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Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.
N Engl J Med. 2014;371(26):2488-2498 - PMID: 25426837 - PMCID: PMC4306669 - DOI: 10.1056/NEJMoa1408617

Foy BH, Petherbridge R, Roth MT, Zhang C, De Souza DC, Mow C, Patel HR, Patel CH, Ho SN, Lam E, Powe CE, Hasserjian RP, Karczewski KJ, Tozzo V, Higgins JM

Haematological setpoints are a stable and patient-specific deep phenotype.
Nature. 2024;637(8045):430-438 - PMID: 39663453 - PMCID: PMC12085991 - DOI: 10.1038/s41586-024-08264-5

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149

Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES

Detecting recent positive selection in the human genome from haplotype structure.
Nature. 2002;419(6909):832-7 - PMID: 12397357 - DOI: 10.1038/nature01140

Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D

The structure of haplotype blocks in the human genome.
Science. 2002;296(5576):2225-9 - PMID: 12029063 - DOI: 10.1126/science.1069424

Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D

Human genome sequence variation and the influence of gene history, mutation and recombination.
Nat Genet. 2002;32(1):135-42 - PMID: 12161752 - DOI: 10.1038/ng947

Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M

B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.
Nat Immunol. 2022;23(4):605-618 - PMID: 35352063 - PMCID: PMC8989652 - DOI: 10.1038/s41590-022-01165-7

Higgins JM, Sloan SR

Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.
Blood. 2008;112(6):2546-53 - PMID: 18535200 - DOI: 10.1182/blood-2008-03-146415

Miller P, Fell G, Foy B, Scherer A, Gibson CJ, Sperling AS, Burugula BB, Nakao T, Uddin MM, Warren H, Bry L, Pozdnyakova O, Frigault MJ, Bick AG, Neuberg D, Higgins JM, Mansour M, Natarajan P, Kim AS, Kitzman J, Ebert BL

Clonal Hematopoiesis of Indeterminate Potential and Risk of Death from COVID-19.
Blood. 2022;140(18):1993-1997 - PMID: 36096050 - PMCID: PMC9474399 - DOI: 10.1182/blood.2022018052

Higgins JM, Sloan SR

Response: Other factors may contribute to differences between sickle cell and non-sickle cell patients.
Blood. 2010;115(21):4315-6 - PMID: 20508172

Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M

Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction.
J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - PMCID: PMC7254576 - DOI: 10.1016/j.jacc.2019.12.056

Malka R, Nathan DM, Higgins JM

Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring
Sci Transl Med. 2016;8:359ra130 - PMID: 27708063 - PMCID: PMC5714656 - DOI: 10.1126/scitranslmed.aaf9304

Wood DK, Soriano A, Mahadevan L, Higgins JM, Bhatia SN

A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease.
Sci Transl Med. 2012;4(123):123ra26 - PMID: 22378926 - PMCID: PMC3633235 - DOI: 10.1126/scitranslmed.3002738

Tozzo V, Genco M, Omololu SO, Mow C, Patel HR, Patel CH, Ho SN, Lam E, Abdulsater B, Patel N, Cohen RM, Nathan DM, Powe CE, Wexler DJ, Higgins JM

Estimating Glycemia From HbA1c and CGM: Analysis of Accuracy and Sources of Discrepancy.
Diabetes Care. 2024;47(3):460-466 - PMID: 38394636 - PMCID: PMC10909686 - DOI: 10.2337/dc23-1177

Patel NJ, Tozzo V, Higgins JM, Stone JH

The effects of daily prednisone and tocilizumab on hemoglobin A1c during the treatment of giant cell arteritis.
Arthritis Rheumatol. 2022;75(4):586-594 - PMID: 36383175 - DOI: 10.1002/art.42405

Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM

Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2

De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
Nat Commun. 2023;14(1):5850 - PMID: 37730674 - PMCID: PMC10511721 - DOI: 10.1038/s41467-023-40923-5

Foy BH, Carlson JCT, Aguirre AD, Higgins JM

Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.
Nat Commun. 2025;16(1):1113 - PMID: 39875373 - PMCID: PMC11775293 - DOI: 10.1038/s41467-025-56251-9

Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
J Exp Med. 2012;209(1):123-37 - PMID: 22213805 - PMCID: PMC3260875 - DOI: 10.1084/jem.20111009

Szafraniec HM, Bull F, Higgins JM, Stone HA, Krüger T, Pearce P, Wood DK

Suspension physics govern the multiscale dynamics of blood flow in sickle cell disease.
Sci Adv. 2026;12(1):eadx3842 - PMID: 41477838 - PMCID: PMC12757044 - DOI: 10.1126/sciadv.adx3842

Foy BH, Gonçalves BP, Higgins JM

Unraveling Disease Pathophysiology with Mathematical Modeling.
Annu Rev Pathol. 2020;15:371-394 - PMID: 31977295 - DOI: 10.1146/annurev-pathmechdis-012419-032557

Qiang Y, Sissoko A, Liu ZL, Dong T, Zheng F, Kong F, Higgins JM, Karniadakis GE, Buffet PA, Suresh S, Dao M

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease.
Proc Natl Acad Sci U S A. 2023;120(6):e2217607120 - PMID: 36730189 - PMCID: PMC9963977 - DOI: 10.1073/pnas.2217607120

Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR

Measuring single-cell density.
Proc Natl Acad Sci U S A. 2011;108(27):10992-10996 - PMID: 21690360 - PMCID: PMC3131325 - DOI: 10.1073/pnas.1104651108

Higgins JM, Mahadevan L

Physiological and pathological population dynamics of circulating human red blood cells.
Proc Natl Acad Sci U S A. 2010;107(47):20587-92 - PMID: 21059904 - PMCID: PMC2996693 - DOI: 10.1073/pnas.1012747107

Di Caprio G, Stokes C, Higgins JM, Schonbrun E

Single-cell measurement of red blood cell oxygen affinity.
Proc Natl Acad Sci U S A. 2015;112(32):9984-9 - PMID: 26216973 - PMCID: PMC4538663 - DOI: 10.1073/pnas.1509252112

Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT

Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.
Proc Natl Acad Sci U S A. 2016;113(34):9527-32 - PMID: 27512047 - PMCID: PMC5003247 - DOI: 10.1073/pnas.1610435113

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L

Sickle cell vasoocclusion and rescue in a microfluidic device.
Proc Natl Acad Sci U S A. 2007;104(51):20496-500 - PMID: 18077341 - PMCID: PMC2154459 - DOI: 10.1073/pnas.0707122105

Di Caprio G*, Schonbrun E*, Gonçalves BP, Valdez JM, Wood DK, Higgins JM

High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension.
Proc Natl Acad Sci U S A. 2019;116(50):25236-25242 - PMID: 31767751 - PMCID: PMC6911208 - DOI: 10.1073/pnas.1914056116

Chaudhury A, Noiret L, Higgins JM

White blood cell population dynamics for risk stratification of acute coronary syndrome.
Proc Natl Acad Sci U S A. 2017;114(46):12344-12349 - PMID: 29087321 - PMCID: PMC5699055 - DOI: 10.1073/pnas.1709228114

Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto I, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M

Neutrophils incite and macrophages avert electrical storm after myocardial infarction
Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w

Geisness AC, Azul M, Williams D, Szafraniec H, De Souza DC, Higgins JM, Wood DK

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease.
Haematologica. 2021;107(6):1438-1447 - PMID: 34706495 - PMCID: PMC9152977 - DOI: 10.3324/haematol.2021.278666

Chaudhury A, Miller GD, Eichner D, Higgins JM

Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss.
eLife. 2019;8:ePub - PMID: 31845889 - PMCID: PMC6917488 - DOI: 10.7554/eLife.48590

Malka R, Brugnara C, Cialic R, Higgins JM

Non-Parametric Combined Reference Regions and Prediction of Clinical Risk.
Clin Chem. 2020;66(2):363-372 - PMID: 32040586 - PMCID: PMC7055670 - DOI: 10.1093/clinchem/hvz020

Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Gonçalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR

MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.
Blood Adv. 2021;5(5):1388-1402 - PMID: 33661300 - PMCID: PMC7948285 - DOI: 10.1182/bloodadvances.2020003670

Foy B, Stefely J, Bendapudi PK, Hasserjian RP, Al-Samkari H, Louissaint A, Fitzpatrick M, Hutchison B, Mow C, Collins J, Patel H, Patel C, Patel N, Ho S, Kaufman RM, Dzik W', Higgins JM, Makar RS

Computer vision quantitation of erythrocyte shape abnormalities provides diagnostic, prognostic, and mechanistic insight.
Blood Adv. 2023;7(16):4621-4630 - PMID: 37146262 - PMCID: PMC10448422 - DOI: 10.1182/bloodadvances.2022008967

Szafraniec HM, Valdez JM, Iffrig E, Lam WA, Higgins JM, Pearce P, Wood DK

Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.
Lab Chip. 2022;22(8):1565-1575 - PMID: 35315465 - PMCID: PMC9004467 - DOI: 10.1039/d1lc01133b

Truslow JG, Goto S, Homilius M, Mow C, Higgins JM, MacRae CA, Deo RC

Cardiovascular Risk Assessment Using Artificial Intelligence-Enabled Event Adjudication and Hematologic Predictors.
Circ Cardiovasc Qual Outcomes. 2022;15(6):e008007 - PMID: 35477255 - PMCID: PMC9208816 - DOI: 10.1161/CIRCOUTCOMES.121.008007

Edelson PK, James KE, Leong A, Arenas J, Cayford M, Callahan MJ, Bernstein SN, Tangren JS, Hivert MF, Higgins JM, Nathan DM, Powe CE

Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum.
J Clin Endocrinol Metab. 2020;105(5):e1999-2007 - PMID: 32010954 - PMCID: PMC7236626 - DOI: 10.1210/clinem/dgaa053

Cohen RM, Franco RS, Smith EP, Higgins JM

When the A1c and the blood glucose don't match: how much is determined by race, by genetics, by differences in mean red blood cell age?
J Clin Endocrinol Metab. 2019;104(3):707-710 - PMID: 30445523 - DOI: 10.1210/jc.2018-02409

Powe CE, James K, Higgins JM

Response to Letter to the Editor from Marie Monlun: "Longitudinal changes in the relationship between Hemoglobin A1c and glucose tolerance across pregnancy and post-partum".
J Clin Endocrinol Metab. 2021;106(1):e401-e402 - PMID: 32589732 - PMCID: PMC7765642 - DOI: 10.1210/clinem/dgaa402

Valdez JM, Datta YH, Higgins JM, Wood DK

A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood.
APL Bioeng. 2019;3(4):046102 - PMID: 31803859 - PMCID: PMC6881198 - DOI: 10.1063/1.5118212

Golub MS, Hogrefe CE, Malka R, Higgins JM

Developmental Plasticity of red blood cell homeostasis.
Am J Hematol. 2014;89(5):459-66 - PMID: 24415575 - PMCID: PMC4086753 - DOI: 10.1002/ajh.23666

Lu X, Chaudhury A, Higgins JM, Wood DK

Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments.
Am J Hematol. 2018;93(10):1227-1235 - PMID: 30033564 - PMCID: PMC6604607 - DOI: 10.1002/ajh.25227

Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG

Hereditary xerocytosis revisited.
Am J Hematol. 2014;89(12):1142-1146 - PMID: 25044010 - PMCID: PMC4237618 - DOI: 10.1002/ajh.23799

Foy BH, Li A, McClung J, Ranganath R, Higgins JM

Data-driven physiologic thresholds for iron deficiency associated with hematologic decline.
Am J Hematol. 2019;95(3):302-309 - PMID: 31849101 - DOI: 10.1002/ajh.25706

Patel H, Patel H, Higgins JM

Modulation of Red Blood Cell Population Dynamics is a Fundamental Homeostatic Response to Disease.
Am J Hematol. 2015;90(5):422-8 - PMID: 25691355 - PMCID: PMC4717489 - DOI: 10.1002/ajh.23982

Byun H, Hillman TR, Higgins JM, Diez-Silva M, Peng Z, Dao M, Dasari RR, Suresh S, Park Y

Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient.
Acta Biomater. 2012;8(11):4130-8 - PMID: 22820310 - PMCID: PMC3576574 - DOI: 10.1016/j.actbio.2012.07.011

Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J

Propranolol and the risk of hospitalized myopathy: Translating chemical genomics findings into population-level hypotheses.
Am Heart J. 2010;159(3):428-433 - PMID: 20211305 - DOI: 10.1016/j.ahj.2009.12.008

Tozzo V, Nathan DM, Krause-Steinrauf H, Lachin JM, Mow C, Butera N, Cohen RM, Higgins JM, GRADE Research Group

Differences Between Glycemia Estimates from Hemoglobin A1c and Continuous Glucose Monitoring and Their Association with Complete Blood Counts.
Diabetes Technol Ther. 2025;28(5):490-500 - PMID: 41439332 - PMCID: PMC12970290 - DOI: 10.1177/15209156251395036

Larkin M, Nathan DM, Bebu I, Krause-Steinrauf H, Herman WH, Higgins JM, Tiktin M, Cohen RM, Lund C, Bergenstal RM, Johnson M, Arends V, Research Group G

Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring.
Diabetes Technol Ther. 2019;21(12):682-690 - PMID: 31393176 - PMCID: PMC7207016 - DOI: 10.1089/dia.2019.0202
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