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Babitt JL, Lin HY
BuMPing iron with modified heparins.
Blood. 2014;123(10):1440-1 - PMID: 24627550 - PMCID: PMC3945857 - DOI: 10.1182/blood-2014-01-549519
Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy.
Cell Rep. 2014;9(1):180-92 - PMID: 25284779 - PMCID: PMC4555847 - DOI: 10.1016/j.celrep.2014.08.074
Turan S, Fernandez-Rebollo E, Aydin C, Zoto T, Reyes M, Bounoutas G, Chen M, Weinstein LS, Erben RG, Marshansky V, Bastepe M
Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone-resistance due to heterozygous Gαs disruption.
J Bone Miner Res. 2014;29(3):749-60 - PMID: 23956044 - PMCID: PMC3926912 - DOI: 10.1002/jbmr.2070
Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
J Cell Sci. 2014;127(Pt 20):4396-408 - PMID: 25107366 - PMCID: PMC4197086 - DOI: 10.1242/jcs.148098
Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.
Endocrinology. 2014;155(9):3661-73 - PMID: 24971615 - PMCID: PMC4138574 - DOI: 10.1210/en.2014-1341
Zumbrennen-Bullough K, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D, Babitt JL
MicroRNA-130a is upregulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.
J Biol Chem. 2014;289(34):23796-808 - PMID: 25002578 - PMCID: PMC4156078 - DOI: 10.1074/jbc.M114.577387
Marshansky V, Rubinstein JL, Grüber G
Eukaryotic V-ATPase: Novel Structural Findings and Functional Insights.
Biochim Biophys Acta. 2014;1837(6):857-879 - PMID: 24508215 - DOI: 10.1016/j.bbabio.2014.01.018
Păunescu TG, Shum WW, Huynh C, Lechner L, Goetze B, Brown D, Breton S
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
Mol Hum Reprod. 2014;20(10):929-37 - PMID: 25015675 - PMCID: PMC4172170 - DOI: 10.1093/molehr/gau052
Kim B, Roy J, Shum WW, Da Silva N, Breton S
Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis.
Biol Reprod. 2014;92(1):9 - PMID: 25411392 - PMCID: PMC4434934 - DOI: 10.1095/biolreprod.114.123943
Shum WW, Smith TB, Cortez-Retamozo V, Grigoryeva LS, Roy JW, Hill E, Pittet MJ, Breton S, Da Silva N
Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis.
Biol Reprod. 2014;90(5):90 - PMID: 24648397 - PMCID: PMC4076373 - DOI: 10.1095/biolreprod.113.116681
Miranda KC, Bond DT, Levin JZ, Adiconis X, Sivachenko A, Russ C, Brown D, Nusbaum C, Russo LM
Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA.
PLoS ONE. 2014;9(5):e96094 - PMID: 24816817 - PMCID: PMC4015934 - DOI: 10.1371/journal.pone.0096094
Nomura N, Nunes P, Bouley R, Nair AV, Shaw S, Ueda E, Pathomthongtaweechai N, Lu HA, Brown D
High throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.
Am J Physiol Cell Physiol. 2014;307(7):C597-605 - PMID: 24944200 - PMCID: PMC4187055 - DOI: 10.1152/ajpcell.00154.2014
Smith TB, Cortez-Retamozo V, Grigoryeva LS, Hill E, Pittet MJ, Da Silva N
Mononuclear phagocytes rapidly clear apoptotic epithelial cells in the proximal epididymis.
Andrology. 2014;2(5):755-62 - PMID: 25082073 - PMCID: PMC4396827 - DOI: 10.1111/j.2047-2927.2014.00251.x
Pauk M, Grgurevic L, Brkljacic J, Kufner V, Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, Babitt JL, Lin HY, Volarevic S, Vukicevic S
Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.
Int Orthop. 2014;39(1):161-172 - PMID: 25300398 - DOI: 10.1007/s00264-014-2550-4
Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ
Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.
Physiol Rep. 2014;2(12):ePub - PMID: 25472608 - PMCID: PMC4332208 - DOI: 10.14814/phy2.12226
Wang CY, Meynard D, Lin HY
The role of TMPRSS6/matriptase-2 in iron regulation and anemia.
Front Pharmacol. 2014;5:114 - PMID: 24966834 - PMCID: PMC4053654 - DOI: 10.3389/fphar.2014.00114
Core AB, Canali S, Babitt JL
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.
Front Pharmacol. 2014;5:104 - PMID: 24860505 - PMCID: PMC4026703 - DOI: 10.3389/fphar.2014.00104
Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J
Dedifferentiation of committed epithelial cells into stem cells in vivo.
Nature. 2013;503(7475):218-23 - PMID: 24196716 - PMCID: PMC4035230 - DOI: 10.1038/nature12777
Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT
Differential regulation of myeloid leukemias by the bone marrow microenvironment.
Nature Med. 2013;19(11):1513-7 - PMID: 24162813 - PMCID: PMC3827980 - DOI: 10.1038/nm.3364
Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW
Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.
Nat Commun. 2013;4:2189 - PMID: 23877263 - PMCID: PMC3740589 - DOI: 10.1038/ncomms3189
Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U
Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.
Autophagy. 2013;9(4):550-67 - PMID: 23380587 - PMCID: PMC3627670 - DOI: 10.4161/auto.23662
Brown D, Jenny Lu HA
Aquaporin-2 Inhibitors: Fishing in the Chemical Pool.
J Am Soc Nephrol. 2013;24(5):685-6 - PMID: 23599384 - DOI: 10.1681/ASN.2013030243
Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D,
Defining Kidney Biology to Understand Renal Disease.
Clin J Am Soc Nephrol. 2013;9(4):809-11 - PMID: 24370769 - PMCID: PMC3974369 - DOI: 10.2215/CJN.10851013
Huang J, McKee M, Huang HD, Xiang A, Davidson AJ, Lu HA
A zebrafish model of conditional targeted podocyte ablation and regeneration.
Kidney Int. 2013;83(6):1193-200 - PMID: 23466998 - PMCID: PMC3672345 - DOI: 10.1038/ki.2013.6
Breton S, Brown D
Regulation of Luminal Acidification by the V-ATPase.
Physiology (Bethesda). 2013;28(5):318-29 - PMID: 23997191 - PMCID: PMC3768094 - DOI: 10.1152/physiol.00007.2013
Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP
Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.
J Biol Chem. 2013;288(39):27849-60 - PMID: 23935101 - PMCID: PMC3784700 - DOI: 10.1074/jbc.M112.445098
Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Gruber G, Marshansky V
The N-terminus of a-Subunit Isoforms is Involved in Signaling between V-ATPase and Cytohesin-2.
J Biol Chem. 2013;288(8):5896-913 - PMID: 23288846 - PMCID: PMC3581410 - DOI: 10.1074/jbc.M112.409169
Meynard D, Sun CC, Wu Q, Chen W, Chen S, Nelson CN, Waters MJ, Babitt JL, Lin HY
Inflammation Regulates TMPRSS6 Expression via STAT5.
PLoS ONE. 2013;8(12):e82127 - PMID: 24376517 - PMCID: PMC3871639 - DOI: 10.1371/journal.pone.0082127
Rice WL, Van Hoek AN, Păunescu TG, Huynh C, Goetze B, Singh B, Scipioni L, Stern LA, Brown D
High resolution helium ion scanning microscopy of the rat kidney.
PLoS ONE. 2013;8(3):e57051 - PMID: 23505418 - PMCID: PMC3591388 - DOI: 10.1371/journal.pone.0057051
Roy JW, Hill E, Ruan YC, Vedovelli L, Paunescu T, Brown D, Breton S
Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis.
Am J Physiol Cell Physiol. 2013;305(4):C436-46 - PMID: 23761626 - PMCID: PMC3891217 - DOI: 10.1152/ajpcell.00410.2012
Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D
Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.
Am J Physiol Renal Physiol. 2013;305(12):F1783-F1795 - PMID: 24133120 - PMCID: PMC3882446 - DOI: 10.1152/ajprenal.00622.2012
Shum W, Hill E, Brown D, Breton S
Plasticity of basal cells during postnatal development in the rat epididymis.
Reproduction. 2013;146(5):455-469 - PMID: 23960170 - PMCID: PMC4106237 - DOI: 10.1530/REP-12-0510
Zumbrennen-Bullough K, Babitt JL
The iron cycle in CKD: from genetics and experimental models to CKD patients.
Nephrol Dial Transplant. 2013;29(2):263-73 - PMID: 24235084 - PMCID: PMC3910345 - DOI: 10.1093/ndt/gft443
Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL
A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.
Nephrol Dial Transplant. 2013;28(7):1733-1743 - PMID: 23345622 - PMCID: PMC3707526 - DOI: 10.1093/ndt/gfs584
Chen W, Sun CC, Chen S, Meynard D, Babitt JL, Lin HY
A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum.
Haematologica. 2012;98(2):296-304 - PMID: 22875629 - PMCID: PMC3561439 - DOI: 10.3324/haematol.2012.070136
Babitt JL, Lin HY
Mechanisms of Anemia in CKD.
J Am Soc Nephrol. 2012;23(10):1631-4 - PMID: 22935483 - PMCID: PMC3458456 - DOI: 10.1681/ASN.2011111078
Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA
Aquaporin 2 Promotes Cell Migration and Epithelial Morphogenesis.
J Am Soc Nephrol. 2012;23(9):1506-17 - PMID: 22859853 - PMCID: PMC3431417 - DOI: 10.1681/ASN.2012010079
Brown D, Wagner CA
Molecular Mechanisms of Acid-Base Sensing by the Kidney.
J Am Soc Nephrol. 2012;23(5):774-80 - PMID: 22362904 - PMCID: PMC3338302 - DOI: 10.1681/ASN.2012010029
Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W
Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure.
Cell Rep. 2012;2(1):52-61 - PMID: 22840396 - PMCID: PMC3627357 - DOI: 10.1016/j.celrep.2012.06.002
Bouley R
Corin: a key protein of an adaptive renal mechanism to respond to salt variation?
Kidney Int. 2012;82(1):7-8 - PMID: 22699378 - DOI: 10.1038/ki.2012.123
Hennings JC, Picard N, Huebner AK, Stauber T, Maier H, Brown D, Jentsch TJ, Vargas-Poussou R, Eladari D, Hübner CA
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
EMBO Mol Med. 2012;4(10):1057-71 - PMID: 22933323 - PMCID: PMC3491836 - DOI: 10.1002/emmm.201201527
Sun CC, Vaja V, Babitt JL, Lin HY
Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.
Am J Hematol. 2012;87(4):392-400 - PMID: 22290531 - PMCID: PMC3653431 - DOI: 10.1002/ajh.23110
Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease.
Inflamm Bowel Dis. 2012;18(1):112-9 - PMID: 21351217 - PMCID: PMC3139830 - DOI: 10.1002/ibd.21675
Ruan YC, Shum WW, Belleannée C, Da Silva N, Breton S
ATP secretion in the male reproductive tract: essential role of CFTR.
J Physiol. 2012;590(Pt 17):4209-22 - PMID: 22711960 - PMCID: PMC3473280 - DOI: 10.1113/jphysiol.2012.230581
Kim JK, Vinarsky V, Wain JC, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH
In vivo imaging of tracheal epithelial cells in mice during airway regeneration.
Am J Respir Cell Mol Biol. 2012;47(6):864-8 - PMID: 22984086 - PMCID: PMC3547097 - DOI: 10.1165/rcmb.2012-0164OC
Krapf D, Chun Ruan Y, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S, Visconti PE
cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit.
Dev Biol. 2012;369(1):43-53 - PMID: 22750823 - PMCID: PMC3424100 - DOI: 10.1016/j.ydbio.2012.06.017
Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y
Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent.
PLoS ONE. 2012;7(9):e44622 - PMID: 23028567 - PMCID: PMC3441567 - DOI: 10.1371/journal.pone.0044622
Păunescu TG, Rodriguez S, Benz E, McKee M, Tyszkowski R, Albers MW, Brown D
Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function.
PLoS ONE. 2012;7(9):e45395 - PMID: 23028982 - PMCID: PMC3447883 - DOI: 10.1371/journal.pone.0045395
Wu Q, Sun CC, Lin HY, Babitt JL
Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs).
PLoS ONE. 2012;7(9):e46307 - PMID: 23029472 - PMCID: PMC3459908 - DOI: 10.1371/journal.pone.0046307
Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL
Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System.
PLoS ONE. 2012;7(6):e38310 - PMID: 22701626 - PMCID: PMC3368842 - DOI: 10.1371/journal.pone.0038310
Rice WL, Zhang Y, Chen Y, Matsuzaki T, Brown D, Lu HA
Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells.
PLoS ONE. 2012;7(2):e32843 - PMID: 22403603 - PMCID: PMC3293519 - DOI: 10.1371/journal.pone.0032843
Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D
Basolateral targeting and microtubule dependent transcytosis of the aquaporin-2 water channel.
Am J Physiol Cell Physiol. 2012;304(1):C38-48 - PMID: 23015545 - PMCID: PMC3543574 - DOI: 10.1152/ajpcell.00109.2012
Brown D, Bouley R, Paunescu TG, Breton S, Lu HA
New insights into the dynamic regulation of water and acid/base balance by renal epithelial cells.
Am J Physiol Cell Physiol. 2012;302(10):C1421-33 - PMID: 22460710 - PMCID: PMC3362000 - DOI: 10.1152/ajpcell.00085.2012
Vedovelli L, Rothermel JT, Finberg KE, Wagner CA, Azroyan A, Hill E, Breton S, Brown D, Paunescu TG
Altered V-ATPase expression in renal intercalated cells isolated from B1-subunit deficient mice by fluorescence activated cell sorting.
Am J Physiol Renal Physiol. 2012;304(5):F522-32 - PMID: 23269648 - PMCID: PMC3602708 - DOI: 10.1152/ajprenal.00394.2012
Bouley R, Nunes P, Andriopoulos B, McLaughlin MM, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D
Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.
Am J Physiol Renal Physiol. 2012;304(5):F553-64 - PMID: 23235478 - PMCID: PMC3602717 - DOI: 10.1152/ajprenal.00438.2011
Lin HY
Transforming Growth Factor-β and the Kidney Revisited: Introduction.
Semin Nephrol. 2012;32(3):225-7 - PMID: 22835452 - DOI: 10.1016/j.semnephrol.2012.04.010
Gutiérrez OM, Sun CC, Chen W, Babitt JL, Lin HY
Statement of Concern about a Commercial Assay Used to Measure Soluble Hemojuvelin in Humans.
Am J Nephrol. 2012;36(4):332-333 - PMID: 23006450 - DOI: 10.1159/000342519
Dip PV, Saw WG, Roessle M, Marshansky V, Grüber G
Solution structure of subunit a, a (104-363), of the Saccharomyces cerevisiae V-ATPase and the importance of its C-terminus in structure formation.
J Bioenerg Biomembr. 2012;44(3):341-50 - PMID: 22562380 - DOI: 10.1007/s10863-012-9442-3
Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE
Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.
Gastroenterology. 2011;141(5):1907-14 - PMID: 21745449 - PMCID: PMC3634343 - DOI: 10.1053/j.gastro.2011.06.077
Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic disease in rats.
Blood. 2011;118(18):4977-84 - PMID: 21730356 - PMCID: PMC3208302 - DOI: 10.1182/blood-2011-03-345066
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, Lopez-Otin C, Grgurevic L, Hong CC, Stirnberg M, Gutschow M, Vukicevic S, Babitt JL, Lin HY
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.
Blood. 2011;118(3):747-56 - PMID: 21622652 - PMCID: PMC3142910 - DOI: 10.1182/blood-2011-04-348698
Corradini E, Meynard D, Wu Q, Chen S, Ventura P, Pietrangelo A, Babitt JL
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice.
Hepatology. 2011;54(1):273-84 - PMID: 21488083 - PMCID: PMC3277401 - DOI: 10.1002/hep.24359
Babitt JL, Lin HY
The molecular pathogenesis of hereditary hemochromatosis.
Semin Liver Dis. 2011;31(3):280-92 - PMID: 21901658 - DOI: 10.1055/s-0031-1286059
Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA
The BMP Coreceptor RGMb Promotes While the Endogenous BMP Antagonist Noggin Reduces Neurite Outgrowth and Peripheral Nerve Regeneration by Modulating BMP Signaling.
J Neurosci. 2011;31(50):18391-18400 - PMID: 22171041 - PMCID: PMC3243947 - DOI: 10.1523/JNEUROSCI.4550-11.2011
Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R
Visualizing Microtubule-Dependent Vasopressin Type 2 Receptor Trafficking Using a New High-Affinity Fluorescent Vasopressin Ligand.
Endocrinology. 2011;152(10):3893-904 - PMID: 21828182 - PMCID: PMC3176653 - DOI: 10.1210/en.2011-1049
Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, Weinstein LS, Chen M, Marshansky V, Frohlich LF, Bastepe M
Transgenic Overexpression of the Extra-Large Gs{alpha} Variant XL{alpha}s Enhances Gs{alpha}-Mediated Responses in the Mouse Renal Proximal Tubule in Vivo.
Endocrinology. 2011;152(4):1222-33 - PMID: 21303955 - PMCID: PMC3060637 - DOI: 10.1210/en.2010-1034
Gibert Y, Lattanzi VJ, Zhen AW, Vedder L, Brunet F, Faasse SA, Babitt JL, Lin HY, Hammerschmidt M, Fraenkel PG
BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin.
PLoS ONE. 2011;6(1):e14553 - PMID: 21283739 - PMCID: PMC3024971 - DOI: 10.1371/journal.pone.0014553
Winter C, Kampik NB, Vedovelli L, Rothenberger F, Paunescu TG, Stehberger PA, Brown D, John H, Wagner CA
Aldosterone stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C dependent pathway.
Am J Physiol Cell Physiol. 2011;301(5):C1251-61 - PMID: 21832245 - PMCID: PMC3213922 - DOI: 10.1152/ajpcell.00076.2011
Shum WW, Da Silva N, Belleannee C, McKee M, Brown D, Breton S
Regulation of V-ATPase recycling via a RhoA and ROCKII dependent pathway in epididymal clear cells.
Am J Physiol Cell Physiol. 2011;301(1):C31-43 - PMID: 21411727 - PMCID: PMC3129830 - DOI: 10.1152/ajpcell.00198.2010
Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V
Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.
Am J Physiol Cell Physiol. 2011;300(6):C1442-55 - PMID: 21307348 - PMCID: PMC3118619 - DOI: 10.1152/ajpcell.00076.2010
Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA
Simvastatin Enhances Aquaporin 2 Surface Expression and Urinary Concentration in Vasopressin Deficient Brattleboro Rats through Modulation of Rho GTPase.
Am J Physiol Renal Physiol. 2011;301(2):F309-18 - PMID: 21511701 - PMCID: PMC3154588 - DOI: 10.1152/ajprenal.00001.2011
Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP
Angiotensin II Stimulates H-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts.
Cell Physiol Biochem. 2011;28(3):513-20 - PMID: 22116365 - PMCID: PMC3709473 - DOI: 10.1159/000335112
Shum WW, Ruan YC, Da Silva N, Breton S
Establishment of Cell-Cell Crosstalk in the Epididymis: Control of Luminal Acidification.
J Androl. 2011;32(6):576-86 - PMID: 21441423 - PMCID: PMC3753098 - DOI: 10.2164/jandrol.111.012971
Yui N, Lu HJ, Bouley R, Brown D
AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.
Biol Open. 2011;1(2):101-8 - PMID: 23213402 - PMCID: PMC3507199 - DOI: 10.1242/bio.2011042
Corradini E, Schmidt PJ, Meynard D, Garuti C, Montosi G, Chen S, Vukicevic S, Pietrangelo A, Lin HY, Babitt JL
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice.
Gastroenterology. 2010;139(5):1721-9 - PMID: 20682319 - PMCID: PMC3295242 - DOI: 10.1053/j.gastro.2010.07.044
Gao X, Eladari D, Leviel F, Tew BY, Miro-Julia
Deletion of hensin/DMBT1 blocks conversion of {beta}- to {alpha}-intercalated cells and induces distal renal tubular acidosis.
Proc Natl Acad Sci U S A. 2010;107(50):21872-7 - PMID: 21098262 - PMCID: PMC3003085 - DOI: 10.1073/pnas.1010364107
Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D
Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration.
J Am Soc Nephrol. 2010;22(1):59-72 - PMID: 21071524 - PMCID: PMC3014035 - DOI: 10.1681/ASN.2009121267
Xia Y, Babitt JL, Bouley R, Zhang Y, Silva ND, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY
Dragon Enhances BMP Signaling and Increases Transepithelial Resistance in Kidney Epithelial Cells.
J Am Soc Nephrol. 2010;21(4):666-77 - PMID: 20167703 - PMCID: PMC2844302 - DOI: 10.1681/ASN.2009050511
Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E
The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.
Kidney Int. 2010;78(4):382-8 - PMID: 20531453 - PMCID: PMC3684398 - DOI: 10.1038/ki.2010.166
Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, Brown D, Russo LM
Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease.
Kidney Int. 2010;78(2):191-9 - PMID: 20428099 - PMCID: PMC4451567 - DOI: 10.1038/ki.2010.106
Babitt JL, Lin HY
Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD.
Am J Kidney Dis. 2010;55(4):726-41 - PMID: 20189278 - PMCID: PMC2905036 - DOI: 10.1053/j.ajkd.2009.12.030
Merkulova M, Bakulina A, Thaker YR, Gruber G, Marshansky V
Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.
Biochim Biophys Acta. 2010;1797(8):1398-1409 - PMID: 20153292 - DOI: 10.1016/j.bbabio.2010.02.009
Miranda KC, Karet FE, Brown D
An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants.
PLoS ONE. 2010;5(3):e9531 - PMID: 20224822 - PMCID: PMC2835735 - DOI: 10.1371/journal.pone.0009531
Da Silva N, Pisitkun T, Belleannee C, Miller LR, Nelson RD, Knepper MA, Brown D, Breton S
Proteomic analysis of V-ATPase-rich cells harvested from the kidney and epididymis by fluorescence activated cell sorting.
Am J Physiol Cell Physiol. 2010;298(6):C1326-42 - PMID: 20181927 - PMCID: PMC2889637 - DOI: 10.1152/ajpcell.00552.2009
Belleannee C, Da Silva N, Shum WW, Brown D, Breton S
Role of purinergic signaling pathways in V-ATPase recruitment to the apical membrane of acidifying epididymal clear cells.
Am J Physiol Cell Physiol. 2010;298(4):C817-30 - PMID: 20071692 - PMCID: PMC2853219 - DOI: 10.1152/ajpcell.00460.2009
Zhuang Z, Marshansky V, Breton S, Brown D
Is caveolin involved in normal proximal tubule (PT) function? Presence in model PT systems but absence in situ.
Am J Physiol Renal Physiol. 2010;300(1):F199-206 - PMID: 20980408 - PMCID: PMC3023221 - DOI: 10.1152/ajprenal.00513.2010
Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D
Cyclic AMP stimulates apical V-ATPase accumulation, microvillar elongation and proton extrusion in kidney collecting duct A-intercalated cells.
Am J Physiol Renal Physiol. 2010;298(3):F643-54 - PMID: 20053793 - PMCID: PMC2838605 - DOI: 10.1152/ajprenal.00584.2009
Merkulova M, McKee M, Dip PV, Gruber G, Marshansky V
N-terminal domain of the V-ATPase a2-subunit displays integral membrane protein properties.
Protein Sci. 2010;19(10):1850-1862 - PMID: 20669186 - PMCID: PMC2998721 - DOI: 10.1002/pro.470
Bolondi G, Garuti C, Corradini E, Zoller H, Vogel W, Finkenstedt A, Babitt JL, Lin HY, Pietrangelo A
Altered hepatic BMP signaling pathway in human HFE hemochromatosis.
Blood Cells Mol Dis. 2010;45(4):308-12 - PMID: 20863724 - PMCID: PMC3295241 - DOI: 10.1016/j.bcmd.2010.08.010
Andriopoulos Jr B, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.
Nat Genet. 2009;41(4):482-7 - PMID: 19252486 - PMCID: PMC2810136 - DOI: 10.1038/ng.335
Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B, Lin HY, Pietrangelo A, Babitt JL
Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis.
Gastroenterology. 2009;137(4):1489-97 - PMID: 19591830 - PMCID: PMC2757523 - DOI: 10.1053/j.gastro.2009.06.057
Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.
J Clin Invest. 2009;119(11):3322-8 - PMID: 19809161 - PMCID: PMC2769199 - DOI: 10.1172/JCI39939
Corradini E, Babitt JL, Lin HY
The RGM/DRAGON family of BMP co-receptors.
Cytokine Growth Factor Rev. 2009;20(5-6):389-98 - PMID: 19897400 - PMCID: PMC3715994 - DOI: 10.1016/j.cytogfr.2009.10.008
Brown D, Breton S, Ausiello DA, Marshansky V
Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology.
Traffic. 2009;10(3):275-84 - PMID: 19170982 - PMCID: PMC2896909 - DOI: 10.1111/j.1600-0854.2008.00867.x
Belleannee C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S
Segmental Expression of the Bradykinin Type 2 Receptor in Rat Efferent Ducts and Epididymis and Its Role in the Regulation of Aquaporin 9.
Biol Reprod. 2009;80(1):134-43 - PMID: 18829705 - PMCID: PMC2804812 - DOI: 10.1095/biolreprod.108.070797
Vidarsson H, Westergren R, Heglind M, Blomqvist SR, Breton S, Enerback S
The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis.
PLoS ONE. 2009;4(2):e4471 - PMID: 19214237 - PMCID: PMC2637605 - DOI: 10.1371/journal.pone.0004471
Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF
Angiotensin II and Hypertonicity Modulate Proximal Tubular Aquaporin 1 (AQP1) Expression.
Am J Physiol Renal Physiol. 2009;297(6):F1575-86 - PMID: 19776169 - PMCID: PMC2801332 - DOI: 10.1152/ajprenal.90762.2008
Van Hoek AN, Bouley R, Lu YX, Silberstein CM, Brown D, Wax MB, Patil RV
Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays.
Am J Physiol Renal Physiol. 2009;296(6):F1396-404 - PMID: 19297454 - PMCID: PMC2692439 - DOI: 10.1152/ajprenal.00018.2009
Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S
Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones.
Reproduction. 2009;139(3):613-21 - PMID: 19948840 - PMCID: PMC3773695 - DOI: 10.1530/REP-09-0284
Brown D, Paunescu TG, Breton S, Marshansky V
Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking.
J Exp Biol. 2009;212(Pt 11):1762-72 - PMID: 19448085 - PMCID: PMC2683016 - DOI: 10.1242/jeb.028803
Shum WW, Da Silva N, Brown D, Breton S
Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk.
J Exp Biol. 2009;212(Pt 11):1753-61 - PMID: 19448084 - PMCID: PMC2683015 - DOI: 10.1242/jeb.027284
Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S
Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia
Cell. 2008;135:1108-17 - PMID: 19070580 - PMCID: PMC2646085 - DOI: 10.1016/j.cell.2008.10.020
Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
Blood. 2008;111(10):5195-204 - PMID: 18326817 - PMCID: PMC2384142 - DOI: 10.1182/blood-2007-09-111567
Marshansky V, Futai M
The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function.
Curr Opin Cell Biol. 2008;20(4):415-26 - PMID: 18511251 - PMCID: PMC7111286 - DOI: 10.1016/j.ceb.2008.03.015
Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D
Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy.
J Am Soc Nephrol. 2008;20(3):489-94 - PMID: 19118149 - PMCID: PMC2653682 - DOI: 10.1681/ASN.2008050503
Miller RL, Lucero OM, Riemondy KA, Baumgartner BK, Brown D, Breton S, Nelson RD
The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney.
Kidney Int. 2008;75(4):435-9 - PMID: 19052537 - PMCID: PMC4301582 - DOI: 10.1038/ki.2008.569
Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA
Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.
Kidney Int. 2008;74(12):1557-67 - PMID: 18813286 - PMCID: PMC3730289 - DOI: 10.1038/ki.2008.412
Grüber G, Marshansky V
New insights into structure-function relationships between archeal ATP synthase (A1A0) and vacuolar type ATPase (V1V0).
Bioessays. 2008;30(11-12):1096-109 - PMID: 18937357 - DOI: 10.1002/bies.20827
Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S
Role of NHERF1, CFTR and cAMP in the regulation of aquaporin 9
J Biol Chem. 2008;283:2986-96 - PMID: 18055461 - DOI: 10.1074/jbc.M704678200
Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D
Acute hypertonicity alters aquaporin-2 trafficking and induces a MAP kinase-dependent accumulation at the plasma membrane of renal epithelial cells.
J Biol Chem. 2008;283(39):26643-61 - PMID: 18664568 - PMCID: PMC2546545 - DOI: 10.1074/jbc.M801071200
Russo LM, Brown D, Lin HY
The soluble transforming growth factor-beta receptor: Advantages and applications.
Int J Biochem Cell B. 2008;41(3):472-6 - PMID: 18339576 - DOI: 10.1016/j.biocel.2008.01.026
Brown D, Hasler U, Nunes P, Bouley R, Lu H
Phosphorylation events and the modulation of aquaporin 2 cell surface expression.
Curr Opin Nephrol Hypertens. 2008;17(5):491-8 - PMID: 18695390 - PMCID: PMC3774073 - DOI: 10.1097/MNH.0b013e3283094eb1
Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D
A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2 (AQP2).
Am J Physiol Cell Physiol. 2008;295(6):C1476-87 - PMID: 18799651 - PMCID: PMC2603565 - DOI: 10.1152/ajpcell.00344.2008
Paunescu TG, Jones AC, Tyszkowski R, Brown D
V-ATPase expression in the mouse olfactory epithelium.
Am J Physiol Cell Physiol. 2008;295(4):C923-30 - PMID: 18667600 - PMCID: PMC2575830 - DOI: 10.1152/ajpcell.00237.2008
Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S
Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells.
Am J Physiol Cell Physiol. 2008;294:C488-94 - PMID: 18160485 - PMCID: PMC4303256 - DOI: 10.1152/ajpcell.00537.2007
Lu HA, Matsuzaki T, Bouley R, Hasler U, Qin Q, Brown D
The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.
Am J Physiol Renal Physiol. 2008;295(1):F290-4 - PMID: 18434387 - PMCID: PMC2494506 - DOI: 10.1152/ajprenal.00072.2008
Brown D
Aquaporins and vasopressin signaling in kidney health and disease: introduction.
Semin Nephrol. 2008;28:215-6 - PMID: 18519082 - DOI: 10.1016/j.semnephrol.2008.03.001
Bouley R, Hasler U, Lu HA, Nunes P, Brown D
Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.
Semin Nephrol. 2008;28:266-78 - PMID: 18519087 - PMCID: PMC2494582 - DOI: 10.1016/j.semnephrol.2008.03.010
Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.
Nat Chem Biol. 2007;4(1):33-41 - PMID: 18026094 - PMCID: PMC2727650 - DOI: 10.1038/nchembio.2007.54
Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.
J Clin Invest. 2007;117(7):1933-1939 - PMID: 17607365 - PMCID: PMC1904317 - DOI: 10.1172/JCI31342
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Response to ''Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique''
Kidney Int. 2007;72:1411 - PMID: 18004315
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Response to ''On the origin of albuminuria''
Kidney Int. 2007;72:1409-10 - PMID: 18004312
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Controversies in nephrology: Response to ''renal albumin handling, facts, and artifacts''
Kidney Int. 2007;72(10):1195-7 - PMID: 17851467 - DOI: 10.1038/sj.ki.5002528
Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD
The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.
Kidney Int. 2007;71(6):504-13 - PMID: 17228368 - DOI: 10.1038/sj.ki.5002041
Russo LM, del Re E, Brown D, Lin HY
Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor.
Diabetes. 2007;56(2):380-8 - PMID: 17259382 - DOI: 10.2337/db06-1018
Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D
Heat shock protein 70 interacts with aquaporin-2 (AQP2) and regulates its trafficking.
J Biol Chem. 2007;282(39):28721-32 - PMID: 17636261 - DOI: 10.1074/jbc.M611101200
Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Am J Physiol Cell Physiol. 2007;293(1):C199-210 - PMID: 17392376 - DOI: 10.1152/ajpcell.00596.2006
Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D
Association Of Soluble Adenylyl Cyclase (sAC) With The V-ATPase In Renal Epithelial Cells.
Am J Physiol Renal Physiol. 2007;294(1):F130-8 - PMID: 17959750 - DOI: 10.1152/ajprenal.00406.2007
Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA
Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.
Am J Physiol Renal Physiol. 2007;292(5):F1303-13 - PMID: 17287200 - DOI: 10.1152/ajprenal.00441.2005
Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.
Am J Physiol Renal Physiol. 2007;293(6):F1915-26 - PMID: 17898041 - DOI: 10.1152/ajprenal.00160.2007
Marshansky V
The V-ATPase a2-subunit as a putative endosomal pH-sensor.
Biochem Soc T. 2007;35:1092-9 - PMID: 17956287 - DOI: 10.1042/BST0351092
Da Silva N, Shum WW, Breton S
Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis.
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Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.
Nat Genet. 2006;38(5):531-9 - PMID: 16604073 - DOI: 10.1038/ng1777
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Nat Cell Biol. 2006;8(2):124-36 - PMID: 16415858 - DOI: 10.1038/ncb1348
Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Desch
Pendrin regulation in mouse kidney primarily is chloride-dependent.
J Am Soc Nephrol. 2006;17(8):2153-63 - PMID: 16825334 - DOI: 10.1681/ASN.2005101054
Da Silva N, Pietrement C, Brown D, Breton S
Segmental and cellular expression of aquaporins in the male excurrent duct.
Biochim Biophys Acta. 2006;1758(8):1025-33 - PMID: 16935257 - DOI: 10.1016/j.bbamem.2006.06.026
Breton S, Brown D
New insights into the regulation of V-ATPase-dependent proton secretion.
Am J Physiol Renal Physiol. 2006;292(1):F1-10 - PMID: 17032935 - DOI: 10.1152/ajprenal.00340.2006
Bouley R, Hawthorn G, Russo L, Lin H, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment.
Biol Cell. 2006;98(4):215-32 - PMID: 16563128 - DOI: 10.1042/BC20040054
Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Nat Genet. 2005;37(7):739-44 - PMID: 15924139 - PMCID: PMC1360984 - DOI: 10.1038/ng1592
Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP
The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.
Proc Natl Acad Sci U S A. 2005;102(38):13616-21 - PMID: 16174750 - PMCID: PMC1224669 - DOI: 10.1073/pnas.0506769102
Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A
Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis.
Endocrinology. 2005;146(8):3614-21 - PMID: 15890774 - PMCID: PMC1351303 - DOI: 10.1210/en.2004-1676
Babitt J, Zhang Y, Samad T, Xia Y, Tang J, Campagna J, Schneyer A, Woolf C, Lin HY
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
J Biol Chem. 2005;280(33):29820-7 - PMID: 15975920 - DOI: 10.1074/jbc.M503511200
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
DRAGON, a bone morphogenetic protein co-receptor.
J Biol Chem. 2005;280(14):14122-9 - PMID: 15671031 - DOI: 10.1074/jbc.M410034200
Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S
Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.
J Biol Chem. 2005;280(9):8452-63 - PMID: 15591047 - DOI: 10.1074/jbc.M412750200
Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S
Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.
Biol Reprod. 2005;74(1):185-94 - PMID: 16192400 - DOI: 10.1095/biolreprod.105.043752
Da Silva N, Silberstein C, Beaulieu V, Pietrement C, Van Hoek AN, Brown D, Breton S
Postnatal expression of aquaporins in epithelial cells of the rat epididymis.
Biol Reprod. 2005;74(2):427-38 - PMID: 16221990 - DOI: 10.1095/biolreprod.105.044735
Sabolic I, Herak-Kramberger CM, Antolovic R, Breton S, Brown D
Loss of basolateral invaginations in proximal tubules of cadmium-intoxicated rats is independent of microtubules and clathrin.
Toxicology. 2005;218(2-3):149-63 - PMID: 16288946 - DOI: 10.1016/j.tox.2005.10.009
Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo A, Marcocci C, Brown D, McCluskey RT, Marinò M
Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.
Am J Physiol Cell Physiol. 2005;290(4):C1160-7 - PMID: 16306127 - DOI: 10.1152/ajpcell.00382.2005
Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA
Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.
Am J Physiol Cell Physiol. 2005;288(6):C1390-401 - PMID: 15677378 - DOI: 10.1152/ajpcell.00353.2004
Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD
V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice.
Am J Physiol Cell Physiol. 2005;288(5):C1134-44 - PMID: 15634743 - DOI: 10.1152/ajpcell.00084.2004
Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D
Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).
Am J Physiol Renal Physiol. 2005;288(6):F1103-12 - PMID: 15644488 - DOI: 10.1152/ajprenal.00337.2004
Bouley R, Hawthorn G, Russo L, Lin HY, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in "endocytosis-resistant" membrane domains after vasopressin treatment.
Abdom Imaging. 2005;:ePub - PMID: 16104839
Pastor-Soler N, Pietrement C, Breton S
Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction.
2005;20:417-28 - PMID: 16287991 - DOI: 10.1152/physiol.00036.2005
Samad T, Srinivasan A, Karchewski L, Jeong S, Campagna J, Ji R, Fabrizio D, Zhang Y, Lin HY, Bell E, Woolf C
DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.
J Neurosci. 2004;24(8):2027-36 - PMID: 14985445 - PMCID: PMC6730385 - DOI: 10.1523/JNEUROSCI.4115-03.2004
Alvarez de la Rosa D, Paunescu TG, Els WJ, Helman SI, Canessa CM
Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells.
J Gen Physiol. 2004;124(4):395-407 - PMID: 15452200 - PMCID: PMC2233909 - DOI: 10.1085/jgp.200409120
del Re E, Sidis Y, Fabrizio D, Lin HY, Schneyer A
Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system.
J Biol Chem. 2004;279(51):53126-35 - PMID: 15475360 - DOI: 10.1074/jbc.M408090200
del Re E, Babitt J, Pirani A, Schneyer A, Lin HY
In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2.
J Biol Chem. 2004;279(21):22765-72 - PMID: 14996829 - DOI: 10.1074/jbc.M401350200
Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D
Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.
Am J Physiol Cell Physiol. 2004;287(1):C149-62 - PMID: 15013950 - DOI: 10.1152/ajpcell.00464.2003
Yeung CH, Breton S, Setiawan I, Xu Y, Lang F, Cooper TG
Increased luminal pH in the epididymis of infertile c-ros knockout mice and the expression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase.
Mol Reprod Dev. 2004;68(2):159-68 - PMID: 15095336 - DOI: 10.1002/mrd.20067
Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP
Renal vacuolar H+-ATPase.
2004;84(4):1263-314 - PMID: 15383652 - DOI: 10.1152/physrev.00045.2003
Wagner CA, L
A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse.
Pflug Arch Eur J Phy. 2003;446(5):623-32 - PMID: 12748863 - DOI: 10.1007/s00424-003-1082-3
El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V
Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ.
Am J Physiol Cell Physiol. 2003;286(4):C768-78 - PMID: 14684384 - DOI: 10.1152/ajpcell.00250.2003
Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S
Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM.
Am J Physiol Cell Physiol. 2003;284(1):C220-32 - PMID: 12475763 - DOI: 10.1152/ajpcell.00374.2001
van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM
Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.
J Biol Chem. 2002;278(2):1101-7 - PMID: 12374804 - DOI: 10.1074/jbc.M207339200
Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S
Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens.
Biol Reprod. 2002;66(6):1716-22 - PMID: 12021052 - DOI: 10.1095/biolreprod66.6.1716
Fisher JS, Pastor-Soler N, Sharpe RM, Breton S
Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis.
Biol Reprod. 2002;67(4):1106-14 - PMID: 12297525 - DOI: 10.1095/biolreprod67.4.1106
Marshansky V, Ausiello DA, Brown D
Physiological importance of endosomal acidification: potential role in proximal tubulopathies.
Curr Opin Nephrol Hypertens. 2002;11(5):527-37 - PMID: 12187318 - DOI: 10.1097/00041552-200209000-00009
Tremblay J, Chen H, Peng J, Kunes J, Vu MD, Der Sarkissian S, deBlois D, Bolton AE, Gaboury L, Marshansky V, Gouadon E, Hamet P
Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy.
Transplantation. 2002;74(10):1425-33 - PMID: 12451244 - DOI: 10.1097/00007890-200211270-00015
Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD
Renal principal cell-specific expression of green fluorescent protein in transgenic mice.
Am J Physiol Renal Physiol. 2002;283(6):F1351-64 - PMID: 12426236 - DOI: 10.1152/ajprenal.0224.2001
Breton S, Inoue T, Knepper MA, Brown D
Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia.
Am J Physiol Renal Physiol. 2002;282(3):F523-9 - PMID: 11832435 - DOI: 10.1152/ajprenal.00128.2001
Marshansky V, Wang X, Bertrand R, Luo H, Duguid W, Chinnadurai G, Kanaan N, Vu MD, Wu J
Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells.
J Immunol. 2001;166(5):3130-42 - PMID: 11207265 - DOI: 10.4049/jimmunol.166.5.3130
Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V
Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.
J Biol Chem. 2001;276(21):18540-50 - PMID: 11278939 - DOI: 10.1074/jbc.M011577200
Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D
Aquaporin 9 expression along the male reproductive tract.
Biol Reprod. 2001;65(2):384-93 - PMID: 11466204 - DOI: 10.1095/biolreprod65.2.384
Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I
Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract.
Biol Reprod. 2001;64(6):1699-707 - PMID: 11369598 - DOI: 10.1095/biolreprod64.6.1699
Bagnis C, Marsolais M, Biemesderfer D, Laprade R, Breton S
Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis.
Am J Physiol Renal Physiol. 2001;280(3):F426-36 - PMID: 11181404 - DOI: 10.1152/ajprenal.2001.280.3.F426
Bagnis C, Marshansky V, Breton S, Brown D
Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition.
Am J Physiol Renal Physiol. 2001;280(3):F437-48 - PMID: 11181405 - DOI: 10.1152/ajprenal.2001.280.3.F437
Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W
Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
Brain Res Mol Brain Res. 2001;96(1-2):14-20 - PMID: 11731004 - DOI: 10.1016/s0169-328x(01)00250-9
Breton S
The cellular physiology of carbonic anhydrases.
JOP. 2001;2(4 Suppl):159-64 - PMID: 11875253
Choukroun GJ, Marshansky V, Gustafson CE, McKee M, Hajjar RJ, Rosenzweig A, Brown D, Bonventre JV
Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins.
J Clin Invest. 2000;106(8):983-93 - PMID: 11032858 - PMCID: PMC314339 - DOI: 10.1172/JCI8914
Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D
Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.
J Clin Invest. 2000;106(9):1115-26 - PMID: 11067864 - PMCID: PMC301414 - DOI: 10.1172/JCI9594
Brown D, Breton S
Sorting proteins to their target membranes.
Kidney Int. 2000;57(3):816-24 - PMID: 10720934 - DOI: 10.1046/j.1523-1755.2000.00920.x
Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D
The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.
J Biol Chem. 2000;275(24):18219-24 - PMID: 10748165 - DOI: 10.1074/jbc.M909857199
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM
RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
Mol Biol Cell. 2000;11(9):3155-68 - PMID: 10982407 - PMCID: PMC14982 - DOI: 10.1091/mbc.11.9.3155
Herak-Kramberger CM, Sabolić I, Blanusa M, Smith PJ, Brown D, Breton S
Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis.
Biol Reprod. 2000;63(2):599-606 - PMID: 10906070 - DOI: 10.1095/biolreprod63.2.599
Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D
Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens.
Am J Physiol Cell Physiol. 2000;278(4):C791-802 - PMID: 10751327 - DOI: 10.1152/ajpcell.2000.278.4.C791
Silver RB, Breton S, Brown D
Potassium depletion increases proton pump (H(+)-ATPase) activity in intercalated cells of cortical collecting duct.
Am J Physiol Renal Physiol. 2000;279(1):F195-202 - PMID: 10894802 - DOI: 10.1152/ajprenal.2000.279.1.F195
Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D
Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract.
Am J Physiol Renal Physiol. 2000;278(5):F717-25 - PMID: 10807583 - DOI: 10.1152/ajprenal.2000.278.5.F717
Brown D, Breton S
H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways.
J Exp Biol. 2000;203(Pt 1):137-45 - PMID: 10600682 - DOI: 10.1242/jeb.203.1.137
Sabolić I, Herak-Kramberger CM, Breton S, Brown D
Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval.
J Am Soc Nephrol. 1999;10(5):913-22 - PMID: 10232676 - DOI: 10.1681/ASN.V105913
Shayakul C, Breton S, Brown D, Alper SL
Gene therapy of inherited renal tubular disease.
Am J Kidney Dis. 1999;34(2):374-9 - PMID: 10430991 - DOI: 10.1016/s0272-6386(99)70372-0
Jensen LJ, Stuart-Tilley AK, Peters LL, Lux SE, Alper SL, Breton S
Immunolocalization of AE2 anion exchanger in rat and mouse epididymis.
Biol Reprod. 1999;61(4):973-80 - PMID: 10491632 - DOI: 10.1095/biolreprod61.4.973
Jensen LJ, Schmitt BM, Berger UV, Nsumu NN, Boron WF, Hediger MA, Brown D, Breton S
Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis.
Biol Reprod. 1999;60(3):573-9 - PMID: 10026101 - DOI: 10.1095/biolreprod60.3.573
Breton S, Tyszkowski R, Sabolic I, Brown D
Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis.
Histochem Cell Biol. 1999;111(2):97-105 - PMID: 10090570 - DOI: 10.1007/s004180050339
Breton S, Brown D
Cold-induced microtubule disruption and relocalization of membrane proteins in kidney epithelial cells.
J Am Soc Nephrol. 1998;9(2):155-66 - PMID: 9527391 - DOI: 10.1681/ASN.V92155
Zuk A, Bonventre JV, Brown D, Matlin KS
Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney.
Am J Physiol Cell Physiol. 1998;275(3):C711-C731 - PMID: 29585718 - DOI: 10.1152/ajpcell.1998.275.3.C711
Breton S, Hammar K, Smith PJS, Brown D
Proton secretion in the male reproductive tract: involvement of Cl--independent HCO 3 - transport.
Am J Physiol Cell Physiol. 1998;275(4):C1134-C1142 - PMID: 29585324 - DOI: 10.1152/ajpcell.1998.275.4.C1134
Emma F, Breton S, Morrison R, Wright S, Strange K
Effect of cell swelling on membrane and cytoplasmic distribution of pICln.
Am J Physiol. 1998;274(6 Pt 1):C1545-51 - PMID: 9696697 - DOI: 10.1152/ajpcell.1998.274.6.C1545
Breton S, Hammar K, Smith PJ, Brown D
Proton secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport.
Am J Physiol. 1998;275(4 Pt 1):C1134-42 - PMID: 9755067 - DOI: 10.1152/ajpcell.1998.275.4.C1134
Breton S, Lisanti MP, Tyszkowski R, McLaughlin M, Brown D
Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells.
J Histochem Cytochem. 1998;46(2):205-14 - PMID: 9446827 - DOI: 10.1177/002215549804600209
Brown D, Sabolic I, Breton S
Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways.
Adv Nephrol Necker Hosp. 1998;27:297-315 - PMID: 9408453
Alper SL, Stuart-Tilley AK, Biemesderfer D, Shmukler BE, Brown D
Immunolocalization of AE2 anion exchanger in rat kidney.
Am J Physiol Renal Physiol. 1997;273(4):F601-F614 - PMID: 29587100 - DOI: 10.1152/ajprenal.1997.273.4.F601
Shayakul C, Kanai Y, Lee WS, Brown D, Rothstein JD, Hediger MA
Localization of the high-affinity glutamate transporter EAAC1 in rat kidney.
Am J Physiol Renal Physiol. 1997;273(6):F1023-F1029 - PMID: 29586122 - DOI: 10.1152/ajprenal.1997.273.6.F1023
Kawachi H, Kurihara H, Topham PS, Brown D, Shia MA, Orikasa M, Shimizu F, Salant DJ
Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes.
Am J Physiol Renal Physiol. 1997;273(6):F984-F993 - PMID: 29586119 - DOI: 10.1152/ajprenal.1997.273.6.F984
Brown D, Lee R, Bonventre JV
Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion.
Am J Physiol Renal Physiol. 1997;273(6):F1003-F1012 - PMID: 29586118 - DOI: 10.1152/ajprenal.1997.273.6.F1003
Brown D, Smith PJ, Breton S
Role of V-ATPase-rich cells in acidification of the male reproductive tract.
J Exp Biol. 1997;200(Pt 2):257-62 - PMID: 9050233 - DOI: 10.1242/jeb.200.2.257
Breton S, Smith PJS, Brown D
Presence de cellules acidifiantes dans l'epididyme et le canal deferent: implication de la pompe a protons
Medecine/Sciences. 1997;13:57-61
Breton S, Smith PJ, Lui B, Brown D
Acidification of the male reproductive tract by a proton pumping (H+)-ATPase.
Nature Med. 1996;2(4):470-2 - PMID: 8597961 - DOI: 10.1038/nm0496-470
Brown D, Breton S
Mitochondria-rich, proton-secreting epithelial cells.
J Exp Biol. 1996;199(Pt 11):2345-58 - PMID: 9114500 - DOI: 10.1242/jeb.199.11.2345
Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D
Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice.
Am J Physiol. 1995;269(6 Pt 2):F761-74 - PMID: 8594870 - DOI: 10.1152/ajprenal.1995.269.6.F761
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