087321 - PMCID: PMC5699055 - DOI: 10.1073/pnas.1709228114
Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Proc Natl Acad Sci U S A. 2017;114(46):E9989-E9998 - PMID: 29089413 - PMCID: PMC5699061 - DOI: 10.1073/pnas.1710964114
Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I
Stress granule-associated protein G3BP2 regulates breast tumor initiation.
Proc Natl Acad Sci U S A. 2017;114(5):1033-1038 - PMID: 28096337 - PMCID: PMC5293063 - DOI: 10.1073/pnas.1525387114
Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK
Hypermutable DNA chronicles the evolution of human colon cancer.
Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111
Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109
Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Reply to Edemir: Physiological regulation and single-cell RNA sequencing.
Proc Natl Acad Sci U S A. 2018;115(3):E351-E352 - PMID: 29311339 - PMCID: PMC5777009 - DOI: 10.1073/pnas.1720333115
Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Proc Natl Acad Sci U S A. 2018;115(15):3912-3917 - PMID: 29581255 - PMCID: PMC5899492 - DOI: 10.1073/pnas.1801524115
Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT, Barker FG, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DP
Genotype-targeted local therapy of glioma.
Proc Natl Acad Sci U S A. 2018;115(36):E8388-E8394 - PMID: 30082399 - PMCID: PMC6130372 - DOI: 10.1073/pnas.1805751115
Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C
Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.
Proc Natl Acad Sci U S A. 2018;115(45):E10672-E10681 - PMID: 30348759 - PMCID: PMC6233093 - DOI: 10.1073/pnas.1810580115
Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ
Site occupancy calibration of taxane pharmacology in live cells and tissues
Proc Natl Acad Sci U S A. 2018;115(48):E11406-E11414 - PMID: 30429313 - PMCID: PMC6275538 - DOI: 10.1073/pnas.1800047115
Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - PMCID: PMC6561160 - DOI: 10.1073/pnas.1819889116
Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor
Proc Natl Acad Sci U S A. 2019;116(23):11444-11453 - PMID: 31101720 - PMCID: PMC6561274 - DOI: 10.1073/pnas.1702372116
Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116
Heyde A, Reiter JG, Naxerova K, Nowak MA
Consecutive seeding and transfer of genetic diversity in metastasis.
Proc Natl Acad Sci U S A. 2019;116(28):14129-14137 - PMID: 31239334 - PMCID: PMC6628640 - DOI: 10.1073/pnas.1819408116
Di Caprio G*, Schonbrun E*, Gonçalves BP, Valdez JM, Wood DK, Higgins JM
High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension.
Proc Natl Acad Sci U S A. 2019;116(50):25236-25242 - PMID: 31767751 - PMCID: PMC6911208 - DOI: 10.1073/pnas.1914056116
Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Proc Natl Acad Sci U S A. 2020;117(16):8900-8911 - PMID: 32253314 - PMCID: PMC7183223 - DOI: 10.1073/pnas.1913788117
Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
Proc Natl Acad Sci U S A. 2020;117(38):23684-23694 - PMID: 32907939 - PMCID: PMC7519254 - DOI: 10.1073/pnas.2002806117
Zaidman NA, Tomilin VN, Hassanzadeh Khayyat N, Damarla M, Tidmore J, Capen DE, Brown D, Pochynyuk OM, Pluznick JL
Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
Proc Natl Acad Sci U S A. 2020;117(42):26470-26481 - PMID: 33004624 - PMCID: PMC7584995 - DOI: 10.1073/pnas.2007620117
Zhang Y, Kohrn BF, Yang M, Nachmanson D, Soong TR, Lee IH, Tao Y, Clevers H, Swisher EM, Brentnall TA, Loeb LA, Kennedy SR, Salk JJ, Naxerova K, Risques RA
PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.
Proc Natl Acad Sci U S A. 2021;118(31):ePub - PMID: 34330826 - PMCID: PMC8346827 - DOI: 10.1073/pnas.2023373118
Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz GR, Schmidt S, Chau C, Narsimhan R, Kullenberg EG, Zhu C, Linnoila J, Yao Z, Chen JW
d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation.
Proc Natl Acad Sci U S A. 2021;118(44):ePub - PMID: 34702739 - PMCID: PMC8673064 - DOI: 10.1073/pnas.2107663118
Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118
Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
Ann Neurol. 2005;57(1):34-41 - PMID: 15622535 - DOI: 10.1002/ana.20306
Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA
Extra-axial inflammatory signal in parameninges in migraine with visual aura.
Ann Neurol. 2020;87(6):939-949 - PMID: 32239542 - PMCID: PMC7313427 - DOI: 10.1002/ana.25731
Kim J, Jang HJ, Schellingerhout D, Lee SK, Kim H, Kim YD, Lee KY, Choi HY, Cho HJ, Jang SS, Jeon S, Kwon IC, Kim K, Ryu WS, Nahrendorf M, Choi S, Kim DE
Short-Term Cessation of Dabigatran Causes a Paradoxical Prothrombotic State.
Ann Neurol. 2020;89(3):444-458 - PMID: 33219556 - DOI: 10.1002/ana.25964
Ryu WS, Schellingerhout D, Hong KS, Jeong SW, Kim BJ, Kim JT, Lee KB, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Nahrendorf M, Lee J, Bae HJ, Kim DE
Relation of Pre-stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.
Ann Neurol. 2021;90(5):763-776 - PMID: 34536234 - PMCID: PMC9292882 - DOI: 10.1002/ana.26219
Pfirschke C, Zilionis R, Engblom C, Messemaker M, Zou AE, Rickelt S, Gort-Freitas NA, Lin Y, Bill R, Siwicki M, Gungabeesoon J, Sprachman MM, Marquard AN, Rodell CB, Cuccarese MF, Quintana J, Ahmed MS, Kohler RH, Savova V, Weissleder R, Klein AM, Pittet MJ
Macrophage-targeted therapy unlocks antitumoral crosstalk between IFN𝛾-secreting lymphocytes and IL12-producing dendritic cells.
Cancer Immunol Res. 2021;10(1):40-55 - PMID: 34795032 - DOI: 10.1158/2326-6066.CIR-21-0326
Johnson J, Wiley R, Fattouh R, Swirski F, Gajewska B, Coyle A, Gutierrez-Ramos J, Ellis R, Inman M, Jordana M
Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling.
Am J Resp Crit Care. 2004;169(3):378-85 - PMID: 14597485 - DOI: 10.1164/rccm.200308-1094OC
Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L
Large and small extracellular vesicles released by glioma cells in vitro and in vivo.
J Extracell Vesicles. 2019;9(1):1689784 - PMID: 31839905 - PMCID: PMC6896449 - DOI: 10.1080/20013078.2019.1689784
Nahrendorf M, Spindler M, Hu K, Bauer L, Ritter O, Nordbeck P, Quaschning T, Hiller K, Wallis J, Ertl G, Bauer W, Neubauer S
Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction.
Cardiovasc Res. 2005;65(2):419-27 - PMID: 15639481 - DOI: 10.1016/j.cardiores.2004.10.006
Nahrendorf M, Frantz S, Hu K, von zur Mahlen C, Tomaszewski M, Scheuermann H, Kaiser R, Jazbutyte V, Beer S, Bauer W, Neubauer S, Ertl G, Allolio B, Callies F
Effect of testosterone on post-myocardial infarction remodeling and function.
Cardiovasc Res. 2003;57(2):370-8 - PMID: 12566109 - DOI: 10.1016/s0008-6363(02)00701-0
Pelzer T, Jazbutyte V, Hu K, Segerer S, Nahrendorf M, Nordbeck P, Bonz AW, Muck J, Fritzemeier KH, Hegele-Hartung C, Ertl G, Neyses L
The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats.
Cardiovasc Res. 2005;67(4):604-12 - PMID: 15950203 - DOI: 10.1016/j.cardiores.2005.04.035
Hu K, Gaudron P, Anders HJ, Weidemann F, Turschner O, Nahrendorf M, Ertl G
Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin.
Cardiovasc Res. 1998;39(2):401-12 - PMID: 9798525 - DOI: 10.1016/s0008-6363(98)00090-x
Frantz S, Nahrendorf M
Cardiac macrophages and their role in ischemic heart disease.
Cardiovasc Res. 2014;102(2):240-8 - PMID: 24501331 - PMCID: PMC3989449 - DOI: 10.1093/cvr/cvu025
Verweij SL, Duivenvoorden R, Stiekema LCA, Nurmohamed NS, van der Valk FM, Versloot M, Verberne HJ, Stroes ESG, Nahrendorf M, Bekkering S, Bernelot Moens SJ
CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease.
Cardiovasc Res. 2018;114(3):468-475 - PMID: 29186373 - DOI: 10.1093/cvr/cvx224
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Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Păunescu TG
Characterization and Correction of Olfactory Deficits in Kidney Disease.
J Am Soc Nephrol. 2017;28(11):3395-3403 - PMID: 28775001 - PMCID: PMC5661283 - DOI: 10.1681/ASN.2016121308
Battistone MA, Nair AV, Barton CR, Liberman RN, Peralta MA, Capen DE, Brown D, Breton S
Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells.
J Am Soc Nephrol. 2017;29(2):545-556 - PMID: 29222395 - PMCID: PMC5791049 - DOI: 10.1681/ASN.2017060643
Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS
Iron, Hepcidin, and Death in Human AKI.
J Am Soc Nephrol. 2019;30(3):493-504 - PMID: 30737269 - PMCID: PMC6405140 - DOI: 10.1681/ASN.2018100979
Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D,
Defining Kidney Biology to Understand Renal Disease.
Clin J Am Soc Nephrol. 2013;9(4):809-11 - PMID: 24370769 - PMCID: PMC3974369 - DOI: 10.2215/CJN.10851013
Hilderbrand SA, Weissleder R
Near-infrared fluorescence: application to in vivo molecular imaging.
Curr Opin Chem Biol. 2009;14:1-9 - PMID: 19879798 - DOI: 10.1016/j.cbpa.2009.09.029
Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH, Berton O
Antidepressant-Like Properties of Novel HDAC6 Selective Inhibitors with Improved Brain Bioavailability.
Neuropsychopharmacology. 2013;39(2):389-400 - PMID: 23954848 - PMCID: PMC3870780 - DOI: 10.1038/npp.2013.207
Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK
Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Cell Syst. 2020;11(5):478-494.e9 - PMID: 33113355 - PMCID: PMC8009031 - DOI: 10.1016/j.cels.2020.10.002
Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas
Cancer Res. 2004;64:273-8 - PMID: 14729634 - DOI: 10.1158/0008-5472.can-03-1123
Grimm J, Perez JM, Josephson L, Weissleder R
Novel nanosensors for rapid analysis of telomerase activity
Cancer Res. 2004;64:639-43 - PMID: 14744779 - DOI: 10.1158/0008-5472.can-03-2798
Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr
Near-infrared fluorescent imaging of tumor apoptosis
Cancer Res. 2003;63:1936-42 - PMID: 12702586
Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
Cancer Res. 2003;63:6838-46 - PMID: 14583481
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
Cancer Res. 2003;63:8122-5 - PMID: 14678964
Tung CH, Mahmood U, Bredow S, Weissleder R
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
Cancer Res. 2000;60:4953-8 - PMID: 10987312
Simonova M, Wall A, Weissleder R, Bogdanov A Jr
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
Cancer Res. 2000;60:6656-62 - PMID: 11118049
Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R
In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch
Cancer Res. 2004;64:1579-1583 - PMID: 14996712 - DOI: 10.1158/0008-5472.can-03-3226
Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
Cancer Res. 2004;64(9):3236-42 - PMID: 15126365 - DOI: 10.1158/0008-5472.can-03-3516
Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Cancer Res. 2004;64(12):4069-77 - PMID: 15205313 - DOI: 10.1158/0008-5472.CAN-04-1243
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.
Cancer Res. 2004;64(17):6247-51 - PMID: 15342411 - DOI: 10.1158/0008-5472.CAN-04-0817
Montet X, Ntziachristos V, Grimm J, Weissleder R.
Tomographic Fluorescence Mapping of Tumor Targets
Cancer Res. 2005;65 (14):6330-6336 - PMID: 16024635 - DOI: 10.1158/0008-5472.CAN-05-0382
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging
Cancer Res. 2005;65(18):8324-30 - PMID: 16166309 - DOI: 10.1158/0008-5472.CAN-05-0027
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor
Cancer Res. 2005;65(20):9253-60 - PMID: 16230386 - DOI: 10.1158/0008-5472.CAN-03-2619
Choi YD, Weissleder R, Tung CH.
Selective antitumor effect of novel protease-mediated photodynamic agent
Cancer Res. 2006;66 (14):7225-7229 - PMID: 16849570 - DOI: 10.1158/0008-5472.CAN-06-0448
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203 - DOI: 10.1158/0008-5472.CAN-07-0077
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K
MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas.
Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999 - DOI: 10.1158/0008-5472.CAN-07-1045
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer Res. 2007;67(19):9398-406 - PMID: 17909049 - PMCID: PMC2850558 - DOI: 10.1158/0008-5472.CAN-07-1063
Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R
Detection of early prostate cancer using a hepsin-targeted imaging agent.
Cancer Res. 2008;68(7):2286-91 - PMID: 18381435 - PMCID: PMC2709884 - DOI: 10.1158/0008-5472.CAN-07-1349
Zippelius A, Batard P, Rubio-Godoy V, Bioley G, Lienard D, Lejeune F, Rimoldi D, Guillaume P, Meidenbauer N, Mackensen A, Rufer N, Lubenow N, Speiser D, Cerottini J, Romero P, Pittet M
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance.
Cancer Res. 2004;64:2865-73 - PMID: 15087405 - DOI: 10.1158/0008-5472.can-03-3066
Meidenbauer N, Zippelius A, Pittet M, Laumer M, Vogl S, Heymann J, Rehli M, Seliger B, Schwarz S, Le Gal F, Dietrich P, Andreesen R, Romero P, Mackensen A
High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.
Cancer Res. 2004;64:6319-26 - PMID: 15342421 - DOI: 10.1158/0008-5472.CAN-04-1341
Movassagh M, Spatz A, Davoust J, Lebecque S, Romero P, Pittet M, Rimoldi D, Lienard D, Gugerli O, Ferradini L, Robert C, Avril M, Zitvogel L, Angevin E
Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.
Cancer Res. 2004;64:2192-8 - PMID: 15026362 - DOI: 10.1158/0008-5472.can-03-2969
Valmori D, Pittet M, Vonarbourg C, Rimoldi D, Lienard D, Speiser D, Dunbar R, Cerundolo V, Cerottini J, Romero P
Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.
Cancer Res. 1999;59:4050-5 - PMID: 10463606
Valmori D, Dutoit V, Lienard D, Rimoldi D, Pittet M, Champagne P, Ellefsen K, Sahin U, Speiser D, Lejeune F, Cerottini J, Romero P
Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.
Cancer Res. 2000;60:4499-506 - PMID: 10969798
Valmori D, Pittet M, Rimoldi D, Lienard D, Dunbar R, Cerundolo V, Lejeune F, Cerottini J, Romero P
An antigen-targeted approach to adoptive transfer therapy of cancer.
Cancer Res. 1999;59:2167-73 - PMID: 10232604
Kelly K, Manos E, Jensen G, Nadauld L, Jones D
APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death.
Cancer Res. 2000;60:1021-7 - PMID: 10706119
Wakimoto H, Kesari S, Farrell CJ, Curry WT, Zaupa C, Aghi M, Kuroda T, Stemmer-Rachamimov A, Shah K, Liu TC, Jeyaretna DS, Debasitis J, Pruszak J, Martuza RL, Rabkin SD
Human Glioblastoma-Derived Cancer Stem Cells: Establishment of Invasive Glioma Models and Treatment with Oncolytic Herpes Simplex Virus Vectors.
Cancer Res. 2009;69(8):3472-81 - PMID: 19351838 - PMCID: PMC2785462 - DOI: 10.1158/0008-5472.CAN-08-3886
Georgakoudi I, Solban N, Novak J, Rice WL, Wei X, Hasan T, Lin CP
In vivo flow cytometry: a new method for enumerating circulating cancer cells.
Cancer Res. 2004;64(15):5044-7 - PMID: 15289300 - PMCID: PMC2824432 - DOI: 10.1158/0008-5472.CAN-04-1058
Yoo BK, Chen D, Su ZZ, Gredler R, Yoo J, Shah K, Fisher PB, Sarkar D
Molecular Mechanism of Chemoresistance by Astrocyte Elevated Gene-1.
Cancer Res. 2010;70(8):3249-58 - PMID: 20388796 - PMCID: PMC2855753 - DOI: 10.1158/0008-5472.CAN-09-4009
Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Aleman JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR
The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.
Cancer Res. 2010;70(13):5305-5315 - PMID: 20530665 - PMCID: PMC3204358 - DOI: 10.1158/0008-5472.CAN-09-3399
Bagci-Onder T, Wakimoto H, Anderegg M, Cameron C, Shah K
A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell delivered TRAIL in experimental glioma models.
Cancer Res. 2010;71(1):154-63 - PMID: 21084267 - DOI: 10.1158/0008-5472.CAN-10-1601
Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ
Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics.
Cancer Res. 2011;71(13):4608-16 - PMID: 21712408 - PMCID: PMC3129392 - DOI: 10.1158/0008-5472.CAN-11-0412
Earley S, Vinegoni C, Dunham J, Gorbatov R, Fumene Feruglio P, Weissleder R
In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution.
Cancer Res. 2012;72(12):2949-56 - PMID: 22505651 - PMCID: PMC3603290 - DOI: 10.1158/0008-5472.CAN-11-4096
Beck S, Bernstein BE, Campbell RM, Costello JF, Dhanak D, Ecker JR, Greally JM, Issa JP, Laird PW, Polyak K, Tycko B, Jones PA,
A Blueprint for an International Cancer Epigenome Consortium. A Report from the AACR Cancer Epigenome Task Force.
Cancer Res. 2012;72(24):6319-6324 - PMID: 23188507 - DOI: 10.1158/0008-5472.CAN-12-3658
Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari KI, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J
Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1.
Cancer Res. 2013;74(3):738-50 - PMID: 24310399 - PMCID: PMC3928601 - DOI: 10.1158/0008-5472.CAN-13-2650
Viaud S, Daillère R, Boneca IG, Lepage P, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L
Harnessing the Intestinal Microbiome for Optimal Therapeutic Immunomodulation.
Cancer Res. 2014;74(16):4217-4221 - PMID: 25074615 - PMCID: PMC6700746 - DOI: 10.1158/0008-5472.CAN-14-0987
Chan CT, Qi J, Smith W, Paranal R, Mazitschek R, West N, Reeves R, Chiosis G, Schreiber SL, Bradner JE, Paulmurugan R, Gambhir SS
Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase (HDAC) Inhibitors by Multimodality Molecular Imaging in Living Subjects.
Cancer Res. 2014;74(24):7475-86 - PMID: 25320008 - PMCID: PMC4315624 - DOI: 10.1158/0008-5472.CAN-14-0197
Tesfay L, Clausen KA, Kim JW, Hedge P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV
Hepcidin regulation in prostate and its disruption in prostate cancer.
Cancer Res. 2015;75(11):2254-63 - PMID: 25858146 - PMCID: PMC4454355 - DOI: 10.1158/0008-5472.CAN-14-2465
Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A
Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity.
Cancer Res. 2016;76(10):2876-2881 - PMID: 27013191 - PMCID: PMC4873326 - DOI: 10.1158/0008-5472.CAN-15-3432
Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.
Cancer Res. 2013;73(6):1733-41 - PMID: 23288508 - PMCID: PMC3602406 - DOI: 10.1158/0008-5472.CAN-12-2384
Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI
PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs.
Cancer Res. 2017;77(22):6365-6374 - PMID: 28947422 - PMCID: PMC5690870 - DOI: 10.1158/0008-5472.CAN-16-3453
Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF, Wu TC, Kim TW
Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.
Cancer Res. 2010;70(8):3062-70 - PMID: 20395201 - PMCID: PMC2861497 - DOI: 10.1158/0008-5472.CAN-09-3856
Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, Hung CF, Trimble C, Lim JS, Kim TW, Wu TC
Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination.
Cancer Res. 2007;67(2):802-11 - PMID: 17234792 - PMCID: PMC3181129 - DOI: 10.1158/0008-5472.CAN-06-2638
Pai SI, Wu GS, Ozören N, Wu L, Jen J, Sidransky D, El-Deiry WS
Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
Cancer Res. 1998;58(16):3513-8 - PMID: 9721851
Miller MA, Arlauckas S, Weissleder R
Prediction of Anti-cancer Nanotherapy Efficacy by Imaging
Nanotheranostics. 2017;1(3):296-312 - PMID: 29071194 - PMCID: PMC5646731 - DOI: 10.7150/ntno.20564
Arlauckas S, Oh N, Li R, Weissleder R, Miller MA
Macrophage imaging and subset analysis using single-cell RNA sequencing.
Nanotheranostics. 2021;5(1):36-56 - PMID: 33391974 - PMCID: PMC7738942 - DOI: 10.7150/ntno.50185
Choy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D
Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines
PLoS Genet. 2008;4(11):e1000287 - PMID: 19043577 - PMCID: PMC2583954 - DOI: 10.1371/journal.pgen.1000287
Ku M, Koche R, Rheinbay E, Mendenhall E, Endoh M, Mikkelsen T, Presser A, Nusbaum C, Xie X, Chi A, Adli M, Kasif S, Ptaszek L, Cowan C, Lander E, Koseki H, Bernstein B
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.
PLoS Genet. 2008;4(10):e1000242 - PMID: 18974828 - PMCID: PMC2567431 - DOI: 10.1371/journal.pgen.1000242
Mendenhall EM, Koche RP, Truong T, Zhou VW, Issac B, Chi AS, Ku M, Bernstein BE
GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells.
PLoS Genet. 2010;6(12):e1001244 - PMID: 21170310 - PMCID: PMC3000368 - DOI: 10.1371/journal.pgen.1001244
Ziller MJ, Müller F, Liao J, Zhang Y, Gu H, Bock C, Boyle P, Epstein CB, Bernstein BE, Lengauer T, Gnirke A, Meissner A
Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types.
PLoS Genet. 2011;7(12):e1002389 - PMID: 22174693 - PMCID: PMC3234221 - DOI: 10.1371/journal.pgen.1002389
Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H
Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity.
PLoS Genet. 2012;8(7):e1002774 - PMID: 22844243 - PMCID: PMC3405999 - DOI: 10.1371/journal.pgen.1002774
Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
PLoS Genet. 2019;15(5):e1008084 - PMID: 31059511 - PMCID: PMC6502318 - DOI: 10.1371/journal.pgen.1008084
Viaud S, Daillère R, Boneca IG, Lepage P, Langella P, Chamaillard M, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L
Gut microbiome and anticancer immune response: really hot Sh*t!
Cell Death Differ. 2014;22(2):199-214 - PMID: 24832470 - PMCID: PMC4291500 - DOI: 10.1038/cdd.2014.56
Shtatland T, Gill S, Javornik B, Johansson H, Singer B, Uhlenbeck O, Zichi D, Gold L
Interactions of Escherichia coli RNA with bacteriophage MS2 coat protein: genomic SELEX.
Nucleic Acids Res. 2000;28:E93 - PMID: 11058143 - PMCID: PMC113162 - DOI: 10.1093/nar/28.21.e93
Abrams E, Shtatland T, Lerman L
PCR assay for a polymorphic TaqI site in the human K-ras-2 gene on chromosome 12p (KRAS2).
Nucleic Acids Res. 1991;19:4795 - PMID: 1679926 - PMCID: PMC328755 - DOI: 10.1093/nar/19.17.4795
Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.
Nucleic Acids Res. 2013;41(19):e181 - PMID: 23945932 - PMCID: PMC3799455 - DOI: 10.1093/nar/gkt716
Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, Parmar RG, Zlatev I, Schlegel MK, Nair JK, Jayaraman M, Manoharan M, Brown D, Maier MA, Jadhav V
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Nucleic Acids Res. 2020;48(21):11827-11844 - PMID: 32808038 - PMCID: PMC7708070 - DOI: 10.1093/nar/gkaa670
Babitt JL, Lin HY
The molecular pathogenesis of hereditary hemochromatosis.
Semin Liver Dis. 2011;31(3):280-92 - PMID: 21901658 - DOI: 10.1055/s-0031-1286059
Calcagno DM, Ng RP, Toomu A, Zhang C, Huang K, Aguirre AD, Weissleder R, Daniels LB, Fu Z, King KR
Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3
Sci Immunol. 2020;5(51):ePub - PMID: 32978242 - PMCID: PMC7808338 - DOI: 10.1126/sciimmunol.aaz1974
Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):ePub - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083
She A, Kurtser I, Reis SA, Hennig K, Lai J, Lang A, Zhao WN, Mazitschek R, Dickerson BC, Herz J, Haggarty SJ
Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.
Cell Chem Biol. 2017;24(7):892-906.e5 - PMID: 28712747 - PMCID: PMC5695697 - DOI: 10.1016/j.chembiol.2017.06.010
Koch PD, Rodell CB, Kohler RH, Pittet MJ, Weissleder R
Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy.
Cell Chem Biol. 2020;27(1):94-104.e5 - PMID: 31902676 - PMCID: PMC7422681 - DOI: 10.1016/j.chembiol.2019.12.007
Payne NC, Mazitschek R
Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors.
Cell Chem Biol. 2022;29(7):1140-1152.e5 - PMID: 35298895 - DOI: 10.1016/j.chembiol.2022.03.002
Payne NC, Maksoud S, Tannous BA, Mazitschek R
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader.
Cell Chem Biol. 2022;29(8):1333-1340.e5 - PMID: 35649410 - PMCID: PMC9391279 - DOI: 10.1016/j.chembiol.2022.05.003
Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier RJ, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ
Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Cell Rep. 2012;1(4):1-8 - PMID: 22545247 - PMCID: PMC3334310 - DOI: 10.1016/j.celrep.2012.02.009
Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W
Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure.
Cell Rep. 2012;2(1):52-61 - PMID: 22840396 - PMCID: PMC3627357 - DOI: 10.1016/j.celrep.2012.06.002
Mak AB, Nixon AM, Kittanakom S, Stewart JM, Chen GI, Curak J, Gingras AC, Mazitschek R, Neel BG, Stagljar I, Moffat J
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation.
Cell Rep. 2012;2(4):951-63 - PMID: 23084749 - PMCID: PMC3590846 - DOI: 10.1016/j.celrep.2012.09.016
Rheinbay E, Suvà ML, Gillespie SM, Wakimoto H, Patel AP, Shahid M, Oksuz O, Rabkin SD, Martuza RL, Rivera MN, Louis DN, Kasif S, Chi AS, Bernstein BE
An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma.
Cell Rep. 2013;3(5):1567-1579 - PMID: 23707066 - PMCID: PMC3774301 - DOI: 10.1016/j.celrep.2013.04.021
Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy.
Cell Rep. 2014;9(1):180-92 - PMID: 25284779 - PMCID: PMC4555847 - DOI: 10.1016/j.celrep.2014.08.074
Levy O, Mortensen LJ, Boquet G, Tong Z, Perrault C, Benhamou B, Zhang J, Stratton T, Han E, Safaee H, Musabeyezu J, Yang Z, Multon MC, Rothblatt J, Deleuze JF, Lin CP, Karp JM
A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells.
Cell Rep. 2015;10(8):1261-1268 - PMID: 25732817 - PMCID: PMC4361231 - DOI: 10.1016/j.celrep.2015.01.057
Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ
PF4 Promotes Platelet Production and Lung Cancer Growth.
Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031
Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS
A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.
Cell Rep. 2017;21(3):784-797 - PMID: 29045844 - PMCID: PMC5687286 - DOI: 10.1016/j.celrep.2017.09.066
Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.
Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - PMCID: PMC6528836 - DOI: 10.1016/j.celrep.2019.03.003
Shikatani EA, Besla R, Ensan S, Upadhye A, Khyzha N, Li A, Emoto T, Chiu F, Degousee N, Moreau JM, Perry HM, Thayaparan D, Cheng HS, Pacheco S, Smyth D, Noyan H, Zavitz CCJ, Bauer CMT, Hilgendorf I, Libby P, Swirski FK, Gommerman JL, Fish JE, Stampfli MR, Cybulsky MI, Rubin BB, Paige CJ, Bender TP, McNamara CA, Husain M, Robbins CS
c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.
Cell Rep. 2019;27(8):2304-2312.e6 - PMID: 31116977 - DOI: 10.1016/j.celrep.2019.04.090
Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A
Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.
Cell Rep. 2019;27(13):3972-3987.e6 - PMID: 31242427 - PMCID: PMC6604862 - DOI: 10.1016/j.celrep.2019.05.089
Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, Messemaker M, Siwicki M, Gerhard GM, Kohl A, Meylan E, Weissleder R, Klein AM, Pittet MJ
Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils.
Cell Rep. 2020;32(12):108164 - PMID: 32966785 - PMCID: PMC7508173 - DOI: 10.1016/j.celrep.2020.108164
Kim IS, Wu J, Rahme GJ, Battaglia S, Dixit A, Gaskell E, Chen H, Pinello L, Bernstein BE
Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies.
Cell Rep. 2020;33(1):108222 - PMID: 33027665 - PMCID: PMC7646252 - DOI: 10.1016/j.celrep.2020.108222
Barrett TJ, Corr EM, van Solingen C, Schlamp F, Brown EJ, Koelwyn GJ, Lee AH, Shanley LC, Spruill TM, Bozal F, de Jong A, Newman AAC, Drenkova K, Silvestro M, Ramkhelawon B, Reynolds HR, Hochman JS, Nahrendorf M, Swirski FK, Fisher EA, Berger JS, Moore KJ
Chronic stress primes innate immune responses in mice and humans.
Cell Rep. 2021;36(10):109595 - PMID: 34496250 - PMCID: PMC8493594 - DOI: 10.1016/j.celrep.2021.109595
Malka R, Brugnara C, Cialic R, Higgins JM
Non-Parametric Combined Reference Regions and Prediction of Clinical Risk.
Clin Chem. 2020;66(2):363-372 - PMID: 32040586 - PMCID: PMC7055670 - DOI: 10.1093/clinchem/hvz020
Pittet M, Swirski F, Reynolds F, Josephson L, Weissleder R.
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
Nat Protoc. 2006;1(1):73-79 - PMID: 17406214 - DOI: 10.1038/nprot.2006.11
Lo Celso C, Lin CP, Scadden DT
In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow.
Nat Protoc. 2010;6(1):1-14 - PMID: 21212779 - PMCID: PMC3382040 - DOI: 10.1038/nprot.2010.168
Adli M, Bernstein BE
Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq.
Nat Protoc. 2011;6(10):1656-68 - PMID: 21959244 - PMCID: PMC4493313 - DOI: 10.1038/nprot.2011.402
Vinegoni C, Aguirre AD, Lee S, Weissleder R
Imaging the beating heart in the mouse using intravital microscopy techniques.
Nat Protoc. 2015;10(11):1802-1819 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119
Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R
Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.
Nat Protoc. 2017;12(7):1472-1497 - PMID: 28686582 - PMCID: PMC5928516 - DOI: 10.1038/nprot.2017.043
Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - PMCID: PMC6571021 - DOI: 10.1038/s41596-018-0105-7
Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R
Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice
Radiology. 2003;226:214-20 - PMID: 12511693 - DOI: 10.1148/radiol.2261012140
Mahmood U, Tung CH, Tang Y, Weissleder R
Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice
Radiology. 2002;224:446-51 - PMID: 12147841 - DOI: 10.1148/radiol.2242011589
Bremer C, Tung CH, Bogdanov A Jr, Weissleder R
Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes
Radiology. 2002;222:814-8 - PMID: 11867806 - DOI: 10.1148/radiol.2223010812
Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R
Human transferrin receptor gene as a marker gene for MR imaging
Radiology. 2001;221:244-50 - PMID: 11568347 - DOI: 10.1148/radiol.2211001784
Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH
Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model
Radiology. 2001;221:523-9 - PMID: 11687699 - DOI: 10.1148/radiol.2212010368
Moore A, Marecos E, Bogdanov A Jr, Weissleder R
Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model
Radiology. 2000;214:568-74 - PMID: 10671613 - DOI: 10.1148/radiology.214.2.r00fe19568
Funovics MA, Weissleder R, Mahmood U
Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.
Radiology. 2004;231(3):659-66 - PMID: 15163807 - DOI: 10.1148/radiol.2313030831
Mahmood U
Can MR Imaging Be Used to Track Delivery of Intravascularly Administered Stem Cells?
Radiology. 2004;233(3):625-6 - PMID: 15564396 - DOI: 10.1148/radiol.2333041190
Chen JW, Querol Sans M, Bogdanov Jr A, Weissleder R
Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
Radiology. 2006;240 (2):473-81 - PMID: 16864673 - DOI: 10.1148/radiol.2402050994
Mahmood U
Can a clinically used chemoembolization vehicle improve transgene delivery?
Radiology. 2006;240(3):619-20 - PMID: 16926318 - DOI: 10.1148/radiol.2403060761
Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D
Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging.
Radiology. 2006;241(3):822-830 - PMID: 17114629 - DOI: 10.1148/radiol.2413050466
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.
Tomographic fluorescence imaging of tumor vascular volume in mice.
Radiology. 2007;242 (3):751-758 - PMID: 17325064 - DOI: 10.1148/radiol.2423052065
Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U
Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection.
Radiology. 2007;244(1):232-8 - PMID: 17507718 - DOI: 10.1148/radiol.2441052114
Upadhyay R, Sheth RA, Weissleder R, Mahmood U
Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice.
Radiology. 2007;245(2):523-31 - PMID: 17940307 - DOI: 10.1148/radiol.2452061613
Nahrendorf M, Hiller K, Theisen D, Hu K, Waller C, Kaiser R, Haase A, Ertl G, Brinkmann R, Bauer W
Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats.
Radiology. 2002;225(2):487-93 - PMID: 12409584 - DOI: 10.1148/radiol.2252011325
Goldberg M, Gazelle G, Boland G, Hahn P, Mayo-Smith W, Pivovarov M, Halpern E, Wittenberg J
Focal hepatic lesions: effect of three-dimensional wavelet compression on detection at CT.
Radiology. 1997;202:159-65 - PMID: 8988206 - DOI: 10.1148/radiology.202.1.8988206
Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U
Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy.
Radiology. 2008;248(3):925-35 - PMID: 18647846 - PMCID: PMC2798096 - DOI: 10.1148/radiol.2482071496
Korosoglou G, Shah S, Vonken EJ, Gilson WD, Schar M, Tang L, Kraitchman DL, Boston RC, Sosnovik DE, Weiss RG, Weissleder R, Stuber M
Off-Resonance Angiography: A New Method to Depict Vessels--Phantom and Rabbit Studies.
Radiology. 2008;249(2)::501-509 - PMID: 18780823 - PMCID: PMC2657865 - DOI: 10.1148/radiol.2491071706
Sosnovik DE
Will molecular MR imaging play a role in identification and treatment of patients with vulnerable atherosclerotic plaques?
Radiology. 2009;251:309-10 - PMID: 19401565 - DOI: 10.1148/radiol.2512090268
Sheth RA, Tam JM, Maricevich MA, Josephson L, Mahmood U
Quantitative Endovascular Fluorescence-based Molecular Imaging through Blood of Arterial Wall Inflammation.
Radiology. 2009;251(3):813-21 - PMID: 19474377 - PMCID: PMC2687531 - DOI: 10.1148/radiol.2513081450
Pandharipande PV, Gervais DA, Hartman RI, Harisinghani MG, Feldman AS, Mueller PR, Gazelle GS
Renal Mass Biopsy to Guide Treatment Decisions for Small Incidental Renal Tumors: A Cost-effectiveness Analysis.
Radiology. 2010;256(3):836-46 - PMID: 20720070 - PMCID: PMC2923731 - DOI: 10.1148/radiol.10092013
de Marco G, Bogdanov A, Marecos E, Moore A, Simonova M, Weissleder R
MR imaging of gene delivery to the central nervous system with an artificial vector.
Radiology. 1998;208(1):65-71 - PMID: 9646794 - DOI: 10.1148/radiology.208.1.9646794
Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A
MR imaging and scintigraphy of gene expression through melanin induction.
Radiology. 1997;204(2):425-9 - PMID: 9240530 - DOI: 10.1148/radiology.204.2.9240530
Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R
Paramagnetic metal scavenging by melanin: MR imaging.
Radiology. 1997;204(2):417-23 - PMID: 9240529 - DOI: 10.1148/radiology.204.2.9240529
Harisinghani MG, Saini S, Weissleder R, Halpern EF, Schima W, Rubin DL, Stillman AE, Sica GT, Small WC, Hahn PF
Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227.
Radiology. 1997;202(3):687-91 - PMID: 9051017 - DOI: 10.1148/radiology.202.3.9051017
Harika L, Weissleder R, Poss K, Papisov MI
Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies.
Radiology. 1996;198(2):365-70 - PMID: 8596833 - DOI: 10.1148/radiology.198.2.8596833
Gupta H, Wilkinson RA, Bogdanov AA, Callahan RJ, Weissleder R
Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer.
Radiology. 1995;197(3):665-9 - PMID: 7480736 - DOI: 10.1148/radiology.197.3.7480736
Zimmer C, Weissleder R, Poss K, Bogdanova A, Wright SC, Enochs WS
MR imaging of phagocytosis in experimental gliomas.
Radiology. 1995;197(2):533-8 - PMID: 7480707 - DOI: 10.1148/radiology.197.2.7480707
Zimmer C, Weissleder R, O'Connor D, LaPointe L, Brady TJ, Enochs WS
Cerebral iron oxide distribution: in vivo mapping with MR imaging.
Radiology. 1995;196(2):521-7 - PMID: 7617871 - DOI: 10.1148/radiology.196.2.7617871
Gupta H, Weissleder R, Bogdanov AA, Brady TJ
Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy.
Radiology. 1995;196(1):239-44 - PMID: 7784574 - DOI: 10.1148/radiology.196.1.7784574
Reimer P, Weissleder R, Shen T, Knoefel WT, Brady TJ
Pancreatic receptors: initial feasibility studies with a targeted contrast agent for MR imaging.
Radiology. 1994;193(2):527-31 - PMID: 7972773 - DOI: 10.1148/radiology.193.2.7972773
van Everdingen KJ, Enochs WS, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R
Determinants of in vivo MR imaging of slow axonal transport.
Radiology. 1994;193(2):485-91 - PMID: 7526413 - DOI: 10.1148/radiology.193.2.7526413
Weissleder R, Heautot JF, Schaffer BK, Nossiff N, Papisov MI, Bogdanov A, Brady TJ
MR lymphography: study of a high-efficiency lymphotrophic agent.
Radiology. 1994;191(1):225-30 - PMID: 8134576 - DOI: 10.1148/radiology.191.1.8134576
Bogdanov AA, Weissleder R, Frank HW, Bogdanova AV, Nossif N, Schaffer BK, Tsai E, Papisov MI, Brady TJ
A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies.
Radiology. 1993;187(3):701-6 - PMID: 8497616 - DOI: 10.1148/radiology.187.3.8497616
Reimer P, Weissleder R, Wittenberg J, Brady TJ
Receptor-directed contrast agents for MR imaging: preclinical evaluation with affinity assays.
Radiology. 1992;182(2):565-9 - PMID: 1732982 - DOI: 10.1148/radiology.182.2.1732982
Weissleder R, Lee AS, Khaw BA, Shen T, Brady TJ
Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging.
Radiology. 1992;182(2):381-5 - PMID: 1732953 - DOI: 10.1148/radiology.182.2.1732953
Weissleder R, Lee AS, Fischman AJ, Reimer P, Shen T, Wilkinson R, Callahan RJ, Brady TJ
Polyclonal human immunoglobulin G labeled with polymeric iron oxide: antibody MR imaging.
Radiology. 1991;181(1):245-9 - PMID: 1887040 - DOI: 10.1148/radiology.181.1.1887040
Reimer P, Weissleder R, Brady TJ, Yeager AE, Baldwin BH, Tennant BC, Wittenberg J
Experimental hepatocellular carcinoma: MR receptor imaging.
Radiology. 1991;180(3):641-5 - PMID: 1871273 - DOI: 10.1148/radiology.180.3.1871273
Seneterre E, Weissleder R, Jaramillo D, Reimer P, Lee AS, Brady TJ, Wittenberg J
Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging.
Radiology. 1991;179(2):529-33 - PMID: 2014305 - DOI: 10.1148/radiology.179.2.2014305
Reimer P, Weissleder R, Lee AS, Buettner S, Wittenberg J, Brady TJ
Asialoglycoprotein receptor function in benign liver disease: evaluation with MR imaging.
Radiology. 1991;178(3):769-74 - PMID: 1994416 - DOI: 10.1148/radiology.178.3.1994416
Reimer P, Weissleder R, Lee AS, Wittenberg J, Brady TJ
Receptor imaging: application to MR imaging of liver cancer.
Radiology. 1990;177(3):729-34 - PMID: 2243978 - DOI: 10.1148/radiology.177.3.2243978
Hahn PF, Stark DD, Lewis JM, Saini S, Elizondo G, Weissleder R, Fretz CJ, Ferrucci JT
First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging.
Radiology. 1990;175(3):695-700 - PMID: 2343116 - DOI: 10.1148/radiology.175.3.2343116
Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ
Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.
Radiology. 1990;175(2):494-8 - PMID: 2326475 - DOI: 10.1148/radiology.175.2.2326475
Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
Radiology. 1990;175(2):489-93 - PMID: 2326474 - DOI: 10.1148/radiology.175.2.2326474
Elizondo G, Weissleder R, Stark DD, Guerra J, Garza J, Fretz CJ, Todd LE, Ferrucci JT
Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide.
Radiology. 1990;174(3 Pt 1):797-801 - PMID: 2305063 - DOI: 10.1148/radiology.174.3.2305063
Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferrucci JT
Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors.
Radiology. 1990;174(2):361-6 - PMID: 2296646 - DOI: 10.1148/radiology.174.2.2296646
Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT
Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer.
Radiology. 1989;172(2):393-7 - PMID: 2748820 - DOI: 10.1148/radiology.172.2.2748820
Weissleder R, Elizondo G, Josephson L, Compton CC, Fretz CJ, Stark DD, Ferrucci JT
Experimental lymph node metastases: enhanced detection with MR lymphography.
Radiology. 1989;171(3):835-9 - PMID: 2717761 - DOI: 10.1148/radiology.171.3.2717761
Dousset M, Weissleder R, Hendrick RE, Stark DD, Fretz CJ, Elizondo G, Hahn PF, Saini S, Ferrucci JT
Short TI inversion-recovery imaging of the liver: pulse-sequence optimization and comparison with spin-echo imaging.
Radiology. 1989;171(2):327-33 - PMID: 2704797 - DOI: 10.1148/radiology.171.2.2704797
Rummeny E, Weissleder R, Sironi S, Stark DD, Comptom CC, Hahn PF, Saini S, Wittenberg J, Ferrucci JT
Central scars in primary liver tumors: MR features, specificity, and pathologic correlation.
Radiology. 1989;171(2):323-6 - PMID: 2539605 - DOI: 10.1148/radiology.171.2.2539605
Weissleder H, Weissleder R
Interstitial lymphangiography: initial clinical experience with a dimeric nonionic contrast agent.
Radiology. 1989;170(2):371-4 - PMID: 2911660 - DOI: 10.1148/radiology.170.2.2911660
Weissleder R, Hahn PF, Stark DD, Elizondo G, Saini S, Todd LE, Wittenberg J, Ferrucci JT
Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging.
Radiology. 1988;169(2):399-403 - PMID: 3174987 - DOI: 10.1148/radiology.169.2.3174987
Stark DD, Weissleder R, Elizondo G, Hahn PF, Saini S, Todd LE, Wittenberg J, Ferrucci JT
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.
Radiology. 1988;168(2):297-301 - PMID: 3393649 - DOI: 10.1148/radiology.168.2.3393649
Weissleder H, Weissleder R
Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients.
Radiology. 1988;167(3):729-35 - PMID: 3363131 - DOI: 10.1148/radiology.167.3.3363131
Tsang YM, Stark DD, Chen MC, Weissleder R, Wittenberg J, Ferrucci JT
Hepatic micrometastases in the rat: ferrite-enhanced MR imaging.
Radiology. 1988;167(1):21-4 - PMID: 3347724 - DOI: 10.1148/radiology.167.1.3347724
Weissleder R, Stark DD, Rummeny EJ, Compton CC, Ferrucci JT
Splenic lymphoma: ferrite-enhanced MR imaging in rats.
Radiology. 1988;166(2):423-30 - PMID: 3336717 - DOI: 10.1148/radiology.166.2.3336717
Elizondo G, Weissleder R, Stark DD, Todd LE, Compton C, Wittenberg J, Ferrucci JT
Amebic liver abscess: diagnosis and treatment evaluation with MR imaging.
Radiology. 1987;165(3):795-800 - PMID: 2891154 - DOI: 10.1148/radiology.165.3.2891154
Waller C, Kahler E, Hiller KH, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer WR
Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique.
Radiology. 2000;215(1):189-97 - PMID: 10751486 - DOI: 10.1148/radiology.215.1.r00ap07189
Nahrendorf M, Sosnovik DE
Science to practice: will magnetic guidance of microbubbles play a role in clinical molecular imaging?
Radiology. 2011;260(2):309-10 - PMID: 21778448 - DOI: 10.1148/radiol.11111017
Su HS, Nahrendorf M, Panizzi PR, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW
Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase.
Radiology. 2011;262(1):181-90 - PMID: 22084204 - PMCID: PMC3244672 - DOI: 10.1148/radiol.11110040
Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW
Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target.
Radiology. 2012;263(2):451-60 - PMID: 22438365 - PMCID: PMC3329272 - DOI: 10.1148/radiol.12111593
Sosnovik DE, Nahrendorf M, Caravan P
Science to Practice: How Will Myocardial Inflammation Be Imaged with MR Imaging?
Radiology. 2012;264(2):309-11 - PMID: 22821689 - PMCID: PMC6939999 - DOI: 10.1148/radiol.12121094
Pulli B, Bure L, Wojtkiewicz GR, Iwamoto Y, Ali M, Li D, Schob S, Li-Chun Hsieh K, Jacobs AH, Chen JW
Multiple Sclerosis: Myeloperoxidase Immunoradiology Improves Detection of Acute and Chronic Disease in Experimental Model.
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Myeloperoxidase Nuclear Imaging for Epileptogenesis.
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Spinal Cord Inflammation: Molecular Imaging after Thoracic Aortic Ischemia Reperfusion Injury.
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Pulli B, Wojtkiewicz G, Iwamoto Y, Ali M, Zeller MW, Bure L, Wang C, Choi Y, Masia R, Guimaraes AR, Corey KE, Chen JW
Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease.
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Hoffmann A, Pfeil J, Mueller AK, Jin J, Deumelandt K, Helluy X, Wang C, Heiland S, Platten M, Chen JW, Bendszus M, Breckwoldt MO
MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria.
Radiology. 2018;290(2):359-367 - PMID: 30615566 - DOI: 10.1148/radiol.2018181051
Li A, Wu Y, Pulli B, Wojtkiewicz GR, Iwamoto Y, Wang C, Li JH, Ali M, Feng X, Yao Z, Chen JW
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Radiology. 2019;293(1):158-165 - PMID: 31478802 - PMCID: PMC6776885 - DOI: 10.1148/radiol.2019182492
Ng TSC, Gunda V, Li R, Prytyskach M, Iwamoto Y, Kohler RH, Parangi S, Weissleder R, Miller MA
Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer
Radiology. 2020;298(1):123-132 - PMID: 33107799 - PMCID: PMC7771993 - DOI: 10.1148/radiol.2020201791
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Controversies in nephrology: Response to ''renal albumin handling, facts, and artifacts''
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Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
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Kidney Int. 2007;72:1411 - PMID: 18004315
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
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Kidney Int. 2007;72:1409-10 - PMID: 18004312
Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA
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Kidney Int. 2008;74(12):1557-67 - PMID: 18813286 - PMCID: PMC3730289 - DOI: 10.1038/ki.2008.412
Miller RL, Lucero OM, Riemondy KA, Baumgartner BK, Brown D, Breton S, Nelson RD
The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney.
Kidney Int. 2008;75(4):435-9 - PMID: 19052537 - PMCID: PMC4301582 - DOI: 10.1038/ki.2008.569
Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, Brown D, Russo LM
Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease.
Kidney Int. 2010;78(2):191-9 - PMID: 20428099 - PMCID: PMC4451567 - DOI: 10.1038/ki.2010.106
Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E
The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.
Kidney Int. 2010;78(4):382-8 - PMID: 20531453 - PMCID: PMC3684398 - DOI: 10.1038/ki.2010.166
Bouley R
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Kidney Int. 2012;82(1):7-8 - PMID: 22699378 - DOI: 10.1038/ki.2012.123
Huang J, McKee M, Huang HD, Xiang A, Davidson AJ, Lu HA
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David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, Zumbrennen-Bullough KB, Sun CC, Lin HY, Babitt JL, Wolf M
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Kidney Int. 2016;89(1):135-46 - PMID: 26535997 - PMCID: PMC4854810 - DOI: 10.1038/ki.2015.290
Sise ME, Wisocky J, Rosales IA, Chute D, Holmes JA, Corapi KM, Babitt JL, Tangren JS, Hashemi N, Lundquist AL, Williams WW, Mount DB, Andersson KL, Rennke HG, Smith RN, Colvin R, Thadhani RI, Chung RT
Lupus-like Immune Complex-mediated Glomerulonephritis in Patients with Hepatitis C Virus Infection Treated with Oral, Interferon-free, Direct-acting Antiviral Therapy.
Kidney Int. 2016;1(3):135-143 - PMID: 27990496 - PMCID: PMC5155703 - DOI: 10.1016/j.ekir.2016.06.006
Bourgeois S, Bounoure L, Mouro-Chanteloup I, Colin Y, Brown D, Wagner CA
The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells.
Kidney Int. 2017;93(2):390-402 - PMID: 29054531 - PMCID: PMC6166241 - DOI: 10.1016/j.kint.2017.07.027
Moore A, Bonner-Weir S, Weissleder R
Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes
Diabetes. 2001;50:2231-6 - PMID: 11574403 - DOI: 10.2337/diabetes.50.10.2231
Russo LM, del Re E, Brown D, Lin HY
Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor.
Diabetes. 2007;56(2):380-8 - PMID: 17259382 - DOI: 10.2337/db06-1018
Cameron-Vendrig A, Reheman A, Siraj MA, Xu XR, Wang Y, Lei X, Afroze T, Shikatani E, El-Mounayri O, Noyan H, Weissleder R, Ni H, Husain M
Glucagon-like peptide-1 receptor activation attenuates platelet aggregation and thrombosis.
Diabetes. 2016;65(6):1714-23 - PMID: 26936963 - DOI: 10.2337/db15-1141
Cruz DN, Perazella MA, Bellomo R, de Cal M, Polanco N, Corradi V, Lentini P, Nalesso F, Ueno T, Ranieri VM, Ronco C
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Crit Care. 2008;11(2):R47 - PMID: 17448226 - PMCID: PMC2206475 - DOI: 10.1186/cc5780
McCarthy J, Jaffer F, Weissleder R.
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications
Small. 2006;2(8-9):983-987 - PMID: 17193154 - DOI: 10.1002/smll.200600139
Sun EY, Weissleder R, Josephson L.
Continuous Analyte Sensing with Magnetic Nanoswitches
Small. 2006;(2) 10:1144-1147 - PMID: 17193579 - DOI: 10.1002/smll.200600204
McCarthy JR, Korngold E, Weissleder R, Jaffer FA
A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis.
Small. 2010;6(18):2041-9 - PMID: 20721949 - PMCID: PMC3018665 - DOI: 10.1002/smll.201000596
Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R
Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking.
Small. 2012;9(2):222-7 - PMID: 22996932 - PMCID: PMC3552149 - DOI: 10.1002/smll.201201007
Liu R, Rallo R, Weissleder R, Tassa C, Shaw S, Cohen Y
Nano-SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries.
Small. 2013;9(9-10):1842-52 - PMID: 23423856 - DOI: 10.1002/smll.201201903
Im H, Oh SH
Oxidation sharpening, template stripping, and passivation of ultra-sharp metallic pyramids and wedges.
Small. 2013;10(4):680-4 - PMID: 24123889 - DOI: 10.1002/smll.201301475
Koo H, Choi M, Kim E, Hahn SK, Weissleder R, Yun SH
Bioorthogonal Click Chemistry-Based Synthetic Cell Glue.
Small. 2015;11(48):6458-66 - PMID: 26768353 - PMCID: PMC5556392 - DOI: 10.1002/smll.201502972
Im H, Oh SH
Oxidation sharpening, template stripping, and passivation of ultra-sharp metallic pyramids and wedges.
Small. 2013;10(4):680-4 - PMID: 24123889 - DOI: 10.1002/smll.201301475
Hennings JC, Picard N, Huebner AK, Stauber T, Maier H, Brown D, Jentsch TJ, Vargas-Poussou R, Eladari D, Hübner CA
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
EMBO Mol Med. 2012;4(10):1057-71 - PMID: 22933323 - PMCID: PMC3491836 - DOI: 10.1002/emmm.201201527
Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F
The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction.
EMBO Mol Med. 2017;9(9):1279-1293 - PMID: 28774883 - PMCID: PMC5582413 - DOI: 10.15252/emmm.201707565
Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K
Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules.
Stem Cells. 2010;28(4):832-41 - PMID: 20127797 - PMCID: PMC3021283 - DOI: 10.1002/stem.313
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Stem Cells. 2015;33(1):265-277 - PMID: 25263183 - PMCID: PMC4270897 - DOI: 10.1002/stem.1848
Dykstra B, Lee J, Mortensen LJ, Yu H, Wu ZL, Lin CP, Rossi DJ, Sackstein R
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Stem Cells. 2016;34(10):2501-2511 - PMID: 27335219 - PMCID: PMC5064874 - DOI: 10.1002/stem.2435
Hewett J, Nery F, Niland B, Ge P, Tan P, Hadwiger P, Tannous B, Sah D, Breakefield X
siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells.
Hum Mol Genet. 2008;17:1436-45 - PMID: 18258738 - PMCID: PMC2861568 - DOI: 10.1093/hmg/ddn032
Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, Macdonald ME, Seong IS
Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
Hum Mol Genet. 2011;20(12):2344-55 - PMID: 21447599 - PMCID: PMC3098733 - DOI: 10.1093/hmg/ddr127
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Hum Mol Genet. 2015;24(21):6254-63 - PMID: 26310624 - PMCID: PMC4599680 - DOI: 10.1093/hmg/ddv348
Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I
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Pulli B, Ali M, Iwamoto Y, Zeller MW, Schob S, Linnoila JJ, Chen JW
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Lauriol J, Keith K, Jaffré F, Couvillon A, Saci A, Goonasekera SA, McCarthy JR, Kessinger CW, Wang J, Ke Q, Kang PM, Molkentin JD, Carpenter C, Kontaridis MI
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Sci Signal. 2014;7(348):ra100 - PMID: 25336613 - PMCID: PMC4300109 - DOI: 10.1126/scisignal.2005262
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Sci Signal. 2013;6(287):ra66 - PMID: 23921085 - PMCID: PMC3947921 - DOI: 10.1126/scisignal.2004155
McCarthy J, Kelly KA, Sun EY, Weissleder R.
Targeted delivery of multifunctional magnetic nanoparticles
Nanomedicine. 2007;2(2):153-167 - PMID: 17716118 - DOI: 10.2217/17435889.2.2.153
Martinez-Boubeta C, Balcells L, Cristool R, Sanfeliu C, Rodriguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martinez B
Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia.
Nanomedicine. 2009;6(2):362-370 - PMID: 19800988 - DOI: 10.1016/j.nano.2009.09.003
Ghazani A, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.
Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008
Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R
Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood.
Nanomedicine. 2016;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428 - DOI: 10.1016/j.nano.2016.12.006
Engelmayr G, Rabkin E, Sutherland F, Schoen F, Mayer J, Sacks M
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Ramaswamy S, Gottlieb D, Engelmayr GC, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer JE, Sacks MS
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Kraehenbuehl TP, Ferreira LS, Hayward AM, Nahrendorf M, van der Vlies AJ, Vasile E, Weissleder R, Langer R, Hubbell JA
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Biomaterials . 2010;32(4):1102-9 - PMID: 21035182 - PMCID: PMC6805145 - DOI: 10.1016/j.biomaterials.2010.10.005
Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG
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Wright ME, Yu JK, Jain D, Maeda A, Yeh SA, DaCosta RS, Lin CP, Santerre JP
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The Innate Immune System After Ischemic Injury: Lessons to Be Learned From the Heart and Brain.
JAMA Neurol. 2014;71(2):233-6 - PMID: 24296962 - PMCID: PMC3946050 - DOI: 10.1001/jamaneurol.2013.5026
Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.
eLife. 2014;3:e04631 - PMID: 25407682 - PMCID: PMC4270084 - DOI: 10.7554/eLife.04631
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eLife. 2016;5:ePub - PMID: 26895087 - PMCID: PMC4769157 - DOI: 10.7554/eLife.10051
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458 - DOI: 10.1002/art.20379
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214 - DOI: 10.1002/art.22303
Khazaie K, von Boehmer H
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Speiser D, Pittet M, Rimoldi D, Guillaume P, Luescher I, Lienard D, Lejeune F, Cerottini J, Romero P
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Semin Cancer Biol. 2003;13:461-72 - PMID: 15001165 - DOI: 10.1016/j.semcancer.2003.09.010
Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ
Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.
Mucosal Immunol. 2017;11(3):703-715 - PMID: 29139475 - PMCID: PMC5953762 - DOI: 10.1038/mi.2017.91
Shah K, Tang Y, Breakefield X, Weissleder R
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
Oncogene. 2003;22:6865-72 - PMID: 14534533 - DOI: 10.1038/sj.onc.1206748
van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Oncogene. 2010;29(22):3185-95 - PMID: 20305695 - PMCID: PMC3390229 - DOI: 10.1038/onc.2010.75
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Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.
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Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R
Single Extracellular Vesicle Protein Analysis Using Immuno- Droplet Digital Polymerase Chain Reaction Amplification
Adv Biosyst. 2020;:ePub - DOI: 10.1002/adbi.201900307
Van Deun J, Jo A, Li H, Lin HY, Weissleder R, Im H, Lee H
Integrated Dual-Mode Chromatography to Enrich Extracellular Vesicles from Plasma.
Adv Biosyst. 2020;4(12):e1900310 - PMID: 32351054 - PMCID: PMC7606548 - DOI: 10.1002/adbi.201900310
Min J, Son T, Hong JS, Cheah PS Wegemann A, Murlidharan K, Weissleder R, Lee H, Im H
Plasmon-Enhanced Biosensing for Multiplexed Profiling of Extracellular Vesicles
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Yang KS, Lin HY, Curley C, Welch MW, Wolpin BM, Lee H, Weissleder R, Im H*, Castro CM*
Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry.
Adv Biosyst. 2020;4(12):e2000203 - PMID: 33103361 - PMCID: PMC7718389 - DOI: 10.1002/adbi.202000203
Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R
Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification.
Adv Biosyst. 2020;4(12):e1900307 - PMID: 33274611 - PMCID: PMC8491538 - DOI: 10.1002/adbi.201900307
Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO.
Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo
Mol Ther. 2005;11(3):435-43 - PMID: 15727940 - DOI: 10.1016/j.ymthe.2004.10.016
Shah K, Tung CH, Breakefield X, Weissleder R.
In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
Mol Ther. 2005;11 (6):926-931 - PMID: 15922963 - DOI: 10.1016/j.ymthe.2005.01.017
Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging.
Mol Ther. 2006;4(6):779-88 - PMID: 16996314 - PMCID: PMC2819149 - DOI: 10.1016/j.ymthe.2006.08.008
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Mol Ther. 2010;18(6):1130-42 - PMID: 20179672 - PMCID: PMC2889737 - DOI: 10.1038/mt.2010.29
Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL
Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma.
Mol Ther. 2011;20(1):37-45 - PMID: 21915104 - PMCID: PMC3255598 - DOI: 10.1038/mt.2011.187
Noh KH, Kang TH, Kim JH, Pai SI, Lin KY, Hung CF, Wu TC, Kim TW
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Mol Ther. 2008;17(3):439-47 - PMID: 19107122 - PMCID: PMC2835083 - DOI: 10.1038/mt.2008.255
Wilk K, Yeh SA, Mortensen LJ, Ghaffarigarakani S, Lombardo CM, Bassir SH, Aldawood ZA, Lin CP, Intini G
Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration.
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Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024
Liu CL, Liu X, Wang Y, Deng Z, Liu T, Sukhova GK, Wojtkiewicz GR, Tang R, Zhang JY, Achilefu S, Nahrendorf M, Libby P, Wang X, Shi GP
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Hypertension. 2020;76(1):87-100 - PMID: 32475310 - PMCID: PMC7289683 - DOI: 10.1161/HYPERTENSIONAHA.119.14485
Basilion JP, Yeon S, Botnar R
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Curr Top Dev Biol. 2005;70(c):1-33 - PMID: 16338335 - DOI: 10.1016/S0070-2153(05)70001-6
Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ
WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud.
Curr Top Dev Biol. 2010;20(22):1993-2002 - PMID: 21055947 - PMCID: PMC2998074 - DOI: 10.1016/j.cub.2010.09.063
Mahmood U, Josephson L
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P IEEE. 0;93 (4):800-808
Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model.
J Neurosci. 2008;28:4406-13 - PMID: 18434519 - PMCID: PMC3021321 - DOI: 10.1523/JNEUROSCI.0296-08.2008
Samad T, Srinivasan A, Karchewski L, Jeong S, Campagna J, Ji R, Fabrizio D, Zhang Y, Lin HY, Bell E, Woolf C
DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.
J Neurosci. 2004;24(8):2027-36 - PMID: 14985445 - PMCID: PMC6730385 - DOI: 10.1523/JNEUROSCI.4115-03.2004
Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA
The BMP Coreceptor RGMb Promotes While the Endogenous BMP Antagonist Noggin Reduces Neurite Outgrowth and Peripheral Nerve Regeneration by Modulating BMP Signaling.
J Neurosci. 2011;31(50):18391-18400 - PMID: 22171041 - PMCID: PMC3243947 - DOI: 10.1523/JNEUROSCI.4550-11.2011
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Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System
ACS Photonics. 2017;5(2):487-494 - PMID: 29805987 - PMCID: PMC5966285 - DOI: 10.1021/acsphotonics.7b00992
Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X
New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium.
Clin Pharmacol Ther. 2022;112(3):540-561 - PMID: 35488474 - PMCID: PMC9398938 - DOI: 10.1002/cpt.2627
Lee H, Liu Y, Ham D, Westervelt RM
Integrated cell manipulation system--CMOS/microfluidic hybrid.
Lab Chip. 2007;7(3):331-7 - PMID: 17330164 - DOI: 10.1039/b700373k
Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H
Self-assembled magnetic filter for highly efficient immunomagnetic separation.
Lab Chip. 2010;11(1):147-51 - PMID: 20949198 - PMCID: PMC3005961 - DOI: 10.1039/c0lc00149j
Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee H
Miniature magnetic resonance system for point-of-care diagnostics.
Lab Chip. 2011;11(13):2282-7 - PMID: 21547317 - PMCID: PMC3115660 - DOI: 10.1039/c1lc20177h
Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY
On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics.
Lab Chip. 2012;12(17):3103-10 - PMID: 22760641 - PMCID: PMC3411869 - DOI: 10.1039/c2lc40337d
Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H
Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.
Lab Chip. 2013;14(1):14-23 - PMID: 23835814 - PMCID: PMC3844052 - DOI: 10.1039/c3lc50621e
Issadore D, Park YI, Shao H, Min C, Lee K, Liong M, Weissleder R*, Lee H*
Magnetic sensing technology for molecular analyses.
Lab Chip. 2014;14(14):2385-97 - PMID: 24887807 - PMCID: PMC4098149 - DOI: 10.1039/c4lc00314d
Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H
Digital diffraction detection of protein markers for avian influenza.
Lab Chip. 2016;16(8):1340-5 - PMID: 26980325 - PMCID: PMC4829473 - DOI: 10.1039/c5lc01558h
Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH
Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array.
Lab Chip. 2015;15(4):1153-9 - PMID: 25553996 - DOI: 10.1039/c4lc01162g
Lindquist NC, Lesuffleur A, Im H, Oh SH
Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation.
Lab Chip. 2008;9(3):382-7 - PMID: 19156286 - DOI: 10.1039/b816735d
Im H, Lee K, Weissleder R, Lee H, Castro CM
Novel nanosensing technologies for exosome detection and profiling.
Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e
Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H
Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.
Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h
Szafraniec HM, Valdez JM, Iffrig E, Lam WA, Higgins JM, Pearce P, Wood DK
Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.
Lab Chip. 2022;22(8):1565-1575 - PMID: 35315465 - PMCID: PMC9004467 - DOI: 10.1039/d1lc01133b
Lucas K, Oh J, Hoelzl J, Weissleder R
Cellular point-of-care diagnostics using an inexpensive layer-stack microfluidic device.
Lab Chip. 2022;22:2145 - 2154 - PMID: 35514273 - PMCID: PMC9214713 - DOI: 10.1039/d2lc00162d
Iyer V, Yang Z, Ko J, Weissleder R, Issadore D
Advancing microfluidic diagnostic chips into clinical use: a review of current challenges and opportunities.
Lab Chip. 2022;22(17):3110-3121 - PMID: 35674283 - DOI: 10.1039/d2lc00024e
Gonçalves I, den Ruijter H, Nahrendorf M, Pasterkamp G
Detecting the vulnerable plaque in patients.
J Intern Med. 2015;278(5):520-30 - PMID: 26306911 - DOI: 10.1111/joim.12414
Shaw SY, Cheng S, Cupples LA, Larson MG, McCabe EL, Ngwa JS, Wang YA, Martin RP, Klein RJ, Hashmi B, Ajijola OA, Lau E, O'Donnell CJ, Vasan RS, Cohen KS, Wang TJ
Genetic and Clinical Correlates of Early Outgrowth Colony Forming Units.
Circ Cardiovasc Genet. 2011;4(3):296-304 - PMID: 21493818 - PMCID: PMC3339257 - DOI: 10.1161/CIRCGENETICS.110.958470
Hall JL, Ryan JJ, Bray BE, Brown C, Lanfear D, Newby LK, Relling MV, Risch NJ, Roden DM, Shaw SY, Tcheng JE, Tenenbaum J, Wang TN, Weintraub WS
Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association.
Circ Cardiovasc Genet. 2016;9(2):193-202 - PMID: 26976545 - PMCID: PMC5646218 - DOI: 10.1161/HCG.0000000000000029
He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK
Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.
Circ Heart Fail. 2015;8(5):980-7 - PMID: 26232205 - PMCID: PMC4568849 - DOI: 10.1161/CIRCHEARTFAILURE.115.002334
Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.
Circ Heart Fail. 2016;9(1):e002724 - PMID: 26721917 - PMCID: PMC4698901 - DOI: 10.1161/CIRCHEARTFAILURE.115.002724
Ananthakrishnan AN, Cheng SC, Cai T, Cagan A, Gainer VS, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP
Association Between Reduced Plasma 25-hydroxy Vitamin D and Increased Risk of Cancer in Patients with Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2013;12(5):821-7 - PMID: 24161349 - PMCID: PMC3995841 - DOI: 10.1016/j.cgh.2013.10.011
Ananthakrishnan AN, Cheng SC, Cai T, Cagan A, Gainer VS, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP
Serum Inflammatory Markers and Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2014;12(8):1342-1348.e1 - PMID: 24407106 - PMCID: PMC4085150 - DOI: 10.1016/j.cgh.2013.12.030
Ananthakrishnan AN, Cagan A, Gainer VS, Cheng SC, Cai T, Scoville E, Konijeti GG, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP
Thromboprophylaxis is associated with reduced post-hospitalization venous thromboembolic events in patients with inflammatory bowel diseases.
Clin Gastroenterol Hepatol. 2014;12(11):1905-1910 - PMID: 24632349 - PMCID: PMC4162859 - DOI: 10.1016/j.cgh.2014.02.034
Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP
Colonoscopy is Associated with a Reduced Risk for Colon Cancer and Mortality in Patients with Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2014;13(2):322-329.e1 - PMID: 25041865 - PMCID: PMC4297589 - DOI: 10.1016/j.cgh.2014.07.018
Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Liao KP, Kohane I
Statin use is Associated With Reduced Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2016;14(7):973-9 - PMID: 26905907 - PMCID: PMC4912917 - DOI: 10.1016/j.cgh.2016.02.017
Sanford NN, Mahal BA, Royce TJ, Pike LRG, Hwang WL
Sex Disparity and Copy Number Alterations in Esophageal Squamous Cell Carcinoma.
Clin Gastroenterol Hepatol. 2018;17(6):1207-1209 - PMID: 30120994 - DOI: 10.1016/j.cgh.2018.08.026
Jalali Motlagh N, Wang C, Kuellenberg EG, Wojtkiewicz GR, Schmidt S, Chen JW
D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity.
Cancers (Basel). 2021;13(24):ePub - PMID: 34944979 - PMCID: PMC8699108 - DOI: 10.3390/cancers13246360
Jaffer FA, Tung CH, Gerszten RE, Weissleder R
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
Arterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227 - DOI: 10.1161/01.atv.0000033089.56970.2d
Simoncini T, Rabkin E, Liao J
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Arterioscler Thromb Vasc Biol. 2003;23:198-203 - PMID: 12588759 - DOI: 10.1161/01.atv.0000053846.71621.93
Jaffer FA, Libby P, Weissleder R
Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2009;29(7):1017-24 - PMID: 19359659 - PMCID: PMC2733228 - DOI: 10.1161/ATVBAHA.108.165530
Swirski FK, Weissleder R, Pittet MJ
Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2009;29(10):1424-32 - PMID: 19372462 - PMCID: PMC2746262 - DOI: 10.1161/ATVBAHA.108.180521
Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R
Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors.
Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086
Deguchi JO, Yamazaki H, Aikawa E, Aikawa M
Chronic Hypoxia Activates the Akt and {beta}-Catenin Pathways in Human Macrophages.
Arterioscler Thromb Vasc Biol. 2009;29(10):1664-70 - PMID: 19644051 - DOI: 10.1161/ATVBAHA.109.194043
Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA
Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis. Novel Detection by Dual-Target Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475 - DOI: 10.1161/ATVBAHA.110.206342
Nahrendorf M, Keliher E, Marinelli B, Leuschner F, Robins CS, Gerszten RE, Pittet MJ, Swirski FK, Weissleder R
Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography.
Arterioscler Thromb Vasc Biol. 2011;31(4):750-7 - PMID: 21252070 - PMCID: PMC3060293 - DOI: 10.1161/ATVBAHA.110.221499
Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622 - DOI: 10.1161/ATVBAHA.112.251983
Calcagno C, Mulder WJ, Nahrendorf M, Fayad ZA
Systems Biology and Noninvasive Imaging of Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2016;36(2):e1-8 - PMID: 26819466 - PMCID: PMC4861402 - DOI: 10.1161/ATVBAHA.115.306350
Babaev VR, Ding L, Zhang Y, May JM, Lin CP, Fazio S, Linton MF
Macrophage IκB Kinase α Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2016;36(4):598-607 - PMID: 26848161 - PMCID: PMC4808396 - DOI: 10.1161/ATVBAHA.115.306931
Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M
E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.
Arterioscler Thromb Vasc Biol. 2016;36(9):1802-8 - PMID: 27470513 - PMCID: PMC5001901 - DOI: 10.1161/ATVBAHA.116.307519
Vergallo R, Uemura S, Soeda T, Minami Y, Cho JM, Ong DS, Aguirre AD, Gao L, Biasucci LM, Crea F, Yu B, Lee H, Kim CJ, Jang IK
Prevalence and Predictors of Multiple Coronary Plaque Ruptures: In Vivo 3-Vessel Optical Coherence Tomography Imaging Study.
Arterioscler Thromb Vasc Biol. 2016;36(11):2229-2238 - PMID: 27634834 - DOI: 10.1161/ATVBAHA.116.307891
Libby P, King K
Biomarkers: A Challenging Conundrum in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2015;35(12):2491-5 - PMID: 26543097 - DOI: 10.1161/ATVBAHA.115.305233
Fenn AM, Swirski FK
Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them.
Arterioscler Thromb Vasc Biol. 2017;37(2):173-175 - PMID: 28122772 - DOI: 10.1161/ATVBAHA.116.308768
Kumar V, Donahue DM, Patel N
An unexpected complication during cardiac catheterization: blood clot cast of the tracheobronchial tree: first case during cardiac catheterization.
JACC Cardiovasc Interv. 2013;6(4):e19 - PMID: 23597616 - DOI: 10.1016/j.jcin.2012.11.007
Zeng X, Zou L, Levine RA, Guerrero JL, Handschumacher MD, Sullivan SM, Braithwaite GJ, Stone JR, Solis J, Muratoglu OK, Vlahakes GJ, Hung J
Efficacy of Polymer Injection for Ischemic Mitral Regurgitation: Persistent Reduction of Mitral Regurgitation and Attenuation of Left Ventricular Remodeling.
JACC Cardiovasc Interv. 2015;8(2):355-63 - PMID: 25596792 - PMCID: PMC5645299 - DOI: 10.1016/j.jcin.2014.09.016
Querol M, Chen JW, Weissleder R, Bogdanov A Jr.
DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging
Org Lett. 2005;7(9):1719-22 - PMID: 15844889 - DOI: 10.1021/ol050208v
Bouffard J, Kim Y, Swager TM, Weissleder R, Hilderbrand SA
A Highly Selective Fluorescent Probe for Thiol Bioimaging.
Org Lett. 2007;10 :37-40 - PMID: 18062694 - DOI: 10.1021/ol702539v
McCarthy JR, Jenkins HA, Bruckner C
Free base meso-tetraaryl-morpholinochlorins and porpholactone from meso-tetraaryl-2,3-dihydroxy-chlorin.
Org Lett. 2003;5(1):19-22
Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R
A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent in vivo Antimalaria Activity.
Org Lett. 2010;12(18):3998-4001 - PMID: 20718474 - PMCID: PMC7479540 - DOI: 10.1021/ol101566h
Castro CM, Im H, Le C, Lee H, Weissleder R, Birrer MJ
Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies.
Cancer Metastasis Rev. 2015;34(1):75-82 - PMID: 25543192 - PMCID: PMC5474936 - DOI: 10.1007/s10555-014-9546-9
Tong T, Yang Z, Chen JW, Zhu J, Yao Z
Dynamic 1H-MRS assessment of brain tumors: A novel approach for differential diagnosis of glioma.
Oncotarget. 2015;6(31):32257-32265 - PMID: 26337080 - PMCID: PMC4741675 - DOI: 10.18632/oncotarget.4899
Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M
The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.
Oncotarget. 2016;7(29):46142-46157 - PMID: 27323815 - PMCID: PMC5216787 - DOI: 10.18632/oncotarget.10063
Huang P, Almeciga-Pinto I, Jarpe M, van Duzer JH, Mazitschek R, Yang M, Jones SS, Quayle SN
Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models.
Oncotarget. 2017;8(2):2694-2707 - PMID: 27926524 - PMCID: PMC5356834 - DOI: 10.18632/oncotarget.13738
Hideshima T, Mazitschek R, Qi J, Mimura N, Tseng JC, Kung AL, Bradner JE, Anderson KC
HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.
Oncotarget. 2017;8(46):80109-80123 - PMID: 29113288 - PMCID: PMC5655183 - DOI: 10.18632/oncotarget.19019
Hideshima T, Mazitschek R, Qi J, Mimura N, Tseng JC, Kung AL, Bradner JE, Anderson KC
HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.
Oncotarget. 2017;8(46):80109-80123 - PMID: 29113288 - PMCID: PMC5655183 - DOI: 10.18632/oncotarget.19019
Seldon CS, Meiyappan K, Hoffman H, Guo JA, Goel N, Hwang WL, Nguyen PL, Mahal BA, Alshalalfa M
Genomic alterations predictive of poor clinical outcomes in pan-cancer.
Oncotarget. 2022;13:1069-1077 - PMID: 36187555 - PMCID: PMC9518688 - DOI: 10.18632/oncotarget.28276
Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J
FOXO protects against age-progressive axonal degeneration.
Aging Cell. 2017;17(1):ePub - PMID: 29178390 - PMCID: PMC5771393 - DOI: 10.1111/acel.12701
Lan YY, Heather JM, Eisenhaure T, Garris CS, Lieb D, Raychowdhury R, Hacohen N
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation.
Aging Cell. 2019;18(2):e12901 - PMID: 30706626 - PMCID: PMC6413746 - DOI: 10.1111/acel.12901
Hilderbrand S, Weissleder R.
Optimized pH-responsive cyanine fluorochromes for detection of acidic environments
Chem Commun. 2007;(26):2747-9 - PMID: 17594041 - DOI: 10.1039/b703764c
Kim YM, Hilderbrand S, Weissleder R, Tung CH
Sugar sensing based on induced pH changes
Chem Commun. 2007;(22):2299-2301 - PMID: 17534523 - DOI: 10.1039/b700741h
McCarthy JR, Hyland MA, Bruckner C
Indaphyrin, a meso-tetraphenylsecochlorin-derived chromophore incorporating o-phenyl-to-β-linkages
Chem Commun. 2003;:1738-9
Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L
Simplified syntheses of complex multifunctional nanomaterials.
Chem Commun. 2008;39:4792-4 - PMID: 18830495 - PMCID: PMC2692914 - DOI: 10.1039/b809537j
Hilderbrand SA, Shao F, Salthouse C, Mahmood U, Weissleder R
Upconverting luminescent nanomaterials: application to in vivo bioimaging.
Chem Commun. 2009;28:4188-90 - PMID: 19585016 - PMCID: PMC2748243 - DOI: 10.1039/b905927j
Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L
A DNA-binding Gd chelate for the detection of cell death by MRI.
Chem Commun. 2009;(29):4444-6 - PMID: 19597620 - PMCID: PMC2754278 - DOI: 10.1039/b907375b
Agasti SS, Laughney AM, Kohler RH, Weissleder R
A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport
Chem Commun. 2013;49(94):11050-2 - PMID: 24135896 - PMCID: PMC3856557 - DOI: 10.1039/c3cc46089d
Kim E, Yang KS, Giedt RJ, Weissleder R
Red Si-rhodamine drug conjugates enable imaging in GFP cells.
Chem Commun. 2014;50(34):4504-7 - PMID: 24663433 - PMCID: PMC4028821 - DOI: 10.1039/c4cc00144c
Meimetis LG, Giedt R, Mikyla H, Carlson J, Kohler R, Pirovich DB, Weissleder R
Fluorescent vinblastine probes for live cell imaging
Chem Commun. 2016;52(64):9953-6 - PMID: 27439765 - PMCID: PMC4970878 - DOI: 10.1039/c6cc04129a
Hong S, Park KS, Weissleder R, Castro CM, Lee H
Facile silicification of plastic surface for bioassays.
Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k
Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b
Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia D
Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.
Crit Care Med. 2016;44(5):e241-52 - PMID: 26509319 - PMCID: PMC4833510 - DOI: 10.1097/CCM.0000000000001397
McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2008;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831 - DOI: 10.1016/j.neuroimage.2008.12.022
Hyde D, de Kleine R, MacLaurin S, Miller E, Brooks D, Krucker T, Ntziachristos V
Hybrid FMT-CT imaging of amyloid-beta plaques in a murine Alzheimer's disease model.
Neuroimage. 2009;44(4):1304-11 - PMID: 19041402 - DOI: 10.1016/j.neuroimage.2008.10.038
Shiau C, Su J, Guo JA, Hong TS, Wo JY, Jagadeesh KA, Hwang WL
Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution.
Front Oncol. 2022;12:929950 - PMID: 36185212 - PMCID: PMC9524152 - DOI: 10.3389/fonc.2022.929950
Yuan H, Luo J, Weissleder R, Cantley L, Josephson L
Wortmannin-C20 Conjugates Generate Wortmannin.
J Med Chem. 2006;49(2):740-747 - PMID: 16420059 - DOI: 10.1021/jm050699p
Galande A, Hilderbrand S, Weissleder R, Tung CH.
Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core
J Med Chem. 2006;49(15):4715-20 - PMID: 16854078 - DOI: 10.1021/jm051001a
Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L.
Multivalent effects of RGD peptides obtained by nanoparticle display
J Med Chem. 2006;49(20):6087-6093
Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L
Slow Self-Activation Enhances The Potency of Viridin Prodrugs.
J Med Chem. 2008;51(15):4699-707 - PMID: 18630894 - PMCID: PMC2663427 - DOI: 10.1021/jm800374f
Estiu G, Greenberg E, Harrison C, Kwiatkowski N, Mazitschek R, Bradner J, Wiest O
Structural origin of selectivity in class II-selective histone deacetylase inhibitors.
J Med Chem. 2008;51:2898-906 - PMID: 18412327 - DOI: 10.1021/jm7015254
Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J
Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from Plasmodium falciparum.
J Med Chem. 2009;52(8):2185-7 - PMID: 19317450 - PMCID: PMC2669731 - DOI: 10.1021/jm801654y
Hendricks JA, Keliher EJ, Marinelli B, Reiner T, Weissleder R, Mazitschek R
In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA).
J Med Chem. 2011;54(15):5576-82 - PMID: 21721525 - PMCID: PMC3150598 - DOI: 10.1021/jm200620f
Kissau L, Stahl P, Mazitschek R, Giannis A, Waldmann H
Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold.
J Med Chem. 2003;46(14):2917-31 - PMID: 12825933 - DOI: 10.1021/jm0307943
Wang C, Cheng D, Jalali Motlagh N, Kuellenberg EG, Wojtkiewicz GR, Schmidt SP, Stocker R, Chen JW
Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity.
J Med Chem. 2021;64(9):5874-5885 - PMID: 33945286 - PMCID: PMC8564765 - DOI: 10.1021/acs.jmedchem.1c00038
Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U.
A novel mouse model for segmental orthotopic colon cancer
Int J Cancer. 2005;117(3):335-9 - PMID: 15900588 - DOI: 10.1002/ijc.21185
Figueiredo JL, Alencar H, Weissleder R, Mahmood U
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
Int J Cancer. 2006;118(11):2672-7 - PMID: 16380983 - DOI: 10.1002/ijc.21713
Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072 - DOI: 10.1002/ijc.22995
Kirkin V, Thiele W, Baumann P, Mazitschek R, Rohde K, Fellbrich G, Weich H, Waltenberger J, Giannis A, Sleeman JP
MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo.
Int J Cancer. 2004;112(6):986-93 - PMID: 15386354 - DOI: 10.1002/ijc.20509
Brotherton JM, Jit M, Gravitt PE, Brisson M, Kreimer AR, Pai SI, Fakhry C, Monsonego J, Franceschi S
Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines.
Int J Cancer. 2016;139(3):510-7 - PMID: 26916230 - PMCID: PMC7388730 - DOI: 10.1002/ijc.30063
Lacy-Hulbert A*, Ueno T*, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H, Sayegh MH, Hynes RO, Abdi R
Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.
Am J Transplant. 2007;7(5):1080-90 - PMID: 17359504 - DOI: 10.1111/j.1600-6143.2007.01757.x
Yamaura K, Boenisch O, Watanabe T, Ueno T, Vanguri V, Yang J, Tanaka K, Guleria I, Borst J, Zhai Y, Kupiec-Weglinski JW, Najafian N
Differential Requirement of CD27 Costimulatory Signaling for Naive Versus Alloantigen-Primed Effector/Memory CD8(+) T Cells.
Am J Transplant. 2010;10(5):1210-20 - PMID: 20353477 - PMCID: PMC2889922 - DOI: 10.1111/j.1600-6143.2010.03089.x
Jurewicz M, Ueno T, Azzi J, Tanaka K, Murayama T, Yang S, Sayegh MH, Niimi M, Abdi R
Donor Antioxidant Strategy Prolongs Cardiac Allograft Survival by Attenuating Tissue Dendritic Cell Immunogenicity.
Am J Transplant. 2010;11(2):348-355 - PMID: 21182586 - DOI: 10.1111/j.1600-6143.2010.03360.x
Starling RC, Stehlik J, Baran DA, Armstrong B, Stone JR, Ikle D, Morrison Y, Bridges ND, Putheti P, Strom TB, Bhasin M, Guleria I, Chandraker A, Sayegh M, Daly KP, Briscoe DM, Heeger PS,
Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study.
Am J Transplant. 2015;16(1):121-36 - PMID: 26260101 - PMCID: PMC4948061 - DOI: 10.1111/ajt.13422
Zhang Y, Dong H, Seeburg DP, Wojtkiewicz GR, Waterman P, Pulli B, Forghani R, Ali M, Iwamoto Y, Swirski FK, Chen JW
Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation.
Mol Neurobiol. 2018;56(2):954-962 - PMID: 29808380 - PMCID: PMC6261713 - DOI: 10.1007/s12035-018-1137-2
Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH
Consensus statement on the pathology of IgG4-related disease.
Mod Pathol. 2012;25(9):1181-92 - PMID: 22596100 - DOI: 10.1038/modpathol.2012.72
Siddiquee Z, Smith RN, Stone JR
An elevated IgG4 response in chronic infectious aortitis is associated with aortic atherosclerosis.
Mod Pathol. 2015;28(11):1428-34 - PMID: 26336884 - DOI: 10.1038/modpathol.2015.105
Hara T, Bhayana B, Thompson B, Kessinger CW, Khatri A, McCarthy JR, Weissleder R, Lin CP, Tearney GJ, Jaffer FA
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017
Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M
Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway.
JACC Cardiovasc Imaging. 2012;5(11):1127-38 - PMID: 23153913 - PMCID: PMC3502014 - DOI: 10.1016/j.jcmg.2012.01.025
Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A
Splenic Metabolic Activity Predicts Risk of Future Cardiovascular Events: Demonstration of a Cardiosplenic Axis in Humans.
JACC Cardiovasc Imaging. 2015;8(2):121-30 - PMID: 25577441 - PMCID: PMC6855915 - DOI: 10.1016/j.jcmg.2014.10.009
Nahrendorf M, Swirski FK
PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction.
JACC Cardiovasc Imaging. 2015;8(12):1427-9 - PMID: 26699111 - DOI: 10.1016/j.jcmg.2015.10.004
Nahrendorf M, Vandoorne K
Albumin-Binding MR Probe Detects High-Risk Coronary Plaques in Patients.
JACC Cardiovasc Imaging. 2018;12(2):307-309 - PMID: 29361477 - DOI: 10.1016/j.jcmg.2017.11.026
Nahrendorf M
Multiorgan Imaging of Comorbidity and Cardiovascular Risk.
JACC Cardiovasc Imaging. 2018;13(2 Pt 1):478-480 - PMID: 30448129 - DOI: 10.1016/j.jcmg.2018.09.017
Zaharchuk G, Mandeville JB, Bogdanov AA Jr, Weissleder R, Rosen BR, Marota JJ
Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension
Stroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929 - DOI: 10.1161/01.str.30.10.2197
Kim DE, Kim JY, Nahrendorf M, Lee SK, Ryu JH, Kim K, Kwon IC, Schellingerhout D
Direct Thrombus Imaging as a Means to Control the Variability of Mouse Embolic Infarct Models: The Role of Optical Molecular Imaging.
Stroke. 2011;42(12):3566-73 - PMID: 22020025 - DOI: 10.1161/STROKEAHA.111.629428
Kim DE, Kim JY, Schellingerhout D, Ryu JH, Lee SK, Jeon S, Lee JS, Kim J, Jang HJ, Park JE, Kim EJ, Kwon IC, Ahn CH, Nahrendorf M, Kim K
Quantitative Imaging of Cerebral Thromboemboli In Vivo: The Effects of Tissue-Type Plasminogen Activator.
Stroke. 2017;48(5):1376-1385 - PMID: 28432262 - DOI: 10.1161/STROKEAHA.117.016511
Law B, Curino A, Bugge TH, Weissleder R, Tung CH
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter.
Chem Biol. 2004;11(1):99-106 - PMID: 15112999 - DOI: 10.1016/j.chembiol.2003.12.017
Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L
Covalent Reactions of Wortmannin under Physiological Conditions.
Chem Biol. 2007;14(3):321-8 - PMID: 17379147 - DOI: 10.1016/j.chembiol.2007.02.007
Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.
Chem Biol. 2007;14:1221-31 - PMID: 18022561 - PMCID: PMC2785040 - DOI: 10.1016/j.chembiol.2007.10.005
Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R
Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc(1) Inhibitors.
Chem Biol. 2011;18(12):1602-10 - PMID: 22195562 - PMCID: PMC3474356 - DOI: 10.1016/j.chembiol.2011.09.016
Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN
A robust small-molecule microarray platform for screening cell lysates.
Chem Biol. 2006;13(5):493-504 - PMID: 16720270 - DOI: 10.1016/j.chembiol.2006.03.004
Kozloff KM, Weissleder R, Mahmood U
Non-Invasive Optical Detection of Bone Mineral.
J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196 - DOI: 10.1359/jbmr.070504
Turan S, Fernandez-Rebollo E, Aydin C, Zoto T, Reyes M, Bounoutas G, Chen M, Weinstein LS, Erben RG, Marshansky V, Bastepe M
Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone-resistance due to heterozygous Gαs disruption.
J Bone Miner Res. 2014;29(3):749-60 - PMID: 23956044 - PMCID: PMC3926912 - DOI: 10.1002/jbmr.2070
Tokarz D, Martins JS, Petit ET, Lin CP, Demay MB, Liu ES
Hormonal regulation of osteocyte perilacunar and canalicular remodeling in the Hyp mouse model of XLH.
J Bone Miner Res. 2017;33(3):499-509 - PMID: 29083055 - PMCID: PMC6005377 - DOI: 10.1002/jbmr.3327
Quillard T, Croce K, Jaffer FA, Weissleder R, Libby P
Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo.
Thromb Haemostasis. 2011;105(5):828-36 - PMID: 21225096 - PMCID: PMC3087830 - DOI: 10.1160/TH10-09-0589
Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R.
Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent Protein
Anal Chem. 2005;77:2862-2867 - PMID: 15859603 - DOI: 10.1021/ac0480747
Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L
Multiparameter Magnetic Relaxation Switch Assays.
Anal Chem. 2007;(79) 23:8863-9 - PMID: 17983206 - DOI: 10.1021/ac701976p
Koh I, Hong R, Weissleder R, Josephson L
Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions.
Anal Chem. 2009;81(9):3618-22 - PMID: 19323458 - PMCID: PMC2690647 - DOI: 10.1021/ac802717c
Niers JM, Chen JW, Weissleder R, Tannous BA
Enhanced in Vivo Imaging of Metabolically Biotinylated Cell Surface Reporters.
Anal Chem. 2011;83(3):994-9 - PMID: 21214190 - PMCID: PMC3059349 - DOI: 10.1021/ac102758m
Roussakis E, Spencer JA, Lin CP, Vinogradov SA
Two-Photon Antenna-Core Oxygen Probe with Enhanced Performance.
Anal Chem. 2014;86(12):5937-45 - PMID: 24848643 - PMCID: PMC4066907 - DOI: 10.1021/ac501028m
Wittenberg NJ, Im H, Xu X, Wootla B, Watzlawik J, Warrington AE, Rodriguez M, Oh SH
High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.
Anal Chem. 2012;84(14):6031-9 - PMID: 22762372 - PMCID: PMC3417152 - DOI: 10.1021/ac300819a
Im H, Sutherland JN, Maynard JA, Oh SH
Nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics.
Anal Chem. 2012;84(4):1941-7 - PMID: 22235895 - PMCID: PMC3307221 - DOI: 10.1021/ac300070t
Im H, Lesuffleur A, Lindquist NC, Oh SH
Plasmonic nanoholes in a multichannel microarray format for parallel kinetic assays and differential sensing.
Anal Chem. 2009;81(8):2854-9 - PMID: 19284776 - PMCID: PMC2720634 - DOI: 10.1021/ac802276x
Ng EX, Sun G, Wei SC, Miller MA, Dasgupta R, Lam PYP, Chen CH
Ultrafast Single-Cell Level Enzymatic Tumor Profiling.
Anal Chem. 2018;91(2):1277-1285 - PMID: 30362713 - DOI: 10.1021/acs.analchem.8b02576
Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R
Advances in measuring single-cell pharmacokinetics and pharmacology in vivo.
Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011
Nordbeck P, Bauer WR, Fidler F, Warmuth M, Hiller KH, Nahrendorf M, Maxfield M, Wurtz S, Geistert W, Broscheit J, Jakob PM, Ritter O
Feasibility of Real-Time MRI With a Novel Carbon Catheter for Interventional Electrophysiology
Circ Arrhythmia Electrophysiol. 2009;2(3):258-267 - PMID: 19808476 - DOI: 10.1161/CIRCEP.108.778357
Cook L, Sengelmann M, Winkler B, Nagl C, Koch S, Schlomann U, Slater EP, Miller MA, von Strandmann EP, Dorsam B, Preuber C, Bartsch JW
ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9.
Int J Mol Sci. 2022;23(4):ePub - PMID: 35216088 - PMCID: PMC8875419 - DOI: 10.3390/ijms23041976
Sosnovik DE, Nahrendorf M, Weissleder R
Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.
Basic Res Cardiol. 2008;103(2):122-30 - PMID: 18324368 - PMCID: PMC2597271 - DOI: 10.1007/s00395-008-0710-7
Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von Zur Mühlen C, Bode C, Zirlik A, Hilgendorf I
Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.
Basic Res Cardiol. 2016;111(2):20 - PMID: 26891724 - PMCID: PMC4759214 - DOI: 10.1007/s00395-016-0535-8
Härdtner C, Kornemann J, Krebs K, Ehlert CA, Jander A, Zou J, Starz C, Rauterberg S, Sharipova D, Dufner B, Hoppe N, Dederichs TS, Willecke F, Stachon P, Heidt T, Wolf D, von Zur Mühlen C, Madl J, Kohl P, Kaeser R, Boettler T, Pieterman EJ, Princen HMG, Ho-Tin-Noé B, Swirski FK, Robbins CS, Bode C, Zirlik A, Hilgendorf I
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering.
Basic Res Cardiol. 2020;115(6):78 - PMID: 33296022 - PMCID: PMC7725697 - DOI: 10.1007/s00395-020-00838-4
Truslow JG, Goto S, Homilius M, Mow C, Higgins JM, MacRae CA, Deo RC
Cardiovascular Risk Assessment Using Artificial Intelligence-Enabled Event Adjudication and Hematologic Predictors.
Circ Cardiovasc Qual Outcomes. 2022;15(6):e008007 - PMID: 35477255 - PMCID: PMC9208816 - DOI: 10.1161/CIRCOUTCOMES.121.008007
Groen A, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison T
A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.
J Cell Sci. 2008;121(Pt 14):2293-300 - PMID: 18559893 - PMCID: PMC2902979 - DOI: 10.1242/jcs.024018
Zilberman Y, Ballestrem C, Carramusa L, Mazitschek R, Khochbin S, Bershadsky A
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.
J Cell Sci. 2009;122(Pt 19):3531-41 - PMID: 19737819 - DOI: 10.1242/jcs.046813
Tran AD, Marmo TP, Salam AA, Che S, Finkelstein E, Kabarriti R, Xenias HS, Mazitschek R, Hubbert C, Kawaguchi Y, Sheetz MP, Yao TP, Bulinski JC
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions.
J Cell Sci. 2007;120(Pt 8):1469-79 - PMID: 17389687 - DOI: 10.1242/jcs.03431
Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
J Cell Sci. 2014;127(Pt 20):4396-408 - PMID: 25107366 - PMCID: PMC4197086 - DOI: 10.1242/jcs.148098
Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Păunescu TG, Brown D, Lu HAJ
Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking.
J Cell Sci. 2017;130(17):2914-2925 - PMID: 28754689 - PMCID: PMC5612225 - DOI: 10.1242/jcs.204842
Battistone MA, Spallanzani RG, Mendelsohn AC, Capen D, Nair AV, Brown D, Breton S
Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity.
J Cell Sci. 2019;133(5):ePub - PMID: 31636115 - PMCID: PMC7003979 - DOI: 10.1242/jcs.233239
Sinusas AJ, Bengel F, Nahrendorf M, Epstein FH, Wu JC, Villanueva FS, Fayad ZA and Gropler RJ
Multimodality Cardiovascular Molecular Imaging, Part I
Circ Cardiovasc Imaging. 2008;1(3):244-256 - PMID: 19808549 - DOI: 10.1161/CIRCIMAGING.108.824359
Nahrendorf M, Sosnovik D, French B, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ
Multimodality Cardiovascular Molecular Imaging, Part II
Circ Cardiovasc Imaging. 2009;2:56-70 - PMID: 19808565 - PMCID: PMC2760054 - DOI: 10.1161/CIRCIMAGING.108.839092
Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ and Wedeen VJ
Diffusion Spectrum MRI Tractography Reveals the Presence
of a Complex Network of Residual Myofibers in Infarcted Myocardium
Circ Cardiovasc Imaging. 2009;2:206-212 - PMID: 19808594 - PMCID: PMC2760045 - DOI: 10.1161/CIRCIMAGING.108.815050
Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A
Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure.
Circ Cardiovasc Imaging. 2009;2(6):468-475 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779
Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L
Molecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo: Potential for Midmyocardial Salvage in Acute Ischemia.
Circ Cardiovasc Imaging. 2009;2(6):460-467 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678
Nordbeck P, Hiller KH, Fidler F, Warmuth M, Burkard N, Nahrendorf M, Jakob PM, Quick HH, Ertl G, Bauer WR, Ritter O
Feasibility of Contrast Enhanced and Non-Enhanced MRI for Intra- and Postprocedural Lesion Visualization in Interventional Electrophysiology: Animal Studies and Early Delineation of Isthmus Ablation Lesions in Patients with Typical Atrial Flutter.
Circ Cardiovasc Imaging. 2011;4(3):282-94 - PMID: 21415125 - DOI: 10.1161/CIRCIMAGING.110.957670
Nahrendorf M
Imaging of infarct healing predicts left ventricular remodeling and evolution of heart failure: focus on protease activity.
Circ Cardiovasc Imaging. 2011;4(4):351-3 - PMID: 21772011 - PMCID: PMC3141180 - DOI: 10.1161/CIRCIMAGING.111.966671
Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE
Molecular MRI of Acute Necrosis with a Novel DNA-Binding Gadolinium Chelate: Kinetics of Cell Death and Clearance in Infarcted Myocardium.
Circ Cardiovasc Imaging. 2011;4(6):729-737 - PMID: 21836081 - PMCID: PMC3370828 - DOI: 10.1161/CIRCIMAGING.111.966374
Sosnovik DE, Nahrendorf M
Cells and Iron Oxide Nanoparticles on the Move: Magnetic Resonance Imaging of Monocyte Homing and Myocardial Inflammation in Patients With ST-Elevation Myocardial Infarction.
Circ Cardiovasc Imaging. 2012;5(5):551-4 - PMID: 22991284 - PMCID: PMC3529959 - DOI: 10.1161/CIRCIMAGING.112.978932
Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE
Fluorescence Tomography of Rapamycin-Induced Autophagy and Cardioprotection In Vivo.
Circ Cardiovasc Imaging. 2013;6(3):441-7 - PMID: 23537953 - PMCID: PMC3805276 - DOI: 10.1161/CIRCIMAGING.112.000074
Ueno T, Dutta P, Keliher E, Leuschner F, Majmudar M, Marinelli B, Iwamoto Y, Figueiredo JL, Christen T, Swirski FK, Libby P, Weissleder R, Nahrendorf M
Nanoparticle PET-CT Detects Rejection and Immunomodulation in Cardiac Allografts.
Circ Cardiovasc Imaging. 2013;6(4):568-73 - PMID: 23771986 - PMCID: PMC3734553 - DOI: 10.1161/CIRCIMAGING.113.000481
Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P
Increased Microvascularization and Vessel Permeability Associate with Active Inflammation in Human Atheromata.
Circ Cardiovasc Imaging. 2014;7(6):920-929 - PMID: 25170063 - PMCID: PMC4237630 - DOI: 10.1161/CIRCIMAGING.114.002113
Nahrendorf M, Swirski FK
Imaging systemic inflammation in patients with acute myocardial infarction.
Circ Cardiovasc Imaging. 2014;7(5):762-4 - PMID: 25227235 - DOI: 10.1161/CIRCIMAGING.114.002410
Rischpler C, Dirschinger RJ, Nekolla SG, Kossmann H, Nicolosi S, Hanus F, van Marwick S, Kunze KP, Meinicke A, Götze K, Kastrati A, Langwieser N, Ibrahim T, Nahrendorf M, Schwaiger M, Laufwitz KL
Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in Postischemic Myocardium by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging as a Prognostic Marker of Functional Outcome
Circ Cardiovasc Imaging. 2016;9:e004316 - PMID: 27056601 - PMCID: PMC4826716 - DOI: 10.1161/CIRCIMAGING.115.004316
Stein-Merlob AF, Hara T, McCarthy JR, Mauskapf A, Hamilton JA, Ntziachristos V, Libby P, Jaffer FA
Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging.
Circ Cardiovasc Imaging. 2017;10(5):ePub - PMID: 28487316 - PMCID: PMC5509162 - DOI: 10.1161/CIRCIMAGING.116.005813
Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM
Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs.
Circ Cardiovasc Imaging. 2020;13(10):e010586 - PMID: 33076700 - PMCID: PMC7583675 - DOI: 10.1161/CIRCIMAGING.120.010586
Libby P, DiCarli M, Weissleder R
The Vascular Biology of Atherosclerosis and Imaging Targets.
J Nucl Med. 2010;51 Suppl 1:33S-37S - PMID: 20395349 - DOI: 10.2967/jnumed.109.069633
Kramer CM, Sinusas AJ, Sosnovik DE, French BA, Bengel FM
Multimodality Imaging of Myocardial Injury and Remodeling.
J Nucl Med. 2010;51 Suppl 1:107S-121S - PMID: 20395347 - PMCID: PMC3078824 - DOI: 10.2967/jnumed.109.068221
Bogdanov AA, Callahan RJ, Wilkinson RA, Martin C, Cameron JA, Fischman AJ, Brady TJ, Weissleder R
Synthetic copolymer kit for radionuclide blood-pool imaging.
J Nucl Med. 1994;35(11):1880-6 - PMID: 7965173
Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry.
J Nucl Med. 2013;54(8):1389-96 - PMID: 23708196 - PMCID: PMC4151562 - DOI: 10.2967/jnumed.112.115840
Kilcoyne A, Harisinghani MG, Mahmood U
Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles.
J Nucl Med. 2016;57(Suppl 3):105S-110S - PMID: 27694162 - DOI: 10.2967/jnumed.115.170738
Nahrendorf M, Wiesmann F, Hiller K, Han H, Hu K, Waller C, Ruff J, Haase A, Ertl G, Bauer W
In vivo assessment of cardiac remodeling after myocardial infarction in rats by cine-magnetic resonance imaging.
J Cardiovasc Magn Reson. 2001;2(3):171-80 - PMID: 11545114 - DOI: 10.3109/10976640009146565
Sosnovik DE, Caravan P
Molecular MRI of Atherosclerotic
Plaque With Targeted Contrast Agents
J Cardiovasc Magn Reson. 2009;2:87-94
Mekkaoui C, Huang S, Chen HH, Dai G, Reese TG, Kostis WJ, Thiagalingam A, Maurovich-Horvat P, Ruskin JN, Hoffmann U, Jackowski MP, Sosnovik DE
Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation.
J Cardiovasc Magn Reson. 2012;14(1):70 - PMID: 23061749 - PMCID: PMC3506570 - DOI: 10.1186/1532-429X-14-70
Global Cardiovascular Magnetic Resonance Registry (GCMR) Investigators, Kwong RY, Petersen SE, Schulz-Menger J, Arai AE, Bingham SE, Chen Y, Choi YL, Cury RC, Ferreira VM, Flamm SD, Steel K, Bandettini WP, Martin ET, Nallamshetty L, Neubauer S, Raman SV, Schelbert EB, Valeti US, Cao JJ, Reichek N, Young AA, Fexon L, Pivovarov M, Ferrari VA, Simonetti OP
The global cardiovascular magnetic resonance registry (GCMR) of the society for cardiovascular magnetic resonance (SCMR): its goals, rationale, data infrastructure, and current developments.
J Cardiovasc Magn Reson. 2017;19(1):23 - PMID: 28187739 - PMCID: PMC5303267 - DOI: 10.1186/s12968-016-0321-7
Law B, Weissleder R, Tung CH
Peptide-based Biomaterials for Protease-Enhanced Drug Delivery
Biomacromolecules. 2006;7(4):1261-1265 - PMID: 16602747 - DOI: 10.1021/bm050920f
Law B, Tung CH
Structural modification of protease inducible preprogrammed nanofiber precursor.
Biomacromolecules. 2008;9:421-5 - PMID: 18177006 - DOI: 10.1021/bm7012026
Yoshida S, Shimada M, Ueno T, Kitamura Y, Matsuzaki S, Nishikubo S, Nagae M, Nakanishi K, Murata J, Yoshino M
Successful endoscopic submucosal dissection of duodenal cancer.
Endoscopy. 2008;40 Suppl 2:E132-3 - PMID: 18633861 - DOI: 10.1055/s-2007-995685
Yoshida S, Shimada M, Ueno T, Kato A, Yoshino M
Latex hand glove: a safe and convenient device for the endoscopic removal of foreign bodies.
Endoscopy. 2008;40 Suppl 2:E195-6 - PMID: 18709613 - DOI: 10.1055/s-2008-1077420
Yoshida S, Shimada M, Ueno T, Yoshino M
Exuberant mucosal granulation by a self-expanding metal stent leading to complete closure of esophageal perforation.
Endoscopy. 2008;40 Suppl 2:E244-5 - PMID: 18991221 - DOI: 10.1055/s-2008-1077526
Park KS, Charles RC, Ryan ET, Weissleder R*, Lee H*
Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease
Chem Eur J. 2015;21(46):16359-63 - PMID: 26420633 - PMCID: PMC4816641 - DOI: 10.1002/chem.201502934
Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L
Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy
Neoplasia. 2003;5:187-92 - PMID: 12869301 - PMCID: PMC1502408 - DOI: 10.1016/S1476-5586(03)80050-7
Allport JR, Weissleder R
Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro
Neoplasia. 2003;5:205-17 - PMID: 12869304 - PMCID: PMC1502407 - DOI: 10.1016/S1476-5586(03)80053-2
Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO
Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2
Neoplasia. 2002;4:501-9 - PMID: 12407444 - PMCID: PMC1503664 - DOI: 10.1038/sj.neo.7900265
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model
Neoplasia. 2002;4:3-8 - PMID: 11922388 
