Imaging in the era of molecular oncology
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
HDAC2 negatively regulates memory formation and synaptic plasticity.
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.
Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149
Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140
Epigenetic memory in induced pluripotent stem cells.
Initial genome sequencing and analysis of multiple myeloma.
Mapping and analysis of chromatin state dynamics in nine human cell types.
In vivo imaging of T(reg) cells providing immune privilege to the haematopoietic stem-cell niche.
Myocardial infarction accelerates atherosclerosis
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
An integrated encyclopedia of DNA elements in the human genome.
Charting a dynamic DNA methylation landscape of the human genome.
Dedifferentiation of committed epithelial cells into stem cells in vivo.
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.
Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Dissecting direct reprogramming through integrative genomic analysis.
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.
Nat Mater. 2006;5(2):118-22 - PMID: 16444262 - DOI: 10.1038/nmat1571
Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303 - DOI: 10.1038/nrd1007
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
Cell-surface sensors for real-time probing of cellular environments.
Nat Nanotechnol. 2011;6(8):524-31 - PMID: 21765401 - PMCID: PMC3163485 - DOI: 10.1038/nnano.2011.101
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.
A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria
A dielectric-modulated field-effect transistor for biosensing.
Nat Nanotechnol. 2007;2(7):430-4 - PMID: 18654328 - DOI: 10.1038/nnano.2007.180
Molecular Imaging in Cancer
Science. 2006;312:1168-1171 - PMID: 16728630 - DOI: 10.1126/science.1125949
Knotting of a DNA chain during ring closure.
Science. 1993;260(5107):533-6 - PMID: 8475384 - DOI: 10.1126/science.8475384
Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response.
Science. 2009;324(5932):1334-1338 - PMID: 19498172 - PMCID: PMC2803727 - DOI: 10.1126/science.1172638
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
Developmental biology. Pluripotent chromatin state.
Optical coherence tomography.
Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses.
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
The structure of haplotype blocks in the human genome.
Science. 2002;296(5576):2225-9 - PMID: 12029063 - DOI: 10.1126/science.1069424
Innate Response Activator B Cells Protect Against Microbial Sepsis
Molecular biology. Genetic events that shape the cancer epigenome.
Science. 2012;336(6088):1513-4 - PMID: 22723401 - DOI: 10.1126/science.1223730
Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.
Epigenetic reprogramming in cancer.
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications.
Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization.
Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles.
Self-assembled plasmonic nanoring cavity arrays for SERS and LSPR biosensing.
Adv Mater. 2013;25(19):2678-85 - PMID: 23436239 - DOI: 10.1002/adma.201204283
Molecular Imaging in the Clinical Arena
JAMA. 2005;293(7):855-62 - PMID: 15713776 - DOI: 10.1001/jama.293.7.855
Diagnostic Accuracy of Fractional Flow Reserve From Anatomic CT Angiography.
Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer.
Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558