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Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.
N Engl J Med. 2014;371(26):2488-2498 - PMID: 25426837 - PMCID: PMC4306669 - DOI: 10.1056/NEJMoa1408617

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149

Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES

Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140

Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D

The structure of haplotype blocks in the human genome.
Science. 2002;296(5576):2225-9 - PMID: 12029063 - DOI: 10.1126/science.1069424

Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D

Human genome sequence variation and the influence of gene history, mutation and recombination.
Nat Genet. 2002;32(1):135-42 - PMID: 12161752 - DOI: 10.1038/ng947

Higgins JM, Sloan SR

Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.
Blood. 2008;112(6):2546-53 - PMID: 18535200 - DOI: 10.1182/blood-2008-03-146415

Higgins JM, Sloan SR

Response: Other factors may contribute to differences between sickle cell and non-sickle cell patients.
Blood. 2010;115(21):4315-6 - PMID: 20508172

Malka R, Nathan DM, Higgins JM

Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring
Sci Transl Med. 2016;8:359ra130 - PMID: 27708063 - PMCID: PMC5714656 - DOI: 10.1126/scitranslmed.aaf9304

Wood DK, Soriano A, Mahadevan L, Higgins JM, Bhatia SN

A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease.
Sci Transl Med. 2012;4(123):123ra26 - PMID: 22378926 - PMCID: PMC3633235 - DOI: 10.1126/scitranslmed.3002738

Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
J Exp Med. 2012;209(1):123-37 - PMID: 22213805 - PMCID: PMC3260875 - DOI: 10.1084/jem.20111009

Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR

Measuring single-cell density.
Proc Natl Acad Sci U S A. 2011;108(27):10992-10996 - PMID: 21690360 - PMCID: PMC3131325 - DOI: 10.1073/pnas.1104651108

Di Caprio G, Stokes C, Higgins JM, Schonbrun E

Single-cell measurement of red blood cell oxygen affinity.
Proc Natl Acad Sci U S A. 2015;112(32):9984-9 - PMID: 26216973 - PMCID: PMC4538663 - DOI: 10.1073/pnas.1509252112

Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT

Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.
Proc Natl Acad Sci U S A. 2016;113(34):9527-32 - PMID: 27512047 - PMCID: PMC5003247 - DOI: 10.1073/pnas.1610435113

Chaudhury A, Noiret L, Higgins JM

White blood cell population dynamics for risk stratification of acute coronary syndrome.
Proc Natl Acad Sci U S A. 2017;114(46):12344-12349 - PMID: 29087321 - PMCID: PMC5699055 - DOI: 10.1073/pnas.1709228114

Higgins JM, Mahadevan L

Physiological and pathological population dynamics of circulating human red blood cells.
Proc Natl Acad Sci U S A. 2010;107(47):20587-92 - PMID: 21059904 - PMCID: PMC2996693 - DOI: 10.1073/pnas.1012747107

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L

Sickle cell vasoocclusion and rescue in a microfluidic device.
Proc Natl Acad Sci U S A. 2007;104(51):20496-500 - PMID: 18077341 - PMCID: PMC2154459 - DOI: 10.1073/pnas.0707122105

Golub MS, Hogrefe CE, Malka R, Higgins JM

Developmental Plasticity of red blood cell homeostasis.
Am J Hematol. 2014;89(5):459-66 - PMID: 24415575 - PMCID: PMC4086753 - DOI: 10.1002/ajh.23666

Lu X, Chaudhury A, Higgins JM, Wood DK

Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments.
Am J Hematol. 2018;93(10):1227-1235 - PMID: 30033564 - PMCID: PMC6604607 - DOI: 10.1002/ajh.25227

Patel H, Patel H, Higgins JM

Modulation of Red Blood Cell Population Dynamics is a Fundamental Homeostatic Response to Disease.
Am J Hematol. 2015;90(5):422-8 - PMID: 25691355 - PMCID: PMC4717489 - DOI: 10.1002/ajh.23982

Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG

Hereditary xerocytosis revisited.
Am J Hematol. 2014;89(12):1142-1146 - PMID: 25044010 - PMCID: PMC4237618 - DOI: 10.1002/ajh.23799

Byun H, Hillman TR, Higgins JM, Diez-Silva M, Peng Z, Dao M, Dasari RR, Suresh S, Park Y

Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient.
Acta Biomater. 2012;8(11):4130-8 - PMID: 22820310 - PMCID: PMC3576574 - DOI: 10.1016/j.actbio.2012.07.011

Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J

Propranolol and the risk of hospitalized myopathy: Translating chemical genomics findings into population-level hypotheses.
Am Heart J. 2010;159(3):428-433 - PMID: 20211305 - DOI: 10.1016/j.ahj.2009.12.008

Malka R, Delgado FF, Manalis SR, Higgins JM

In Vivo Volume and Hemoglobin Dynamics of Human Red Blood Cells.
PLoS Comput Biol. 2014;10(10):e1003839 - PMID: 25299941 - PMCID: PMC4191880 - DOI: 10.1371/journal.pcbi.1003839

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L

Statistical dynamics of flowing red blood cells by morphological image processing.
PLoS Comput Biol. 2009;5(2):e1000288 - PMID: 19214200 - PMCID: PMC2631282 - DOI: 10.1371/journal.pcbi.1000288

Feijó Delgado F, Cermak N, Hecht VC, Son S, Li Y, Knudsen SM, Olcum S, Higgins JM, Chen J, Grover WH, Manalis SR

Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells.
PLoS ONE. 2013;8(7):e67590 - PMID: 23844039 - PMCID: PMC3699654 - DOI: 10.1371/journal.pone.0067590

Schonbrun E, Malka R, Di Caprio G, Schaak D, Higgins JM

Quantitative absorption cytometry for measuring red blood cell hemoglobin mass and volume.
Cytometry A. 2014;85(4):332-8 - PMID: 24677669 - PMCID: PMC4717472 - DOI: 10.1002/cyto.a.22450

Lu X, Wood DK, Higgins JM

Deoxygenation Reduces Sickle Cell Blood Flow at Arterial Oxygen Tension.
Biophys J. 2016;110(12):2751-8 - PMID: 27332133 - PMCID: PMC4919586 - DOI: 10.1016/j.bpj.2016.04.050

Noiret L, Slater A, Higgins JM

Determinants of red blood cell alloantibody detection duration: analysis of multiply alloimmunized patients supports peritransfusion factors.
Transfusion. 2017;57(8):1930-1937 - PMID: 28639314 - DOI: 10.1111/trf.14157

Kim Y, Higgins JM, Dasari RR, Suresh S, Park Y

Anisotropic light scattering of individual sickle red blood cells.
J Biomed Opt. 2012;17(4):040501 - PMID: 22559667 - PMCID: PMC3602817 - DOI: 10.1117/1.JBO.17.4.040501

Louis DN, Gerber GK, Baron JM, Bry L, Dighe AS, Getz G, Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, Golden JA

Computational pathology: an emerging definition.
Arch Pathol Lab Med. 2014;138(9):1133-8 - PMID: 25171694 - DOI: 10.5858/arpa.2014-0034-ED

Lu X, Galarneau MM, Higgins JM, Wood DK

A microfluidic platform to study the effects of vascular architecture and oxygen gradients on sickle blood flow.
Microcirculation. 2017;24(5):ePub - PMID: 28129479 - PMCID: PMC5505799 - DOI: 10.1111/micc.12357

Huck A, Pozdnyakova O, Brunner A, Higgins JM, Fathi AT, Hasserjian RP

Prior cytopenia predicts worse clinical outcome in acute myeloid leukemia.
Leuk Res. 2015;39(10):1034-40 - PMID: 26220865 - PMCID: PMC5764101 - DOI: 10.1016/j.leukres.2015.06.012

Baron JM, Higgins JM, Dzik WH

A Revised Timeline for the Origin of Plasmodium falciparum as a Human Pathogen.
J Mol Evol. 2011;73(5-6):297-304 - PMID: 22183792 - DOI: 10.1007/s00239-011-9476-x

Higgins JM

Red Blood Cell Population Dynamics.
Clin Lab Med. 2014;35(1):43-57 - PMID: 25676371 - PMCID: PMC4717490 - DOI: 10.1016/j.cll.2014.10.002

Baron JM, Dighe AS, Arnaout R, Balis UJ, Black-Schaffer WS, Carter AB, Henricks WH, Higgins JM, Jackson BR, Kim J, Klepeis VE, Le LP, Louis DN, Mandelker D, Mermel CH, Michaelson JS, Nagarajan R, Platt ME, Quinn AM, Rao L, Shirts BH, Gilbertson JR

The 2013 symposium on pathology data integration and clinical decision support and the current state of field.
J Pathol Inform. 2014;5:2 - PMID: 24672737 - PMCID: PMC3952400 - DOI: 10.4103/2153-3539.126145
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