Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R
Noninvasive detection of clinically occult lymph-node metastases in prostate cancerN Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749
Weissleder R
Scaling down imaging: molecular mapping of cancer in miceNat Rev Cancer. 2002;2:1-8 - PMID: 11902581 - DOI: 10.1038/nrc701
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T
Restoration of p53 function leads to tumour regression in vivo.Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541
Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R
Magnetic relaxation switches capable of sensing molecular interactionsNat Biotechnol. 2002;20:816-20 - PMID: 12134166 - DOI: 10.1038/nbt720
Weissleder R
A clearer vision for in vivo imagingNat Biotechnol. 2001;19:316-7 - PMID: 11283581 - DOI: 10.1038/86684
Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cellsNat Biotechnol. 2000;18:410-4 - PMID: 10748521 - DOI: 10.1038/74464
Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr
In vivo imaging of tumors with protease-activated near-infrared fluorescent probesNat Biotechnol. 1999;17:375-8 - PMID: 10207887 - DOI: 10.1038/7933
Ntziachristos V, Ripoll J, Wang L, Weissleder R
Looking and Listening to light: the evolution of whole-body photonic imagingNat Biotechnol. 2005;23:313-320 - PMID: 15765087 - DOI: 10.1038/nbt1074
Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L.
Cell-specific targeting of nanoparticles by multivalent attachment of small moleculesNat Biotechnol. 2005;23:1418-1423 - PMID: 16244656 - DOI: 10.1038/nbt1159
Metabolic Biotinylation of Cell Surface Receptors for in vivo ImagingNat Methods. 2006;3(5):391-396 - PMID: 16628210 - DOI: 10.1038/nmeth875
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axisCancer Cell. 2002;1:269-77 - PMID: 12086863 - DOI: 10.1016/s1535-6108(02)00046-6
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.Cancer Cell. 2006;9(6):485-95 - PMID: 16730237 - DOI: 10.1016/j.ccr.2006.04.022
Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R
Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.Circulation. 2004;110(2):170-6 - PMID: 15210587 - DOI: 10.1161/01.CIR.0000134484.11052.44
Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial InfarctionCirculation. 2005;111:1800-1805 - PMID: 15809374 - PMCID: PMC3733536 - DOI: 10.1161/01.CIR.0000160936.91849.9F
Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed G, Jakob P, Rosenzweig A, Bauer W, Weissleder R, Ertl G.
Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial InfarctionCirculation. 2006;113(9):1196-1202 - PMID: 16505171 - PMCID: PMC4066325 - DOI: 10.1161/CIRCULATIONAHA.105.602094
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P
Inflammation in Atherosclerosis. Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo.Circulation. 2006;114:55-62 - PMID: 16801460 - DOI: 10.1161/CIRCULATIONAHA.106.619056
Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis.Circulation. 2006;114:1504-1511 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.Circulation. 2007;115:377-386 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo.Circulation. 2007;115:1384-1391 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.Circulation. 2007;115(17):2292-8 - PMID: 17420353 - DOI: 10.1161/CIRCULATIONAHA.106.660340
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D
Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U.
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiationImmunity. 2006;25(1):129-41 - PMID: 16860762 - DOI: 10.1016/j.immuni.2006.04.015
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C
Particularities of the vasculature can promote the organ specificity of autoimmune attack.Nat Immunol. 2006;7(3):284-92 - PMID: 16444258 - DOI: 10.1038/ni1306
Jaffer F, Libby P, Weissleder R.
Molecular and Cellular Imaging of Atherosclerosis, Emerging ApplicationsJ Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517 - DOI: 10.1016/j.jacc.2006.01.029
Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomasCancer Res. 2004;64:273-8 - PMID: 14729634 - DOI: 10.1158/0008-5472.can-03-1123
Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumorsCancer Res. 2003;63:6838-46 - PMID: 14583481
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineationCancer Res. 2003;63:8122-5 - PMID: 14678964
In vivo imaging of proteolytic enzyme activity using a novel molecular reporterCancer Res. 2000;60:4953-8 - PMID: 10987312
Simonova M, Wall A, Weissleder R, Bogdanov A Jr
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cellsCancer Res. 2000;60:6656-62 - PMID: 11118049
Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R
In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent SwitchCancer Res. 2004;64:1579-1583 - PMID: 14996712 - DOI: 10.1158/0008-5472.can-03-3226
Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L
Magnetic Relaxation Switch Immunosensors Detect Enantiomeric ImpuritiesAngew Chem Int Ed Engl. 2004;43(18):2395-2399 - PMID: 15114571 - DOI: 10.1002/anie.200352998
Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapyCancer Res. 2004;64(9):3236-42 - PMID: 15126365 - DOI: 10.1158/0008-5472.can-03-3516
Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.Cancer Res. 2004;64(12):4069-77 - PMID: 15205313 - DOI: 10.1158/0008-5472.CAN-04-1243
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.Cancer Res. 2004;64(17):6247-51 - PMID: 15342411 - DOI: 10.1158/0008-5472.CAN-04-0817
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imagingCancer Res. 2005;65(18):8324-30 - PMID: 16166309 - DOI: 10.1158/0008-5472.CAN-05-0027
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase InhibitorCancer Res. 2005;65(20):9253-60 - PMID: 16230386 - DOI: 10.1158/0008-5472.CAN-03-2619
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivoCancer Res. 2007;67 (15):7335-7342 - PMID: 17671203 - DOI: 10.1158/0008-5472.CAN-07-0077
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K
MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas.Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999 - DOI: 10.1158/0008-5472.CAN-07-1045
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.Cancer Res. 2007;67(19):9398-406 - PMID: 17909049 - PMCID: PMC2850558 - DOI: 10.1158/0008-5472.CAN-07-1063
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R.
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal NanoparticleCirc Res. 2005;96(3):327-36 - PMID: 15653572 - DOI: 10.1161/01.RES.0000155722.17881.dd
Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R.
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarctCirc Res. 2007;100:1218-1225 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31
Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R
Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological mediaJ Am Chem Soc. 2003;125:10192-3 - PMID: 12926940 - DOI: 10.1021/ja036409g
Perez JM, O'Loughin T, Simeone F J, Weissleder R, Josephson L
DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agentsJ Am Chem Soc. 2002;124:2856-7 - PMID: 11902860 - DOI: 10.1021/ja017773n
Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC
Identification of the target self-antigens in reperfusion injury.J Exp Med. 2006;203(1):141-152 - PMID: 16390934 - PMCID: PMC2118091 - DOI: 10.1084/jem.20050390
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talkJ Exp Med. 2007;204:1911-1922 - PMID: 17646407 - PMCID: PMC2118664 - DOI: 10.1084/jem.20070285
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D.
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetesJ Clin Invest. 2005;115(9):2454-2461 - PMID: 16110329 - PMCID: PMC1187933 - DOI: 10.1172/JCI25048
Long-circulating iron oxides for MR imagingAdv Drug Deliv Rev. 1995;16:321-334
Bogdanov A, Weissleder R, Brady T
Long-circulating blood pool imaging agentsAdv Drug Deliv Rev. 1995;15:335-348
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R
Imaging inflammation of the pancreatic islets in type 1 diabetes.Proc Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109 - DOI: 10.1073/pnas.0404307101
Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.Proc Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472 - DOI: 10.1073/pnas.0401137101
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivoProc Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311 - DOI: 10.1073/pnas.0408197102
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Use of gene expression profiling to direct in vivo molecular imaging of lung cancerProc Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291 - DOI: 10.1073/pnas.0503920102
Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.
Volumetric tomography of fluorescent proteins through small animals in vivoProc Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905 - DOI: 10.1073/pnas.0504628102
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.Proc Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678 - DOI: 10.1073/pnas.0601273103
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A.
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responsesProc Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940 - DOI: 10.1073/pnas.0605496103
Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapyProc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104
Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K
Mast cells are an essential hematopoietic component for polyp development.Proc Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408 - DOI: 10.1073/pnas.0704620104
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Bronson R, Chen J, Weissleder R, Housman D, Charest A.
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesisProc Natl Acad Sci U S A. 0;:ePub
Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O
The progress and promise of molecular imaging probes in oncologic drug development.Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226 - DOI: 10.1158/1078-0432.CCR-05-1302
McCarthy J, Jaffer F, Weissleder R.
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications Small. 2006;2(8-9):983-987 - PMID: 17193154 - DOI: 10.1002/smll.200600139
Sun EY, Weissleder R, Josephson L.
Continuous Analyte Sensing with Magnetic NanoswitchesSmall. 2006;(2) 10:1144-1147 - PMID: 17193579 - DOI: 10.1002/smll.200600204
Perez JM, Simeone FJ, Tsourkas A, Josephson L, Weissleder R
Peroxidase substrate nanosensors for MR imagingNano Lett. 0;4:119-122
McCarthy JR, Perez JM, Brueckner C, Weissleder R
Polymeric Nanoparticle Preparation that Eradicates Tumors.Nano Lett. 2005;5:2552-6 - PMID: 16351214 - DOI: 10.1021/nl0519229
Quinti L, Weissleder R, Tung CH
A Fluorescent Nanosensor for Apoptotic CellsNano Lett. 2006;6 (3):488-490 - PMID: 16522048 - DOI: 10.1021/nl0524694
Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO.
Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivoMol Ther. 2005;11(3):435-43 - PMID: 15727940 - DOI: 10.1016/j.ymthe.2004.10.016
Shah K, Tung CH, Breakefield X, Weissleder R.
In vivo imaging of S-TRAIL-mediated tumor regression and apoptosisMol Ther. 2005;11 (6):926-931 - PMID: 15922963 - DOI: 10.1016/j.ymthe.2005.01.017
Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging.Mol Ther. 2006;4(6):779-88 - PMID: 16996314 - PMCID: PMC2819149 - DOI: 10.1016/j.ymthe.2006.08.008
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B.
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus TherapyJ Natl Cancer Inst. 2007;(99) 23:1768-1781 - PMID: 18042934 - DOI: 10.1093/jnci/djm229
Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regressionAnn Neurol. 2005;57(1):34-41 - PMID: 15622535 - DOI: 10.1002/ana.20306
Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotensionStroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929 - DOI: 10.1161/01.str.30.10.2197
Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R
The development of in vivo imaging systems to study gene expression.Trends Biotechnol. 1998;16(1):5-10 - PMID: 9470227 - DOI: 10.1016/S0167-7799(97)01150-5
Zhao M, Weissleder R
Intracellular cargo delivery using tat peptide and derivativesMed Res Rev. 2004;24:1-12 - PMID: 14595670 - DOI: 10.1002/med.10056
Bogdanov AA, Callahan RJ, Wilkinson RA, Martin C, Cameron JA, Fischman AJ, Brady TJ, Weissleder R
Pittet M, Swirski F, Reynolds F, Josephson L, Weissleder R.
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticlesNat Protoc. 2006;1(1):73-79 - PMID: 17406214 - DOI: 10.1038/nprot.2006.11
Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R
Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in miceRadiology. 2003;226:214-20 - PMID: 12511693 - DOI: 10.1148/radiol.2261012140
Mahmood U, Tung CH, Tang Y, Weissleder R
Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in miceRadiology. 2002;224:446-51 - PMID: 12147841 - DOI: 10.1148/radiol.2242011589
Bremer C, Tung CH, Bogdanov A Jr, Weissleder R
Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypesRadiology. 2002;222:814-8 - PMID: 11867806 - DOI: 10.1148/radiol.2223010812
Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R
Human transferrin receptor gene as a marker gene for MR imagingRadiology. 2001;221:244-50 - PMID: 11568347 - DOI: 10.1148/radiol.2211001784
Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH
Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse modelRadiology. 2001;221:523-9 - PMID: 11687699 - DOI: 10.1148/radiol.2212010368
Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.Radiology. 2004;231(3):659-66 - PMID: 15163807 - DOI: 10.1148/radiol.2313030831
Chen JW, Querol Sans M, Bogdanov Jr A, Weissleder R
Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substratesRadiology. 2006;240 (2):473-81 - PMID: 16864673 - DOI: 10.1148/radiol.2402050994
Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D
Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging.Radiology. 2006;241(3):822-830 - PMID: 17114629 - DOI: 10.1148/radiol.2413050466
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.
Tomographic fluorescence imaging of tumor vascular volume in mice.Radiology. 2007;242 (3):751-758 - PMID: 17325064 - DOI: 10.1148/radiol.2423052065
Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent modelRadiology. 2000;214:568-74 - PMID: 10671613 - DOI: 10.1148/radiology.214.2.r00fe19568
Elizondo G, Weissleder R, Stark DD, Todd LE, Compton C, Wittenberg J, Ferrucci JT
Amebic liver abscess: diagnosis and treatment evaluation with MR imaging.Radiology. 1987;165(3):795-800 - PMID: 2891154 - DOI: 10.1148/radiology.165.3.2891154
Weissleder R, Stark DD, Rummeny EJ, Compton CC, Ferrucci JT
de Marco G, Bogdanov A, Marecos E, Moore A, Simonova M, Weissleder R
MR imaging of gene delivery to the central nervous system with an artificial vector.Radiology. 1998;208(1):65-71 - PMID: 9646794 - DOI: 10.1148/radiology.208.1.9646794
Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A
MR imaging and scintigraphy of gene expression through melanin induction.Radiology. 1997;204(2):425-9 - PMID: 9240530 - DOI: 10.1148/radiology.204.2.9240530
Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R
Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227.Radiology. 1997;202(3):687-91 - PMID: 9051017 - DOI: 10.1148/radiology.202.3.9051017
Harika L, Weissleder R, Poss K, Papisov MI
Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies.Radiology. 1996;198(2):365-70 - PMID: 8596833 - DOI: 10.1148/radiology.198.2.8596833
Gupta H, Wilkinson RA, Bogdanov AA, Callahan RJ, Weissleder R
Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer.Radiology. 1995;197(3):665-9 - PMID: 7480736 - DOI: 10.1148/radiology.197.3.7480736
Bogdanov AA, Weissleder R, Frank HW, Bogdanova AV, Nossif N, Schaffer BK, Tsai E, Papisov MI, Brady TJ
A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies.Radiology. 1993;187(3):701-6 - PMID: 8497616 - DOI: 10.1148/radiology.187.3.8497616
Reimer P, Weissleder R, Wittenberg J, Brady TJ
Receptor-directed contrast agents for MR imaging: preclinical evaluation with affinity assays.Radiology. 1992;182(2):565-9 - PMID: 1732982 - DOI: 10.1148/radiology.182.2.1732982
Weissleder R, Lee AS, Khaw BA, Shen T, Brady TJ
Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging.Radiology. 1992;182(2):381-5 - PMID: 1732953 - DOI: 10.1148/radiology.182.2.1732953
Polyclonal human immunoglobulin G labeled with polymeric iron oxide: antibody MR imaging.Radiology. 1991;181(1):245-9 - PMID: 1887040 - DOI: 10.1148/radiology.181.1.1887040
Hahn PF, Stark DD, Lewis JM, Saini S, Elizondo G, Weissleder R, Fretz CJ, Ferrucci JT
First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging.Radiology. 1990;175(3):695-700 - PMID: 2343116 - DOI: 10.1148/radiology.175.3.2343116
Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.Radiology. 1990;175(2):494-8 - PMID: 2326475 - DOI: 10.1148/radiology.175.2.2326475
Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.Radiology. 1990;175(2):489-93 - PMID: 2326474 - DOI: 10.1148/radiology.175.2.2326474
Elizondo G, Weissleder R, Stark DD, Guerra J, Garza J, Fretz CJ, Todd LE, Ferrucci JT
Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide.Radiology. 1990;174(3 Pt 1):797-801 - PMID: 2305063 - DOI: 10.1148/radiology.174.3.2305063
Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferrucci JT
Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors.Radiology. 1990;174(2):361-6 - PMID: 2296646 - DOI: 10.1148/radiology.174.2.2296646
Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT
Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer.Radiology. 1989;172(2):393-7 - PMID: 2748820 - DOI: 10.1148/radiology.172.2.2748820
Dousset M, Weissleder R, Hendrick RE, Stark DD, Fretz CJ, Elizondo G, Hahn PF, Saini S, Ferrucci JT
Short TI inversion-recovery imaging of the liver: pulse-sequence optimization and comparison with spin-echo imaging.Radiology. 1989;171(2):327-33 - PMID: 2704797 - DOI: 10.1148/radiology.171.2.2704797
Rummeny E, Weissleder R, Sironi S, Stark DD, Comptom CC, Hahn PF, Saini S, Wittenberg J, Ferrucci JT
Central scars in primary liver tumors: MR features, specificity, and pathologic correlation.Radiology. 1989;171(2):323-6 - PMID: 2539605 - DOI: 10.1148/radiology.171.2.2539605
Weissleder H, Weissleder R
Interstitial lymphangiography: initial clinical experience with a dimeric nonionic contrast agent.Radiology. 1989;170(2):371-4 - PMID: 2911660 - DOI: 10.1148/radiology.170.2.2911660
Weissleder R, Hahn PF, Stark DD, Elizondo G, Saini S, Todd LE, Wittenberg J, Ferrucci JT
Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging.Radiology. 1988;169(2):399-403 - PMID: 3174987 - DOI: 10.1148/radiology.169.2.3174987
Stark DD, Weissleder R, Elizondo G, Hahn PF, Saini S, Todd LE, Wittenberg J, Ferrucci JT
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.Radiology. 1988;168(2):297-301 - PMID: 3393649 - DOI: 10.1148/radiology.168.2.3393649
Weissleder H, Weissleder R
Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients.Radiology. 1988;167(3):729-35 - PMID: 3363131 - DOI: 10.1148/radiology.167.3.3363131
Tsang YM, Stark DD, Chen MC, Weissleder R, Wittenberg J, Ferrucci JT
Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetesDiabetes. 2001;50:2231-6 - PMID: 11574403 - DOI: 10.2337/diabetes.50.10.2231
McCarthy J, Kelly KA, Sun EY, Weissleder R.
Targeted delivery of multifunctional magnetic nanoparticlesNanomedicine. 2007;2(2):153-167 - PMID: 17716118 - DOI: 10.2217/17435889.2.2.153
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458 - DOI: 10.1002/art.20379
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214 - DOI: 10.1002/art.22303
Shah K, Tang Y, Breakefield X, Weissleder R
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivoOncogene. 2003;22:6865-72 - PMID: 14534533 - DOI: 10.1038/sj.onc.1206748
Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R.
Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomyInt J Radiat Oncol Biol Phys. 2005;63(4):1262-9 - PMID: 16253781 - DOI: 10.1016/j.ijrobp.2005.07.952
Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R.
Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent ProteinAnal Chem. 2005;77:2862-2867 - PMID: 15859603 - DOI: 10.1021/ac0480747
Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probeArterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227 - DOI: 10.1161/01.atv.0000033089.56970.2d
Querol M, Chen JW, Weissleder R, Bogdanov A Jr.
DTPA-bisamide-Based MR Sensor Agents for Peroxidase ImagingOrg Lett. 2005;7(9):1719-22 - PMID: 15844889 - DOI: 10.1021/ol050208v
Hilderbrand S, Weissleder R.
Optimized pH-responsive cyanine fluorochromes for detection of acidic environmentsChem Commun. 2007;(26):2747-9 - PMID: 17594041 - DOI: 10.1039/b703764c
Kim YM, Hilderbrand S, Weissleder R, Tung CH
Sugar sensing based on induced pH changesChem Commun. 2007;(22):2299-2301 - PMID: 17534523 - DOI: 10.1039/b700741h
Yuan H, Luo J, Weissleder R, Cantley L, Josephson L
Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.Chem Biol. 2007;14:1221-31 - PMID: 18022561 - PMCID: PMC2785040 - DOI: 10.1016/j.chembiol.2007.10.005
Kozloff KM, Weissleder R, Mahmood U
Non-Invasive Optical Detection of Bone Mineral.J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196 - DOI: 10.1359/jbmr.070504
Law B, Weissleder R, Tung CH
Peptide-based Biomaterials for Protease-Enhanced Drug DeliveryBiomacromolecules. 2006;7(4):1261-1265 - PMID: 16602747 - DOI: 10.1021/bm050920f
Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L
Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitroNeoplasia. 2003;5:205-17 - PMID: 12869304 - PMCID: PMC1502407 - DOI: 10.1016/S1476-5586(03)80053-2
Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO
Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2Neoplasia. 2002;4:501-9 - PMID: 12407444 - PMCID: PMC1503664 - DOI: 10.1038/sj.neo.7900265
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic modelNeoplasia. 2002;4:3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209
Ichikawa T, Hogemann D, Saeki Y, Tyminski E, Terada K, Weissleder R, Chiocca EA, Basilion JP
MRI of transgene expression: correlation to therapeutic gene expressionNeoplasia. 2002;4:523-30 - PMID: 12407446 - PMCID: PMC1503666 - DOI: 10.1038/sj.neo.7900266
Bogdanov AA Jr, Lin CP, Simonova M, Matuszewski L, Weissleder R
Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironmentNeoplasia. 2002;4:228-36 - PMID: 11988842 - PMCID: PMC1531696 - DOI: 10.1038/sj/neo/7900238
Bogdanov A Jr, Marecos E, Cheng HC, Chandrasekaran L, Krutzsch HC, Roberts DD, Weissleder R
Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging studyNeoplasia. 1999;1:438-45 - PMID: 10933059 - PMCID: PMC1508110 - DOI: 10.1038/sj.neo.7900044
Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.Neoplasia. 2004;6(2):95-105 - PMID: 15140398 - PMCID: PMC1502090 - DOI: 10.1593/neo.03214
Shinde Patil VR, Friedrich EB, Wolley AE, Gerszten RE, Allport JR, Weissleder R.
Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung CarcinomaNeoplasia. 2005;7(3):234-40 - PMID: 15799823 - PMCID: PMC1501134 - DOI: 10.1593/neo.04523
Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr.
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma modelNeoplasia. 2005;7(9):847-53 - PMID: 16229807 - PMCID: PMC1351316 - DOI: 10.1593/neo.05139
Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L.
Nanoparticles for the Optical Imaging of Tumor E-selectinNeoplasia. 2005;7(10):904-11 - PMID: 16242073 - DOI: 10.1593/neo.05352
Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R
Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.Neoplasia. 2006;8(9):772-80 - PMID: 16984734 - PMCID: PMC1584300 - DOI: 10.1593/neo.06331
Kelly KA, Waterman P, Weissleder R.
In vivo imaging of molecularly targeted phageNeoplasia. 2006;8 (12):1011-1018
Kock N, Kasmieh R, Weissleder R, Shah K
Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL.Neoplasia. 2007;9(5):435-42 - PMID: 17534449 - PMCID: PMC1877976 - DOI: 10.1593/neo.07223
Harisinghani M, Ross R, Guimaraes A, Weissleder R
Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer StagingNeoplasia. 2007;(9)12:1160-1165 - PMID: 18084623 - PMCID: PMC2134912 - DOI: 10.1593/neo.07940
Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D.
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosisJ Cereb Blood Flow Metab. 2005;25(2):226-33 - PMID: 15678125 - DOI: 10.1038/sj.jcbfm.9600023
Mahmood U, Weissleder R
Near-infrared optical imaging of proteases in cancerMol Cancer Ther. 2003;2:489-96 - PMID: 12748311
Law B, Quinti L, Choi YD, Weissleder R, Tung CH
A Mitochondrial Targeted Fusion Peptide Exhibits Remarkable CytotoxicityMol Cancer Ther. 2006;5 (8):1944-1949 - PMID: 16928814 - DOI: 10.1158/1535-7163.MCT-05-0509
Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palu G, Irimia D, Toner M, Weissleder R, Poznansky MC
Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control.J Immunol. 2006;176(5):2902-14 - PMID: 16493048 - DOI: 10.4049/jimmunol.176.5.2902
Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity.J Immunol. 2006;177:6991-8 - PMID: 17082614 - DOI: 10.4049/jimmunol.177.10.6991
Frank H, Loewe R, Loewe C, Oberhuber G, Schwaighofer B, Huber K, Weissleder R
Efficacy of thrombolytic therapy in pulmonary embolism determined by MION-enhanced MRA: an experimental study in rabbits.Invest Radiol. 1998;33(12):853-7 - PMID: 9851818 - DOI: 10.1097/00004424-199812000-00002
Cheng HC, Khan MA, Bogdanov A, Kwong K, Weissleder R
Relative blood volume measurements by magnetic resonance imaging facilitate detection of testicular torsion.Invest Radiol. 1997;32(12):763-9 - PMID: 9406017 - DOI: 10.1097/00004424-199712000-00007
Schulze E, Ferrucci JT, Poss K, Lapointe L, Bogdanova A, Weissleder R
Cellular uptake and trafficking of a prototypical magnetic iron oxide label in vitro.Invest Radiol. 1995;30(10):604-10 - PMID: 8557500 - DOI: 10.1097/00004424-199510000-00006
Weissleder R, Bogdanov A, Frank H, Nossiff N, Bogdanova A, Schaffer BK, Brady T, Wittenberg J
AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy.Invest Radiol. 1993;28(12):1083-9 - PMID: 8307710 - DOI: 10.1097/00004424-199312000-00001
Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.RNA. 2006;12(5):797-806 - PMID: 16556935 - PMCID: PMC1440893 - DOI: 10.1261/rna.2300406
Bredow S, Lewin M, Hofmann B, Marecos E, Weissleder R
Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglinEur J Cancer. 2000;36:675-81 - PMID: 10738134 - DOI: 10.1016/s0959-8049(99)00335-4
Weissleder R, Cheng HC, Marecos E, Kwong K, Bogdanov A
Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions.Eur J Cancer. 1998;34(9):1448-54 - PMID: 9849430 - DOI: 10.1016/s0959-8049(98)00195-6
Galande A, Weissleder R, Tung CH.
An Effective Method of On-Resin Disulfide Bond Formation in PeptidesJ Comb Chem. 2005;7:174-177 - PMID: 15762743 - DOI: 10.1021/cc049839r
Weissleder R, Marfil A, Martinez HR, Rangel-Guerra RA
Limb girdle type muscular dystrophy associated with a Wolff-Parkinson-White syndrome.J Neurol Neurosurg Psych. 1987;50(4):500-1 - PMID: 3585373 - PMCID: PMC1031899 - DOI: 10.1136/jnnp.50.4.500
Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R
Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.Exp Neurol. 1997;143(1):61-9 - PMID: 9000446 - DOI: 10.1006/exnr.1996.6350
Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R
MR imaging of slow axonal transport in vivo.Exp Neurol. 1993;123(2):235-42 - PMID: 8405287 - DOI: 10.1006/exnr.1993.1156
Bogdanov A Jr, Tung CH, Bredow S, Weissleder R
DNA binding chelates for nonviral gene delivery imagingGene Ther. 2001;8:515-22 - PMID: 11319618 - DOI: 10.1038/sj.gt.3301410
Schellingerhout D, Rainov NG, Breakefield XO, Weissleder R
Quantitation of HSV mass distribution in a rodent brain tumor modelGene Ther. 2000;7:1648-55 - PMID: 11083473 - DOI: 10.1038/sj.gt.3301272
Shah K, Jacobs A, Breakefield XO, Weissleder R
Molecular imaging of gene therapy for cancerGene Ther. 2004;11(15):1175-87 - PMID: 15141158 - DOI: 10.1038/sj.gt.3302278
Design of metal-binding green fluorescent protein variants.Biochim Biophys Acta. 1998;1397(1):56-64 - PMID: 9545533 - DOI: 10.1016/s0167-4781(97)00221-2
Bogdanov AA, Martin C, Weissleder R, Brady TJ
Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes.Biochim Biophys Acta. 1994;1193(1):212-8 - PMID: 7518693 - DOI: 10.1016/0005-2736(94)90350-6
Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A
Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.Antimicrob Agents Chemother. 1995;39(4):839-45 - PMID: 7785981 - PMCID: PMC162639 - DOI: 10.1128/aac.39.4.839
Tung CH, Quinti L, Jaffer F, Weissleder R
A Branched Fluorescent Peptide Probe for Imaging of Activated PlateletsMol Pharmacol. 2005;2:92-95 - PMID: 15804182 - DOI: 10.1021/mp0499048
Chen WT, Mahmood U, Weissleder R, Tung CH
Arthritis imaging using a near-infrared fluorescence folate-targeted probeArthritis Res Ther. 2005;7:R310-R317 - PMID: 15743478 - PMCID: PMC1065321 - DOI: 10.1186/ar1483
Graves EE, Weissleder R, Ntziachristos V
Fluorescence molecular imaging of small animal tumor models.Curr Mol Med. 2004;4(4):419-30 - PMID: 15354872 - DOI: 10.2174/1566524043360555
Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.Am J Pathol. 1995;147(6):1840-51 - PMID: 7495307 - PMCID: PMC1869962
Zacharakis G, Ripoll J, Weissleder R, Ntziachristos V.
Fluorescent protein tomography scanner for small animal imagingIEEE T Med Imaging. 2005;24(7):878-85 - PMID: 16011317 - DOI: 10.1109/tmi.2004.843254
Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R
In vivo tracking of neural progenitor cell migration to glioblastomasHum Gene Ther. 2003;14:1247-54 - PMID: 12952596 - DOI: 10.1089/104303403767740786
Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.Hum Gene Ther. 2005;16:1367-76 - PMID: 16390268 - DOI: 10.1089/hum.2005.16.1367
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.Hum Gene Ther. 2006;17(1):20-30 - PMID: 16409122 - DOI: 10.1089/hum.2006.17.20
Schellingerhout D, Bogdanov A, Marecos E, Spear M, Breakefield X, Weissleder R
Mapping the in vivo distribution of herpes simplex virions.Hum Gene Ther. 1998;9(11):1543-9 - PMID: 9694153 - DOI: 10.1089/hum.1998.9.11-1543
Rainov NG, Zimmer C, Chase M, Kramm CM, Chiocca EA, Weissleder R, Breakefield XO
Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.Hum Gene Ther. 1995;6(12):1543-52 - PMID: 8664379 - DOI: 10.1089/hum.1995.6.12-1543
Kang HW, Torres D, Wald L, Weissleder R, Bogdanov AA
Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer.Lab Invest. 2006;86(6):599-609 - PMID: 16607378 - DOI: 10.1038/labinvest.3700421
Montet X, Yuan H, Weissleder R, Josephson L
Enzyme-based visualization of receptor-ligand binding in tissues.Lab Invest. 2006;86(5):517-25 - PMID: 16568109 - DOI: 10.1038/labinvest.3700404
Kang HW, Weissleder R, Bogdanov A Jr
Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitroAmino Acids. 2002;23:301-8 - PMID: 12373551 - DOI: 10.1007/s00726-001-0142-2
Pham W, Lai WF, Weissleder R, Tung CH
High efficiency synthesis of a bioconjugatable near-infrared fluorochromeBioconjug Chem. 2003;14:1048-51 - PMID: 13129411 - DOI: 10.1021/bc034070h
Moon, WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugateBioconjug Chem. 2003;14:539-45 - PMID: 12757377 - DOI: 10.1021/bc0340114
Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cellsBioconjug Chem. 2003;14:1115-21 - PMID: 14624624 - DOI: 10.1021/bc034123v
Zhao M, Kircher MF, Josephson L, Weissleder R
Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptakeBioconjug Chem. 2002;13:840-4 - PMID: 12121140 - DOI: 10.1021/bc0255236
Wunderbaldinger P, Josephson L, Weissleder R
Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticlesBioconjug Chem. 2002;13:264-8 - PMID: 11906263 - DOI: 10.1021/bc015563u
Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A Jr
Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell cultureBioconjug Chem. 2002;13:122-7 - PMID: 11792187 - DOI: 10.1021/bc0155521
Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R
Hogemann D, Ntziachristos V, Josephson L, Weissleder R
High throughput magnetic resonance imaging for evaluating targeted nanoparticle probesBioconjug Chem. 2002;13:116-21 - PMID: 11792186 - DOI: 10.1021/bc015549h
Weissleder R, Bogdanov A Jr, Tung CH, Weinmann HJ
Size optimization of synthetic graft copolymers for in vivo angiogenesis imagingBioconjug Chem. 2001;12:213-9 - PMID: 11312682 - DOI: 10.1021/bc000091p
Improvement of MRI probes to allow efficient detection of gene expressionBioconjug Chem. 2000;11:941-6 - PMID: 11087345 - DOI: 10.1021/bc000079x
Bhorade R, Weissleder R, Nakakoshi T, Moore A, Tung CH
Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptideBioconjug Chem. 2000;11:301-5 - PMID: 10821645 - DOI: 10.1021/bc990168d
Tung CH, Bredow S, Mahmood U, Weissleder R
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imagingBioconjug Chem. 1999;10:892-6 - PMID: 10502358 - DOI: 10.1021/bc990052h
Josephson L, Tung CH, Moore A, Weissleder R
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugatesBioconjug Chem. 1999;10:186-91 - PMID: 10077466 - DOI: 10.1021/bc980125h
Kircher MF, Weissleder R, Josephson L
A dual fluorochrome probe for imaging proteasesBioconjug Chem. 2004;15:242-8 - PMID: 15025519 - DOI: 10.1021/bc034151d
Banerjee P, Reichardt W, Weissleder R, Bogdanov A Jr
Novel hyperbranched dendron for gene transfer in vitro and in vivo.Bioconjug Chem. 2004;15(5):960-8 - PMID: 15366948 - DOI: 10.1021/bc0342128
Schellenberger EA, Sosnovik D, Weissleder R, Josephson L
Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing.Bioconjug Chem. 2004;15(6):1403-1407 - PMID: 15546208 - DOI: 10.1021/bc049924s
Metelev V, Weissleder R, Bogdanov A Jr
Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys.Bioconjug Chem. 2004;15(6):1481-1487 - PMID: 15546218 - DOI: 10.1021/bc049916b
Tsourkas A, Shinde-Patil VR, Kelly KA, Patel P, Wolley A, Allport JR, Weissleder R.
In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical ProbeBioconjug Chem. 2005;(3):576-581 - PMID: 15898724 - DOI: 10.1021/bc050002e
Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L.
Synthesis and Activity of C11-Modified Wortmannin Probes for P13 KinaseBioconjug Chem. 2005;(3):669-675 - PMID: 15898736 - DOI: 10.1021/bc049714f
Reynolds F, Weissleder R, Josephson L.
Protamine as an efficient membrane-translocating PeptideBioconjug Chem. 2005;16(5):1240-5 - PMID: 16173804 - DOI: 10.1021/bc0501451
Development of nanoparticle libraries for biosensing.Bioconjug Chem. 2006;17(1):109-13 - PMID: 16417258 - DOI: 10.1021/bc050290e
Banerjee P, Weissleder R, Bogdanov A
Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core: A Copolymer for Gene Delivery.Bioconjug Chem. 2006;17(1):125-31 - PMID: 16417260 - DOI: 10.1021/bc050083e
Galande A, Weissleder R, Tung CH.
Fluorescence Probe with a pH-Sensitive TriggerBioconjug Chem. 2006;17 (2):255-257 - PMID: 16536452 - DOI: 10.1021/bc050330e
Montet X, Weissleder R, Josephson L.
Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreasBioconjug Chem. 2006;17(4):905-911 - PMID: 16848396 - DOI: 10.1021/bc060035+
Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L
Fate of a Bioactive Fluorescent Wortmannin Derivative in Cells.Bioconjug Chem. 2007;19:130-137 - PMID: 17988080 - DOI: 10.1021/bc7002204
Marecos E, Weissleder R, Bogdanov A
Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model.Bioconjug Chem. 1998;9(2):184-91 - PMID: 9548533 - DOI: 10.1021/bc970146w
Shen TT, Bogdanov A, Bogdanova A, Poss K, Brady TJ, Weissleder R
Bogdanov AA, Martin C, Bogdanova AV, Brady TJ, Weissleder R
An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties.Bioconjug Chem. 1996;7(1):144-9 - PMID: 8742003 - DOI: 10.1021/bc950089b
Shah K, Weissleder R
Molecular Optical Imaging: Applications Leading to the Development of Present Day TherapeuticsNeuroRx. 2005;2:215-225 - PMID: 15897946 - PMCID: PMC1064987 - DOI: 10.1602/neurorx.2.2.215
Wunderbaldinger P, Josephson L, Weissleder R
Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agentsAcad Radiol. 2002;9 Suppl 2:S304-6 - PMID: 12188255 - DOI: 10.1016/s1076-6332(03)80210-6
Schellenberger EA, Hogemann D, Josephson L, Weissleder R
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRIAcad Radiol. 2002;9 Suppl 2:S310-1 - PMID: 12188257 - DOI: 10.1016/s1076-6332(03)80212-x
Ntziachristos, V, Bremer C, Tung C, Weissleder R
Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT)Acad Radiol. 2002;9 Suppl 2:S323-5 - PMID: 12188262 - DOI: 10.1016/s1076-6332(03)80217-9
Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging.PLoS ONE. 2007;2:e665 - PMID: 17653285 - PMCID: PMC1919420 - DOI: 10.1371/journal.pone.0000665
Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.PLoS ONE. 2007;2(10):e1075 - PMID: 17957257 - PMCID: PMC2034600 - DOI: 10.1371/journal.pone.0001075
Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY
Neural stem cell biology may be well suited for improving brain tumor therapiesCancer J. 2003;9:189-204 - PMID: 12952304 - DOI: 10.1097/00130404-200305000-00007
Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R
High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT.Am J Physiol-Heart C. 2007;292(6):3172-8 - PMID: 17322414 - PMCID: PMC2680216 - DOI: 10.1152/ajpheart.01307.2006
Montet X, Rajopadhye M, Weissleder R.
An albumin-activated far-red fluorochrome for in vivo imagingChemMedChem. 2006;1(1):66-69 - PMID: 16892337 - DOI: 10.1002/cmdc.200500028
Choi YD, McCarthy J, Weissleder R, Tung CH
Conjugation of a Photosensitizer to an Oligoarginine-based Cell-penetrating Peptide Increases the Efficacy of Photodynamic TherapyChemMedChem. 2006;1(4):458-463 - PMID: 16892381 - DOI: 10.1002/cmdc.200500036
Choi Y, Weissleder R, Tung CH
Protease-mediated phototoxicity of a polylysine-chlorin(E6) conjugate.ChemMedChem. 2006;1:698-701 - PMID: 16902920 - DOI: 10.1002/cmdc.200600053
McCarthy JR, Weissleder R
Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins.ChemMedChem. 2007;2:360-365 - PMID: 17245681 - DOI: 10.1002/cmdc.200600244
Reimer P, Bader A, Weissleder R
Application of a stable cell culture assay for the functional assessment of novel MR contrast agents.Eur Radiol. 1997;7(4):527-31 - PMID: 9204333 - DOI: 10.1007/s003300050197
Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD
A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRIMol Imaging. 2003;2:324-32 - PMID: 14717331 - DOI: 10.1162/15353500200303163
Lin Y, Weissleder R, Tung CH
Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imagingMol Imaging. 2003;2:87-92 - PMID: 12964306 - DOI: 10.1162/15353500200303121
Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R
Pan and sentinel lymph node visualization using a near-infrared fluorescent probeMol Imaging. 2003;2:18-23 - PMID: 12926234 - DOI: 10.1162/15353500200302154
Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U
Miniaturized multichannel near infrared endoscope for mouse imagingMol Imaging. 2003;2:350-7 - PMID: 14717334 - DOI: 10.1162/15353500200303166
Schellingerhout D, Accorsi R, Mahmood U, Idoine J, Lanza RC, Weissleder R
Coded aperture nuclear scintigraphy: a novel small animal imaging techniqueMol Imaging. 2002;1:344-53 - PMID: 12926230 - DOI: 10.1162/15353500200221362
Schellenberger EA, Bogdanov A Jr, Hogemann D, Tait J, Weissleder R, Josephson L
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRIMol Imaging. 2002;1:102-7 - PMID: 12920851 - DOI: 10.1162/15353500200202103
Ntziachristos, V, Bremer C, Graves EE, Ripoll J, Weissleder R
In vivo tomographic imaging of near-infrared fluorescent probesMol Imaging. 2002;1:82-8 - PMID: 12920848 - DOI: 10.1162/15353500200201121
Kircher MF, Josephson L, Weissleder R
Ratio imaging of enzyme activity using dual wavelength optical reportersMol Imaging. 2003;1:89-95 - PMID: 12920849 - DOI: 10.1162/15353500200201124
Bogdanov A Jr, Matuszewski L, Bremer C, Petrovsky A, Weissleder R
Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targetsMol Imaging. 2002;1:16-23 - PMID: 12920857 - DOI: 10.1162/15353500200200001
Jaffer F, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent NanomaterialsMol Imaging. 2006;(5) 2 :85-92 - PMID: 16954022
Zacharakis G, Shih H, Ripoll J, Weissleder R, Ntziachristos V
Normalized transillumination of fluorescent proteins in small animals.Mol Imaging. 2006;5 (2):153-9 - PMID: 16954030
Montet-Abou K, Montet X, Weissleder R, Josephson L
Cell internalization of magnetic nanoparticles using transfection agents.Mol Imaging. 2007;(6) 1:1-9 - PMID: 17311760
Sheth RA, Upadhyay R, Weissleder R, Mahmood U
Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems.Mol Imaging. 2007;6(3):147-55 - PMID: 17532881
Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.Mol Imaging. 2007;6(4):269-76 - PMID: 17711782
Ntziachristos V, Weissleder R
Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation.Opt Lett. 2001;26(12):893-5 - PMID: 18040483 - DOI: 10.1364/ol.26.000893
Ntziachristos V, Ripoll J, Weissleder R
Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata.Opt Lett. 2002;27(18):1652 - PMID: 18026531 - DOI: 10.1364/ol.27.001652
Ripoll J, Nieto-Vesperinas M, Weissleder R, Ntziachristos V
Fast analytical approximation for arbitrary geometries in diffuse optical tomography.Opt Lett. 2002;27(7):527-9 - PMID: 18007854 - DOI: 10.1364/ol.27.000527
Ntziachristos V, Ripoll J, Weissleder R
Would near-infrared fluorescence signals propagate through large human organs for clinical studies?Opt Lett. 2002;27(5):333-5 - PMID: 18007794 - DOI: 10.1364/ol.27.000333
Allport JR, Shinde Patil VR, Weissleder R
Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms.Cancer Biol Ther. 2004;3(9):838-44 - PMID: 15254391 - DOI: 10.4161/cbt.3.9.1036
Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R
Detection of lymph node metastases by contrast-enhanced MRI in an experimental modelMagn Reson Med. 2002;47:292-7 - PMID: 11810672 - DOI: 10.1002/mrm.10068
Moore, A, Sun PZ, Cory D, Hogemann D, Weissleder R, Lipes MA
MRI of insulitis in autoimmune diabetesMagn Reson Med. 2002;47:751-8 - PMID: 11948737 - DOI: 10.1002/mrm.10110
Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A Jr
Measurement of tumor interstitial volume fraction: Method and implication for drug deliveryMagn Reson Med. 2004;52(3):485-94 - PMID: 15334566 - DOI: 10.1002/mrm.20182
Chen JW, Pham W, Weissleder R, Bogdanov A Jr
Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis.Magn Reson Med. 2004;52(5):1021-8 - PMID: 15508166 - DOI: 10.1002/mrm.20270
Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L.
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticleMagn Reson Med. 2005;54(3):718-724 - PMID: 16086367 - DOI: 10.1002/mrm.20617
Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction.Magn Reson Med. 1998;40(5):666-78 - PMID: 9797148 - DOI: 10.1002/mrm.1910400504
Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation.Magn Reson Med. 1998;39(4):615-24 - PMID: 9543424 - DOI: 10.1002/mrm.1910390415
Mandeville JB, Moore J, Chesler DA, Garrido L, Weissleder R, Weisskoff RM
Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast.Magn Reson Med. 1997;37(6):885-90 - PMID: 9178240 - DOI: 10.1002/mrm.1910370613
Use of magnetic nanoparticles as nanosensors to probe for molecular interactionsChembiochem. 2004;5:261-4 - PMID: 14997516 - DOI: 10.1002/cbic.200300730
Schellenberger EA, Reynolds F, Weissleder R, Josephson L
Optimal modification of annexin v with fluorescent dyesChembiochem. 2004;5:271-4 - PMID: 14997518 - DOI: 10.1002/cbic.200300741
Pham W, Kircher MF, Weissleder R, Tung CH
Enhancing membrane permeability by Fatty acylation of oligoarginine peptides.Chembiochem. 2004;5(8):1148-51 - PMID: 15300843 - DOI: 10.1002/cbic.200400063
Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L.
Transport Of Surface-Modified Nanoparticles Through Cell MonolayersChembiochem. 2005;6(2):337-345 - PMID: 15651046 - DOI: 10.1002/cbic.200400174
Law B, Weissleder R, Tung CH.
Mechanism-Based Fluorescent Reporter for Protein Kinase A DetectionChembiochem. 2005;6(8):1361-1367 - PMID: 16010698 - DOI: 10.1002/cbic.200500027
Ho NH, Weissleder R, Tung CH
A Self-Immolative Reporter For beta-Galactosidase Sensing.Chembiochem. 2007;8:560-566 - PMID: 17300128 - DOI: 10.1002/cbic.200600386
Remsen LG, McCormick CI, Roman-Goldstein S, Nilaver G, Weissleder R, Bogdanov A, Hellström I, Kroll RA, Neuwelt EA
MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis.AJNR Am J Neuroradiol. 1996;17(3):411-8 - PMID: 8881233 - PMCID: PMC8337991
Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.J Neurosurg. 2006;105:445-54 - PMID: 16961141 - DOI: 10.3171/jns.2006.105.3.445
Tung CH, Mueller S, Weissleder R
Novel branching membrane translocational peptide as gene delivery vectorBioorg Med Chem. 2002;10:3609-14 - PMID: 12213476 - DOI: 10.1016/s0968-0896(02)00248-1
Ho NH, Weissleder R, Tung CH
Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate.Bioorg Med Chem. 2006;16:2599-2602 - PMID: 16517162 - DOI: 10.1016/j.bmcl.2006.02.045
Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cellsCancer Gene Ther. 2001;8:506-11 - PMID: 11498772 - DOI: 10.1038/sj.cgt.7700334
Moore A, Marecos E, Simonova M, Weissleder R, Bogdanov A
Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis.Microvasc Res. 1998;56(3):145-53 - PMID: 9828152 - DOI: 10.1006/mvre.1998.2102
Graves EE, Ripoll J, Weissleder R, Ntziachristos V
A submillimeter resolution fluorescence molecular imaging system for small animal imagingMed Phys. 2003;30:901-11 - PMID: 12772999 - DOI: 10.1118/1.1568977
Ntziachristos V, Weissleder R
Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid mediaMed Phys. 2002;29:803-9 - PMID: 12033576 - DOI: 10.1118/1.1470209
O'Neill MJ, Weissleder R, Gervais DA, Hahn PF, Mueller PR
Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of malignant ascitesAJR Am J Roentgenol. 2001;177:615-8 - PMID: 11517056 - DOI: 10.2214/ajr.177.3.1770615
MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlationAJR Am J Roentgenol. 1999;172:1347-51 - PMID: 10227514 - DOI: 10.2214/ajr.172.5.10227514
Harisinghani MG, Saksena MA, Hahn PF, King B, Kim J, Torabi MT, Weissleder R
Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?AJR Am J Roentgenol. 2006;186(1):144-8 - PMID: 16357394 - DOI: 10.2214/AJR.04.1287
Saksena M, Harisinghani M, Hahn P, Kim J, Saokar A, King B, Weissleder R
Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers.AJR Am J Roentgenol. 2006;187(6):W582-8 - PMID: 17114509 - DOI: 10.2214/AJR.05.0873
Weissleder R, Hahn PF, Stark DD, Rummeny E, Saini S, Wittenberg J, Ferrucci JT
MR imaging of splenic metastases: ferrite-enhanced detection in rats.AJR Am J Roentgenol. 1987;149(4):723-6 - PMID: 3498320 - DOI: 10.2214/ajr.149.4.723
Callahan RJ, Bogdanov A, Fischman AJ, Brady TJ, Weissleder R
Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging.AJR Am J Roentgenol. 1998;171(1):137-43 - PMID: 9648777 - DOI: 10.2214/ajr.171.1.9648777
Weissleder R
Can gadolinium be safely given in renal failure?AJR Am J Roentgenol. 1996;167(1):278-9 - PMID: 8659405 - DOI: 10.2214/ajr.167.1.8659405
Lu DS, Saini S, Hahn PF, Goldberg M, Lee MJ, Weissleder R, Gerard B, Halpern E, Cats A
T2-weighted MR imaging of the upper part of the abdomen: should fat suppression be used routinely?AJR Am J Roentgenol. 1994;162(5):1095-100 - PMID: 8165989 - DOI: 10.2214/ajr.162.5.8165989
Frank H, Weissleder R, Bogdanov AA, Brady TJ
Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits.AJR Am J Roentgenol. 1994;162(5):1041-6 - PMID: 8165978 - DOI: 10.2214/ajr.162.5.8165978
Frank H, Weissleder R, Brady TJ
Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals.AJR Am J Roentgenol. 1994;162(1):209-13 - PMID: 8273667 - DOI: 10.2214/ajr.162.1.8273667
Weissleder R, Reimer P, Lee AS, Wittenberg J, Brady TJ
MR receptor imaging: ultrasmall iron oxide particles targeted to asialoglycoprotein receptors.AJR Am J Roentgenol. 1990;155(6):1161-7 - PMID: 2122660 - DOI: 10.2214/ajr.155.6.2122660
Fretz CJ, Stark DD, Metz CE, Elizondo G, Weissleder R, Shen JH, Wittenberg J, Simeone J, Ferrucci JT
Detection of hepatic metastases: comparison of contrast-enhanced CT, unenhanced MR imaging, and iron oxide-enhanced MR imaging.AJR Am J Roentgenol. 1990;155(4):763-70 - PMID: 2119106 - DOI: 10.2214/ajr.155.4.2119106
Hahn PF, Stark DD, Saini S, Rummeny E, Elizondo G, Weissleder R, Wittenberg J, Ferrucci JT
The differential diagnosis of ringed hepatic lesions in MR imaging.AJR Am J Roentgenol. 1990;154(2):287-90 - PMID: 2153330 - DOI: 10.2214/ajr.154.2.2153330
Rummeny E, Saini S, Stark DD, Weissleder R, Compton CC, Ferrucci JT
Detection of hepatic metastases with MR imaging: spin-echo vs phase-contrast pulse sequences at 0.6 T.AJR Am J Roentgenol. 1989;153(6):1207-11 - PMID: 2683677 - DOI: 10.2214/ajr.153.6.1207
Rummeny E, Saini S, Wittenberg J, Compton C, Hahn PF, Mueller PR, Simeone JF, Stark DD, Weissleder R, Dousset MG
MR imaging of liver neoplasms.AJR Am J Roentgenol. 1989;152(3):493-9 - PMID: 2536996 - DOI: 10.2214/ajr.152.3.493
Weissleder R, Elizondo G, Stark DD, Hahn PF, Marfil J, Gonzalez JF, Saini S, Todd LE, Ferrucci JT
The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron oxide.AJR Am J Roentgenol. 1989;152(1):175-80 - PMID: 2783273 - DOI: 10.2214/ajr.152.1.175
Weissleder R, Stark DD, Engelstad BL, Bacon BR, Compton CC, White DL, Jacobs P, Lewis J
Superparamagnetic iron oxide: pharmacokinetics and toxicity.AJR Am J Roentgenol. 1989;152(1):167-73 - PMID: 2783272 - DOI: 10.2214/ajr.152.1.167
Rummeny E, Weissleder R, Stark DD, Saini S, Compton CC, Bennett W, Hahn PF, Wittenberg J, Malt RA, Ferrucci JT
Primary liver tumors: diagnosis by MR imaging.AJR Am J Roentgenol. 1989;152(1):63-72 - PMID: 2535770 - DOI: 10.2214/ajr.152.1.63
Wittenberg J, Stark DD, Forman BH, Hahn PF, Saini S, Weissleder R, Rummeny E, Ferrucci JT
Differentiation of hepatic metastases from hepatic hemangiomas and cysts by using MR imaging.AJR Am J Roentgenol. 1988;151(1):79-84 - PMID: 3259825 - DOI: 10.2214/ajr.151.1.79
Weissleder R, Saini S, Stark DD, Wittenberg J, Ferrucci JT
Dual-contrast MR imaging of liver cancer in rats.AJR Am J Roentgenol. 1988;150(3):561-6 - PMID: 3257610 - DOI: 10.2214/ajr.150.3.561
Hahn PF, Weissleder R, Stark DD, Saini S, Elizondo G, Ferrucci JT
MR imaging of focal splenic tumors.AJR Am J Roentgenol. 1988;150(4):823-7 - PMID: 3279735 - DOI: 10.2214/ajr.150.4.823
Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V.
Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomographyJ Biomed Opt. 2005;10(4):44019 - PMID: 16178652 - DOI: 10.1117/1.1993427
Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.J Biomed Opt. 2006;11(2):21009 - PMID: 16674184 - DOI: 10.1117/1.2186337
Bogdanov A, Wright SC, Marecos EM, Bogdanova A, Martin C, Petherick P, Weissleder R
A long-circulating co-polymer in "passive targeting" to solid tumors.J Drug Target. 1997;4(5):321-30 - PMID: 9169989 - DOI: 10.3109/10611869708995848
Papisov M, Weissleder R
Drug delivery to lymphatic tissue.Crit Rev Ther Drug Carrier Syst. 1996;13(1-2):57-84 - PMID: 8853959
Kelly KA, Reynolds F, Weissleder R, Josephson L
Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions.Anal Biochem. 2004;330(2):181-5 - PMID: 15203322 - DOI: 10.1016/j.ab.2004.02.035
Law B, Hsiao JK, Bugge TH, Weissleder R, Tung CH.
Optical zymography for specific detection of urokinase plasminogen activator activity in biological samplesAnal Biochem. 2005;338(1):151-158 - PMID: 15707946 - DOI: 10.1016/j.ab.2004.11.039
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R
PepBank - a database of peptides based on sequence text mining and public peptide data sources.BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427 - DOI: 10.1186/1471-2105-8-280
Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detectionJ Phys D Appl Phys. 2005;38:2701-2707
Bogdanov A, Petherick P, Marecos E, Weissleder R
In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation.Nucl Med Biol. 1997;24(8):739-42 - PMID: 9428599 - DOI: 10.1016/s0969-8051(97)00117-0
Ntziachristos V, Bremer C, Weissleder R
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imagingEur J Radiol. 2002;13:195-208 - PMID: 12541130 - DOI: 10.1007/s00330-002-1524-x
Bremer C, Ntziachristos V, Weissleder R
Optical-based molecular imaging: contrast agents and potential medical applicationsEur J Radiol. 2002;13:231-43 - PMID: 12598985 - DOI: 10.1007/s00330-002-1610-0
Iron oxide based magnetopharmaceuticals for MR imagingEur J Radiol. 1993;3:198-212
Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R
A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation.Urology. 2005;66(5):1066-71 - PMID: 16286125 - DOI: 10.1016/j.urology.2005.05.049
Simonova M, Weissleder R, Sergeyev N, Vilissova N, Bogdanov A Jr
Targeting of green fluorescent protein expression to the cell surfaceBiochem Bioph Res Co. 1999;262:638-42 - PMID: 10471377 - DOI: 10.1006/bbrc.1999.1251
Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V.
Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histologyCell Oncol. 2005;27(3):183-90 - PMID: 16037639 - PMCID: PMC4615174 - DOI: 10.1155/2005/791936
Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R
Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01
A practical approach for the preparation of monofunctional azulenyl squaraine dye.Tetrahedron Lett. 2003;44(20):3975-3978 - PMID: 20740053 - PMCID: PMC2926986 - DOI: 10.1016/S0040-4039(03)00819-0
Pham W, Weissleder R, Tung CH
Intermolecular [8+2] cycloaddition reactions of 2H-3-methoxycarbonylcyclohepta[b]furan-2-one with vinyl ethers: an approach to bicyclo[5.3.0]azulene derivatives.Tetrahedron Lett. 2002;43(1):19-20 - PMID: 20740048 - PMCID: PMC2926969 - DOI: 10.1016/S0040-4039(01)02061-5
Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticlesJ Immunol Methods. 2001;256:89-105 - PMID: 11516758 - DOI: 10.1016/s0022-1759(01)00433-1
Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A Jr
Engineering of technetium-99m-binding artificial receptors for imaging gene expressionJ Gene Med. 2003;5:1056-66 - PMID: 14661181 - DOI: 10.1002/jgm.448
Petersein J, Saini S, Weissleder R
Liver. II: Iron oxide-based reticuloendothelial contrast agents for MR imaging. Clinical review.Magn Reson Imaging. 1996;4(1):53-60 - PMID: 8673716
Bader A, Reimer P, Knop E, Boker K, Christians U, Weissleder R, Sewing KF
An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents.Magn Reson Imaging. 1996;13(7):991-1002 - PMID: 8583878 - DOI: 10.1016/0730-725x(95)00053-j
Schaffer BK, Linker C, Papisov M, Tsai E, Nossiff N, Shibata T, Bogdanov A, Brady TJ, Weissleder R
Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative studyTechnol Cancer Res T. 2002;1:489-95 - PMID: 12625776 - DOI: 10.1177/153303460200100609
Bogdanov AA Jr, Simonova M, Weissleder R
Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell trackingQ J Nucl Med Mol IM. 2000;44:224-35 - PMID: 11105587
Graves EE, Culver JP, Ripoll J, Weissleder R, Ntziachristos V
Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomographyJ Opt Soc Am A . 2004;21(2):231-41 - PMID: 14763766 - DOI: 10.1364/josaa.21.000231
Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF
[Development and experimental use of receptor-specific MR contrast media]Radiologe. 1996;36(2):153-63 - PMID: 8867433 - DOI: 10.1007/s001170050053
Rummeny E, Weissleder R, Stark DD, Elizondo G, Ferrucci JT
[Magnetic resonance tomography of focal liver and spleen lesions. Experiences using ferrite, a new RES-specific MR contrast medium]Radiologe. 1988;28(8):380-6 - PMID: 3174975
Weissleder R, Galarza D, Garza MA
Lupus nephritis: Classification, clinical features and treatmentRev Invest Clin. 1987;39:263-276
Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R.
Magnetic resonance signal amplification probesErnst Schering Res Found Workshop. 2005;49:147-57 - PMID: 15524215 - DOI: 10.1007/3-540-26809-x_8
Sosnovik D, Weissleder R
Magnetic resonance and fluorescence based molecular imaging technologies.Prog Drug Res. 2005;62:83-115 - PMID: 16329255 - DOI: 10.1007/3-7643-7426-8_3
Tsourkas A, Weissleder R
Illuminating the dynamics of intracellular activity with Mech Chem Biosyst. 2004;1:133-45 - PMID: 16783939
Mohr U, Weissleder R
[Lymph node diagnosis with imaging methods. An overview with special reference to recent developments in the area of MR contrast media]Z Lymphol. 1996;20(1):15-20 - PMID: 8768044
Frank H, Weissleder R, Papisov M
[Presentation and quantification of acute myocardial infarct using antibody-bound MR contrast medium]Z Kardiol. 1995;84(4):311-5 - PMID: 7785304
Weissleder R, Bogdanov A, Papisov M
Drug targeting in magnetic resonance imaging.Magn Reson Q. 1992;8(1):55-63 - PMID: 1567758
Josephson L, Groman E, Weissleder R
Contrast agents for magnetic resonance imaging of the liver.Targeted Diagn Ther. 1992;4:163-87 - PMID: 1797156
Weissleder R, Stark DD
Magnetic resonance imaging of the liver.Magn Reson Q. 1989;5(2):97-121 - PMID: 2701280
Riojas GE, Weissleder R, Gonzalez HG, Miguel MC, Riojas AE, Morantes JG, Perez LET
Physical principles of magnetic resonance imagingRev Mex Radiol. 1989;43:3-12
Contag C, Weissleder R, Bachmann M, Fraser S
Appllications of In Vivo Molecular Imaging in Biology and MedicineNeoreviews. 2000;1:233-240
Contag C, Fraser S, Weissleder, R
Strategies in in vivo molecular imagingNeoreviews. 2000;1:225-232