MGH Center for Systems Biology

Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L

Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities

Angew Chem Int Ed Engl. 2004;43(18):2395-2399 - PMID: 15114571 - DOI: 10.1002/anie.200352998

Koh I, Hong R, Weissleder R, Josephson L

Sensitive NMR Sensors Detect Antibodies to Influenza.

Angew Chem Int Ed Engl. 2008;47(22):4119-4121 - PMID: 18428168 - PMCID: PMC2668198 - DOI: 10.1002/anie.200800069

Lee H*, Yoon TJ*, Weissleder R

Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.

Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791

Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R

Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition.

Angew Chem Int Ed Engl. 2009;48(38):7013-6 - PMID: 19697389 - PMCID: PMC2790075 - DOI: 10.1002/anie.200903233

Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.

Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120

Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R

Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method.

Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579

Yoon TJ*, Lee H*, Shao H, Weissleder R

Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.

Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101

Budin G, Yang KS, Reiner T, Weissleder R

Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification.

Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273

Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R

Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.

Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670

Karver MR, Weissleder R, Hilderbrand SA

Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging.

Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389

Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H

Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors.

Angew Chem Int Ed Engl. 2004;43(2):224-8 - PMID: 14695616 - DOI: 10.1002/anie.200352582

Huwe A, Mazitschek R, Giannis A

Small molecules as inhibitors of cyclin-dependent kinases.

Angew Chem Int Ed Engl. 2003;42(19):2122-38 - PMID: 12761741 - DOI: 10.1002/anie.200200540

Stahl P, Kissau L, Mazitschek R, Giannis A, Waldmann H

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors.

Angew Chem Int Ed Engl. 2002;41(7):1174-8 - PMID: 12491250 - DOI: 10.1002/1521-3773(20020402)41:7<1174::aid-anie1174>3.0.co;2-v

Stieber F, Mazitschek R, Soric N, Giannis A, Waldmann H

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.

Angew Chem Int Ed Engl. 2002;41(24):4757-61 - PMID: 12481350 - DOI: 10.1002/anie.200290040

Mazitschek R, Mülbaier M, Giannis A

IBX-mediated oxidation of primary alcohols and aldehydes to form carboxylic acids.

Angew Chem Int Ed Engl. 2002;41(21):4059-61 - PMID: 12412081 - DOI: 10.1002/1521-3773(20021104)41:21<4059::AID-ANIE4059>3.0.CO;2-R

Baumhof P, Mazitschek R, Giannis A

A Mild and Effective Method for the Transesterification of Carboxylic Acid Esters P.B. and R.M. are grateful to the Land Baden-Württemberg for a scholarship from the Landesgraduiertenförderung.

Angew Chem Int Ed Engl. 2001;40(19):3672-3674 - PMID: 11592218 - DOI: 10.1002/1521-3773(20011001)40:19<3672::aid-anie3672>3.0.co;2-y

Wernert N, Stanjek A, Kiriakidis S, Hügel A, Jha HC, Mazitschek R, Giannis A

Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin.

Angew Chem Int Ed Engl. 1999;38(21):3228-3231 - PMID: 10556911 - DOI: 10.1002/(sici)1521-3773(19991102)38:21<3228::aid-anie3228>3.0.co;2-8

Hendricks JA, Keliher EJ, Wan D, Hilderbrand SA, Weissleder R, Mazitschek R

Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.

Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957

Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R

Bioorthogonal Imaging of Aurora Kinase A in Live Cells.

Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994

Budin G*, Chung HJ*, Lee H, Weissleder R

A Magnetic Gram Stain for Bacterial Detection.

Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982

Carlson JC, Meimetis LG, Hilderbrand SA, Weissleder R

BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes.

Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100

Yang* KS, Budin* G, Tassa C, Kister O, Weissleder R

Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells

Angew Chem Int Ed Engl. 2013;52(40):10593-7 - PMID: 23960025 - PMCID: PMC3856564 - DOI: 10.1002/anie.201304096

Josephson L, Perez JM, Weissleder R

Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.

Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H

Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB

Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis.

Mol Cell. 2009;36(4):682-95 - PMID: 19941827 - PMCID: PMC2800995 - DOI: 10.1016/j.molcel.2009.11.002

Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals.

Mol Cell. 2012;47(5):810-22 - PMID: 22940246 - PMCID: PMC3873101 - DOI: 10.1016/j.molcel.2012.07.030

Harisinghani MG, Weissleder R

Sensitive, noninvasive detection of lymph node metastases.

PLoS Med. 2004;1(3):e66 - PMID: 15630471 - PMCID: PMC539052 - DOI: 10.1371/journal.pmed.0010066

Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R

Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.

PLoS Med. 2008;5(4):e85 - PMID: 18416599 - PMCID: PMC2292750 - DOI: 10.1371/journal.pmed.0050085

Condeelis J, Weissleder R

In Vivo Imaging in Cancer.

Cold Spring Harb Perspect Biol. 2010;2(12):a003848 - PMID: 20861158 - PMCID: PMC2982169 - DOI: 10.1101/cshperspect.a003848

Ozsolak F, Goren A, Gymrek MA, Guttman M, Regev A, Bernstein BE, Milos PM

Digital transcriptome profiling from attomole-level RNA samples.

Genome Res. 2010;20(4):519-25 - PMID: 20133332 - PMCID: PMC2847755 - DOI: 10.1101/gr.102129.109

Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, Desalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

Genome Res. 2012;22(9):1813-31 - PMID: 22955991 - PMCID: PMC3431496 - DOI: 10.1101/gr.136184.111

Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R

Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media

J Am Chem Soc. 2003;125:10192-3 - PMID: 12926940 - DOI: 10.1021/ja036409g

Perez JM, O'Loughin T, Simeone F J, Weissleder R, Josephson L

DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents

J Am Chem Soc. 2002;124:2856-7 - PMID: 11902860 - DOI: 10.1021/ja017773n

E.C. Wiener, F.P. Auteri, J.W. Chen, M.W. Brechbiel, O.A. Gansow, D.J. Schneider, R.L. Belford, R.B. Clarkson, P.C. Lauterbur

Molecular Dynamics of Ion-Chelate Complexes Attached to Starburst(TM) Dendrimers

J Am Chem Soc. 1996;118:7774-7782

Hilderbrand S, Lim M, Lippard S

Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors.

J Am Chem Soc. 2004;126:4972-8 - PMID: 15080703 - DOI: 10.1021/ja038471j

Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA

Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation.

J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134 - DOI: 10.1021/ja903922u

Rodriguez E, Nilges M, Weissleder R, Chen JW

Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.

J Am Chem Soc. 2010;132(1):168-77 - PMID: 19968300 - PMCID: PMC2802665 - DOI: 10.1021/ja905274f

Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG

Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine-Norbornene Cycloaddition.

J Am Chem Soc. 2010;132(23):7838-9 - PMID: 20481508 - PMCID: PMC2892974 - DOI: 10.1021/ja101677r

Brueckner C, Gotz DC, Fox SP, Ryppa C, McCarthy JR, Bruhn T, Akhigbe J, Banerjee S, Daddario P, Daniell HW, Zeller M, Boyle R, Bringmann G

Helimeric Porphyrinoids: Stereostructure and Chiral Resolution of meso-Tetraarylmorpholinochlorins.

J Am Chem Soc. 2011;133(22):8740-8752 - PMID: 21534626 - DOI: 10.1021/ja202451t

Stahl P, Kissau L, Mazitschek R, Huwe A, Furet P, Giannis A, Waldmann H

Total synthesis and biological evaluation of the nakijiquinones.

J Am Chem Soc. 2001;123(47):11586-93 - PMID: 11716712 - DOI: 10.1021/ja011413i

Niers JM*, Chen JW*, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA

Single Reporter for Targeted Multimodal in Vivo Imaging.

J Am Chem Soc. 2012;134(11):5149-56 - PMID: 22397453 - PMCID: PMC3310895 - DOI: 10.1021/ja209868g

Agasti SS, Liong M, Peterson VM, Lee H, Weissleder R

Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell.

J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w

Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J

Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator.

J Am Chem Soc. 2011;133(27):10368-71 - PMID: 21671557 - PMCID: PMC3165005 - DOI: 10.1021/ja2036628

Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J

Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.

J Am Chem Soc. 2012;135(5):1645-8 - PMID: 23157326 - PMCID: PMC3566300 - DOI: 10.1021/ja307866z

Syeda R, Holden MA, Hwang WL, Bayley H

Screening blockers against a potassium channel with a droplet interface bilayer array.

J Am Chem Soc. 2008;130(46):15543-8 - PMID: 18950170 - DOI: 10.1021/ja804968g

Hwang WL, Chen M, Cronin B, Holden MA, Bayley H

Asymmetric droplet interface bilayers.

J Am Chem Soc. 2008;130(18):5878-9 - PMID: 18407631 - DOI: 10.1021/ja802089s

Hwang WL, Holden MA, White S, Bayley H

Electrical behavior of droplet interface bilayer networks: experimental analysis and modeling.

J Am Chem Soc. 2007;129(38):11854-64 - PMID: 17764183 - DOI: 10.1021/ja074071a

Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC

Identification of the target self-antigens in reperfusion injury.

J Exp Med. 2006;203(1):141-152 - PMID: 16390934 - PMCID: PMC2118091 - DOI: 10.1084/jem.20050390

Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk

J Exp Med. 2007;204:1911-1922 - PMID: 17646407 - PMCID: PMC2118664 - DOI: 10.1084/jem.20070285

Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.

J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885

Zippelius A, Pittet M, Batard P, Rufer N, de Smedt M, Guillaume P, Ellefsen K, Valmori D, Lienard D, Plum J, MacDonald H, Speiser D, Cerottini J, Romero P

Thymic selection generates a large T cell pool recognizing a self-peptide in humans.

J Exp Med. 2002;195:485-94 - PMID: 11854361 - PMCID: PMC2193620 - DOI: 10.1084/jem.20011658